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Erschienen in: Der Orthopäde 8/2012

01.08.2012 | Leitthema

Management der Wirbelsäulenmetastasen, Strategien und operative Indikationen

verfasst von: M. Akbar, A. Ayache, M. Eichler, M. Klotz, B. Wiedenhöfer, Dr. B. Lehner

Erschienen in: Die Orthopädie | Ausgabe 8/2012

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Zusammenfassung

Metastasen sind die häufigste maligne Läsion der Wirbelsäule unabhängig vom Primarius und Indikator für ein disseminiertes Tumorleiden. Aufgrund der Optimierung der spezifischen onkologischen Therapiestrategien in den letzten Dekaden und der damit assoziierten steigenden Lebenserwartung stellen Wirbelsäulemetastasen ein wachsendes Problem dar. Deshalb muss gerade bei diesen Patienten eine onkologisch optimale, sinnvolle und patientengerechte Wahl des Therapieverfahrens unter Einbeziehung der Tumorbiologie, Prognose der Überlebenszeit, Vorliegen neurologischer Defizite, Instabilität und Allgemeinzustand des Patienten erfolgen. Die Therapie muss die Lebensqualität des Patienten berücksichtigen. Die Therapieoptionen reichen von einer rein konservativen Behandlung bis zu einer En-bloc-Spondylektomie der metastatischen Läsion. Basierend auf prognostischen Scores muss die chirurgische Entscheidungsfindung unter Berücksichtigung der Differenzialindikationen zu verschiedenen chirurgischen Therapieverfahren individuell entschieden werden.
Literatur
1.
Zurück zum Zitat Akeyson EW, Mccutcheon IE (1996) Single-stage posterior vertebrectomy and replacement combined with posterior instrumentation for spinal metastasis. J Neurosurg 85:211–220PubMedCrossRef Akeyson EW, Mccutcheon IE (1996) Single-stage posterior vertebrectomy and replacement combined with posterior instrumentation for spinal metastasis. J Neurosurg 85:211–220PubMedCrossRef
2.
Zurück zum Zitat Allan JM, Travis LB (2005) Mechanisms of therapy-related carcinogenesis. Nature reviews. Cancer 5:943–955PubMed Allan JM, Travis LB (2005) Mechanisms of therapy-related carcinogenesis. Nature reviews. Cancer 5:943–955PubMed
3.
Zurück zum Zitat Barron KD, Hirano A, Araki S et al (1959) Experiences with metastatic neoplasms involving the spinal cord. Neurology 9:91–106PubMedCrossRef Barron KD, Hirano A, Araki S et al (1959) Experiences with metastatic neoplasms involving the spinal cord. Neurology 9:91–106PubMedCrossRef
4.
Zurück zum Zitat Bauer HC, Wedin R (1995) Survival after surgery for spinal and extremity metastases. Prognostication in 241 patients. Acta Orthop Scand 66:143–146PubMedCrossRef Bauer HC, Wedin R (1995) Survival after surgery for spinal and extremity metastases. Prognostication in 241 patients. Acta Orthop Scand 66:143–146PubMedCrossRef
5.
Zurück zum Zitat Bentzen SM (2006) Preventing or reducing late side effects of radiation therapy: radiobiology meets molecular pathology. Nature reviews. Cancer 6:702–713PubMed Bentzen SM (2006) Preventing or reducing late side effects of radiation therapy: radiobiology meets molecular pathology. Nature reviews. Cancer 6:702–713PubMed
6.
Zurück zum Zitat Bilsky M, Smith M (2006) Surgical approach to epidural spinal cord compression. Hematol Oncol Clin North Am 20:1307–1317PubMedCrossRef Bilsky M, Smith M (2006) Surgical approach to epidural spinal cord compression. Hematol Oncol Clin North Am 20:1307–1317PubMedCrossRef
7.
Zurück zum Zitat Bilsky MH, Laufer I, Burch S (2009) Shifting paradigms in the treatment of metastatic spine disease. Spine (Phila Pa 1976) 34:S101–107 Bilsky MH, Laufer I, Burch S (2009) Shifting paradigms in the treatment of metastatic spine disease. Spine (Phila Pa 1976) 34:S101–107
8.
Zurück zum Zitat Bilsky MH, Lis E, Raizer J et al (1999) The diagnosis and treatment of metastatic spinal tumor. Oncologist 4:459–469PubMed Bilsky MH, Lis E, Raizer J et al (1999) The diagnosis and treatment of metastatic spinal tumor. Oncologist 4:459–469PubMed
9.
