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Erschienen in:

01.08.2023 | Original Article

The attenuated live vaccine strain W2512 provides protection against novel variant infectious bursal disease virus

verfasst von: Mei Leng, Xiaomeng Bian, Yazheng Chen, Zhishan Liang, Jiamin Lian, Meng Chen, Feng Chen, Zhanxin Wang, Wencheng Lin

Erschienen in: Archives of Virology | Ausgabe 8/2023

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Abstract

Infectious bursal disease virus (IBDV) causes an acute and highly contagious infectious disease characterized by severe immunosuppression, causing great economic losses to the poultry industry globally. Over the past 30 years, this disease has been well controlled through vaccination and strict biosafety measures. However, novel variant IBDV strains have emerged in recent years, posing a new threat to the poultry industry. Our previous epidemiological survey showed that few novel variant IBDV strains had been isolated from chickens immunized with the attenuated live vaccine W2512-, suggesting that this vaccine is efficacious against novel variant strains. Here, we report the protective effect of the W2512 vaccine against novel variant strains in SPF chickens and commercial yellow-feathered broilers. We found that W2512 causes severe atrophy of the bursa of Fabricius in SPF chickens and commercial yellow-feathered broilers, induces high levels of antibodies against IBDV, and protects chickens from infection with the novel variant strains via a placeholder effect. This study highlights the protective effect of commercial attenuated live vaccines against the novel IBDV variant and provides guidance for the prevention and control of this disease.

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Titel: The attenuated live vaccine strain W2512 provides protection against novel variant infectious bursal disease virus
verfasst von: Mei Leng
Xiaomeng Bian
Yazheng Chen
Zhishan Liang
Jiamin Lian
Meng Chen
Feng Chen
Zhanxin Wang
Wencheng Lin
Publikationsdatum: 01.08.2023
Verlag: Springer Vienna
Erschienen in: Archives of Virology / Ausgabe 8/2023
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-023-05828-0

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The attenuated live vaccine strain W2512 provides protection against novel variant infectious bursal disease virus

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