European Journal of Pediatrics OnlineFirst articles

Open Access 31.05.2024 | RESEARCH

Determinant factors for first-line treatment choice and effectiveness in pediatric eosinophilic esophagitis: an analysis of the EUREOS EoE CONNECT registry

This study compared short-term effectiveness of proton pump inhibitors (PPI), swallowed topical corticosteroids (STC), and dietary therapies in reversing clinical and histological features in pediatric patients with eosinophilic esophagitits …

verfasst von:: Pilar Navarro, Sara Feo‐Ortega, Sergio Casabona‐Francés, Carolina Gutiérrez‐Junquera, Edoardo V. Savarino, Edurne Amorena, Sonia Fernández‐Fernández, Isabel Pérez‐Martínez, Salvatore Oliva, Jesús Barrio, Maria Lluisa Masiques‐Mas, Antonio Guardiola‐Arévalo, Danila Guagnozzi, Francesca Racca, Elena Betoré, Martina Votto, Alba Rodríguez-Sánchez, Mónica Llorente Barrio, Leonardo Blas‐Jhon, Carlos Teruel Sánchez‐Vegazo, Natalia García-Morales, Anne Lund Krarup, Raffaella Dainese, Verónica Martín‐Dominguez, Alejandro García-Díaz, Daria Maniero, Cecilio Santander, Ángel Arias, Emilio J. Laserna‐Mendieta, Alfredo J. Lucendo

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Open Access 31.05.2024 | RESEARCH

Bowel function in a prospective cohort of 1052 healthy term infants up to 4 months of age

The purpose of this study is to describe the defecation pattern of healthy infants up to 17 weeks of age. We included 1052 healthy term infants from the prospective HELMi cohort (NCT03996304). Parents filled in recurring online questionnaires on …

verfasst von:: Terhi Solasaari, Katri Korpela, Sohvi Lommi, Sanni Hyvönen, Susanna Gardemeister, Laura Merras-Salmio, Anne Salonen, Willem M. de Vos, Kaija-Leena Kolho

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Open Access 29.05.2024 | RESEARCH

Efficacy and acceptability of different probiotic products plus laxatives for pediatric functional constipation: a network meta-analysis of randomized controlled trials

The prevalence of pediatric constipation ranges from 0.7 to 29.6% across different countries. Functional constipation accounts for 95% of pediatric constipation, and the efficacy of pharmacotherapy is limited, with a success rate of 60%. Several …

verfasst von:: Wei-Chieh Yang, Bing-Syuan Zeng, Chih-Sung Liang, Chih-Wei Hsu, Kuan-Pin Su, Yi-Cheng Wu, Yu-Kang Tu, Pao-Yen Lin, Brendon Stubbs, Tien-Yu Chen, Yen-Wen Chen, Yow-Ling Shiue, Bing-Yan Zeng, Mein-Woei Suen, Chao-Ming Hung, Ming-Kung Wu, Ping-Tao Tseng

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29.05.2024 | RESEARCH

How consistent are the key recommendations, and what is the quality of guidelines and expert consensus regarding paediatric cow’s milk protein allergy?

The objective of this study was to assess the quality and consistency of recommendations in clinical practice guidelines (CPGs) and expert consensus on paediatric cow’s milk protein allergy (CMPA) to serve as a foundation for future revisions and …

verfasst von:: Tengfei Li, Qingyong Zheng, Mingyue Zhang, Yiyi Li, Yongjia Zhou, Caihua Xu, Bowa Zhang, Zewei Wang, Jinhui Tian, Li Zhou

Open Access 27.05.2024 | RESEARCH

Variability of joint hypermobility in children: a meta-analytic approach to set cut-off scores

Current international consensus of the appropriate Beighton score cut-off to define if a child has generalised joint hypermobile or not is based upon expert opinion. Our aim was to determine the prevalence of Beighton scores of children worldwide …

verfasst von:: Cylie M. Williams, James J. Welch, Mark Scheper, Louise Tofts, Verity Pacey

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25.05.2024 | RESEARCH

Premature newborns with intraventricular hemorrhage do not have vasospasm pattern by cranial Doppler ultrasound: A pilot study

Preterm neonates are at risk for neurodevelopmental impairment, especially those with intraventricular hemorrhage (IVH). Cerebral vasospasm (VSP) is a common complication after subarachnoid hemorrhage (SAH) in adult population, but it is unknown …

verfasst von:: Javier Rodriguez-Fanjul, Iuri Corsini, Clara Sorribes Ortí, Maite Misis, Sara Bobillo-Pérez

24.05.2024 | Research

Current perception and barriers to implementing lung ultrasound in Canadian neonatal intensive care units: a national survey

