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Reviews in Endocrine and Metabolic Disorders
Erschienen in: Reviews in Endocrine and Metabolic Disorders 3/2016

02.07.2016

Stress-related skin disorders

verfasst von: Alex Alexopoulos, George P. Chrousos

Erschienen in: Reviews in Endocrine and Metabolic Disorders | Ausgabe 3/2016

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Abstract

Emerging research has suggested that the skin is not only a target of organismal distress but also an active participant of the stress response through production of local “HPA axis” components, peripheral nerve endings, and resident skin cells, including keratinocytes, mast cells, and immune/immune accessory cells. There are also bidirectional communication pathways between the brain and the skin, which play significant roles in integrating these interactions. In this review, we summarize the intricate relations between stress and several skin conditions. We have tried to identify the underlying mechanisms that link stress to the common dermatoses according to the latest scientific findings.
Literatur
1.
Bolognia JL, Jorizzo JL, Rapini RP. Dermatology. 2nd ed. St Louis, MO: Mosby Elsevier; 2008.
2.
Slominski AT, Zmijewski MA, Skobowiat C, Zbytek B, Slominski RM, Steketee JD. Sensing the environment: regulation of local and global homeostasis by the skin’s neuroendocrine system. Adv Anat Embryol Cell Biol. 2012;212(v, vii):1–115.CrossRef
3.
Elias PM, Choi EH. Interactions among stratum corneum defensive functions. Exp Dermatol. 2005;14:719–26.PubMedCrossRef
4.
5.
Feingold KR, Schmuth M, Elias PM. The regulation of permeability barrier homeostasis. J Invest Dermatol. 2007;127:1574–6.PubMedCrossRef
6.
Elias PM, Menon G, Wetzel BK, Williams J. Barrier requirements as the evolutionary “driver” of epidermal pigmentation in humans. Am J Hum Biol. 2010;22:526–37.PubMedPubMedCentralCrossRef
7.
Slominski A, Tobin DJ, Shibahara S, Wortsman J. Melanin pigmentation in mammalian skin and its hormonal regulation. Physiol Rev. 2004;84:1155–228.PubMedCrossRef
8.
Stenn KS, Paus R. Controls of hair follicle cycling. Physiol Rev. 2001;81:449–94.PubMed
9.
Zouboulis CC, Baron JM, Böhm M, et al. Frontiers in sebaceous gland biology and pathology. Exp Dermatol. 2008;17:542–51.PubMedCrossRef
10.
Slominski A, Wortsman J. Neuroendocrinology of the skin. Endocr Rev. 2000;21:457–87.PubMed
11.
Vale W, Spiess J, Rivier C, Rivier J. Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. Science. 1981;213:1394–7.PubMedCrossRef
12.
Rivier C, Vale W. Modulation of stress-induced ACTH release by corticotropin-releasing factor, catecholamines and vasopressin. Nature. 1983;305:325–7.PubMedCrossRef
13.
Munck A, Guyre PM, Holbrook NJ. Physiological functions of glucocorticoids in stress and their relation to pharmacological actions. Endocr Rev. 1984;5:25–44.PubMedCrossRef
14.
Bamberger CM, Schulte HM, Chrousos GP. Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids. Endocr Rev. 1996;17:245–61.PubMedCrossRef
15.
Tanida M, Katsuyama M, Sakatani K. Relation between mental stress-induced prefrontal cortex activity and skin conditions: a near-infrared spectroscopy study. Brain Res. 2007;1184:210–6.PubMedCrossRef
16.
Dhabhar FS. Psychological stress and immunoprotection versus immunopathology in the skin. Clin Dermatol. 2013;31:18–30.PubMedCrossRef
17.
Skobowiat C, Dowdy JC, Sayre RM, Tuckey RC, Slominski A. Cutaneous hypothalamic-pituitaryadrenal axis homolog: regulation by ultraviolet radiation. Am J Physiol Endocrinol Metab. 2011;301:E484–93.PubMedPubMedCentralCrossRef
18.
Slominski A, Mihm MC. Potential mechanism of skin response to stress. Int J Dermatol. 1996;35:849–51.PubMedCrossRef
19.
