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Arthritis Research & Therapy

Ausgabe 1/2016

Inhalt (306 Artikel)

Open Access Research article

High-mobility group box 1 potentiates antineutrophil cytoplasmic antibody-inducing neutrophil extracellular traps formation

Yun-Hua Ma, Tian-tian Ma, Chen Wang, Huan Wang, Dong-Yuan Chang, Min Chen, Ming-Hui Zhao

Open Access Research article

Serum levels of the proinflammatory cytokine interleukin-6 vary based on diagnoses in individuals with lumbar intervertebral disc diseases

Kathryn T. Weber, D. Olivier Alipui, Cristina P. Sison, Ona Bloom, Shaheda Quraishi, M. Chris Overby, Mitchell Levine, Nadeen O. Chahine

Open Access Editorial

New insights into the regulation of innate immunity by caspase-8

Vitaliya Sagulenko, Kate E. Lawlor, James E. Vince

Open Access Research article

Improved monitoring of clinical response in Systemic Lupus Erythematosus by longitudinal trend in soluble vascular cell adhesion molecule-1

Myles J. Lewis, Simon Vyse, Adrian M. Shields, Lu Zou, Munther Khamashta, Patrick A. Gordon, Costantino Pitzalis, Timothy J. Vyse, David P. D’Cruz

Open Access Research article

Transient receptor potential ankyrin 1 (TRPA1) receptor is involved in chronic arthritis: in vivo study using TRPA1-deficient mice

Ádám Horváth, Valéria Tékus, Melinda Boros, Gábor Pozsgai, Bálint Botz, Éva Borbély, János Szolcsányi, Erika Pintér, Zsuzsanna Helyes

Open Access Research article

Environmental cold exposure increases blood flow and affects pain sensitivity in the knee joints of CFA-induced arthritic mice in a TRPA1-dependent manner

Elizabeth S. Fernandes, Fiona A. Russell, Khadija M. Alawi, Claire Sand, Lihuan Liang, Robin Salamon, Jennifer V. Bodkin, Aisah A. Aubdool, Matthew Arno, Clive Gentry, Sarah-Jane Smillie, Stuart Bevan, Julie E. Keeble, Marzia Malcangio, Susan D. Brain

Open Access Research article

The CII-specific autoimmune T-cell response develops in the presence of FTY720 but is regulated by enhanced Treg cells that inhibit the development of autoimmune arthritis

David C. Miller, Karen B. Whittington, David D. Brand, Karen A. Hasty, Edward F. Rosloniec

Open Access Research article

Overexpression of TLR2 and TLR9 on monocyte subsets of active rheumatoid arthritis patients contributes to enhance responsiveness to TLR agonists

Patricia Lacerte, Alexandre Brunet, Benoit Egarnes, Benjamin Duchêne, Jacques P. Brown, Jean Gosselin

Open Access Review

MicroRNAs in fibrosis: opportunities and challenges

Steven O’Reilly

Open Access Research article

A longitudinal genome-wide association study of anti-tumor necrosis factor response among Japanese patients with rheumatoid arthritis

Kyoko Honne, Ingileif Hallgrímsdóttir, Chunsen Wu, Ronnie Sebro, Nicholas P. Jewell, Takeo Sakurai, Masahiro Iwamoto, Seiji Minota, Damini Jawaheer

Open Access Research article

Early changes in blood-based joint tissue destruction biomarkers are predictive of response to tocilizumab in the LITHE study

Anne C. Bay-Jensen, Adam Platt, Anne Sofie Siebuhr, Claus Christiansen, Inger Byrjalsen, Morten A. Karsdal

Open Access Research article

DKK1 expression by synovial fibroblasts in very early rheumatoid arthritis associates with lymphocyte adhesion in an in vitro flow co-culture system

Maria Juarez, Helen M. McGettrick, Dagmar Scheel-Toellner, Lorraine Yeo, Julia Spengler, Banesa de Paz, Rowan Hardy, Mark Cooper, Karim Raza, Christopher D. Buckley, Andrew Filer

Open Access Research article

In vitro eradication of citrullinated protein specific B-lymphocytes of rheumatoid arthritis patients by targeted bifunctional nanoparticles

Judit Pozsgay, Fruzsina Babos, Katalin Uray, Anna Magyar, Gergő Gyulai, Éva Kiss, György Nagy, Bernadette Rojkovich, Ferenc Hudecz, Gabriella Sármay

Open Access Research article

Perinatal characteristics, older siblings, and risk of ankylosing spondylitis: a case–control study based on national registers

Ulf Lindström, Helena Forsblad-d’Elia, Johan Askling, Lars Erik Kristensen, Elisabeth Lie, Sofia Exarchou, Lennart Jacobsson

Open Access Research article

Effect of M3 muscarinic acetylcholine receptor deficiency on collagen antibody-induced arthritis

Janet Beckmann, Nicole Dittmann, Iris Schütz, Jochen Klein, Katrin Susanne Lips

Open Access Research article

Hyaluronan concentration and size distribution in human knee synovial fluid: variations with age and cartilage degeneration

Michele M. Temple-Wong, Shuwen Ren, Phu Quach, Bradley C. Hansen, Albert C. Chen, Akihiko Hasegawa, Darryl D. D’Lima, Jim Koziol, Koichi Masuda, Martin K. Lotz, Robert L. Sah

Open Access Research article

Higher expression of TNFα-induced genes in the synovium of patients with early rheumatoid arthritis correlates with disease activity, and predicts absence of response to first line therapy

Aurélie De Groof, Julie Ducreux, Frances Humby, Adrien Nzeusseu Toukap, Valérie Badot, Costantino Pitzalis, Frédéric A. Houssiau, Patrick Durez, Bernard R. Lauwerys

Open Access Research article

Genetic susceptibility loci of idiopathic interstitial pneumonia do not represent risk for systemic sclerosis: a case control study in Caucasian patients

Minghua Wu, Shervin Assassi, Gloria A. Salazar, Claudia Pedroza, Olga Y. Gorlova, Wei V. Chen, Julio Charles, Miranda L. Taing, Kelley Liao, Fredrick M. Wigley, Laura K. Hummers, Ami A. Shah, Monique Hinchcliff, Dinesh Khanna, Elena Schiopu, Kristine Phillips, Daniel E. Furst, Virginia Steen, Murray Baron, Marie Hudson, Xiaodong Zhou, Janet Pope, Niall Jones, Peter Docherty, Nader A. Khalidi, David Robinson, Robert W. Simms, Richard M. Silver, Tracy M. Frech, Barri J. Fessler, Marvin J. Fritzler, Jerry A. Molitor, Barbara M. Segal, Malahat Movahedian, Javier Martín, John Varga, Maureen D. Mayes

Open Access Research article

B-cell and T-cell quantification in minor salivary glands in primary Sjögren’s syndrome: development and validation of a pixel-based digital procedure

Sebastian Costa, Sacha Schutz, Divi Cornec, Arnaud Uguen, Isabelle Quintin-Roué, Agnès Lesourd, Jean-Marie Berthelot, Eric Hachulla, Pierre-Yves Hatron, Vincent Goeb, Olivier Vittecoq, Jacques Olivier Pers, Pascale Marcorelles, Alain Saraux, Valérie Devauchelle-Pensec

Open Access Research article

Two-year results of disease activity score (DAS)-remission-steered treatment strategies aiming at drug-free remission in early arthritis patients (the IMPROVED-study)

Lotte Heimans, Gülşah Akdemir, Kirsten V. C. Wevers-de Boer, Yvonne P. Goekoop-Ruiterman, Esmeralda T. Molenaar, Johannes H. L. M. van Groenendael, Andreas J. Peeters, Gerda M. Steup-Beekman, Leroy R. Lard, Peter B. J. de Sonnaville, Bernard A. M. Grillet, Tom W. J. Huizinga, Cornelia F. Allaart

Open Access Research article

Comparable long-term efficacy, as assessed by patient-reported outcomes, safety and pharmacokinetics, of CT-P13 and reference infliximab in patients with ankylosing spondylitis: 54-week results from the randomized, parallel-group PLANETAS study

Won Park, Dae Hyun Yoo, Janusz Jaworski, Jan Brzezicki, Andriy Gnylorybov, Vladimir Kadinov, Irmgadt Goecke Sariego, Carlos Abud-Mendoza, William Jose Otero Escalante, Seong Wook Kang, Daina Andersone, Francisco Blanco, Seung Suh Hong, Sun Hee Lee, Jürgen Braun

Open Access Research article

Reduced pro-inflammatory profile of γδT cells in pregnant patients with rheumatoid arthritis