Despite the growing body of literature supporting the use of point-of-care lung ultrasound (POC-LU) in neonates, its adoption in Canadian neonatal intensive care units (NICUs) remains limited. This study aimed to identify healthcare providers’ …

verfasst von:: Nada Mohsen, Telford Yeung, Nadya Ben Fadel, Muzafar Gani Abdul Wahab, Yasser Elsayed, Nehad Nasef, Adel Mohamed

23.05.2024 | RESEARCH

Cerebral venous thrombosis and deep medullary vein thrombosis: Padua experience over the last two decades

Cerebral venous thrombosis (CVT) in the neonatal period is a recognized cerebrovascular disorder accounting for 20% of perinatal strokes. Incidence varies, with CVT occurring in 0.67 to 2.6–12 per 100,000 neonates [ 1 ]. More recently, thanks to …

verfasst von:: Maria Elena Cavicchiolo, Gloria Brigiari, Margherita Nosadini, Jacopo Norberto Pin, Arianna Vincenti, Irene Toldo, Claudio Ancona, Paolo Simioni, Ignazio D′Errico, Eugenio Baraldi, Stefano Sartori

Open Access 23.05.2024 | RESEARCH

Congenital central hypoventilation syndrome in korea: 20 years of clinical observation and evaluation of the ventilation strategy in a single center

Congenital central hypoventilation syndrome (CCHS) is a rare genetic disorder characterized by hypoventilation due to impaired breathing control by the central nervous system and other symptoms of autonomic dysfunction. Mutations in paired-like …

verfasst von:: Min Jeong Lee, Ji Soo Park, Kyunghoon Kim, Jung Min Ko, June Dong Park, Dong In Suh

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23.05.2024 | Research

Viral load in hospitalized infants with respiratory syncytial virus bronchiolitis: a three-way comparative analysis

Viral load measurement of Respiratory syncytial virus (RSV) in acute bronchiolitis depends on specimen collection, viral load quantification, and transport media. The aim of this study was to investigate viral load in three-way-comparative …

verfasst von:: Inbal Golan- Tripto, Dana Danino, Leon De Waal, Khaled Akel, Yotam Dizitzer- Hillel, Asher Tal, Yasmine Langman, Aviv Goldbart

Open Access 23.05.2024 | Research

Determinants of antibiotic prescription in children with adenovirus respiratory tract infections

We performed this study to evaluate factors associated with antibiotic prescriptions in children with adenovirus infection, since no studies have attempted to address this aspect in the pediatric population. Retrospective study of children younger …

verfasst von:: Danilo Buonsenso, Anna Camporesi, Francesca Viozzi, Ilaria Lazzareschi, Lavinia Manca, Annamaria Caci, Daniele Menna, Rosaria Santangelo, Maurizio Sanguinetti, Francesca Raffaelli, Barbara Fiori, Giuseppe Zampino, Piero Valentini

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21.05.2024 | RESEARCH

Transcultural adaptation and validation of IMPACT-III and IMPACT-III-P in Spanish families: a multicenter study from SEGHNP

IMPACT-III and IMPACT-III-P are health-related quality of life (HRQoL) questionnaires for patients with pediatric inflammatory bowel disease (p-IBD) and their parents/caregivers. We aimed to perform a transcultural adaptation and validation for …

verfasst von:: Marta Velasco Rodríguez-Belvís, Laura Palomino, Gemma Pujol-Muncunill, Rafael Martin-Masot, Enrique Medina Benítez, Ana Estefanía Fernández-Lorenzo, Ana Moreno-Álvarez, Manuel Molina Arias, Inmaculada Hidalgo Montes, Josefa Barrio Torres, Víctor Manuel Navas-López, Javier Martín de Carpi, Ana Lozano Ruf, Javier Blasco-Alonso, Josefa Barrio Torres, Montserrat Montraveta, Luis Peña-Quintana, Natalia Ramos Rueda, Alejandro Rodríguez Martínez, Gonzalo Botija Arcos, Carmen Alonso Vicente, Ana María Castro Millán, Ester Donat, Santiago Fernández Cebrián, César Sánchez Sánchez, Inés Loverdos, Oscar Segarra Cantón, Noelia Ruiz Castellano, Ricardo Torres-Peral, Elena Crehuá-Gaudiza, Antonio Millán Jiménez, Carmen Jovani Casano, Saioa Vicente Santamaría, Ana Tabares González, Ruth Garcia-Romero, Ignacio Ros Arnal, María Jesús Balboa Vega, Laura Escartín Madurga, Nazareth Martinón Torres, Vanesa Crujeiras Martínez, Leticia González-Vives, Begoña Pérez-Moneo, María Llüisa Masiques Mas, Ana María Vegas Álvarez, Luis Grande Herrero, Enrique La Orden Izquierdo, Francisco José Chicano Marín, María de las Mercedes Busto Cuiñas, José Miguel Martínez de Zabarte Fernández, José Ramón Alberto Alonso, Eva María Andrés Esteban