Slominski A, Zbytek B, Nikolakis G, Manna PR, Skobowiat C, et al. Steroidogenesis in the skin: implications for local immune functions. J Steroid Biochem Mol Biol. 2013;137:107–23.PubMedPubMedCentralCrossRef
20.
Ito N, Ito T, Kromminga A, Bettermann A, Takigawa M, et al. Human hair follicles display a functional equivalent of the hypothalamic-pituitary-adrenal axis and synthesize cortisol. FASEB J. 2005;19:1332–4.PubMed
21.
Slominski A, Zbytek B, Szczesniewski A, Semak I, Kaminski J, et al. CRH stimulation of corticosteroids production in melanocytes is mediated by ACTH. Am J Physiol Endocrinol Metab. 2005;288:E701–6.PubMedCrossRef
22.
McCarty R, Horwatt K, Konarska M. Chronic stress and sympathetic-adrenal medullary responsiveness. Soc Sci Med. 1988;26(3):333–41.PubMedCrossRef
23.
Sanders VM, Baker RA, Ramer-Quinn DS, Kasprowicz DJ, Fuchs BA, Street NE. Differential expression of the beta2-adrenergic receptor by Th1 and Th2 clones: implications for cytokine production and B cell help. J Immunol. 1997;158(9):4200–10.PubMed
24.
Marino F, Cosentino M. Adrenergic modulation of immune cells: an update. Amino Acids. 2013;45(1):55–71.PubMedCrossRef
25.
Grando SA, Pittelkow MR, Schallreuter KU. Adrenergic and cholinergic control in the biology of epidermis: physiological and clinical significance. J Invest Dermatol. 2006;126(9):1948–65.PubMedCrossRef
26.
Koizumi H, Tanaka H, Ohkawara A. beta-Adrenergic stimulation induces activation of protein kinase C and inositol 1,4,5-trisphosphate increase in epidermis. Exp Dermatol. 1997;6(3):128–32.PubMedCrossRef
27.
Botchkarev VA, Yaar M, Peters EM, Raychaudhuri SP, Botchkareva NV, Marconi A, et al. Neurotrophins in skin biology and pathology. J Invest Dermatol. 2006;126(8):1719–27.PubMedCrossRef
28.
Singh LK, Pang X, Alexacos N, Letourneau R, Theoharides TC. Acute immobilization stress triggers skin mast cell degranulation via corticotropin releasing hormone, neurotensin, and substance P: a link to neurogenic skin disorders. Brain Behav Immun. 1999;13(3):225–39.PubMedCrossRef
29.
Smith CH, Barker JN, Morris RW, MacDonald DM, Lee TH. Neuropeptides induce rapid expression of endothelial cell adhesion molecules and elicit granulocytic infiltration in human skin. J Immunol. 1993;151(6):3274–82.PubMed
30.
Slominski A, Wortsman J, Tuckey RC, Paus R. Differential expression of HPA axis homolog in the skin. Mol Cell Endocrinol. 2007;265–266:143–9.PubMedCrossRef
31.
Bodó E, Kany B, Gaspar E, et al. Thyroid-stimulating hormone, a novel, locally produced modulator of human epidermal functions, is regulated by thyrotropin-releasing hormone and thyroid hormones. Endocrinology. 2010;151:1633–42.PubMedCrossRef
32.
Slominski A, Tobin DJ, Zmijewski MA, Wortsman J, Paus R. Melatonin in the skin: synthesis, metabolism and functions. Trends Endocrinol Metab. 2008;19:17–24.PubMedCrossRef
33.
Gillbro JM, Marles LK, Hibberts NA, Schallreuter KU. Autocrine catecholamine biosynthesis and the β- adrenoceptor signal promote pigmentation in human epidermal melanocytes. J Invest Dermatol. 2004;123:346–53.PubMedCrossRef
34.
35.
Slominski A, Wortsman J, Linton E, Pisarchik A, Zbytek B. The skin as a model for the immunomodulatory effects of corticotropin-releasing hormone. In: Schaefer M, Stein C, editors. Mind Over Matter— Regulation of Peripheral Inflammation by the CNS. Basel, Boston, Berlin: Birkhaeuser Verlag; 2003. p. 149–76.CrossRef
36.
Slominski A. On the role of the corticotropin-releasing hormone signalling system in the aetiology of inflammatory skin disorders. Br J Dermatol. 2009;160:229–32.PubMedPubMedCentralCrossRef
37.
Theoharides TC, Kalogeromitros D. The critical role of mast cells in allergy and inflammation. Ann NY Acad Sci. 2006;1088:78–99.PubMedCrossRef
38.
Ni C, Chiu MW. Psoriasis and comorbidities: links and risks [review]. Clin Cosmet Investig Dermatol. 2014;7:119–32. eCollection 2014.PubMedPubMedCentral