Manuela Tham, Gabriele R. Schlör, Daniel Yerly, Christina Mueller, Daniel Surbek, Peter M. Villiger, Frauke Förger

Open Access Research article

Stress granules and RNA processing bodies are novel autoantibody targets in systemic sclerosis

Michael E. Johnson, Andrew V. Grassetti, Jaclyn N. Taroni, Shawn M. Lyons, Devin Schweppe, Jessica K. Gordon, Robert F. Spiera, Robert Lafyatis, Paul J. Anderson, Scott A. Gerber, Michael L. Whitfield

Open Access Research article

Anti-RANKL treatment inhibits erosive joint destruction and lowers inflammation but has no effect on bone formation in the delayed-type hypersensitivity arthritis (DTHA) model

Sara Marie Atkinson, Janine Bleil, René Maier, Anja A. Kühl, Mette Thorn, Kyle Serikawa, Brian Fox, Kim Kruse, Claus Haase, Søren Skov, Anneline Nansen, Uta Syrbe

Open Access Research article

Osteogenic differentiation of bone marrow stromal cells is hindered by the presence of intervertebral disc cells

Samantha C. W. Chan, Adel Tekari, Lorin M. Benneker, Paul F. Heini, Benjamin Gantenbein

Open Access Research article

Sex disparities in systemic sclerosis-associated pulmonary arterial hypertension: a cohort study

Christopher R. Pasarikovski, John T. Granton, Adrienne M. Roos, Saghar Sadeghi, Amie T. Kron, John Thenganatt, Jakov Moric, Cathy Chau, Sindhu R. Johnson

Open Access Research article

Correlates of knee bone marrow lesions in younger adults

Benny Antony, Alison Venn, Flavia Cicuttini, Lyn March, Leigh Blizzard, Terence Dwyer, Andrew Halliday, Marita Cross, Graeme Jones, Changhai Ding

Open Access Editorial

Targeting oxidative stress to reduce osteoarthritis

Blandine Poulet, Frank Beier

Open Access Research article

Co-morbidity in patients with early rheumatoid arthritis - inflammation matters

Lena Innala, Clara Sjöberg, Bozena Möller, Lotta Ljung, Torgny Smedby, Anna Södergren, Staffan Magnusson, Solbritt Rantapää-Dahlqvist, Solveig Wållberg-Jonsson

Open Access Research article

Tofacitinib, an oral Janus kinase inhibitor, as monotherapy or with background methotrexate, in Japanese patients with rheumatoid arthritis: an open-label, long-term extension study

Hisashi Yamanaka, Yoshiya Tanaka, Tsutomu Takeuchi, Naonobu Sugiyama, Hirotoshi Yuasa, Shigeyuki Toyoizumi, Yosuke Morishima, Tomohiro Hirose, Samuel Zwillich

Open Access Research article

Inflammation-driven bone formation in a mouse model of ankylosing spondylitis: sequential not parallel processes

Hsu-Wen Tseng, Miranda E. Pitt, Tibor T. Glant, Allan F. McRae, Tony J. Kenna, Matthew A. Brown, Allison R. Pettit, Gethin P. Thomas

Open Access Editorial

The crowded crossroad to angiogenesis in systemic sclerosis: where is the key to the problem?

Mirko Manetti, Serena Guiducci, Marco Matucci-Cerinic

Open Access Research article

Serum levels of 14-3-3η protein supplement C-reactive protein and rheumatoid arthritis-associated antibodies to predict clinical and radiographic outcomes in a prospective cohort of patients with recent-onset inflammatory polyarthritis

Nathalie Carrier, Anthony Marotta, Artur J. de Brum-Fernandes, Patrick Liang, Ariel Masetto, Henri A. Ménard, Walter P. Maksymowych, Gilles Boire

Open Access Research article

Evaluation of treatments for sacroiliitis in spondyloarthropathy using the Spondyloarthritis Research Consortium Canada scoring system

Yang Cui, Jinping Zheng, Xiao Zhang, Hui Zeng, Riqiang Luo

Open Access Research article

Tapering and discontinuation of TNF-α blockers without disease relapse using ultrasonography as a tool to identify patients with rheumatoid arthritis in clinical and histological remission

Stefano Alivernini, Giusy Peluso, Anna Laura Fedele, Barbara Tolusso, Elisa Gremese, Gianfranco Ferraccioli

Open Access Research article

Changes in resting state functional connectivity after repetitive transcranial direct current stimulation applied to motor cortex in fibromyalgia patients

Chelsea M. Cummiford, Thiago D. Nascimento, Bradley R. Foerster, Daniel J. Clauw, Jon-Kar Zubieta, Richard E. Harris, Alexandre F. DaSilva

Open Access Research article

Evaluation of the impact of fibromyalgia in disease activity and treatment effect in spondyloarthritis

Natalia Bello, Adrien Etcheto, Caroline Béal, Maxime Dougados, Anna Moltó

Open Access Research article

Rheumatoid factor isotypes in relation to antibodies against citrullinated peptides and carbamylated proteins before the onset of rheumatoid arthritis

Mikael Brink, Monika Hansson, Linda Mathsson-Alm, Priyantha Wijayatunga, Marije K. Verheul, Leendert A. Trouw, Rikard Holmdahl, Johan Rönnelid, Lars Klareskog, Solbritt Rantapää-Dahlqvist

Open Access Research article

The assessment of serum-mediated phagocytosis of necrotic material by polymorphonuclear leukocytes to diagnose and predict the clinical features of systemic lupus erythematosus: an observational longitudinal study

Michele Compagno, Birgitta Gullstrand, Søren Jacobsen, Gro Ø. Eilertsen, Jan Åke Nilsson, Christian Lood, Andreas Jönsen, Lennart Truedsson, Gunnar Sturfelt, Anders A. Bengtsson

Open Access Letter

Response to: ‘A dose–response relationship between severity of disc degeneration and intervertebral disc height in the lumbosacral spine’—authors’ reply

Andrew J. Teichtahl, Donna M. Urquhart, Yuanyuan Wang, Anita E. Wluka, Stephane Heritier, Flavia M. Cicuttini

Open Access Research article

Sex differences in risk and heritability estimates on primary knee osteoarthritis leading to total knee arthroplasty: a nationwide population based follow up study in Danish twins

Søren Glud Skousgaard, Axel Skytthe, Sören Möller, Søren Overgaard, Lars Peter Andreas Brandt

Open Access Research article

PD-L1-expressing neutrophils as a novel indicator to assess disease activity and severity of systemic lupus erythematosus

Qing Luo, Zikun Huang, Jianqing Ye, Yating Deng, Le Fang, Xue Li, Yang Guo, Hong Jiang, Beihua Ju, Qingshui Huang, Junming Li

Open Access Research article

Comparison of transforming growth factor beta expression in healthy and diseased human tendon

Henry C. J. Goodier, Andrew J. Carr, Sarah J. B. Snelling, Lucy Roche, Kim Wheway, Bridget Watkins, Stephanie G. Dakin

Open Access Research article

Physiological evidence for diversification of IFNα- and IFNβ-mediated response programs in different autoimmune diseases

Tamarah D. de Jong, Saskia Vosslamber, Elise Mantel, Sander de Ridder, John G. Wesseling, Tineke C. T. M. van der Pouw Kraan, Cyra Leurs, Harald Hegen, Florian Deisenhammer, Joep Killestein, Ingrid E. Lundberg, Jiri Vencovsky, Mike T. Nurmohamed, Dirkjan van Schaardenburg, Irene E. M. Bultink, Alexandre E. Voskuyl, D. Michiel Pegtel, Conny J. van der Laken, Johannes W. J. Bijlsma, Cornelis L. Verweij

Open Access Research article

Effectiveness of two different doses of rituximab for the treatment of rheumatoid arthritis in an international cohort: data from the CERERRA collaboration

Katerina Chatzidionysiou, Elisabeth Lie, Evgeny Nasonov, Galina Lukina, Merete Lund Hetland, Ulrik Tarp, Ioan Ancuta, Karel Pavelka, Dan C. Nordström, Cem Gabay, Helene Canhão, Matija Tomsic, Piet L. C. M. van Riel, Juan Gomez-Reino, Tore K. Kvien, Ronald F. van Vollenhoven

Open Access Research article

IL-23/Th17 axis is not influenced by TNF-blocking agents in ankylosing spondylitis patients

Fernanda Manente Milanez, Carla G. S. Saad, Vilma T. Viana, Júlio C. B. Moraes, Grégory Vinícius Périco, Percival Degrava Sampaio-Barros, Célio R. Goncalves, Eloísa Bonfá

