nach oben

Lasers in Medical Science

Erschienen in:

01.12.2024 | Review Article

308 nm excimer laser and tacrolimus ointment in the treatment of facial vitiligo: a systematic review and meta-analysis

verfasst von: Dan-feng Suo, San-wu Zeng, Ling-he Meng

Erschienen in: Lasers in Medical Science | Ausgabe 1/2024

Einloggen, um Zugang zu erhalten

Abstract

This study aimed to investigate the effects and safety of 308 nm excimer laser (308 nm EL) and tacrolimus ointment (TO) in the treatment of facial vitiligo (FV). We searched Cochrane Library, PUBMED, EMBASE, CNKI, and WANGFANG from inception to June 1, 2023. Outcomes included overall response rate (ORR), total adverse reaction rate (TARR), recurrence rate at 3-month (RR-3) and recurrence rate at 6-month (RR-6). The outcome data were presented as odds ratios (OR) with 95% confidence intervals (CI). The risk of bias was assessed by Cochrane risk-of-bias tool and data analysis was performed by RevMan 5.4 software. This study included a total of 19 trials involving 2085 patients. When comparing 308 nm EL monotherapy with 308 nm EL plus TO, significant differences in the ORR (OR = 4.29, 95% CI [2.97, 6.19], I² = 0%, P < 0.001), RR-3 (OR = 0.18, 95% CI [0.05, 0.69], I² = 0%, P = 0.01), and RR-6 (OR = 0.38, 95% CI [0.14, 1.03], I² = 39%, P = 0.06) were found between the two managements. When comparing TO monotherapy with TO plus 308 nm EL, its results showed significant differences in the ORR (OR = 4.21, 95% CI [2.90, 6.11], I² = 0%, P < 0.001), TARR (OR = 0.42, 95% CI [0.22, 0.81], I² = 4%, P = 0.009), and RR-3 (OR = 0.32, 95% CI [0.01, 8.03], P = 0.49) between the two modalities. The results of this study suggest that the combination of 308 nm EL and TO is more effective than either treatment alone for the treatment of FV.

Bergqvist C, Ezzedine K (2020) Vitiligo: a review. Dermatology 236(6):571–592PubMedCrossRef

van Geel N, Speeckaert R (2017) Segmental vitiligo. Dermatol Clin 35(2):145–150PubMedCrossRef

Ezzedine K, Eleftheriadou V, Whitton M, van Geel N (2015) Vitiligo. Lancet 386(9988):74–84PubMedCrossRef

Picardo M, Dell’Anna ML, Ezzedine K, Hamzavi I, Harris JE, Parsad D, Taieb A (2015) Vitiligo. Nat Rev Dis Primers 1:15011PubMedCrossRef

Lotti T, D’Erme AM (2014) Vitiligo as a systemic disease. Clin Dermatol 32(3):430–434PubMedCrossRef

Mohammed GF, Gomaa AH, Al-Dhubaibi MS (2015) Highlights in pathogenesis of vitiligo. World J Clin Cases 3(3):221–230PubMedPubMedCentralCrossRef

Halder RM, Chappell JL (2009) Vitiligo update. Semin Cutan Med Surg 28(2):86–92PubMedCrossRef

Spritz RA (2008) The genetics of generalized vitiligo. Curr Dir Autoimmun 10:244–257PubMedCrossRef

Le Poole IC, Luiten RM (2008) Autoimmune etiology of generalized vitiligo. Curr Dir Autoimmun 10:227–243PubMedCrossRef

10.

Sitek JC (2006) Vitiligo–loss of cutaneous pigmentation. Tidsskr Nor Laegeforen 126(18):2370–2372PubMed

11.

Sehgal VN, Srivastava G (2006) Vitiligo: auto-immunity and immune responses. Int J Dermatol 45(5):583–590PubMedCrossRef

12.

Huggins RH, Schwartz RA, Janniger C (2005) Vitiligo. Acta Dermatovenerol Alp Pannonica Adriat 14(4):137–142PubMed

13.

Boissy RE, Manga P (2004) On the etiology of contact/occupational vitiligo. Pigment Cell Res 17(3):208–214PubMedCrossRef

14.

Hann SK, Park YK, Chun WH (1997) Clinical features of vitiligo. Clin Dermatol 15(6):891–897PubMedCrossRef

15.

Handa S, Kaur I (1999) Vitiligo: clinical findings in 1436 patients. J Dermatol 26(10):653–657PubMedCrossRef

16.

Abdel-Malek ZA, Jordan C, Ho T, Upadhyay PR, Fleischer A, Hamzavi I (2020) The enigma and challenges of vitiligo pathophysiology and treatment. Pigment Cell Melanoma Res 33(6):778–787PubMedCrossRef

17.

Krüger C, Schallreuter KU (2012) A review of the worldwide prevalence of vitiligo in children/adolescents and adults. Int J Dermatol 51(10):1206–1212PubMedCrossRef

18.