39.
Hall JM, Cruser D, Podawiltz A, et al. Psychological stress and the cutaneous immune response: roles of the HPA axis and the sympathetic nervous system in atopic dermatitis and psoriasis. Dermatol Res Pract. 2012;2012:403908. doi:10.​1155/​2012/​403908.
40.
41.
42.
43.
Brunoni AR, Santos IS, Sabbag C, Lotufo PA, Benseñor IM. Psoriasis severity and hypothalamic-pituitary-adrenal axis function: results from the CALIPSO study. Braz J Med Biol Res. 2014;47(12):1102–6.PubMedPubMedCentralCrossRef
44.
45.
46.
Kono M, Nagata H, Umemura S, Kawana S, Osamura RY. In situ expression of corticotropin-releasing hormone (CRH) and proopiomelanocortin (POMC) genes in human skin. FASEB J. 2001;15:2297–9.PubMed
47.
Kim JE, Cho DH, Kim HS, et al. Expression of the corticotropin-releasing hormone-proopiomelanocortin axis in the various clinical types of psoriasis. Exp Dermatol. 2007;16:104–9.PubMedCrossRef
48.
Tagen M, Stiles L, Kalogeromitros D, et al. Skin corticotropin-releasing hormone receptor expression in psoriasis. J Invest Dermatol. 2007;127:1789–91.PubMedCrossRef
49.
Cemil BC, Canpolat F, Yilmazer D, Eskioglu F, Alper M. The association of PASI scores with CRH-R1 expression in patients with psoriasis. Arch Dermatol Res. 2012;304:127–32.PubMedCrossRef
50.
Vasiadi M, Therianou A, Sideri K, et al. Increased serum CRH levels with decreased skin CRHR-1 gene expression in psoriasis and atopic dermatitis. J Allergy Clin Immunol. 2012;129:1410–3.PubMedPubMedCentralCrossRef
51.
Zhou C, Yu X, Cai D, Liu C, Li C. Role of corticotropin-releasing hormone and receptor in the pathogenesis of psoriasis. Med Hypotheses. 2009;73:513–5.PubMedCrossRef
52.
Ito N, Sugawara K, Bodó E, et al. Corticotropin-releasing hormone stimulates the in situ generation of mast cells from precursors in the human hair follicle mesenchyme. J Invest Dermatol. 2010;130:995–1004.PubMedCrossRef
53.
Cao J, Papadopoulou N, Kempuraj D, et al. Human mast cells express corticotropin-releasing hormone (CRH) receptors and CRH leads to selective secretion of vascular endothelial growth factor. J Immunol. 2005;174:7665–75.PubMedCrossRef
54.
Vasiadi M, Therianou A, Alysandratos KD, et al. Serum neurotensin (NT) is increased in psoriasis and NT induces vascular endothelial growth factor release from human mast cells. Br J Dermatol. 2012;166:1349–52.PubMedPubMedCentralCrossRef
55.
Cochrane DE, Carraway RE, Harrington K, Laudano M, Rawlings S, Feldberg RS. HMC-1 human mast cells synthesize neurotensin (NT) precursor, secrete bioactive NT-like peptide(s) and express NT receptor NTS1. Inflamm Res. 2011;60:1139–51.PubMedCrossRef
56.
Donelan J, Boucher W, Papadopoulou N, et al. Corticotropin-releasing hormone induces skin vascular permeability through a neurotensin-dependent process. Proc Natl Acad Sci U S A. 2006;103:7759–64.PubMedPubMedCentralCrossRef
57.
de Brouwer SJM, van Middendorp H, Stormink C, Kraaimaat FW, Sweep FCGJ, de Jong EMGJ, et al. The psychophysiological stress response in psoriasis and rheumatoid arthritis. Br J Dermatol. 2014;170:824–31.PubMedCrossRef
58.
Brunoni AR, Lotufo PA, Sabbag C, Goulart AC, Santos IS, Benseñor IM. Decreased brain-derived neurotrophic factor plasma levels in psoriasis patients. Braz J Med Biol Res. 2015;48(8):711–4.PubMedPubMedCentralCrossRef
59.
60.
61.
62.
Truzzi F, Marconi A, Atzei P, Panza MC, Lotti R, Dallaglio K, et al. p75 neurotrophin receptor mediates apoptosis in transit-amplifying cells and its overexpression restores cell death in psoriatic keratinocytes. Cell Death Differ. 2011;18:948–58. doi:10.​1038/​cdd.​2010.​162.PubMedCrossRef
63.
Consoli SM, Rolhion S, Martin C, Ruel K, Cambazard F, Pellet J, et al. Low levels of emotional awareness predict a better response to dermatological treatment in patients with psoriasis. Dermatology. 2006;212:128–36. doi:10.​1159/​000090653.PubMedCrossRef
