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Clinical Rheumatology

Erschienen in:

01.12.2007 | Review Article

Capillaroscopy: questions and answers

verfasst von: Walter Grassi, Rossella De Angelis

Erschienen in: Clinical Rheumatology | Ausgabe 12/2007

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Abstract

Capillaroscopy is an essential imaging technique used in the study of microcirculation and one of the best diagnostic tools for the early detection of systemic sclerosis and related conditions. However, despite the increasing interest in capillary microscopy, there is still a surprising discrepancy between its potential application and its still limited use in rheumatological practice. This contrast is really surprising because few diagnostic techniques can combine all the positive features typical of capillaroscopy (low cost, uninvasiveness, repeatability, high sensitivity, good specificity, easy interpretation of results). The lack of guidelines and recommendations concerning the right way to carry out a correct capillaroscopic examination and the interpretation of the most relevant capillaroscopic abnormalities may represent one of the major drawbacks for its widespread use. Discussion about controversies on this topic should be encouraged, leading to a progressive development of capillaroscopy as a routine investigation in rheumatology.

Maricq HR (1981) Wide-field capillary microscopy. Arthritis Rheum 24:1159–1165CrossRefPubMed

Houtman PM, Kallenberg CGM, Fidler V et al (1986) Diagnostic significance of nailfold capillary patterns in patients with Raynaud’s phenomenon. J Rheumatol 13:556–563PubMed

Statham BN, Rowell NR (1986) Quantification of the nailfold capillary abnormalities in systemic sclerosis and Raynaud’s phenomenon. Acta Derm Venereol 66:139–143PubMed

Carpentier PH, Maricq HR (1990) Microvasculature in systemic sclerosis. Rheum Dis Clin North Am 16:75–91PubMed

Wong ML, Highton J, Palmer DG (1988) Sequential nailfold capillary microscopy in scleroderma and related disorders. Ann Rheum Dis 47:53–61CrossRefPubMedPubMedCentral

Lefford F, Edwards JCW (1986) Nailfold capillary microscopy in connective tissue disease: a quantitative morphological analysis. Ann Rheum Dis 45:741–749CrossRefPubMedPubMedCentral

Scheja A, Akesson A, Niewierowicz I et al (1996) Computer based quantitative analysis of capillary abnormalities in systemic sclerosis and its relation to plasma concentration of von Willebrand factor. Ann Rheum Dis 55:52–56CrossRefPubMedPubMedCentral

Chen ZY, Silver RM, Ainsworth SK et al (1984) Association between fluorescent antinuclear antibodies, capillary patterns, and clinical features in scleroderma spectrum disorders. Am J Med 77:812–822CrossRefPubMed

Lovy M, MacCarter D, Steigerwald JC (1985) Relationship between nailfold capillary abnormalities and organ involvement in systemic sclerosis. Arthritis Rheum 28:496–501CrossRefPubMed

10.

Schmidt KU, Mensing H (1988) Are nailfold capillary changes indicators of organ involvement in progressive systemic sclerosis? Dermatologica 176:18–21CrossRefPubMed

11.

Cutolo M, Sulli A, Pizzorni C et al (2000) Nailfold videocapillaroscopy assessment of microvascular damage in systemic sclerosis. J Rheumatol 27:155–160PubMed

12.

Grassi W, Core P, Cervini C (1996) Increased capillary permeability in systemic sclerosis: help or hindrance? Ann Rheum Dis 55:603–606CrossRefPubMedPubMedCentral

13.

LeRoy EC, Medsger TA Jr (1992) Raynaud’s phenomenon: a proposal for classification. Clin Exp Rheumatol 10:485–488PubMed

14.

Cutolo M, Grassi W, Matucci Cerinic M (2003) Raynaud’s phenomenon and the role of capillaroscopy. Arthritis Rheum 48:3023–3030CrossRefPubMed

15.

Grassi W, Del Medico P, Izzo F et al (2001) Microvascular involvement in systemic sclerosis: capillaroscopic findings. Semin Arthritis Rheum 30:397–402CrossRefPubMed

16.

Anders HJ, Sigl T, Schattenkirchner N (2001) Differentiation between primary and secondary Raynaud’s phenomenon: a prospective study comparing nailfold capillaroscopy using an ophtalmoscope or stereomicroscope. Ann Rheum Dis 60:407–409CrossRefPubMedPubMedCentral

17.

Bergman R, Sharony L, Schapira D et al (2003) The handheld dermatoscope as a nailfold capillaroscopic instrument. Arch Dermatol 139:1027–1030CrossRefPubMed

18.

Tektonidou M, Kaskani E, Skopouli FN et al (1999) Microvascular abnormalities in Sjögren’s syndrome: nailfold capillaroscopy. Rheumatology 38:826–830CrossRefPubMed

19.

Rozboril MB, Maricq HR, Rodnan GP et al (1983) Capillary microscopy in eosinophilic fasciitis. A comparison with systemic sclerosis. Arthritis Rheum 26:617–622CrossRefPubMed

20.

Zaric D, Worm AM, Stahl D et al (1981) Capillary microscopy of the nailfold in psoriatic and rheumatoid arthritis. Scand J Rheumatol 10:249–252CrossRefPubMed

21.

Grassi W, Core P, Carlino G et al (1992) Nailfold capillary permeability in psoriatic arthritis. Scand J Rheumatol 21:226–230CrossRefPubMed

22.

Dinc A, Melikoglu M, Korkmaz C et al (2001) Nailfold capillary abnormalities in patients with familial Mediterranean fever. Clin Exp Rheumatol 19(Suppl 24):S42–S44PubMed

23.

