Detailed knowledge of the osteology and morphometry of the HC is necessary for the neurosurgeon to plan any surgical interventions in the area and cut morbidity and mortality rates [
12,
13]. The anatomical variations of the HC are important also for anthropologists who can infer possible ethnicity differences from various studies [
4] and for anatomysts, radiologists [
11] and for forensic sciences. The variations in the HC division have been the subject of studies conducted on dried skulls or with neuroradiological methods [
11]. In our study, we found a double unilateral HC channel in 16% of cases (7 on the left and 3 on the right) and bilateral in 2% of cases. Nearly similar results were reported in a neuroradiological study with multislice TAC in a Japanese population where double hypoglossal canal was identified in 16.9% of the patients, and was bilateral in 2.2% [
11]. Osteological studies on skulls belonging to various ethnicities show some differences, regarding the duplication of the hypoglossal canal by a more or less complete septum. Kumar et al. [
15] in an Indian population of 50 dried skulls did not observe complete septa. Meera et al. [
17] in 60 skull bones observed double HC in 12 skulls (20%) out of which 4 were bilateral and 8 were unilateral. Bhuller et al. [
5] found the HC divided into two canals by small bony spicules in 28.12% of cases. Yadav et al. [
28] observed bilateral duplicated HC in 3 skulls (3.75%) while unilateral duplication was seen in 15 skulls (18.75%). Finally complete osseous bridging, in the outer or inner part of the canal, was visible in 19.83% of specimens (46/23) as reported by Paraskevas et al. [
22]. In a large sample of dried skulls (585 skulls) Berry and Berry [
4] discovered a double hypoglossal canal in 14.6%
Double hypoglossal canal is important clinically, it may trap the hypoglossal nerve during ossification of occipital bone The entrapment of CN XII roots due to the incomplete ossification of the occipital bone or variational.
In the present study, the mean length of the canal was 8,67 ± 1,86 mm on the right side and 8,26 ± 1,67 mm on the left side and this difference was similar to the value reported by Lyrtzis et al. [
16], on 141 Greek adult dried skulls (8,89 mm on right side -9,03 mm on left side) and by Berlis et al. [
3], who in a correlative study between CT scan and 60 dried skulls, found a length of 7.78 mm. The diameter of the extracranial end of the right HC in our study was 6,33 mm and the left one was 6,44. The difference between the two sides was not significant. The diameter of the intracranial end of the right HC was 6,03 mm and 6,21 mm was the diameter of the left one;again,the difference in diameter between the two sides was not significant. Our results came close to those of Muthukumar et al. [
18], who on 50 dried skulls found a diameter of the extracranial end of 7,9 mm and an intracranial end of 7,2 mm. According to Kumar et al. [
15], the mean diameter of HC at its intracranial and the extracranial end was 7.48 and 7.59 mm. Very similar to our results were those obtained by Farid et al. [
8] in70 Egyptian skulls: the mean diameter of the intracranial end of the right HC was 6.24 mm and the left one was 6.04 mm. However, the mean diameters of the extracranial ends were 6.18 mm and 6.04 mm. Therefore, for this important parameter, which is the length of the canal, no great differences seem to emerge between the skulls belonging to different ethnicities. The hypoglossal canal can be involved in various pathologies that require the intervention of a neurosurgeon. In these cases, different techniques are used which require the morphometry of the hypoglossal canal. A posterolateral approach to the foramen magnum and transcondylar, supracondylar, and paracondylar approaches are employed for the lower clivus, craniovertebtral junction, hypoglossal canal, and mastoid [
9]. Transcondylar surgery has gained great popularity in the last time as an access route to ventral lesions in the brainstem and cervicomedullary region [
25]. During transcondylar resection,the posterior one-third of OC is resected. Direct visualization of the spinal cord, the previous brain stem and the surface of the tumor can be achieved by OC resection, [
23]. According to Spektor et al. [
25] resection of the OC above the HC can improve the visual angle from 21 to 28% for the petroclival area, as well as provide an exposure increase from 28 to71% by resecting the jugular tubercle. Therefore, the distance between between OC and HC is important [
9]. So the bony anatomy of Hc and its anatomical relationship with the condyles is necessary to plan a surgery [
1]. The distance between the HC and the posterior border of the OC is critical. This measurement gives an indication of the largest amount of resectable condyle without entering the HC. Therefore,our study also concerned the anatomical morphometric relationships between HC and occipital condyle. For this purpose,we measured the distances between HC and the extremity of the condyle and the inferior margin of the same in both sides. Distance between the posterior edge of the internal hole of HC and the posterior edge of the CP on the same side (Dist. I-P) was 11,11 mm on the right and 10,51 on the left (
P = 0,052) almost significant. Similar results were obtained by Kumar et al. [
15] in 50 Indian dried skulls (10,66 on the right and 11,89 on the left), and by Vinay et al. [
27] 12,98 mm still in Indian dried skulls. Our data are also similar to those of Pereira et al. [
23], who finds a distance from the internal orifice of the hypoglossal canal to the posterior margin of OC on the right of 0.10.3 mm and on the left of 11.3 mm. Muthukumar et al. [
18] and Barut et al. [
1] suggested the distance between the HC-OC posterior border is 12 mm and 12.55 mm, as a safe zone of OCs drilling, during transcondylar neurosurgery, while Lyrzits [
16] in a Greek study concluded in a safe zone of 8,17 mm. Wen et al. [
29] reported that the distance between the posterior edge of the OC and the HC is approximately 8.4 mm and that a resection of the OC of that same amount would be sufficient for surgical exposure. Currently, medical practice has undergone tremendous advances,including radiology [
10]. The preoperative study in hypoglossal canal surgery conducted on patients with three-dimensional computer tomography (3-D-CT) allows detailed anatomical information to be obtained. In the neuroradiological study conducted by Bulsara [
6] on 20 patients, the distance from the upper part of the condyle was measured to the internal opening of the hypoglossal canal. was 11.0 + 1.4 mm (range 8.7–12.7 mm). In this way the amount of bone that, can be safely removed without violating the hypoglossal canal, can be determined preoperatively for each patient [
6] With regard to gender differences, none were found except for the distance between the inferior edge of the internal hole and the inferior edge of the condyloid process on the same side (Dist. I-I) which was found to be greater in men than in women, 7,87 ± 1,60 mm mm and 6,76 ± 1,13 mm mm, respectively (
P = 0,011). It is important to emphasize this gender difference that has never been described before by other authors and that may have particular importance in transcondylar surgery in the planning of surgery to cut morbility and mortality. Gender dimorphism was found in the study of Lyrtzis et al. [
16], about the right length of the HC and the left distance of the HC from the posterior edge of the occipital condyles.