64.
Grewe M, Bruijnzeel-Koomen CA, Schopf E, et al. A role for Th1 and Th2 cells in the immunopathogenesis of atopic dermatitis. Immunol Today. 1998;19(8):359–61.PubMedCrossRef
65.
66.
Shimoda T, Liang Z, Suzuki H, et al. Inhibitory effects of antipsychotic and anxiolytic agents on stress-induced degranulation of mouse dermal mast cells: experimental dermatology. Clin Exp Dermatol. 2010;35(5):531–6.PubMedCrossRef
67.
Garg A, Chren MM, Sands LP, et al. Psychological stress perturbs epidermal permeability barrier homeostasis: implications for the pathogenesis of stressassociated skin disorders. Arch Dermatol. 2001;137(1):53–9.PubMedCrossRef
68.
Zbytek B, Pfeffer LM, Slominski AT. Corticotropin-releasing hormone inhibits nuclear factor-kB pathway in human HaCaT keratinocytes. J Invest Dermatol. 2003;121:1496–9.PubMedPubMedCentralCrossRef
69.
Park HJ, Kim HJ, Lee JH, et al. Corticotropin-releasing hormone (CRH) downregulates interleukin-18 expression in human HaCaT keratinocytes by activation of p38 mitogen-activated protein kinase (MAPK) pathway. J Invest Dermatol. 2005;124:751–5.PubMedCrossRef
70.
Slominski A, Wortsman J, Pisarchik A, et al. Cutaneous expression of corticotropin-releasing hormone (CRH), urocortin, and CRH receptors. FASEB J. 2001;15:1678–93.PubMedCrossRef
71.
Zouboulis CC, Seltmann H, Hiroi N, et al. Corticotropin-releasing hormone: an autocrine hormone that promotes lipogenesis in human sebocytes. Proc Natl Acad Sci U S A. 2002;99:7148–53.PubMedPubMedCentralCrossRef
72.
73.
Catania A, Colombo G, Rossi C, et al. Antimicrobial properties of α-MSH and related synthetic melanocortins. ScientificWorldJournal. 2006;6:1241–6.PubMedCrossRef
74.
Rousseau K, Kauser S, Pritchard LE, et al. Proopiomelanocortin (POMC), the ACTH/melanocortin precursor, is secreted by human epidermal keratinocytes and melanocytes and stimulates melanogenesis. FASEB J. 2007;21:1844–56.PubMedPubMedCentralCrossRef
75.
Keita AV, Soderholm JD, Ericson AC. Stress-induced barrier disruption of rat follicle-associated epithelium involves corticotropin-releasing hormone, acetylcholine, substance P, and mast cells. Neurogastroenterol Motil. 2010;22(770–778):e221–2.
76.
Wallon C, Yang PC, Keita AV, et al. Corticotropin-releasing hormone (CRH) regulates macromolecular permeability via mast cells in normal human colonic biopsies in vitro. Gut. 2008;57:50–8.PubMedCrossRef
77.
Eva Milena Johanne P, Michenko A, Jörg K, Wolfgang K, Silke W, Volker N, et al. Mental Stress in Atopic Dermatitis – Neuronal Plasticity and the Cholinergic System Are Affected in Atopic Dermatitis and in Response to Acute Experimental Mental Stress in a Randomized Controlled Pilot Study. 2014. doi:10.​1371/​journal.​pone.​0113552.
78.
Ofek K, Soreq H. Cholinergic involvement and manipulation approaches in multiple system disorders. Chem Biol Interact. 2013;203:113–9.PubMedCrossRef
79.
Segerstrom SC, Miller GE. Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry. Psychol Bull. 2004;130:601–30.PubMedPubMedCentralCrossRef
80.
Giovanoli S, Engler H, Engler A, Richetto J, Voget M, et al. Stress in puberty unmasks latent neuropathological consequences of prenatal immune activation in mice. Science. 2013;339:1095–9.PubMedCrossRef
81.
Megumi M, Masaki Y, Chieko U, Teruhiko M, Tadamichi S. Stress Evaluation in Adult Patients with Atopic Dermatitis Using Salivary Cortisol. 2013. doi:10.​1155/​2013/​138027.
82.
Liezmann C, Klapp B, Peters EMJ. Stress, atopy and allergy: a re-evaluation from a psychoneuroimmunologic persepective. Dermato-Endocrinology. 2011;3(1):37–40.PubMedPubMedCentralCrossRef
83.
Katayama I, Bae SJ, Hamasaki Y, et al. Stress response, tachykinin, and cutaneous inflammation. J Investig Dermatol Symp Proc. 2001;6(1):81–6.PubMedCrossRef