Vaiopoulos G, Pangratis N, Samarkos M et al (1995) Nailfold capillary abnormalities in Behçet’s disease. J Rheumatol 22:1108–1111PubMed

24.

Sulli A, Pizzorni C, Cutolo M (2000) Nailfold videocapillaroscopy in patients with antiphospholipid antibodies. J Rheumatol 27:1574–1576PubMed

25.

Grassi W, Core P, Carlino G et al (1994) Capillary permeability in fibromyalgia. J Rheumatol 21:1328–1331PubMed

26.

Fahrig C, Heidrich H, Voigt B et al (1995) Capillary microscopy of the nailfold in healthy subjects. Int J Microcirc Clin Exp 15:287–292CrossRefPubMed

27.

Herrick AL, Moore T, Hollis S et al (2000) The influence of age on nailfold capillary dimensions in childhood. J Rheumatol 27:797–800PubMed

28.

Merlen JF (1985) Capillaroscopy at the nailbed in functioning people aged 70 and over. Int Angiol 4:285–288PubMed

29.

Michoud E, Poensin D, Carpentier PH (1994) Digitized nailfold capillaroscopy. Vasa 23:35–42PubMed

30.

Bukhari M, Hollis S, Moore T et al (2000) Quantitation of microcirculatory abnormalities in patients with primary Raynaud’s phenomenon and systemic sclerosis by video-capillaroscopy. Rheumatology 39:506–512CrossRefPubMed

31.

Anderson ME, Allen PD, Moore T et al (2005) Computerized nailfold videocapillaroscopy. A new tool for assessment of Raynaud’s phenomenon. J Rheumatol 32:841–848PubMed

32.

Leteurtre E, Hachulla E, Janin A et al (1994) Vascular manifestations of dermatomyositis and polymyositis: clinical, capillaroscopic and histological aspects. Rev Med Interne 15:800–807CrossRefPubMed

33.

De Angelis R, Bugatti L, Del Medico P et al (2002) Videocapillaroscopic findings in the microcirculation of the psoriatic plaque. Dermatology 204:236–239CrossRefPubMed

34.

Chang CH, Tsai RK, Wu WC et al (1997) Use of dynamic capillaroscopy for studying cutaneous microcirculation in patients with diabetes mellitus. Microvasc Res 53:121–127CrossRefPubMed

35.

Monticone G, Colonna L, Palermi G et al (2000) Quantitative nailfold capillary microscopy findings in patients with acrocyanosis compared with patients having systemic sclerosis. J Am Acad Dermatol 42:787–790CrossRefPubMed

36.

Fitzgerald O, C’Connor GT, Spencer-Green G (1988) Prospective study on the evolution of Raynaud’s phenomenon. Am J Med 84:718–726CrossRefPubMed

37.

Spencer-Green G (1998) Outcomes in primary Raynaud’s phenomenon. A meta-analysis of frequency, rates and predictors of transition to secondary disease. Arch Intern Med 158:595–600CrossRefPubMed

38.

Luggen M, Belhorn L, Evans T et al (1995) The evolution of Raynaud’s phenomenon: a longterm prospective study. J Rheumatol 22:2226–2232PubMed

39.

Maricq HR, Harper FE, Khan MM et al (1983) Microvascular abnormalities as possible predictors of disease subsets in Raynaud’s phenomenon and early connective tissue disease. Clin Exp Rheumatol 1:195–205PubMed

40.

ter Borg EJ, Piersma-Wichers G, Smit AJ et al (1994) Serial nailfold capillary microscopy in primary Raynaud’s phenomenon and scleroderma. Semin Arthritis Rheum 24:40–47CrossRefPubMed

41.

Bredemeier M, Xavier RM, Capobianco KG et al (2004) Nailfold capillary microscopy can suggest pulmonary disease activity in systemic sclerosis. J Rheumatol 31:286–294PubMed

42.

Kabasakal Y, Elvins DM, Ring EFJ et al (1996) Quantitative nailfold capillaroscopy findings in a population with connective tissue disease and in normal healthy controls. Ann Rheum Dis 55:507–512CrossRefPubMedPubMedCentral

43.

Cutolo M, Pizzorni C, Tuccio M et al (2004) Nailfold videocapillaroscopic patterns and serum autoantibodies in systemic sclerosis. Rheumatology 43:719–726CrossRefPubMed

44.

Jayson MIV (1984) The microcirculation in systemic sclerosis. Clin Exp Rheumatol 2:85–91PubMed

45.

Wigley FM, Wise RA, Miller R et al (1992) Anticentromere antibody as a predictor of digital ischemic loss in patients with systemic sclerosis. Arthritis Rheum 35:688–693CrossRefPubMed

46.

Grassi W, Core P, Carlino G et al (1994) Effects of peripheral cold exposure on microvascular dynamics in systemic sclerosis. Arthritis Rheum 37:384–390CrossRefPubMed

47.

Filaci G, Cutolo M, Scudeletti M et al (1999) Cyclosporin A and iloprost treatment of systemic sclerosis: clinical results and interleukin-6 serum changes after 12 months of therapy. Rheumatology 38:992–996CrossRefPubMed

48.

Faggioli P, Giani L, Mazzone A (2006) Possibile role of iloprost (stable analogue of PGI2) in promoting neoangiogenesis in systemic sclerosis. Clin Exp Rheumatol 24:220PubMed

Titel: Capillaroscopy: questions and answers
verfasst von: Walter Grassi
Rossella De Angelis
Publikationsdatum: 01.12.2007
Verlag: Springer London
Erschienen in: Clinical Rheumatology / Ausgabe 12/2007
Print ISSN: 0770-3198
Elektronische ISSN: 1434-9949
DOI: https://doi.org/10.1007/s10067-007-0681-3

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