Open Access Research article

Establishment of age- and sex-adjusted reference data for hand bone mass and investigation of hand bone loss in patients with rheumatoid arthritis treated in clinical practice: an observational study from the DANBIO registry and the Copenhagen Osteoarthritis Study

Lykke Midtbøll Ørnbjerg, Mikkel Østergaard, Trine Jensen, Lars Hyldstrup, Pernille Bach-Mortensen, Pernille Bøyesen, Anja Thormann, Ulrik Tarp, Wolfgang Peter Bøhme, Hanne Lindegaard, Uta Engling Poulsen, Anette Schlemmer, Niels Graudal, Anne Rødgaard, Jakob Espesen, Gina Birgitte Kollerup, Bente Glintborg, Ole Rintek Madsen, Dorte Vendelbo Jensen, Merete Lund Hetland

Open Access Research article

Bone marrow lesions detected by specific combination of MRI sequences are associated with severity of osteochondral degeneration

Dzenita Muratovic, Flavia Cicuttini, Anita Wluka, David Findlay, Yuanyuan Wang, Sophia Otto, David Taylor, Julia Humphries, Yearin Lee, Agatha Labrinidis, Ruth Williams, Julia Kuliwaba

Open Access Research article

MMP-3 as a predictor for structural remission in RA patients treated with MTX monotherapy

Kazuko Shiozawa, Takashi Yamane, Miki Murata, Ryosuke Yoshihara, Ken Tsumiyama, Shigeaki Imura, Shunichi Shiozawa

Open Access Research article

Anti-TNF certolizumab pegol induces antioxidant response in human monocytes via reverse signaling

Jean Frédéric Boyer, Michel Baron, Arnaud Constantin, Yannick Degboé, Alain Cantagrel, Jean-Luc Davignon

Open Access Research article

Gout-related inpatient utilization: a study of predictors of outcomes and time trends

Jasvinder A. Singh, Shaohua Yu

Open Access Research article

IgA vasculitis in adults: the performance of the EULAR/PRINTO/PRES classification criteria in adults

Alojzija Hočevar, Ziga Rotar, Vesna Jurčić, Jože Pižem, Saša Čučnik, Alenka Vizjak, Rianne van den Broeke, Matija Tomšič

Open Access Research article

Increased caveolin-1 in intervertebral disc degeneration facilitates repair

Frances C. Bach, Ying Zhang, Alberto Miranda-Bedate, Lucy C. Verdonschot, Niklas Bergknut, Laura B. Creemers, Keita Ito, Daisuke Sakai, Danny Chan, Björn P. Meij, Marianna A. Tryfonidou

Open Access Research article

Initial combination therapy versus step-up therapy in treatment to the target of remission in daily clinical practice in early rheumatoid arthritis patients: results from the DREAM registry

L. M. M. Steunebrink, G. A. Versteeg, H. E. Vonkeman, P. M. ten Klooster, H. H. Kuper, T. R. Zijlstra, P. L. C. M. van Riel, M. A. F. J. van de Laar

Open Access Research article

The interleukin-20 receptor axis in early rheumatoid arthritis: novel links between disease-associated autoantibodies and radiographic progression

Tue Wenzel Kragstrup, Stinne Ravn Greisen, Morten Aagaard Nielsen, Christopher Rhodes, Kristian Stengaard-Pedersen, Merete Lund Hetland, Kim Hørslev-Petersen, Peter Junker, Mikkel Østergaard, Malene Hvid, Thomas Vorup-Jensen, William H. Robinson, Jeremy Sokolove, Bent Deleuran

Open Access Research article

Lymphatic endothelial cells efferent to inflamed joints produce iNOS and inhibit lymphatic vessel contraction and drainage in TNF-induced arthritis in mice

Qianqian Liang, Yawen Ju, Yan Chen, Wensheng Wang, Jinlong Li, Li Zhang, Hao Xu, Ronald W. Wood, Edward. M. Schwarz, Brendan F. Boyce, Yongjun Wang, Lianping Xing

Open Access Research article

Nicotinic acetylcholine receptors modulate osteoclastogenesis

Peter Mandl, Silvia Hayer, Thomas Karonitsch, Petra Scholze, David Győri, Despoina Sykoutri, Stephan Blüml, Attila Mócsai, Gyula Poór, Sigismund Huck, Josef S. Smolen, Kurt Redlich

Open Access Research article

Superficial zone cellularity is deficient in mice lacking lubricin: a stereoscopic analysis

Naga Padmini Karamchedu, Josef N. Tofte, Kimberly A. Waller, Ling X. Zhang, Tarpit K. Patel, Gregory D. Jay

Open Access Research article

Cartilage-specific deletion of ephrin-B2 in mice results in early developmental defects and an osteoarthritis-like phenotype during aging in vivo

Gladys Valverde-Franco, Bertrand Lussier, David Hum, Jiangping Wu, Adjia Hamadjida, Numa Dancause, Hassan Fahmi, Mohit Kapoor, Jean-Pierre Pelletier, Johanne Martel-Pelletier

Open Access Research article

CD271+ stromal cells expand in arthritic synovium and exhibit a proinflammatory phenotype

Manuel J. Del Rey, Regina Faré, Alicia Usategui, Juan D. Cañete, Beatriz Bravo, María Galindo, Gabriel Criado, José L. Pablos

Open Access Research article

Generation mechanism of RANKL+ effector memory B cells: relevance to the pathogenesis of rheumatoid arthritis

Yuri Ota, Hiroaki Niiro, Shun-ichiro Ota, Naoko Ueki, Hirofumi Tsuzuki, Tsuyoshi Nakayama, Koji Mishima, Kazuhiko Higashioka, Siamak Jabbarzadeh-Tabrizi, Hiroki Mitoma, Mitsuteru Akahoshi, Yojiro Arinobu, Akiko Kukita, Hisakata Yamada, Hiroshi Tsukamoto, Koichi Akashi

Open Access Research article

Perceived function and physical performance are associated with pain and fatigue in women with fibromyalgia

Dana L. Dailey, Laura A. Frey Law, Carol G. T. Vance, Barbara A. Rakel, Ericka N. Merriwether, Leon Darghosian, Meenakshi Golchha, Katharine M. Geasland, Rebecca Spitz, Leslie J. Crofford, Kathleen A. Sluka

Open Access Research article

Myocardial infarction and mortality following joint surgery in patients with rheumatoid arthritis: a retrospective cohort study

Joanne Tropea, Caroline A. Brand, Megan Bohensky, Sharon Van Doornum

Open Access Research article

Three-dimensional Doppler ultrasound findings in healthy wrist and finger tendon sheaths - can feeding vessels lead to misinterpretation in Doppler-detected tenosynovitis?

Mads Ammitzbøll-Danielsen, Iustina Janta, Søren Torp-Pedersen, Esperanza Naredo, Mikkel Østergaard, Lene Terslev

Open Access Research article

Does the reason for discontinuation of a first TNF inhibitor influence the effectiveness of a second TNF inhibitor in axial spondyloarthritis? Results from the Swiss Clinical Quality Management Cohort

Adrian Ciurea, Pascale Exer, Ulrich Weber, Giorgio Tamborrini, Beate Steininger, Rudolf O. Kissling, Jürg Bernhard, Almut Scherer

Open Access Research article

Abatacept monotherapy compared with abatacept plus disease-modifying anti-rheumatic drugs in rheumatoid arthritis patients: data from the ORA registry

Marie-Elise Truchetet, Nicolas Poursac, Thomas Barnetche, Emilie Shipley, Jacques-Eric Gottenberg, Bernard Bannwarth, Christophe Richez, Thierry Schaeverbeke

Open Access Research article

High correlation of VAS pain scores after 2 and 6 weeks of treatment with VAS pain scores at 12 weeks in randomised controlled trials in rheumatoid arthritis and osteoarthritis: meta-analysis and implications

Andreas Karabis, Stavros Nikolakopoulos, Shaloo Pandhi, Katerina Papadimitropoulou, Richard Nixon, Ricardo L. Chaves, R. Andrew Moore

Open Access Research article

Immunopathologic characterization of ultrasound-defined synovitis in rheumatoid arthritis patients in clinical remission

Julio Ramírez, Raquel Celis, Alicia Usategui, Virginia Ruiz-Esquide, Regina Faré, Andrea Cuervo, Raimon Sanmartí, José L. Pablos, Juan D. Cañete

Open Access Research article

Colony-stimulating factor (CSF) 1 receptor blockade reduces inflammation in human and murine models of rheumatoid arthritis

