Cascade of Inflammatory, Fibrotic Processes, and Stress-Induced Senescence in Chronic GVHD-Related Dry Eye Disease
Abstract
:1. Introduction
1.1. Mucosal Barrier of the Ocular Surface
Tear Film in GVHD-Related Dry Eye Disease
1.2. Microbiota
2. Ocular Surface Inflammation
2.1. Early Phase of Inflammatory Response
2.2. Chronic Inflammation
2.3. Sterile Inflammation
3. Immune-Mediated Fibrosis
3.1. Bone Marrow-Derived Cells in Pathogenic Fibrosis
3.2. Epithelial–Mesenchymal Transition (EMT)
4. Cellular Senescence in Ocular GVHD
4.1. Oxidative Stress
4.2. Tissue Renin–Angiotensin System (RAS)
4.3. Endoplasmic Reticulum (ER) Stress
4.4. Vascular Adhesion Protein-1
4.5. Stress-Induced Senescence in Ocular GVHD
5. Treatment
6. Future Directions
7. Patents
Author Contributions
Funding
Institutional Review Board Statement
Acknowledgments
Conflicts of Interest
References
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Strategy | Medicine or Device |
---|---|
Retention of tear fluid | Preservative-free artificial tear, Diquafosol [138], Punctal plug [139], Surgical punctal occlusion [140], Oral muscarinic agonists (pilocarpine [141], cevimeline [12]), |
Mucin producing, tear film stabilization | Diquafosol [138], Rebamipide [142] |
Reduction of inflammation and by-products | Preservative-free corticosteroid [143], Cyclosporin [143], Tacrolimus [144,145,146], Tranilast, IL-1 receptor inhibitor, Lifitegrast, DNase [82], immunoglobulin [32], (Basic study; Heparin [81], Systemic vascular adhesion protein-1 inhibitor [111], Phenyl butyric acid [112], Senolytic agent [83,112]. Small molecule inhibitors of lymphocyte signaling [147], Anti-IL-6 receptor antagonist [83]) |
Epithelial support | Hyaluronic acid, Autologeous sera [148,149], Cord blood sera [150,151], Platelet lysate [152,153], Amniotic membrane transplantation [4,154,155,156,157], Cultured epithelial cell transplantation, Medical use contact lenses [158,159,160,161]. |
Prevention of tear evaporation | Moisture goggle, Tetracycline, Warm compression, Lid hygiene. |
Inhibition of refractory ocular and systemic GVHD | Systemic administration (Tacrolimus, Cyclosporin, Corticosteroid, Extracorporeal photopheresis, Rituximab, Sirolimus (Rapamycin), Mycophenolate mofetil) [6] |
Reduction of fibrosis | (Basic study, Angiotensin type I receptor antagonist [110], Vitamin A-coupled liposomes containing HSP47 siRNA [162]) |
Supportive care | Moisture goggle, Prevention of infection (Doxycycline, Minocycline) [3], Maintenance of environmental factor [163] |
Other surgical treatment [5,132] | Epithelial cell debridement [5] Surgical correction of entropion [132,164] Partial tarsorrhaphy Fornix reconstruction Penetrating keratoplasty Lamellar keratoplasty |
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Ogawa, Y.; Kawakami, Y.; Tsubota, K. Cascade of Inflammatory, Fibrotic Processes, and Stress-Induced Senescence in Chronic GVHD-Related Dry Eye Disease. Int. J. Mol. Sci. 2021, 22, 6114. https://doi.org/10.3390/ijms22116114
Ogawa Y, Kawakami Y, Tsubota K. Cascade of Inflammatory, Fibrotic Processes, and Stress-Induced Senescence in Chronic GVHD-Related Dry Eye Disease. International Journal of Molecular Sciences. 2021; 22(11):6114. https://doi.org/10.3390/ijms22116114
Chicago/Turabian StyleOgawa, Yoko, Yutaka Kawakami, and Kazuo Tsubota. 2021. "Cascade of Inflammatory, Fibrotic Processes, and Stress-Induced Senescence in Chronic GVHD-Related Dry Eye Disease" International Journal of Molecular Sciences 22, no. 11: 6114. https://doi.org/10.3390/ijms22116114