84.
Arck PC, Slominski A, Theoharides TC, Peters EMJ, Paus R. Neuroimmunology of stress: skin takes center stage. J Investig Dermatol. 2006;126(8):1697–704.PubMedPubMedCentralCrossRef
85.
Silin P, Huali W, Qian W, Minxuan C, Weimin S, Jing S. Chronic Stress Suppresses the Expression of Cutaneous Hypothalamic–Pituitary–Adrenocortical Axis Elements and Melanogenesis. 2014. doi:10.​1371/​journal.​pone.​0098283.
86.
Levine N, Sheftel SN, Eytan T, et al. Induction of skin tanning by subcutaneous administration of a potent synthetic melanotropin. JAMA. 1991;266:2730–6.PubMedCrossRef
87.
Wakamatsu K, Graham A, Cook D, Thody AJ. Characterisation of ACTH peptides in human skin and their activation of the melanocortin-1 receptor. Pigment Cell Res. 1997;10:288–97.PubMedCrossRef
88.
Tsatmalia M, Wakamatsu K, Graham AJ, Thody AJ. Skin POMC peptides. Their binding affinities and activation of the human MC1 receptor. Ann NY Acad Sci. 1999;885:466–9.PubMedCrossRef
89.
Tsatmali M, Ancans J, Thody AJ. Melanocyte function and its control by melanocortin peptides. J Histochem Cytochem. 2002;50:125–33.PubMedCrossRef
90.
Graham A, Westerhof W, Thody AJ. The expression of α-MSH by melanocytes is reduced in vitiligo. Ann NY Acad Sci. 1999;885:470–3.PubMedCrossRef
91.
Pichler R, Sfetsos K, Badics B, Gutenbrunner S, Aubock J. Vitiligo patients present lower plasma levels of α-melanotropin immunoreactivities. Neuropeptides. 2006;40:177–83.PubMedCrossRef
92.
Kingo K, Aunin E, Karelson M, et al. Gene expression analysis of melanocortin system in vitiligo. J Dermatol Sci. 2007;48:113–22.PubMedCrossRef
93.
Berson JF, Theos AC, Harper DC, Tenza D, Raposo G, Marks MS. Proprotein convertase cleavage liberates a fibrillogenic fragment of a resident glycoprotein to initiate melanosome biogenesis. J Cell Biol. 2003;161:521–33.PubMedPubMedCentralCrossRef
94.
Schallreuter KU, Bahadoran P, Picardo M, et al. Vitiligo pathogenesis: autoimmune disease, genetic defect, excessive reactive oxygen species, calcium imbalance, or what else? Exp Dermatol. 2008;17:139–40. discussion 141–160.PubMedCrossRef
95.
Spencer JD, Gibbons NC, Böhm M, Schallreuter KU. The Ca2+−binding capacity of epidermal furin is disrupted by H2O2-mediated oxidation in vitiligo. Endocrinology. 2008;149:1638–45.PubMedCrossRef
96.
Spencer JD, Gibbons NC, Rokos H, Peters EM, Wood JM, Schallreuter KU. Oxidative stress via hydrogen peroxide affects proopiomelanocortin peptides directly in the epidermis of patients with vitiligo. J Invest Dermatol. 2007;127:411–20.PubMedCrossRef
97.
98.
Zouboulis CC, Eady A, Philpott M, et al. What is the pathogenesis of acne? Exp Dermatol. 2005;14:143–52.PubMedCrossRef
99.
Zouboulis CC, Böhm M. Neuroendocrine regulation of sebocytes—a pathogenetic link between stress and acne. Exp Dermatol. 2004;13 suppl 4:31–5.PubMedCrossRef
100.
Ganceviciene R, Graziene V, Fimmel S, Zouboulis CC. Involvement of the corticotropin-releasing hormone system in the pathogenesis of acne vulgaris. Br J Dermatol. 2009;160:345–52.PubMedCrossRef
101.
Zbytek B, Mysliwski A, Slominski A, Wortsman J, Wei ET, Mysliwska J. Corticotropin-releasing hormone affects cytokine production in human HaCaT keratinocytes. Life Sci. 2002;70(9):1013–21.PubMedCrossRef
102.
Zhang X, Lin S, Funk WE, Hou L. Environmental and occupational exposure to chemicals and telomere length in human studies. Occup Environ Med. 2013;70(10):743–9.PubMedCrossRef
103.
Boesten DM, de Vos-Houben JM, Timmermans L, den Hartog GJ, Bast A, Hageman GJ. Accelerated aging during chronic oxidative stress: a role for PARP-1. Oxid Med Cell Longev. 2013;2013:680414.PubMedPubMedCentralCrossRef
104.
