Background
Methods
Inclusion criteria
Exclusion criteria
Search equations and databases
Selection of articles
Data analysis
Results
Type of study | Lead author Year Reference | Country | Population | Overdiagnosis |
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Observational studies | Haddad E (2019) [10] Haddad E (2019) [11] Itani O (2020) [12] | France France France | 301 patients PTLDS 4 weeks 1 center Male: 60,8% Median age: 50 12–85 years old 1000 patients 3 centers Male: 50% Nancy: Median age: 51 7–86 years old 15 patients 6 months Male: 4/15 Median age: 44 15–89 years old | Overdiagnosis = 80.7% (n = 243) differential diagnosis: psychiatric (depression, post-traumatic stress, burnout syndromes, etc.) 25.2% (n = 76 ) rheumatological (osteoarthritis, scoliosis) 15.9% (n = 48) neurological (Parkinson and amyotrophic lateral sclerosis)12.3% (n = 37) OSA 4.9% (n = 15) No diagnosis 6.6% (n = 20) Overdiagnosis: 90.4, 88, 85% differential diagnoses: psychiatric 25, 19 and 13% rheumatological 16, 14 and 32% neurological 12, 6 and 5% no diagnosis 6, 29 and 26% Overdiagnosis: 100% (n = 15) differential diagnosis: psychiatric FSS 60% (n =9) neurological 20% (n =3), 1 OSA |
Kobayashi Y (2019) [20] | United States | 1261 patients Male 39,2% > 12 years old Median age: 46,7 | Overdiagnosis: 84.1% (n = 1061) | |
Case report | Peri F (2019) [22] | Italy | 7 children Male: 3 12–17 years old | Overdiagnosis: 100% (n = 7) differential diagnosis: psychiatric (n = 6) viral infection (n = 1- |
Strizova Z (2018) [23] | Czech Republic | a 37-year-old Female systemic lupus erythematosus | Attribution to Lyme long-term tetracycline Death of multi-organ failure | |
Nelson C (2015) [25] | United States | 3 patients PTLDS Male: 3 30-30-50 years old ATX treatment (tetracyclines, clarithromycin and hydroxychloroquine) | diagnostic delay pituitary tumor Hodgkin’s lymphoma stage 4 lung cancer | |
Di Battista ME (2018) [26] | Italy | 61-year-old woman patient: doxycycline (21 days and 14 days) | diagnostic delay (4 years) frontotemporal dementia |
RCT | Krupp LB (2003) [15] | United States | 55 PTLDS patients 28 ceftriaxone IV Female 15/28 Median age 48 27 placebo Female 14/27 Median age 47 6 months | AEs: diarrhea ceftriaxone group 43% placebo group 25% Hospitalizations: 4 ceftriaxone group: 1 anaphylaxis, minor anaphylactic reactions: 2 placebo group: 3 IV catheter sepsis |
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Observational studies | Itani O (2020) [12] | France | 15 patients Median age 44 15–89 years old Male: 4/15 On average 6.8 ABX / 476 days | AEs: 27% (n = 4) 1 clostridium difficile colitis 3 fungal infections |
Trautmann A (2020) [19] | France | 16 Disulfiram patients 21–70 years old Gender not available | Various and moderate AEs: 81.2% (n = 13) | |
Goodlet KJ (2018) [21] | United States | 3127 patients Age and gender not available Group 1: 1102 ABX per os Group 2: 150 IV Groupe 3: 1875 placebo | AEs: group 1: 18.7%, group 2: 16.8%, group 3: 13.4% Infections 20.4%, gastrointestinal disorders 6.2%, electrolyte disorders 2.6% Hospitalizations: group 1: 2.2%, group 2: 7.3%, group 3: 0.9% Emergencies: group 1: 3.4%, group 2: 11.3%, group 3: 1.9% | |
Cases report | Johnstone T (2018) [27] | Australia | 41-year-old woman Glutathion + Phosphatidylcholine | AEs: bacterial septicemia then Clostridium Difficile colitis |
Issacs D (2016) [28] | Australia | 15-year-old woman Hyperthermia and ABX IV | AEs: severe dehydration due to Clostridium Difficile diarrhea | |
Shelton A (2019) [29] | United States | 32-year-old woman ABX IV (rifabutin, metronidazole, ivermectin, and pyrimethamine) then ABX per os (meropenem, clindamycin, tigecycline, and ciprofloxacin) | AEs: Mycobacterium goodii multifocal pneumonia on central venous catheter | |
Marcks CM (2016) [30] | United States | 45-year-old woman ABX 3 months per os (doxycycline, minocycline and trimethoprim-sulfamethoxazole | AEs: DRESS Syndrome | |
De Wilde M (2017) [31] | Belgium | 76-year-old woman ceftriaxone IV | AEs: drug-induced immunohemolytic anemia | |
Patel R (2000) [20] | United States | 30-year-old woman Cefotaxime IV | AEs: large Candida parapsilosis septic thrombus |