Zurück zum Zitat Boriani S, Bandiera S, Biagini R et al (2000) The use of the carbon-fiber reinforced modular implant for the reconstruction of the anterior column of the spine. A clinical and experimental study conducted on 42 cases. La Chirurgia degli organi di movimento 85:309–335PubMed Boriani S, Bandiera S, Biagini R et al (2000) The use of the carbon-fiber reinforced modular implant for the reconstruction of the anterior column of the spine. A clinical and experimental study conducted on 42 cases. La Chirurgia degli organi di movimento 85:309–335PubMed
10.
Zurück zum Zitat Broaddus WC, Grady MS, Delashaw JB Jr et al (1990) Preoperative superselective arteriolar embolization: a new approach to enhance resectability of spinal tumors. Neurosurgery 27:755–759PubMedCrossRef Broaddus WC, Grady MS, Delashaw JB Jr et al (1990) Preoperative superselective arteriolar embolization: a new approach to enhance resectability of spinal tumors. Neurosurgery 27:755–759PubMedCrossRef
11.
12.
Zurück zum Zitat Constans JP, De Divitiis E, Donzelli R et al (1983) Spinal metastases with neurological manifestations. Review of 600 cases. J Neurosurg 59:111–118PubMedCrossRef Constans JP, De Divitiis E, Donzelli R et al (1983) Spinal metastases with neurological manifestations. Review of 600 cases. J Neurosurg 59:111–118PubMedCrossRef
13.
Zurück zum Zitat Cox JD, Stetz J, Pajak TF (1995) Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int J Radiat Oncol Biol Phys 31:1341–1346PubMedCrossRef Cox JD, Stetz J, Pajak TF (1995) Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int J Radiat Oncol Biol Phys 31:1341–1346PubMedCrossRef
14.
Zurück zum Zitat Domchek SM, Younger J, Finkelstein DM et al (2000) Predictors of skeletal complications in patients with metastatic breast carcinoma. Cancer 89:363–368PubMedCrossRef Domchek SM, Younger J, Finkelstein DM et al (2000) Predictors of skeletal complications in patients with metastatic breast carcinoma. Cancer 89:363–368PubMedCrossRef
15.
Zurück zum Zitat Ernstberger T, Bruning T, Konig F (2005) Vertebrectomy and anterior reconstruction for the treatment of spinal metastases. Acta Orthop Belg 71:459–466PubMed Ernstberger T, Bruning T, Konig F (2005) Vertebrectomy and anterior reconstruction for the treatment of spinal metastases. Acta Orthop Belg 71:459–466PubMed
16.
Zurück zum Zitat Ernstberger T, Kogel M, Konig F et al (2005) Expandable vertebral body replacement in patients with thoracolumbar spine tumors. Arch Orthop Trauma Surg 125:660–669PubMedCrossRef Ernstberger T, Kogel M, Konig F et al (2005) Expandable vertebral body replacement in patients with thoracolumbar spine tumors. Arch Orthop Trauma Surg 125:660–669PubMedCrossRef
17.
Zurück zum Zitat Galasko CS, Norris HE, Crank S (2000) Spinal instability secondary to metastatic cancer. J Bone Joint Surg [Am] 82:570–594 Galasko CS, Norris HE, Crank S (2000) Spinal instability secondary to metastatic cancer. J Bone Joint Surg [Am] 82:570–594
18.
Zurück zum Zitat Gasbarrini A, Li H, Cappuccio M et al (2010) Efficacy evaluation of a new treatment algorithm for spinal metastases. Spine (Phila Pa 1976) 35:1466–1470 Gasbarrini A, Li H, Cappuccio M et al (2010) Efficacy evaluation of a new treatment algorithm for spinal metastases. Spine (Phila Pa 1976) 35:1466–1470
19.
Zurück zum Zitat Ghogawala Z, Mansfield FL, Borges LF (2001) Spinal radiation before surgical decompression adversely affects outcomes of surgery for symptomatic metastatic spinal cord compression. Spine (Phila Pa 1976) 26:818–824 Ghogawala Z, Mansfield FL, Borges LF (2001) Spinal radiation before surgical decompression adversely affects outcomes of surgery for symptomatic metastatic spinal cord compression. Spine (Phila Pa 1976) 26:818–824
20.
Zurück zum Zitat Gilbert RW, Kim JH, Posner JB (1978) Epidural spinal cord compression from metastatic tumor: diagnosis and treatment. Ann Neurol 3:40–51PubMedCrossRef Gilbert RW, Kim JH, Posner JB (1978) Epidural spinal cord compression from metastatic tumor: diagnosis and treatment. Ann Neurol 3:40–51PubMedCrossRef
22.