Tyrka AR, Price LH, Marsit C, Walters OC, Carpenter LL. Childhood adversity and epigenetic modulation of the leukocyte glucocorticoid receptor: preliminary findings in healthy adults. PLoS One. 2012;7(1):e30148.PubMedPubMedCentralCrossRef
105.
Tyrka AR, Price LH, Kao HT, Porton B, Marsella SA, Carpenter LL. Childhood maltreatment and telomere shortening: preliminary support for an effect of early stress on cellular aging. Biol Psychiatry. 2010;67(6):531–4.PubMedCrossRef
106.
Oyetakin-White P, Koo B, Matsui M, Yarosh D, Fthenakis C, Cooper K, Baron E. In Effects of Sleep Quality on Skin Aging and Function, J. Invest. Dermatol. 2013: S126–S126
107.
Epel ES, Blackburn EH, Lin J, Dhabhar FS, Adler NE, Morrow JD, et al. Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci U S A. 2004;101(49):17312–5.PubMedPubMedCentralCrossRef
108.
Zbytek B, Pikula M, Slominski RM, Mysliwski A, Wei E, Wortsman J, et al. Corticotropinreleasing hormone triggers differentiation in HaCaT keratinocytes. Br J Dermatol. 2005;152(3):474–80.PubMedPubMedCentralCrossRef
109.
Katsarou-Katsari A, Singh LK, Theoharides TC. Alopecia areata and affected skin CRH receptor upregulation induced by acute emotional stress. Dermatology. 2001;203:157–61.PubMedCrossRef
110.
Slominski A, Pisarchik A, Tobin DJ, Mazurkiewicz JE, Wortsman J. Differential expression of a cutaneous corticotropin-releasing hormone system. Endocrinology. 2004;145:941–50.PubMedCrossRef
111.
Katayama M, Aoki E, Suzuki H, Kawana S. Foot shock stress prolongs the telogen stage of the spontaneous hair cycle in a non-depilated mouse model. Exp Dermatol. 2007;16:553–60.PubMedCrossRef
112.
Stenzel-Poore MP, Cameron VA, Vaughan J, Sawchenko PE, Vale W. Development of Cushing’s syndrome in corticotropin-releasing factor transgenic mice. Endocrinology. 1992;130:3378–86.PubMed
113.
Wang L, Million M, Rivier J, et al. CRF receptor antagonist astressin-B reverses and prevents alopecia in CRF over-expressing mice. PLoS One. 2011;6:e16377.PubMedPubMedCentralCrossRef
114.
Willemsen R, Vanderlinden J, Roseeuw D, Haentjens P. Increased history of childhood and lifetime traumatic events among adults with alopecia areata. J Am Acad Dermatol. 2009;60:388–93.PubMedCrossRef
115.
van der Steen P, Boezeman J, Duller P, Happle R. Can alopecia areata be triggered by emotional stress? An uncontrolled evaluation of 178 patients with extensive hair loss. Acta Derm Venereol. 1992;72:279–80.PubMed
116.
Brajac I, Tkalcic M, Dragojevic DM, Gruber F. Roles of stress, stress perception and trait-anxiety in the onset and course of alopecia areata. J Dermatol. 2003;30:871–8.PubMedCrossRef
117.
Paus R, Arck P. Neuroendocrine perspectives in alopecia areata: does stress play a role? J Invest Dermatol. 2009;129:1324–6.PubMedCrossRef
118.
Hordinsky MK, Ericson ME. Relationship between follicular nerve supply and alopecia. Dermatol Clin. 1996;14:651–60.PubMedCrossRef
119.
Kim HS, Cho DH, Kim HJ, Lee JY, Cho BK, Park HJ. Immunoreactivity of corticotropin-releasing hormone, adrenocorticotropic hormone and α-melanocyte-stimulating hormone in alopecia areata. Exp Dermatol. 2006;15:515–22.PubMedCrossRef
120.
Peters EM, Liotiri S, Bodó E, et al. Probing the effects of stress mediators on the human hair follicle: substance P holds central position. Am J Pathol. 2007;171:1872–86.PubMedPubMedCentralCrossRef
121.
122.
Slominski A, Zbytek B, Pisarchik A, Slominski RM, Zmijewski MA, Wortsman J. CRH functions as a growth factor/cytokine in the skin. J Cell Physiol. 2006;206:780–91.PubMedPubMedCentralCrossRef
Metadaten
Titel
Stress-related skin disorders
verfasst von
Alex Alexopoulos
George P. Chrousos
Publikationsdatum
02.07.2016
Verlag
Springer US
Erschienen in
Reviews in Endocrine and Metabolic Disorders / Ausgabe 3/2016
Print ISSN: 1389-9155
Elektronische ISSN: 1573-2606
DOI
https://doi.org/10.1007/s11154-016-9367-y

