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Bias, Confounding, and Effect Modification

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Essentials of Clinical Research
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Abstract

Bias, jaconfounding, and random variation/chance are the reasons for a non-causal association between an exposure and outcome. This chapter will define and discuss these concepts so that they may be appropriately considered whenever one is interpreting the data from a study.

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References

  1. Cited in “Quote Me” How to add wit and wisdom to your conversation. Compiled by J Edward Breslin. Hounslow Press, Ontario, Canada, 1990, p 44.

    Google Scholar 

  2. http://dorakmt.tripod.com/epi/bc/html

  3. http://www.dorak.info/epi/bc.html

  4. http://en.wikipedia.org/wiki/Systematic_bias

  5. Davey Smith G, Ebrahim S. Data dredging, bias, or confounding. BMJ 2002; 325: 1437–1438.

    Article  Google Scholar 

  6. http://dorakmt.tripod.com/epi/bc/html)

  7. http://en.wikipedia.org/wiki/Biased_sample

  8. Sackett DL. Bias in analytic research. J Chronic Dis 1979; 32:51–63

    Article  PubMed  CAS  Google Scholar 

  9. http://publichealth.jbpub.com/aschengrau/ppts/confounding.ppt10.

  10. http://en.wikipedia.org/wiki/Confounding_variable

  11. Pearl, Judea (2000). Causality: Models, Reasoning, and Inference. Cambridge University Press, Cambridge. ISBN 0–521-77362–8.

    Google Scholar 

  12. Bradford Hill, Austin. “The environment or disease: association Or causation?”. Proc Roy Soc Med May 1965; 58:295–300. PMID 14283879

    Google Scholar 

  13. Mayrent, Sherry L. Epidemiology in Medicine. Williams & Wilkins, Baltimore, MD; 1987. ISBN 0–316-35636–0.

    Google Scholar 

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© 2008 Springer Science + Business Media B.V

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Glasser, S.P. (2008). Bias, Confounding, and Effect Modification. In: Glasser, S.P. (eds) Essentials of Clinical Research. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8486-7_17

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  • DOI: https://doi.org/10.1007/978-1-4020-8486-7_17

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-1-4020-8485-0

  • Online ISBN: 978-1-4020-8486-7

  • eBook Packages: MedicineMedicine (R0)

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