Zurück zum Zitat Hess T, Kramann B, Schmidt E et al (1997) Use of preoperative vascular embolisation in spinal metastasis resection. Arch Orthop Trauma Surg 116:279–282PubMedCrossRef Hess T, Kramann B, Schmidt E et al (1997) Use of preoperative vascular embolisation in spinal metastasis resection. Arch Orthop Trauma Surg 116:279–282PubMedCrossRef
23.
Zurück zum Zitat Jacobs WB, Perrin RG (2001) Evaluation and treatment of spinal metastases: an overview. Neurosurg Focus 11:e10PubMedCrossRef Jacobs WB, Perrin RG (2001) Evaluation and treatment of spinal metastases: an overview. Neurosurg Focus 11:e10PubMedCrossRef
24.
Zurück zum Zitat Jefferies S, Rajan B, Ashley S et al (1998) Haematological toxicity of cranio-spinal irradiation. Radiother Oncol 48:23–27PubMedCrossRef Jefferies S, Rajan B, Ashley S et al (1998) Haematological toxicity of cranio-spinal irradiation. Radiother Oncol 48:23–27PubMedCrossRef
25.
Zurück zum Zitat Karnofsky DA, Burchenal JH (1949) The clinical evaluation of chemotherapeutic agents in cancer. In: Macleod CM (ed) Evaluation and chemotherapeutic agents. Columbia University Press, New York, pp 199–205 Karnofsky DA, Burchenal JH (1949) The clinical evaluation of chemotherapeutic agents in cancer. In: Macleod CM (ed) Evaluation and chemotherapeutic agents. Columbia University Press, New York, pp 199–205
26.
Zurück zum Zitat Klimo P Jr, Thompson CJ, Kestle JR et al (2005) A meta-analysis of surgery versus conventional radiotherapy for the treatment of metastatic spinal epidural disease. Neuro Oncol 7:64–76PubMedCrossRef Klimo P Jr, Thompson CJ, Kestle JR et al (2005) A meta-analysis of surgery versus conventional radiotherapy for the treatment of metastatic spinal epidural disease. Neuro Oncol 7:64–76PubMedCrossRef
27.
Zurück zum Zitat Leithner A, Radl R, Gruber G et al (2008) Predictive value of seven preoperative prognostic scoring systems for spinal metastases. Eur Spine J 17:1488–1495PubMedCrossRef Leithner A, Radl R, Gruber G et al (2008) Predictive value of seven preoperative prognostic scoring systems for spinal metastases. Eur Spine J 17:1488–1495PubMedCrossRef
28.
Zurück zum Zitat Merk H, Koch H, Liebau C et al (2000) Implantation of a Harms titanium mesh cylinder for vertebral body replacement in spinal metastases. Z Ortho Ihre Grenzgeb 138:169–173CrossRef Merk H, Koch H, Liebau C et al (2000) Implantation of a Harms titanium mesh cylinder for vertebral body replacement in spinal metastases. Z Ortho Ihre Grenzgeb 138:169–173CrossRef
29.
Zurück zum Zitat O’Rourke T, George CB, Redmond J 3rd et al (1986) Spinal computed tomography and computed tomographic metrizamide myelography in the early diagnosis of metastatic disease. J Clin Oncol 4:576–583 O’Rourke T, George CB, Redmond J 3rd et al (1986) Spinal computed tomography and computed tomographic metrizamide myelography in the early diagnosis of metastatic disease. J Clin Oncol 4:576–583
30.
Zurück zum Zitat Olerud C, Jonsson H Jr, Lofberg AM et al (1993) Embolization of spinal metastases reduces peroperative blood loss. 21 patients operated on for renal cell carcinoma. Acta Orthop Scand 64:9–12PubMedCrossRef Olerud C, Jonsson H Jr, Lofberg AM et al (1993) Embolization of spinal metastases reduces peroperative blood loss. 21 patients operated on for renal cell carcinoma. Acta Orthop Scand 64:9–12PubMedCrossRef
31.
Zurück zum Zitat Patchell RA, Tibbs PA, Regine WF et al (2005) Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial. Lancet 366:643–648PubMedCrossRef Patchell RA, Tibbs PA, Regine WF et al (2005) Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial. Lancet 366:643–648PubMedCrossRef
32.
