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American Journal of Clinical Dermatology

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01.08.2017 | Systematic Review

Topical Botanical Agents for the Treatment of Psoriasis: A Systematic Review

verfasst von: Benjamin Farahnik, Divya Sharma, Joseph Alban, Raja K. Sivamani

Erschienen in: American Journal of Clinical Dermatology | Ausgabe 4/2017

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Abstract

Background

Patients with psoriasis often enquire about the use of numerous botanical therapeutics. It is important for dermatologists to be aware of the current evidence regarding these agents.

Methods

We conducted a systematic literature search using the PubMed, MEDLINE, and EMBASE databases for controlled and uncontrolled clinical trials that assessed the use of topical botanical therapeutics for psoriasis. The search included the following keywords: ‘psoriasis’ and ‘plant’ or ‘herbal’ or ‘botanical’. We also reviewed citations within articles to identify additional relevant sources. We then further refined the results by route of administration and the topical botanical agents are reviewed herein.

Results

A total of 27 controlled and uncontrolled clinical trials addressing the use of topical botanical agents for psoriasis were assessed in this review. We found that the most highly studied and most efficacious topical botanical therapeutics were Mahonia aquifolium, indigo naturalis, aloe vera, and, to a lesser degree, capsaicin. The most commonly reported adverse effects were local skin irritation, erythema, pruritus, burning, and pain. However, the overall evidence for these therapeutics remains limited in quantity and quality.

Conclusion

The literature addresses a large number of studies in regard to botanicals for the treatment of psoriasis. While most agents appear to be safe, further research is necessary before topical botanical agents can be consistently recommended to patients.

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Titel: Topical Botanical Agents for the Treatment of Psoriasis: A Systematic Review
verfasst von: Benjamin Farahnik
Divya Sharma
Joseph Alban
Raja K. Sivamani
Publikationsdatum: 01.08.2017
Verlag: Springer International Publishing
Erschienen in: American Journal of Clinical Dermatology / Ausgabe 4/2017
Print ISSN: 1175-0561
Elektronische ISSN: 1179-1888
DOI: https://doi.org/10.1007/s40257-017-0266-0

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