Samuel Garcia, Linda M. Hartkamp, B Malvar-Fernandez, Inge E. van Es, Haishan Lin, Justin Wong, Li Long, James A. Zanghi, Andrew L. Rankin, Emma L. Masteller, Brian R. Wong, Timothy R. D. J. Radstake, Paul P. Tak, Kris A. Reedquist

Open Access Research article

A prospective cohort study of 14-3-3η in ACPA and/or RF-positive patients with arthralgia

Marian H. van Beers-Tas, Anthony Marotta, Maarten Boers, Walter P. Maksymowych, Dirkjan van Schaardenburg

Open Access Research article

Human embryonic stem cell-derived mesenchymal stromal cells ameliorate collagen-induced arthritis by inducing host-derived indoleamine 2,3 dioxygenase

Elena Gonzalo-Gil, María J. Pérez-Lorenzo, María Galindo, Rafael Díaz de la Guardia, Belén López-Millán, Clara Bueno, Pablo Menéndez, José L. Pablos, Gabriel Criado

Open Access Research article

Patient-reported impact of spondyloarthritis on work disability and working life: the ATLANTIS survey

Roberta Ramonda, Antonio Marchesoni, Antonio Carletto, Gerolamo Bianchi, Maurizio Cutolo, Gianfranco Ferraccioli, Enrico Fusaro, Salvatore De Vita, Mauro Galeazzi, Roberto Gerli, Marco Matucci-Cerinic, Giovanni Minisola, Carlomaurizio Montecucco, Raffaele Pellerito, Fausto Salaffi, Giuseppe Paolazzi, Piercarlo Sarzi-Puttini, Raffaele Scarpa, Gianfilippo Bagnato, Giovanni Triolo, Guido Valesini, Leonardo Punzi, Ignazio Olivieri

Open Access Research article

Novel hyaluronic acid–methotrexate conjugate suppresses joint inflammation in the rat knee: efficacy and safety evaluation in two rat arthritis models

Tatsuya Tamura, Yoshinobu Higuchi, Hidetomo Kitamura, Naoaki Murao, Ryoichi Saitoh, Tadashi Morikawa, Haruhiko Sato

Open Access Research article

Effects of conventional immunosuppressive treatment on CD244+ (CD28null) and FOXP3+ T cells in the inflamed muscle of patients with polymyositis and dermatomyositis

Jayesh M. Pandya, Ingela Loell, Mohammad Shahadat Hossain, Mei Zong, Helene Alexanderson, Sukanya Raghavan, Ingrid E. Lundberg, Vivianne Malmström

Open Access Research article

Association between biomarkers of tissue inflammation and progression of osteoarthritis: evidence from the Rotterdam study cohort

Fatemeh Saberi Hosnijeh, Anne Sofie Siebuhr, Andre G. Uitterlinden, Edwin H. G. Oei, Albert Hofman, Morten A. Karsdal, Sita M. Bierma-Zeinstra, Anne C. Bay-Jensen, Joyce B. J. van Meurs

Open Access Research article

A phase III randomized study to evaluate the efficacy and safety of CT-P13 compared with reference infliximab in patients with active rheumatoid arthritis: 54-week results from the PLANETRA study

Dae Hyun Yoo, Artur Racewicz, Jan Brzezicki, Roman Yatsyshyn, Edgardo Tobias Arteaga, Asta Baranauskaite, Carlos Abud-Mendoza, Sandra Navarra, Vladimir Kadinov, Irmgadt Goecke Sariego, Seung Suh Hong, Sung Young Lee, Won Park

Open Access Research article

From osteoarthritic synovium to synovial-derived cells characterization: synovial macrophages are key effector cells

Cristina Manferdini, Francesca Paolella, Elena Gabusi, Ylenia Silvestri, Laura Gambari, Luca Cattini, Giuseppe Filardo, Sandrine Fleury-Cappellesso, Gina Lisignoli

Open Access Research article

Regulatory and effector B cell cytokine production in patients with relapsing granulomatosis with polyangiitis

Judith Land, Wayel H. Abdulahad, Jan-Stephan F. Sanders, Coen A. Stegeman, Peter Heeringa, Abraham Rutgers

Open Access Research article

Comparison of the efficacy of once- and twice-daily colchicine dosage in pediatric patients with familial Mediterranean fever – a randomized controlled noninferiority trial

Adem Polat, Cengizhan Acikel, Betul Sozeri, Ismail Dursun, Ozgur Kasapcopur, Nesrin Gulez, Dogan Simsek, Mehmet Saldir, Ipek Dokurel, Hakan Poyrazoglu, Sevcan Bakkaloglu, Ali Delibas, Zelal Ekinci, Nuray A. Ayaz, Yasar Kandur, Harun Peru, Yasemin G. Kurt, Safiye R. Polat, Erbil Unsal, Balahan Makay, Faysal Gok, Seza Ozen, Erkan Demirkaya

Open Access Research article

A novel inflammatory biomarker, GlycA, associates with disease activity in rheumatoid arthritis and cardio-metabolic risk in BMI-matched controls

David B. Bartlett, Margery A. Connelly, Hiba AbouAssi, Lori A. Bateman, K. Noelle Tune, Janet L. Huebner, Virginia B. Kraus, Deborah A. Winegar, James D. Otvos, William E. Kraus, Kim M. Huffman

Open Access Research article

Inflammatory properties of inhibitor of DNA binding 1 secreted by synovial fibroblasts in rheumatoid arthritis

Gautam Edhayan, Ray A. Ohara, W. Alex Stinson, M. Asif Amin, Takeo Isozaki, Christine M. Ha, G. Kenneth Haines III, Rachel Morgan, Phillip L. Campbell, Ali S. Arbab, Sean C. Friday, David A. Fox, Jeffrey H. Ruth

Open Access Research article

Change from subcutaneous to intravenous abatacept and back in patients with rheumatoid arthritis as simulation of a vacation: a prospective phase IV, open-label trial (A-BREAK)

Ruediger B. Mueller, Michael Gengenbacher, Symi Richter, Jean Dudler, Burkhard Möller, Johannes von Kempis

Open Access Research article

Self-reported flares are predictors of radiographic progression in rheumatoid arthritis patients in 28-joint disease activity score remission: a 24-month observational study

Francesca Ometto, Bernd Raffeiner, Livio Bernardi, Costantino Botsios, Nicola Veronese, Leonardo Punzi, Andrea Doria

Open Access Research article

CD163+ M2c-like macrophages predominate in renal biopsies from patients with lupus nephritis

Gregor Olmes, Maike Büttner-Herold, Fulvia Ferrazzi, Luitpold Distel, Kerstin Amann, Christoph Daniel

Open Access Research article

HM71224, a novel Bruton’s tyrosine kinase inhibitor, suppresses B cell and monocyte activation and ameliorates arthritis in a mouse model: a potential drug for rheumatoid arthritis

Jin Kyun Park, Joo-Yun Byun, Ji Ah Park, Yu-Yon Kim, Ye Ji Lee, Jeong In Oh, Sun Young Jang, Young Hoon Kim, Yeong Wook Song, Jeewoong Son, Kwee Hyun Suh, Young-Mi Lee, Eun Bong Lee

Open Access Research article

Impaired phagocytosis and reactive oxygen species production in phagocytes is associated with systemic vasculitis

Åsa CM Johansson, Sophie Ohlsson, Åsa Pettersson, Anders A. Bengtsson, Daina Selga, Markus Hansson, Thomas Hellmark

Open Access Research article

Identifying factors associated with concordance with the American College of Rheumatology rheumatoid arthritis treatment recommendations

Leslie R. Harrold, George W. Reed, Joel M. Kremer, Jeffrey R. Curtis, Daniel H. Solomon, Marc C. Hochberg, Arthur Kavanaugh, Katherine C. Saunders, Ying Shan, Tanya M. Spruill, Dimitrios A. Pappas, Jeffrey D. Greenberg

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Sjögren’s syndrome-associated microRNAs in CD14+ monocytes unveils targeted TGFβ signaling

Adrienne E. G. Williams, Kevin Choi, Annie L. Chan, Yun Jong Lee, Westley H. Reeves, Michael R. Bubb, Carol M. Stewart, Seunghee Cha

Open Access Research article

Antibodies to carbamylated α-enolase epitopes in rheumatoid arthritis also bind citrullinated epitopes and are largely indistinct from anti-citrullinated protein antibodies

Evan Reed, Xia Jiang, Nastya Kharlamova, A. Jimmy Ytterberg, Anca I. Catrina, Lena Israelsson, Linda Mathsson-Alm, Monika Hansson, Lars Alfredsson, Johan Rönnelid, Karin Lundberg