Zurück zum Zitat Rades D, Huttenlocher S, Dunst J et al (2010) Matched pair analysis comparing surgery followed by radiotherapy and radiotherapy alone for metastatic spinal cord compression. J Clin Oncol 28:3597–3604PubMedCrossRef Rades D, Huttenlocher S, Dunst J et al (2010) Matched pair analysis comparing surgery followed by radiotherapy and radiotherapy alone for metastatic spinal cord compression. J Clin Oncol 28:3597–3604PubMedCrossRef
33.
Zurück zum Zitat Roscoe MW, Mcbroom RJ, St Louis E et al (1989) Preoperative embolization in the treatment of osseous metastases from renal cell carcinoma. Clin Orthop Relat Res 238:302–307PubMed Roscoe MW, Mcbroom RJ, St Louis E et al (1989) Preoperative embolization in the treatment of osseous metastases from renal cell carcinoma. Clin Orthop Relat Res 238:302–307PubMed
34.
Zurück zum Zitat Rose PS, Laufer I, Boland PJ et al (2009) Risk of fracture after single fraction image-guided intensity-modulated radiation therapy to spinal metastases. J Clin Oncol 27:5075–5079PubMedCrossRef Rose PS, Laufer I, Boland PJ et al (2009) Risk of fracture after single fraction image-guided intensity-modulated radiation therapy to spinal metastases. J Clin Oncol 27:5075–5079PubMedCrossRef
35.
Zurück zum Zitat Ruff RL, Lanska DJ (1989) Epidural metastases in prospectively evaluated veterans with cancer and back pain. Cancer 63:2234–2241PubMedCrossRef Ruff RL, Lanska DJ (1989) Epidural metastases in prospectively evaluated veterans with cancer and back pain. Cancer 63:2234–2241PubMedCrossRef
36.
Zurück zum Zitat Ryken TC, Eichholz KM, Gerszten PC et al (2003) Evidence-based review of the surgical management of vertebral column metastatic disease. Neurosurg Focus 15:E11PubMedCrossRef Ryken TC, Eichholz KM, Gerszten PC et al (2003) Evidence-based review of the surgical management of vertebral column metastatic disease. Neurosurg Focus 15:E11PubMedCrossRef
37.
Zurück zum Zitat Schaberg J, Gainor BJ (1985) A profile of metastatic carcinoma of the spine. Spine (Phila Pa 1976) 10:19–20 Schaberg J, Gainor BJ (1985) A profile of metastatic carcinoma of the spine. Spine (Phila Pa 1976) 10:19–20
38.
Zurück zum Zitat Schaser KD, Melcher I, Mittlmeier T et al (2007) Surgical management of vertebral column metastatic disease. Unfallchirurg 110:137–159 (quiz 160–131)PubMedCrossRef Schaser KD, Melcher I, Mittlmeier T et al (2007) Surgical management of vertebral column metastatic disease. Unfallchirurg 110:137–159 (quiz 160–131)PubMedCrossRef
39.
Zurück zum Zitat Simmons ED, Zheng Y (2006) Vertebral tumors: surgical versus nonsurgical treatment. Clin Orthop Relat Res 443:233–247PubMedCrossRef Simmons ED, Zheng Y (2006) Vertebral tumors: surgical versus nonsurgical treatment. Clin Orthop Relat Res 443:233–247PubMedCrossRef
40.
Zurück zum Zitat Sioutos PJ, Arbit E, Meshulam CF et al (1995) Spinal metastases from solid tumors. Analysis of factors affecting survival. Cancer 76:1453–1459PubMedCrossRef Sioutos PJ, Arbit E, Meshulam CF et al (1995) Spinal metastases from solid tumors. Analysis of factors affecting survival. Cancer 76:1453–1459PubMedCrossRef
41.
Zurück zum Zitat Sundaresan N, Boriani S, Rothman A et al (2004) Tumors of the osseous spine. J Neurooncol 69:273–290PubMedCrossRef Sundaresan N, Boriani S, Rothman A et al (2004) Tumors of the osseous spine. J Neurooncol 69:273–290PubMedCrossRef
42.
Zurück zum Zitat Sundaresan N, Digiacinto GV, Hughes JE et al (1991) Treatment of neoplastic spinal cord compression: results of a prospective study. Neurosurgery 29:645–650PubMedCrossRef Sundaresan N, Digiacinto GV, Hughes JE et al (1991) Treatment of neoplastic spinal cord compression: results of a prospective study. Neurosurgery 29:645–650PubMedCrossRef
43.
