Malaria is a major public health issue in Niger. In 2020, the Niger Malaria Control National Strategic Plan reported 5827 deaths attributable to malaria and 5,141,257 confirmed malaria cases, for an incidence of 19,200 cases per 100,000 …

Malaria remains one of the most important infectious diseases globally with 249 million cases and 608,000 deaths in 2022 [ 1 ]. Approximately 77% of deaths occurred in children under 5 years of age, with the greatest burden in those under 3 years …

Malaria is a mosquito-borne infectious disease caused by protozoan parasites of the genus Plasmodium. Despite some progress in malaria control across the globe, 241 million cases still occurred worldwide in 2020, causing 627,000 deaths, mostly …

Plasmodium falciparum malaria is transmitted by the bite of the Anopheles mosquito, representing a major endemic problem in sub-Saharan African countries. According to the 2022 World Health Organization (WHO) report, there are more than 249 million …

During the erythrocytic stage of the malaria parasite in humans, a fraction of asexual parasites differentiates into gametocytes [ 1 ]. Gametocytes are the sexual form of the parasite transmitted from humans to mosquitoes and are an important …

The most vulnerable population to P. falciparum infection includes pregnant women and children under 5 years old. Specifically, during pregnancy, P. falciparum causes approximately 150,000 fetal deaths and 10,000 maternal deaths annually in …

Conducting experimental infections of Anopheles mosquito vectors with Plasmodium parasites is pivotal in advancing both fundamental and applied malariology. Controlled laboratory infections are essential for unraveling the intricacies of the …

Malaria remains a global public health challenge. An estimated 247 million cases and 619,000 deaths occurred worldwide in 2022 with 95% of these cases and 96% of the deaths recorded from the WHO Africa region [ 1 ]. The vast majority of deaths …

With almost 250 million infections and approximately 600 thousand deaths per year, malaria remains a global health priority. The renewed focus on malaria elimination has increased the priority of research into interventions to block malaria …

Novel vaccines and drugs are urgently needed to alleviate the burden of disease by malaria and reverse the recent resurgence of cases [ 1 – 3 ]. Plasmodium falciparum sporozoites (SPZ), the infective form of malaria, are considered a key target for …

Malaria remains a major public health problem worldwide, with nearly half of the world’s population at risk and lives in areas where malaria transmission occurs, but with the majority of cases and deaths from sub-Saharan (SSA) [ 1 ]. In 2022, over …

Artemisinin-based combination therapy (ACT) remains a treatment of choice for uncomplicated Plasmodium falciparum malaria globally [ 1 , 2 ]. Six artemisinin-based combinations have been pre-qualified by the World Health Organization (WHO) for …

Over the past thirty years, epigenetic regulation of gene expression has gained increasing interest as it was shown to be implicated in illnesses ranging from cancers to parasitic diseases. In the malaria parasite, epigenetics was shown to be …

Pathogen genomics is revolutionizing public health by providing a rich data source for informing real-time, actionable recommendations for public health programmes [ 1 ]. Each pathogen genome is a unique record of its previous transmission history …

Plasmodium falciparum presents a significant public health challenge in sub-Saharan Africa (SSA), constituting the majority of reported malaria cases. In 2022, out of the 249 million malaria cases recorded globally, 233 million occurred in SSA …

Malaria is one of the most important vector-borne diseases of humans with an estimated 241 million cases worldwide in 2020, being Africa the region that recorded the 95% of the malaria cases and the 96% of deaths worldwide [ 1 ]. A huge effort was …

Anti-malarial drugs, particularly artemisinin-based combinations, are recommended and widely used for effective case management, but drug resistance is a major threat that has impacted their effectiveness for malaria control and elimination. The …

Efficacious antimalarial drugs are mainstays of malaria control and elimination programs. Widespread resistance to chloroquine (CQ) and sulfadoxine-pyrimethamine (SP) led to the adoption of artemisinin-based combination therapy (ACT) as the first- …

Malaria continues to be one of the most serious infectious diseases worldwide. There were an estimated 247 million cases of malaria and 619,000 malaria deaths worldwide in 2021, with sub-Saharan Africa bearing the highest proportions of cases [ 1 …

Malaria is a disease caused by infection with Plasmodium parasites, and global cases and deaths have declined substantially since 2000 [ 1 ], with 25 countries achieving zero locally acquired cases and many more approaching this significant …