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Selective inhibition of tropomyosin-receptor-kinase A (TrkA) reduces pain and joint damage in two rat models of inflammatory arthritis

Sadaf Ashraf, Karyn S. Bouhana, Jed Pheneger, Steven W. Andrews, David A. Walsh

Open Access Research article

Frequency of circulating topoisomerase-I-specific CD4 T cells predicts presence and progression of interstitial lung disease in scleroderma

Andrea Fava, Raffaello Cimbro, Fredrick M. Wigley, Qing-Rong Liu, Antony Rosen, Francesco Boin

Open Access Erratum

Erratum to: Incidence of malignancy in adult patients with rheumatoid arthritis: a meta-analysis

Teresa A. Simon, Adam Thompson, Kunal K. Gandhi, Marc C. Hochberg, Samy Suissa

Open Access Erratum

Erratum to: Palmitoylethanolamide and luteolin ameliorate development of arthritis caused by injection of collagen type II in mice

Daniela Impellizzeri, Emanuela Esposito, Rosanna Di Paola, Akbar Ahmad, Michela Campolo, Angelo Peli, Valeria Maria Morittu, Domenico Britti, Salvatore Cuzzocrea

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Reduced glutathione as a physiological co-activator in the activation of peptidylarginine deiminase

Dres Damgaard, Mads Emil Bjørn, Maria A. Steffensen, Ger J. M. Pruijn, Claus H. Nielsen

Open Access Research article

Different expression of β subunits of the KCa1.1 channel by invasive and non-invasive human fibroblast-like synoviocytes

Zoltán Pethő, Mark R. Tanner, Rajeev B. Tajhya, Redwan Huq, Teresina Laragione, Gyorgy Panyi, Pércio S. Gulko, Christine Beeton

Open Access Research article

IL-17A deficiency promotes periosteal bone formation in a model of inflammatory arthritis

Anita T. Shaw, Yukiko Maeda, Ellen M. Gravallese

Open Access Research article

E2 regulates MMP-13 via targeting miR-140 in IL-1β-induced extracellular matrix degradation in human chondrocytes

Yujie Liang, Li Duan, Jianyi Xiong, Weiming Zhu, Qisong Liu, Daming Wang, Wei Liu, Zigang Li, Daping Wang

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Identification of definitive serum biomarkers associated with disease activity in primary Sjögren’s syndrome

Ayumi Nishikawa, Katsuya Suzuki, Yoshiaki Kassai, Yuumi Gotou, Maiko Takiguchi, Takahiro Miyazaki, Keiko Yoshimoto, Hidekata Yasuoka, Kunihiro Yamaoka, Rimpei Morita, Akihiko Yoshimura, Tsutomu Takeuchi

Open Access Research article

Single-cell antibody nanowells: a novel technology in detecting anti-SSA/Ro60- and anti-SSB/La autoantibody-producing cells in peripheral blood of rheumatic disease patients

Lida Esfandiary, Nirupama Gupta, Alexandria Voigt, Arun Wanchoo, Edward K. L. Chan, Sukesh Sukumaran, Cuong Q. Nguyen

Open Access Research article

Differential response of serum amyloid A to different therapies in early rheumatoid arthritis and its potential value as a disease activity biomarker

Yong Gil Hwang, Goundappa K. Balasubramani, Ilinca D. Metes, Marc C. Levesque, S. Louis Bridges Jr., Larry W. Moreland

Open Access Research article

Long non-coding RNA expression profile in minor salivary gland of primary Sjögren’s syndrome

Huan Shi, Ningning Cao, Yiping Pu, Lisong Xie, Lingyan Zheng, Chuangqi Yu

Open Access Erratum

Erratum to: The risk of cancer in patients with rheumatoid arthritis taking tumor necrosis factor antagonists: a nationwide cohort study

Chun-Ying Wu, Der-Yuan Chen, Jui-Lung Shen, Hsiu J. Ho, Chih-Chiang Chen, Ken N. Kuo, Han-Nan Liu, Yun-Ting Chang, Yi-Ju Chen

Open Access Research article

Antiphospholipid antibodies detected by line immunoassay differentiate among patients with antiphospholipid syndrome, with infections and asymptomatic carriers

Dirk Roggenbuck, Maria Orietta Borghi, Valentina Somma, Thomas Büttner, Peter Schierack, Katja Hanack, Claudia Grossi, Caterina Bodio, Paolo Macor, Philipp von Landenberg, Francesco Boccellato, Michael Mahler, Pier Luigi Meroni

Open Access Research article

Alteration of matrix metalloproteinase-3 O-glycan structure as a biomarker for disease activity of rheumatoid arthritis

Masaru Takeshita, Atsushi Kuno, Katsuya Suzuki, Atsushi Matsuda, Hiroko Shimazaki, Tomomi Nakagawa, Yuki Otomo, Yasuaki Kabe, Makoto Suematsu, Hisashi Narimatsu, Tsutomu Takeuchi

Open Access Research article

Knockout of endothelin type B receptor signaling attenuates bleomycin-induced skin sclerosis in mice

Kengo Akashi, Jun Saegusa, Sho Sendo, Keisuke Nishimura, Takuya Okano, Keiko Yagi, Masashi Yanagisawa, Noriaki Emoto, Akio Morinobu

Open Access Research article

Discordance between patient and physician assessments of global disease activity in rheumatoid arthritis and association with work productivity

Josef S. Smolen, Vibeke Strand, Andrew S. Koenig, Annette Szumski, Sameer Kotak, Thomas V. Jones

Open Access Research article

Unexpected arterial wall and cellular inflammation in patients with rheumatoid arthritis in remission using biological therapy: a cross-sectional study

Sophie J. Bernelot Moens, Fleur M. van der Valk, Aart C. Strang, Jeffrey Kroon, Loek P. Smits, Eva L. Kneepkens, Hein J. Verberne, Jaap D. van Buul, Michael T. Nurmohamed, Erik S. G. Stroes

Open Access Research article

Decrease of fear avoidance beliefs following person-centered progressive resistance exercise contributes to reduced pain disability in women with fibromyalgia: secondary exploratory analyses from a randomized controlled trial

Annie Palstam, Anette Larsson, Monika Löfgren, Malin Ernberg, Jan Bjersing, Indre Bileviciute-Ljungar, Björn Gerdle, Eva Kosek, Kaisa Mannerkorpi

Open Access Research article

Monosodium urate crystals induce oxidative stress in human synoviocytes

Yessica Zamudio-Cuevas, Karina Martínez-Flores, Javier Fernández-Torres, Yahir A. Loissell-Baltazar, Daniel Medina-Luna, Ambar López-Macay, Javier Camacho-Galindo, Cristina Hernández-Díaz, Mónica G. Santamaría-Olmedo, Edgar Oliver López-Villegas, Francesca Oliviero, Anna Scanu, Jorge Francisco Cerna-Cortés, Marwin Gutierrez, Carlos Pineda, Alberto López-Reyes

Open Access Research article

B cell depletion therapy upregulates Dkk-1 skin expression in patients with systemic sclerosis: association with enhanced resolution of skin fibrosis

Dimitrios Daoussis, Athanassios Tsamandas, Ioannis Antonopoulos, Alexandra Filippopoulou, Dionysios J. Papachristou, Nicholaos I. Papachristou, Andrew P. Andonopoulos, Stamatis-Nick Liossis

Open Access Research article

Circulating secretory IgA antibodies against cyclic citrullinated peptides in early rheumatoid arthritis associate with inflammatory activity and smoking

Karin Roos, Klara Martinsson, Michael Ziegelasch, Yngve Sommarin, Anna Svärd, Thomas Skogh, Alf Kastbom

Open Access Erratum

Erratum to: Self-reported flares are predictors of radiographic progression in rheumatoid arthritis patients in 28-joint disease activity score remission: a 24-month observational study

Francesca Ometto, Bernd Raffeiner, Livio Bernardi, Costantino Botsios, Nicola Veronese, Leonardo Punzi, Andrea Doria

Open Access Erratum

Erratum to: Novel hyaluronic acid–methotrexate conjugate suppresses joint inflammation in the rat knee: efficacy and safety evaluation in two rat arthritis models

Tatsuya Tamura, Yoshinobu Higuchi, Hidetomo Kitamura, Naoaki Murao, Ryoichi Saitoh, Tadashi Morikawa, Haruhiko Sato

Open Access Erratum

Erratum to: Different expression of β subunits of the KCa1.1 channel by invasive and non-invasive human fibroblast-like synoviocytes