Whitton M, Pinart M, Batchelor JM, Leonardi-Bee J, Gonzalez U, Jiyad Z et al (2016) Evidence-based management of vitiligo: summary of a Cochrane systematic review. Br J Dermatol 174(5):962–969PubMedCrossRef

19.

Nahhas AF, Braunberger TL, Hamzavi IH (2019) Update on the Management of Vitiligo. Skin Therapy Lett 24(3):1–6PubMed

20.

Deng Y, Li J, Yang G (2020) 308-nm excimer laser plus platelet-rich plasma for treatment of stable vitiligo: a prospective, randomized case-control study. Clin Cosmet Investig Dermatol 13:461–467PubMedPubMedCentralCrossRef

21.

Bae JM, Kwon SH, Ju HJ, Kang HY (2020) Suberythemic and erythemic doses of a 308-nm excimer laser treatment of stable vitiligo in combination with topical tacrolimus: A randomized controlled trial. J Am Acad Dermatol 83(5):1463–1464PubMedCrossRef

22.

Shah S, Sakhiya J, Deshpande P, Sakhiya D, Inamadar AC (2020) Safety and efficacy of the combination of 308-nm monochromatic excimer light and topical 0.1% tacrolimus ointment in segmental vitiligo: an open-label study. J Clin Aesthet Dermatol 13(2):E69–E75PubMedPubMedCentral

23.

Wu Y, Sun Y, Qiu L, Wang H, Zhang Y, Chen K et al (2019) A multicentre, randomized, split face and/or neck comparison of 308-nm excimer laser and 01% tacrolimus ointment for stable vitiligo plus intramuscular slow-releasing betamethasone for active vitiligo. Br J Dermatol 181(1):210–211PubMedCrossRef

24.

Wang LM, Lu WJ, Yuan JT, Zeng BB, Li D, Zhang F, Li JJ (2018) Utility of dermoscopy for evaluating the therapeutic efficacy of tacrolimus ointment plus 308-nm excimer laser combination therapy in localized vitiligo patients. Exp Ther Med 15(4):3981–3988PubMedPubMedCentral

25.

Du J, Wang XY, Ding XL, Xu QX, Chen Z, Chang JM, Zhang JZ (2013) Long-term efficacy and safety of tacrolimus ointment in the treatment of vitiligo. J Dermatol 40(11):935–936PubMedCrossRef

26.

Wang X, Liu GY (2017) Progress of 308 nm excimer laser combined with other methods in the treatment of vitiligo. Chin J Dermatol 50(9):695–697

27.

Baltás E, Nagy P (2001) Repigmentation of localized vitiligo with the xenon chloride laser. Br J Dermatol 144(6):1266–1267PubMedCrossRef

28.

Spencer JM, Nossa R, Ajmeri J (2002) Treatment of vitiligo with the 308 nm excimer laser: a pilot study. J Am Acad Dermatol 46:727–731PubMedCrossRef

29.

Mehraban S, Feily A (2014) 308 nm excimer laser in dermatology. J Lasers Med Sci 5:8–12PubMedPubMedCentral

30.

Travis LB, Weinberg JM, Silverberg NB (2003) Successful treatment of vitiligo with 0.1% tacrolimus ointment. Arch Dermatol 139(5):571–574PubMedCrossRef

31.

Matin M, Latifi S, Zoufan N, Koushki D, MirjafariDaryasari SA, Rahdari F (2014) The effectiveness of excimer laser on vitiligo treatment in comparison with a combination therapy of Excimer laser and tacrolimus in an Iranian population. J Cosmet Laser Ther 16(5):241–245PubMedCrossRef

32.

Park OJ, Park GH, Choi JR, Jung HJ, Oh ES, Choi JH, Lee MW, Chang SE (2016) A combination of excimer laser treatment and topical tacrolimus is more effective in treating vitiligo than either therapy alone for the initial 6 months, but not thereafter. Clin Exp Dermatol 41(3):236–241PubMedCrossRef

33.

Chen J, Li YL, Peng SC et al (2021) The efficacy of 308 nm Excimer laser and tacrolimus in the treatment of adult vitiligo on the face. Chin Contemp Med 28(3):38–40

34.

Guan JY, Ge Y, Lai YL et al (2022) The efficacy of tacrolimus ointment combined with 308 nm Excimer laser in the treatment of facial vitiligo in children. J Dermatol Venereol 29(2):130–134

35.

Li ZM, Xie PY, Zhou XY (2017) Clinical efficacy of tacrolimus ointment combined with 308 nm excimer light in the treatment of vitiligo. Chin foreign Med Res 15(24):114–115

36.

Li RZ, Wei L, Wei S et al (2021) The efficacy of 308 nm Excimer laser combined with tacrolimus ointment in the treatment of facial vitiligo and its influence on patients’ psychological status. Psychol Monthly 16(19):49–51

37.

Li HH, Xu WC, Zeng QR (2022) Clinical study of 308 nm Excimer laser combined with 0.1% tacrolimus ointment in the treatment of vitiligo of the face and neck. Primary Care Forum 26(10):11–3

38.

