Investigating the link between rosacea and neurological diseases: an all of us case-control study

Excerpt

Rosacea is a chronic inflammatory skin disorder characterized by recurrent or persistent centrofacial erythema and flushing, commonly considered to have four phenotypic presentations: (1) erythematotelangiectatic, (2) inflammatory papulopustular, (3) phymatous, and (4) ocular [1]. Beyond its dermatological manifestations, rosacea commonly includes symptoms, such as stinging, edema, and burning, that are suggestive of neurogenic contributions to disease pathology [1]. However, full characterization of the neurogenic basis for rosacea pathogenesis remains an ongoing effort [2]. Emerging research has identified potential associations between rosacea and various neurological conditions, such as Parkinson’s disease, migraines, and dementia [3‐5]. However, these associations have largely been limited to European nationwide cohort studies and have not been evaluated within a diverse and underrepresented population cohort in the US. Given this gap in the literature, this study sought to utilize the NIH’s All of Us database to further explore the connection between rosacea and neurological conditions. …