Zoltán Pethő, Mark R. Tanner, Rajeev B. Tajhya, Redwan Huq, Teresina Laragione, Gyorgy Panyi, Pércio S. Gulko, Christine Beeton

Open Access Research article

Cyclophosphamide versus mycophenolate mofetil in scleroderma interstitial lung disease (SSc-ILD) as induction therapy: a single-centre, retrospective analysis

Padmanabha D. Shenoy, Manish Bavaliya, Sujith Sashidharan, Kaveri Nalianda, Sreelakshmi Sreenath

Open Access Research article

MicroRNA-125b: association with disease activity and the treatment response of patients with early rheumatoid arthritis

Veronika Hruskova, Romana Jandova, Lucia Vernerova, Herman Mann, Ondrej Pecha, Klara Prajzlerova, Karel Pavelka, Jiri Vencovsky, Maria Filkova, Ladislav Senolt

Open Access Research article

Notochordal cell conditioned medium (NCCM) regenerates end-stage human osteoarthritic articular chondrocytes and promotes a healthy phenotype

Sebastian Müller, Lina Acevedo, Xiaomei Wang, M. Zia Karim, Ajay Matta, Arne Mehrkens, Stefan Schaeren, Sandra Feliciano, Marcel Jakob, Ivan Martin, Andrea Barbero, W. Mark Erwin

Open Access Editorial

Could we use a lower dose of rituximab to treat rheumatoid arthritis in clinical practice: pros and cons?

Gianfranco Ferraccioli, Barbara Tolusso, Elisa Gremese

Open Access Research article

Antibodies directed against endogenous and exogenous citrullinated antigens pre-date the onset of rheumatoid arthritis

Linda Johansson, Federico Pratesi, Mikael Brink, Lisbeth Ärlestig, Claudia D’Amato, Debora Bartaloni, Paola Migliorini, Solbritt Rantapää-Dahlqvist

Open Access Research article

Curcumin slows osteoarthritis progression and relieves osteoarthritis-associated pain symptoms in a post-traumatic osteoarthritis mouse model

Zhuo Zhang, Daniel J. Leong, Lin Xu, Zhiyong He, Angela Wang, Mahantesh Navati, Sun J. Kim, David M. Hirsh, John A. Hardin, Neil J. Cobelli, Joel M. Friedman, Hui B. Sun

Open Access Research article

Exercise therapy after ultrasound-guided corticosteroid injections in patients with subacromial pain syndrome: a randomized controlled trial

Karen Ellegaard, Robin Christensen, Sara Rosager, Cecilie Bartholdy, Søren Torp-Pedersen, Thomas Bandholm, Bente Danneskiold-Samsøe, Henning Bliddal, Marius Henriksen

Open Access Research article

The isotype repertoire of antibodies against novel UH-RA peptides in rheumatoid arthritis

Liesbeth M. De Winter, Piet Geusens, Jan Lenaerts, Johan Vanhoof, Piet Stinissen, Veerle Somers

Open Access Research article

Safety and tolerability of an anti-CD19 monoclonal antibody, MEDI-551, in subjects with systemic sclerosis: a phase I, randomized, placebo-controlled, escalating single-dose study

Elena Schiopu, Soumya Chatterjee, Vivien Hsu, Armando Flor, Daniel Cimbora, Kaushik Patra, Wenliang Yao, Jing Li, Katie Streicher, Kathleen McKeever, Barbara White, Eliezer Katz, Jorn Drappa, Sarah Sweeny, Ronald Herbst

Open Access Research article

The prevalence and clinical characteristics of nonradiographic axial spondyloarthritis among patients with inflammatory back pain in rheumatology practices: a multinational, multicenter study

Ruben Burgos-Vargas, James Cheng-Chung Wei, Mahboob U. Rahman, Nurullah Akkoc, Syed Atiqul Haq, Mohammed Hammoudeh, Ehab Mahgoub, Ena Singh, Lyndon John Llamado, Khalid Shirazy, Sameer Kotak, Constance Hammond, Ron Pedersen, Qi Shen, Bonnie Vlahos

Open Access Research article

Soluble Siglec-9 suppresses arthritis in a collagen-induced arthritis mouse model and inhibits M1 activation of RAW264.7 macrophages

Takuya Matsumoto, Nobunori Takahashi, Toshihisa Kojima, Yutaka Yoshioka, Jun Ishikawa, Koichi Furukawa, Kenji Ono, Makoto Sawada, Naoki Ishiguro, Akihito Yamamoto

Open Access Research article

JAK3-STAT pathway blocking benefits in experimental lupus nephritis

Èlia Ripoll, Laura de Ramon, Juliana Draibe, Ana Merino, Nuria Bolaños, Montse Goma, Josep M. Cruzado, Josep M. Grinyó, Juan Torras

Open Access Research article

A five-year model to assess the early cost-effectiveness of new diagnostic tests in the early diagnosis of rheumatoid arthritis

Leander R. Buisman, Jolanda J. Luime, Mark Oppe, Johanna M. W. Hazes, Maureen P. M. H. Rutten-van Mölken

Open Access Research article

Effects on muscle tissue remodeling and lipid metabolism in muscle tissue from adult patients with polymyositis or dermatomyositis treated with immunosuppressive agents

Ingela Loell, Joan Raouf, Yi-Wen Chen, Rongye Shi, Inger Nennesmo, Helene Alexanderson, Maryam Dastmalchi, Kanneboyina Nagaraju, Marina Korotkova, Ingrid E. Lundberg

Open Access Research article

Effects of 15 weeks of resistance exercise on pro-inflammatory cytokine levels in the vastus lateralis muscle of patients with fibromyalgia

Malin Ernberg, Nikolaos Christidis, Bijar Ghafouri, Indre Bileviciute-Ljungar, Monika Löfgren, Anette Larsson, Annie Palstam, Jan Bjersing, Kaisa Mannerkorpi, Eva Kosek, Björn Gerdle

Open Access Research article

Mast cell depletion in the preclinical phase of collagen-induced arthritis reduces clinical outcome by lowering the inflammatory cytokine profile

Daniël van der Velden, H. Maxime Lagraauw, Anouk Wezel, Pierre Launay, Johan Kuiper, Tom W. J. Huizinga, René E. M. Toes, Ilze Bot, Jeroen N. Stoop

Open Access Research article

Collagen epitope expression on B cells is sufficient to confer tolerance to collagen-induced arthritis

Sofia E. M. Andersson, Tove Eneljung, Sara Tengvall, Pernilla Jirholt, Anna Stern, Louise Henningsson, Bibo Liang, Katrin Thorarinsdottir, Jan Kihlberg, Rikard Holmdahl, Inga-Lill Mårtensson, Kenth Gustafsson, Inger Gjertsson

Open Access Research article

Chondrocyte activity is increased in psoriatic arthritis and axial spondyloarthritis

Natasja Stæhr Gudmann, Heidi Lausten Munk, Anne Friesgaard Christensen, Leif Ejstrup, Grith Lykke Sørensen, Anne Gitte Loft, Morten Asser Karsdal, Anne-Christine Bay-Jensen, Yi He, Anne Sofie Siebuhr, Peter Junker

Open Access Research article

Optimal responses in disease activity scores to treatment in rheumatoid arthritis: Is a DAS28 reduction of >1.2 sufficient?