Open Access 21.05.2024 | RESEARCH

Breastfeeding and risk of food allergy and allergic rhinitis in offspring: a systematic review and meta-analysis of cohort studies

The association between breastfeeding and the occurrence of allergic rhinitis (AR) and food allergy (FA) in offspring remains inconclusive. This review aims to comprehensively explore the potential relationships between various patterns and …

verfasst von:: Yali Ding, Chengbi Zhu, Shuo Li, Naixu Liu, Qian Liu, Weifeng Li, Changjiang Zhao, Bin Yuan

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21.05.2024 | RESEARCH

Diagnostic yield of bone marrow aspiration in paediatric primary immune thrombocytopenia: impact of evolution and adherence to medical guidelines over the last 25 years

The aim of this study is to analyse the diagnostic value of bone marrow aspiration (BMA) in a retrospective cohort of patients with suspected immune thrombocytopaenia (ITP). We further measure changes in the percentage of patients who underwent …

verfasst von:: Jesús González de Pablo, Josune Zubicaray, June Iriondo, Florencio Pérez Maroto, Daniel Azorín, Ana de la Cruz Benito, Alejandro Sanz, Luis Madero, Marta González-Vicent, Julián Sevilla, Elena Sebastián

21.05.2024 | Research

Reliability and reference values for diaphragmatic excursion, thickness, and thickening fraction and quadriceps femoris muscle thickness in full-term newborns evaluated by ultrasound

To determine the diaphragm thickness, thickening fraction, and excursion and thickness of the quadriceps femoris muscle in full-term newborns and to evaluate the intra- and interrater reliability of these measurements. This was a prospective …

verfasst von:: Milena Siciliano Nascimento, Flávia Sales Leite, Patricia Angelica L. Silva, Gisele Cristina Zamberlan, Priscila Monteiro de Souza, Raquel Afonso Caserta Eid, Romy Schmidt B. Zacharias, Cristiane do Prado, Carla Luciana Batista

20.05.2024 | RESEARCH

Investigation of colistin utilization in the treatment of multidrug-resistant gram-negative nosocomial bloodstream ınfections in children and literature review

This retrospective study aimed to assess the effectiveness and safety of colistin used in combination therapy for treating nosocomial bloodstream infections caused by multi-drug resistant gram-negative pathogens in pediatric patients. Patients …

verfasst von:: Cankat Genis, Ayse Kaman, Betül Öztürk, Gönül Tanır

20.05.2024 | Research

The lung ultrasound in children with SARS-COV-2 infection: a national multicenter prospective study

Coronavirus disease-19 (COVID-19) caused hospitalizations, severe disease, and deaths in any age, including in the youngest children. The aim of this multicenter national study is to characterize the clinical and the prognostic role of lung …

verfasst von:: Maria Chiara Supino, Danilo Buonsenso, Rino Agostiniani, Laura Gori, Vincenzo Tipo, Rosa Morello, Giovanni Del Monaco, Raffaele Falsaperla, Carlotta Biagi, Salvatore Cazzato, Alberto Villani, Anna Maria Musolino, PLUSCOVID-19 Study Group

20.05.2024 | Research

Continuous versus intermittent phototherapy in treatment of neonatal jaundice: a randomized controlled trial

Phototherapy (PT) is a widely used treatment for neonatal jaundice, yet the ideal model of application remains controversial. In this study, the effects of continuous phototherapy (CPT) and intermittent phototherapy (IPT) models were compared in …

verfasst von:: Hande Nur Demirel, Sibel Sevuk Ozumut, Husnu Fahri Ovalı

18.05.2024 | Correction

Correction to: Galectin-3 levels in children with cystic fibrosis

verfasst von:: Dilber Ademhan Tural, Nagehan Emiralioglu, Senay Akin, Didem Alboga, Beste Ozsezen, Halime Nayir Buyuksahin, Ismail Guzelkas, Merve Kasikci, Birce Sunman, Irem Gungor, Ebru Yalcin, Deniz Dogru, Nural Kiper, Ali Haydar Demirel, Ugur Ozcelik

17.05.2024 | BRIEF REPORT

Skin thickness in preterm neonates: relationship with skin bilirubin and predicted mortality

This study investigates the relationship between the thickness of skin in preterm infants and its link with bilirubin and mortality, as this may help understanding the potential deleterious effects of phototherapy. Observational, prospective …

verfasst von:: Silvia Foligno, Valeria Bisceglie, Barbara Loi, Daniele De Luca

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