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„Jeder Fall von plötzlichem Tod muss obduziert werden!“

17.05.2024 Plötzlicher Herztod Nachrichten

Ein signifikanter Anteil der Fälle von plötzlichem Herztod ist genetisch bedingt. Um ihre Verwandten vor diesem Schicksal zu bewahren, sollten jüngere Personen, die plötzlich unerwartet versterben, ausnahmslos einer Autopsie unterzogen werden.

Hirnblutung unter DOAK und VKA ähnlich bedrohlich

17.05.2024 Direkte orale Antikoagulanzien Nachrichten

Kommt es zu einer nichttraumatischen Hirnblutung, spielt es keine große Rolle, ob die Betroffenen zuvor direkt wirksame orale Antikoagulanzien oder Marcumar bekommen haben: Die Prognose ist ähnlich schlecht.

Schlechtere Vorhofflimmern-Prognose bei kleinem linken Ventrikel

17.05.2024 Vorhofflimmern Nachrichten

Nicht nur ein vergrößerter, sondern auch ein kleiner linker Ventrikel ist bei Vorhofflimmern mit einer erhöhten Komplikationsrate assoziiert. Der Zusammenhang besteht nach Daten aus China unabhängig von anderen Risikofaktoren.

Semaglutid bei Herzinsuffizienz: Wie erklärt sich die Wirksamkeit?

17.05.2024 Herzinsuffizienz Nachrichten

Bei adipösen Patienten mit Herzinsuffizienz des HFpEF-Phänotyps ist Semaglutid von symptomatischem Nutzen. Resultiert dieser Benefit allein aus der Gewichtsreduktion oder auch aus spezifischen Effekten auf die Herzinsuffizienz-Pathogenese? Eine neue Analyse gibt Aufschluss.

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