Aneela N. Mian, Fowzia Ibrahim, David L. Scott, James Galloway

Open Access Research article

Collagen-induced arthritis and imiquimod-induced psoriasis develop independently of interleukin-33

Sara Khaleghparast Athari, Elodie Poirier, Jérôme Biton, Luca Semerano, Roxane Hervé, Aurélie Raffaillac, Delphine Lemeiter, André Herbelin, Jean-Philippe Girard, Frédéric Caux, Marie-Christophe Boissier, Natacha Bessis

Open Access Erratum

Erratum to: Effectiveness of two different doses of rituximab for the treatment of rheumatoid arthritis in an international cohort: data from the CERERRA collaboration

Katerina Chatzidionysiou, Elisabeth Lie, Evgeny Nasonov, Galina Lukina, Merete Lund Hetland, Ulrik Tarp, Ioan Ancuta, Karel Pavelka, Dan C. Nordström, Cem Gabay, Helene Canhão, Matija Tomsic, Piet L. C. M. van Riel, Juan Gomez-Reino, Tore K. Kvien, Ronald F. van Vollenhoven

Open Access Research article

Switching from adalimumab to tofacitinib in the treatment of patients with rheumatoid arthritis

Mark C. Genovese, Ronald F. van Vollenhoven, Bethanie Wilkinson, Lisy Wang, Samuel H. Zwillich, David Gruben, Pinaki Biswas, Richard Riese, Liza Takiya, Thomas V. Jones

Open Access Research article

Inflammatory conditions partly impair the mechanically mediated activation of Smad2/3 signaling in articular cartilage

Wojciech Madej, Pieter Buma, Peter van der Kraan

Open Access Research article

Endothelial progenitor cells are differentially impaired in ANCA-associated vasculitis compared to healthy controls

B. Wilde, A. Mertens, S. J. Arends, R. P. Rouhl, R. Bijleveld, J. Huitema, S. A. Timmermans, J. Damoiseaux, O. Witzke, A. M. Duijvestijn, P. van Paassen, R. J. van Oostenbrugge, J. W. Cohen Tervaert

Open Access Research article

Interaction among activated lymphocytes and mesenchymal cells through podoplanin is critical for a high IL-17 secretion

Mélissa Noack, Ndiémé Ndongo-Thiam, Pierre Miossec

Open Access Research article

Body mass index distribution in rheumatoid arthritis: a collaborative analysis from three large German rheumatoid arthritis databases

Katinka Albrecht, Adrian Richter, Johanna Callhoff, Dörte Huscher, Georg Schett, Anja Strangfeld, Angela Zink

Open Access Research article

Concurrent validity of different functional and neuroproteomic pain assessment methods in the rat osteoarthritis monosodium iodoacetate (MIA) model

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Open Access Review

Are estrogen-related drugs new alternatives for the management of osteoarthritis?

Ya-Ping Xiao, Fa-Ming Tian, Mu-Wei Dai, Wen-Ya Wang, Li-Tao Shao, Liu Zhang

Open Access Erratum

Erratum to: JAK3-STAT pathway blocking benefits in experimental lupus nephritis

Èlia Ripoll, Laura de Ramon, Juliana Draibe, Ana Merino, Nuria Bolaños, Montse Goma, Josep M. Cruzado, Josep M. Grinyó, Juan Torras

Open Access Research article

Exercise echocardiography for the assessment of pulmonary hypertension in systemic sclerosis: a systematic review

Rui Baptista, Sara Serra, Rui Martins, Rogério Teixeira, Graça Castro, Maria João Salvador, José António Pereira da Silva, Lèlita Santos, Pedro Monteiro, Mariano Pêgo

Open Access Erratum

Erratum to: The prevalence and clinical characteristics of nonradiographic axial spondyloarthritis among patients with inflammatory back pain in rheumatology practices: a multinational, multicenter study

Ruben Burgos-Vargas, James Cheng-Chung Wei, Mahboob U. Rahman, Nurullah Akkoc, Syed Atiqul Haq, Mohammed Hammoudeh, Ehab Mahgoub, Ena Singh, Lyndon John Llamado, Khalid Shirazy, Sameer Kotak, Constance Hammond, Ron Pedersen, Qi Shen, Bonnie Vlahos

Open Access Research article

miR-155 in the progression of lung fibrosis in systemic sclerosis

Romy B. Christmann, Alicia Wooten, Percival Sampaio-Barros, Claudia L. Borges, Carlos R. R. Carvalho, Ronaldo A. Kairalla, Carol Feghali-Bostwick, Jessica Ziemek, Yu Mei, Salma Goummih, Jiangning Tan, Diana Alvarez, Daniel J. Kass, Mauricio Rojas, Thiago Lemos de Mattos, Edwin Parra, Giuseppina Stifano, Vera L. Capelozzi, Robert W. Simms, Robert Lafyatis

Open Access Research article

Systematic protein-protein interaction and pathway analyses in the idiopathic inflammatory myopathies

Joanna E. Parkes, Simon Rothwell, Philip J. Day, Neil J. McHugh, Zoë E. Betteridge, Robert G. Cooper, William E. Ollier, Hector Chinoy, Janine A. Lamb

Open Access Research article

Whole blood expression profiling from the TREAT trial: insights for the pathogenesis of polyarticular juvenile idiopathic arthritis

Kaiyu Jiang, Laiping Wong, Ashley D. Sawle, M. Barton Frank, Yanmin Chen, Carol A. Wallace, James N. Jarvis

Open Access Research article

H3K27me3 demethylases regulate in vitro chondrogenesis and chondrocyte activity in osteoarthritis

Clarence Yapp, Andrew J. Carr, Andrew Price, Udo Oppermann, Sarah J. B. Snelling

Open Access Research article

Identification of baseline gene expression signatures predicting therapeutic responses to three biologic agents in rheumatoid arthritis: a retrospective observational study

Seiji Nakamura, Katsuya Suzuki, Hiroshi Iijima, Yuko Hata, Chun Ren Lim, Yohei Ishizawa, Hideto Kameda, Koichi Amano, Kenichi Matsubara, Ryo Matoba, Tsutomu Takeuchi

Open Access Research article

Calprotectin and TNF trough serum levels identify power Doppler ultrasound synovitis in rheumatoid arthritis and psoriatic arthritis patients in remission or with low disease activity

José Inciarte-Mundo, Julio Ramirez, Maria Victoria Hernández, Virginia Ruiz-Esquide, Andrea Cuervo, Sonia Raquel Cabrera-Villalba, Mariona Pascal, Jordi Yagüe, Juan D. Cañete, Raimon Sanmarti

Open Access Research article

Periodontal bacterial colonization in synovial tissues exacerbates collagen-induced arthritis in B10.RIII mice

Sasanka Chukkapalli, Mercedes Rivera-Kweh, Prashasnika Gehlot, Irina Velsko, Indraneel Bhattacharyya, S. John Calise, Minoru Satoh, Edward K. L. Chan, Joseph Holoshitz, Lakshmyya Kesavalu

Open Access Research article

Whole-genome transcription and DNA methylation analysis of peripheral blood mononuclear cells identified aberrant gene regulation pathways in systemic lupus erythematosus

Honglin Zhu, Wentao Mi, Hui Luo, Tao Chen, Shengxi Liu, Indu Raman, Xiaoxia Zuo, Quan-Zhen Li

Open Access Research article

Review of biomarkers in systemic juvenile idiopathic arthritis: helpful tools or just playing tricks?

Faekah Gohar, Christoph Kessel, Miha Lavric, Dirk Holzinger, Dirk Foell

Open Access Research article

Incidence and prevalence of gout in Western Sweden

Mats Dehlin, Panagiota Drivelegka, Valgerdur Sigurdardottir, Anna Svärd, Lennart T. H. Jacobsson

Open Access Research article

The type I interferon signature in leukocyte subsets from peripheral blood of patients with early arthritis: a major contribution by granulocytes

Tamarah D. de Jong, Joyce Lübbers, Samina Turk, Saskia Vosslamber, Elise Mantel, Hetty J. Bontkes, Conny J. van der Laken, Johannes W. Bijlsma, Dirkjan van Schaardenburg, Cornelis L. Verweij

Open Access Research article

Bone marrow contribution to synovial hyperplasia following joint surface injury

Ana Sergijenko, Anke J. Roelofs, Anna H. K. Riemen, Cosimo De Bari

Open Access Research article

Enhanced IgG4 production by follicular helper 2 T cells and the involvement of follicular helper 1 T cells in the pathogenesis of IgG4-related disease

Mitsuhiro Akiyama, Hidekata Yasuoka, Kunihiro Yamaoka, Katsuya Suzuki, Yuko Kaneko, Harumi Kondo, Yoshiaki Kassai, Keiko Koga, Takahiro Miyazaki, Rimpei Morita, Akihiko Yoshimura, Tsutomu Takeuchi

Open Access Research article

Long-term outcome of patients with ANCA-associated vasculitis treated with plasma exchange: a retrospective, single-centre study

Doubravka Frausová, Zdenka Hrušková, Věra Lánská, Jana Lachmanová, Vladimír Tesař

Open Access Research article

Inhomogeneity of immune cell composition in the synovial sublining: linear mixed modelling indicates differences in distribution and spatial decline of CD68+ macrophages in osteoarthritis and rheumatoid arthritis

Johanna Mucke, Annika Hoyer, Ralph Brinks, Ellen Bleck, Thomas Pauly, Matthias Schneider, Stefan Vordenbäumen

Open Access Research article

Collagen triple helix repeat containing 1 is a new promigratory marker of arthritic pannus

Mohammed Talha Shekhani, Toni S. Forde, Altynai Adilbayeva, Mohamed Ramez, Askhat Myngbay, Yergali Bexeitov, Volkhard Lindner, Vyacheslav A. Adarichev