Liu JJ, Yang HF, Li YJ et al (2018) Efficacy of 308 nm Excimer laser combined with drugs in the treatment of adult facial vitilig. Shaanxi Med J 47(8):1017–1019

39.

Passeron T, Ostovari N, Zakaria W et al (2004) Topical tacrolimus and the 308-nm excimer laser: a synergistic combination for the treatment of vitiligo. Arch Dermatol 140(9):1065–1069PubMedCrossRef

40.

Pei Y (2020) Tacrolimus combined with 308 nm Excimer laser for the treatment of facial vitiligo. Chin Continuing Med Education 12(13):131–133

41.

Pu Y (2020) Efficacy of 308 nm Excimer laser combined with drugs in the treatment of adult facial vitiligo. Med Aesthetic Cosmetology 29(1):13–14

42.

Suo DF, Zeng SW (2020) Efficacy of 308 nm Excimer laser combined with tacrolimus ointment in the treatment of vitiligo of face and neck. Med Inform 33(11):116–117

43.

Tang HB, Liu X, Chen XY et al (2013) 308 nm excimer light combined with 0.03% tacrolimus ointment in the treatment of facial vitiligo. J Pract Dermatol 6(6):343–5

44.

Wang J (2016) Clinical analysis of 308 nm Excimer laser combined with tacrolimus ointment in the treatment of vitiligo. Chin Cosmetic Med 25(10):83–84

45.

Wang SL (2017) The efficacy of 308 nm Excimer laser combined with tacrolimus in the treatment of facial vitiligo. J Clin Rational Drug Use 10(10):85–86

46.

Wang X (2018) Clinical study of tacrolimus ointment combined with 308 nm Excimer laser in the treatment of facial vitiligo. Modern Drug Use Chin 12(1):116–117ADS

47.

Wen XY, Tian WW, Li G et al (2021) Effect of tacrolimus ointment combined with 308 nm excimer light on adult vitiligo and quality of life. Chin Med Innovation 18(24):134–137

48.

Wen XY, Liu JH, Ding M et al (2022) Clinical study of tacrolimus ointment combined with 308 nm excimer laser photocoagulation in the treatment of adult facial vitiligo. Chin Cosmetic Med 31(6):13–16

49.

Zhang HY (2016) 308 nm high energy excimer light combined with tacrolimus cream in the treatment of facial vitiligo. World Newest Abstracts Med Information 16(53):56–61

50.

Zhang QW, Wang YH (2016) The efficacy of 308 nm Excimer laser combined with tacrolimus in the treatment of stable vitiligo of the head and face. Shandong Med 56(18):107

51.

Zhu Q (2018) The efficacy of 308 nm Excimer laser combined with tacrolimus in the treatment of facial vitiligo was evaluated. Electronic J Clin Med Literature 5(1):117–119

52.

Liu CH, Wahefu A, Lu XY, Abdulla R, Dou J, Zhao HQ et al (2022) Chemical Profiling of Kaliziri Injection and Quantification of Six Caffeoyl Quinic Acids in Beagle Plasma by LC-MS/MS. Pharmaceuticals (Basel) 15(6):663PubMedCrossRef

53.

BikashRanjanKar RR, Singh BSTP, Agrawal I (2022) Treating Vitiligo at the angle of lips: a narrative review. J Cutan Aesthet Surg 15(4):355–362CrossRef

54.

Birlea SA, Goldstein NB, Norris DA (2017) Repigmentation through melanocyte regeneration in vitiligo. Dermatol Clin 35(2):205–218PubMedCrossRef

55.

Rico MJ, Lawrence I (2002) Tacrolimus ointment for the treatment of atopic dermatitis: clinical and pharmacologic effects. Allergy Asthma Proc 23(3):191–197PubMed

Titel: 308 nm excimer laser and tacrolimus ointment in the treatment of facial vitiligo: a systematic review and meta-analysis
verfasst von: Dan-feng Suo
San-wu Zeng
Ling-he Meng
Publikationsdatum: 01.12.2024
Verlag: Springer London
Erschienen in: Lasers in Medical Science / Ausgabe 1/2024
Print ISSN: 0268-8921
Elektronische ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-024-04033-y

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

308 nm excimer laser and tacrolimus ointment in the treatment of facial vitiligo: a systematic review and meta-analysis

Abstract

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2024

Early intervention of carbon dioxide fractional laser in hypertrophic scar through TGFβ-1/ Smad3 signaling pathway

Evaluation of chlorophyll-loaded mesoporous silica nanoparticles for photodynamic therapy on cancer cell lines

Photobiomodulation increases brain metabolic activity through a combination of 810 and 660 wavelengths: a comparative study in male and female rats

755-nm picosecond laser plus topical 20% azelaic acid compared to topical 20% azelaic acid alone for the treatment of melasma: a randomized, split-face and controlled trial

Phase-locked µPIV analysis of flow dynamics in a simulated root canal with different laser-activated irrigations

Evaluation of combining ultrapulse CO2 with fractional CO2 laser for the treatment of atrophic scars in Asians