Zurück zum Zitat Tokuhashi Y, Matsuzaki H, Oda H et al (2005) A revised scoring system for preoperative evaluation of metastatic spine tumor prognosis. Spine (Phila Pa 1976) 30:2186–2191 Tokuhashi Y, Matsuzaki H, Oda H et al (2005) A revised scoring system for preoperative evaluation of metastatic spine tumor prognosis. Spine (Phila Pa 1976) 30:2186–2191
44.
Zurück zum Zitat Tokuhashi Y, Matsuzaki H, Toriyama S et al (1990) Scoring system for the preoperative evaluation of metastatic spine tumor prognosis. Spine (Phila Pa 1976) 15:1110–1113 Tokuhashi Y, Matsuzaki H, Toriyama S et al (1990) Scoring system for the preoperative evaluation of metastatic spine tumor prognosis. Spine (Phila Pa 1976) 15:1110–1113
45.
Zurück zum Zitat Tomita K, Kawahara N, Baba H et al (1997) Total en bloc spondylectomy. A new surgical technique for primary malignant vertebral tumors. Spine (Phila Pa 1976) 22:324–333 Tomita K, Kawahara N, Baba H et al (1997) Total en bloc spondylectomy. A new surgical technique for primary malignant vertebral tumors. Spine (Phila Pa 1976) 22:324–333
46.
Zurück zum Zitat Tomita K, Kawahara N, Kobayashi T et al (2001) Surgical strategy for spinal metastases. Spine (Phila Pa 1976) 26:298–306 Tomita K, Kawahara N, Kobayashi T et al (2001) Surgical strategy for spinal metastases. Spine (Phila Pa 1976) 26:298–306
47.
Zurück zum Zitat Van Der Linden YM, Dijkstra SP, Vonk EJ et al (2005) Prediction of survival in patients with metastases in the spinal column: results based on a randomized trial of radiotherapy. Cancer 103:320–328CrossRef Van Der Linden YM, Dijkstra SP, Vonk EJ et al (2005) Prediction of survival in patients with metastases in the spinal column: results based on a randomized trial of radiotherapy. Cancer 103:320–328CrossRef
48.
Zurück zum Zitat Wang JC, Boland P, Mitra N et al (2004) Single-stage posterolateral transpedicular approach for resection of epidural metastatic spine tumors involving the vertebral body with circumferential reconstruction: results in 140 patients. Invited submission from the Joint Section Meeting on Disorders of the Spine and Peripheral Nerves, March 2004. J Neurosurg Spine 1:287–298PubMedCrossRef Wang JC, Boland P, Mitra N et al (2004) Single-stage posterolateral transpedicular approach for resection of epidural metastatic spine tumors involving the vertebral body with circumferential reconstruction: results in 140 patients. Invited submission from the Joint Section Meeting on Disorders of the Spine and Peripheral Nerves, March 2004. J Neurosurg Spine 1:287–298PubMedCrossRef
49.
Zurück zum Zitat Wibmer C, Leithner A, Hofmann G et al (2011) Survival analysis of 254 patients after manifestation of spinal metastases: evaluation of seven preoperative scoring systems. Spine (Phila Pa 1976) 36:1977–1986 Wibmer C, Leithner A, Hofmann G et al (2011) Survival analysis of 254 patients after manifestation of spinal metastases: evaluation of seven preoperative scoring systems. Spine (Phila Pa 1976) 36:1977–1986
50.
Zurück zum Zitat Wong DA, Fornasier VL, Macnab I (1990) Spinal metastases: the obvious, the occult, and the impostors. Spine (Phila Pa 1976) 15:1–4 Wong DA, Fornasier VL, Macnab I (1990) Spinal metastases: the obvious, the occult, and the impostors. Spine (Phila Pa 1976) 15:1–4
51.
Zurück zum Zitat Young RF, Post EM, King GA (1980) Treatment of spinal epidural metastases. Randomized prospective comparison of laminectomy and radiotherapy. J Neurosurg 53:741–748PubMedCrossRef Young RF, Post EM, King GA (1980) Treatment of spinal epidural metastases. Randomized prospective comparison of laminectomy and radiotherapy. J Neurosurg 53:741–748PubMedCrossRef
Metadaten
Titel
Management der Wirbelsäulenmetastasen, Strategien und operative Indikationen
verfasst von
M. Akbar
A. Ayache
M. Eichler
M. Klotz
B. Wiedenhöfer
Dr. B. Lehner
Publikationsdatum
01.08.2012
Verlag
Springer-Verlag
Erschienen in
Die Orthopädie / Ausgabe 8/2012
Print ISSN: 2731-7145
Elektronische ISSN: 2731-7153
DOI
https://doi.org/10.1007/s00132-012-1910-2

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