Open Access Research article

The unfolded protein response genes in human osteoarthritic chondrocytes: PERK emerges as a potential therapeutic target

Ying-Hua Li, Ginette Tardif, David Hum, Mohit Kapoor, Hassan Fahmi, Jean-Pierre Pelletier, Johanne Martel-Pelletier

Open Access Research article

Tumor necrosis factor alpha, citrullination, and peptidylarginine deiminase 4 in lung and joint inflammation

Mandar Bawadekar, Annette Gendron-Fitzpatrick, Ryan Rebernick, Daeun Shim, Thomas F. Warner, Anthony P. Nicholas, Lennart K. A. Lundblad, Paul R. Thompson, Miriam A. Shelef

Open Access Research article

Familial Mediterranean fever is no longer a rare disease in Japan

Kiyoshi Migita, Yasumori Izumi, Yuka Jiuchi, Nozomi Iwanaga, Chieko Kawahara, Kazunaga Agematsu, Akihiro Yachie, Junya Masumoto, Keita Fujikawa, Satoshi Yamasaki, Tadashi Nakamura, Yoshifumi Ubara, Tomohiro Koga, Yoshikazu Nakashima, Toshimasa Shimizu, Masataka Umeda, Fumiaki Nonaka, Michio Yasunami, Katsumi Eguchi, Koh-ichiro Yoshiura, Atsushi Kawakami

Open Access Research article

Resistance exercise improves physical fatigue in women with fibromyalgia: a randomized controlled trial

Anna Ericsson, Annie Palstam, Anette Larsson, Monika Löfgren, Indre Bileviciute-Ljungar, Jan Bjersing, Björn Gerdle, Eva Kosek, Kaisa Mannerkorpi

Open Access Research article

Association between Staphylococcus aureus nasal carriage and disease phenotype in patients affected by systemic lupus erythematosus

Fabrizio Conti, Fulvia Ceccarelli, Giancarlo Iaiani, Carlo Perricone, Alessandra Giordano, Luigino Amori, Francesca Miranda, Laura Massaro, Viviana Antonella Pacucci, Simona Truglia, Gabriella Girelli, Azis Fakeri, Gloria Taliani, Chiara Temperoni, Francesca Romana Spinelli, Cristiano Alessandri, Guido Valesini

Open Access Research article

The impact of identifying carotid plaque on addressing cardiovascular risk in psoriatic arthritis

Michael Lucke, William Messner, Esther S. H. Kim, M. Elaine Husni

Open Access Research article

MRI-detected osteitis is not associated with the presence or level of ACPA alone, but with the combined presence of ACPA and RF

Debbie M. Boeters, Wouter P. Nieuwenhuis, Marije K. Verheul, Elize C. Newsum, Monique Reijnierse, René E. M. Toes, Leendert A. Trouw, Annette H. M. van der Helm-van Mil

Open Access Research article

Immunoregulatory soluble CTLA-4 modifies effector T-cell responses in systemic lupus erythematosus

Lekh N. Dahal, Neil Basu, Hazem Youssef, Rahul C. Khanolkar, Robert N. Barker, Lars P. Erwig, Frank J. Ward

Open Access Research article

Evaluation of a quantitative measurement of suprapatellar effusion by ultrasonography and its association with symptoms of radiographic knee osteoarthritis: a cross-sectional observational study

Daisuke Chiba, Eiichi Tsuda, Shugo Maeda, Eiji Sasaki, Ippei Takahashi, Shigeyuki Nakaji, Yasuyuki Ishibashi

Open Access Research article

Defective DNA repair and chromatin organization in patients with quiescent systemic lupus erythematosus

Vassilis L. Souliotis, Konstantinos Vougas, Vassilis G. Gorgoulis, Petros P. Sfikakis

Open Access Research article

Impact of disease activity and treatment of comorbidities on the risk of myocardial infarction in rheumatoid arthritis

Yvette Meissner, Angela Zink, Jörn Kekow, Karin Rockwitz, Anke Liebhaber, Silke Zinke, Kerstin Gerhold, Adrian Richter, Joachim Listing, Anja Strangfeld

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Apoptotic cell infusion treats ongoing collagen-induced arthritis, even in the presence of methotrexate, and is synergic with anti-TNF therapy

Francis Bonnefoy, Anna Daoui, Séverine Valmary-Degano, Eric Toussirot, Philippe Saas, Sylvain Perruche

Open Access Research article

Transient receptor potential ankyrin 1 (TRPA1) is functionally expressed in primary human osteoarthritic chondrocytes

Elina Nummenmaa, Mari Hämäläinen, Lauri J. Moilanen, Erja-Leena Paukkeri, Riina M. Nieminen, Teemu Moilanen, Katriina Vuolteenaho, Eeva Moilanen

Open Access Research article

Suppression of the inflammatory response by disease-inducible interleukin-10 gene therapy in a three-dimensional micromass model of the human synovial membrane

Mathijs G. A. Broeren, Marieke de Vries, Miranda B. Bennink, Onno J. Arntz, Peter L. E M. van Lent, Peter M. van der Kraan, Wim B. van den Berg, Frank H. J. van den Hoogen, Marije I. Koenders, Fons A. J. van de Loo

Open Access Research article

Chromogranin-A production and fragmentation in patients with Takayasu arteritis

Enrico Tombetti, Barbara Colombo, Maria Chiara Di Chio, Silvia Sartorelli, Maurizio Papa, Annalaura Salerno, Enrica Paola Bozzolo, Elisabetta Tombolini, Giulia Benedetti, Claudia Godi, Chiara Lanzani, Patrizia Rovere-Querini, Alessandro Del Maschio, Alessandro Ambrosi, Francesco De Cobelli, Maria Grazia Sabbadini, Elena Baldissera, Angelo Corti, Angelo A. Manfredi

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Open Access Erratum

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Extracellular vesicles in the pathogenesis of rheumatoid arthritis and osteoarthritis

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Granulocyte macrophage colony-stimulating factor receptor α expression and its targeting in antigen-induced arthritis and inflammation

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A genetic risk score composed of rheumatoid arthritis risk alleles, HLA-DRB1 haplotypes, and response to TNFi therapy – results from a Swedish cohort study

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Antibodies against carbamylated proteins and cyclic citrullinated peptides in systemic lupus erythematosus: results from two well-defined European cohorts

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Type I interferon response gene expression in established rheumatoid arthritis is not associated with clinical parameters

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Adelmidrol, in combination with hyaluronic acid, displays increased anti-inflammatory and analgesic effects against monosodium iodoacetate-induced osteoarthritis in rats

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CD24 enrichment protects while its loss increases susceptibility of juvenile chondrocytes towards inflammation

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Fewer subsequent relapses and lower levels of IL-17 in Takayasu arteritis developed after the age of 40 years

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Serum IL-33, a new marker predicting response to rituximab in rheumatoid arthritis

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Differential gene and protein expression of chemokines and cytokines in synovial fluid of patients with arthritis

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Impact of body weight on the achievement of minimal disease activity in patients with rheumatic diseases: a systematic review and meta-analysis

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Open Access Erratum

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Open Access Erratum

Erratum to: Prevalence, sensitivity and specificity of antibodies against carbamylated proteins in a monocentric cohort of patients with rheumatoid arthritis and other autoimmune rheumatic diseases

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Open Access Erratum

Erratum to: Rheumatology training experience across Europe: analysis of core competences

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Open Access Research article

Efficacy and safety of adult human bone marrow-derived, cultured, pooled, allogeneic mesenchymal stromal cells (Stempeucel®): preclinical and clinical trial in osteoarthritis of the knee joint

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Open Access Research article

Immune reconstitution 20 years after treatment with alemtuzumab in a rheumatoid arthritis cohort: implications for lymphocyte depleting therapies

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Open Access Research article

Increase in circulating Th17 cells during anti-TNF therapy is associated with ultrasonographic improvement of synovitis in rheumatoid arthritis

Dobrina N. Hull, Helen Cooksley, Shilpa Chokshi, Richard O. Williams, Sonya Abraham, Peter C. Taylor

Open Access Research article

Serum biomarkers and changes in clinical/MRI evidence of golimumab-treated patients with ankylosing spondylitis: results of the randomized, placebo-controlled GO-RAISE study

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Open Access Research article

Changes in plasma CXCL4 levels are associated with improvements in lung function in patients receiving immunosuppressive therapy for systemic sclerosis-related interstitial lung disease

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Open Access Research article

Altered lipoproteins in patients with systemic lupus erythematosus are associated with augmented oxidative stress: a potential role in atherosclerosis

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