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European Archives of Oto-Rhino-Laryngology

Erschienen in:

28.09.2023 | Head and Neck

Serum levels of heavy metals in patients with Bell’s palsy: a case–control study

verfasst von: Nazim Bozan, Ömer Faruk Koçak, Canser Yılmaz Demir, Koray Avcı, Ömer Erdağ, Mahfuz Turan, Halit Demir

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 2/2024

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Abstract

Purpose

The exact etiology of Bell’s palsy (BP) remains unknown, while its potential etiopathology includes neuritis and inflammation-related demyelination as in optic neuritis. It has been reported that disruption of heavy metal homeostasis may be associated with the inflammatory process of optic neuritis; therefore, heavy metals may be involved in the pathogenesis of facial nerve neuritis. In this study, we aimed to investigate serum levels of heavy metals including essential elements [iron (Fe), zinc (Zn), copper (Cu), cobalt (Co), and manganese (Mn)], and nonessential elements [lead (Pb) and cadmium (Cd)] in patients with BP.

Methods

The study included 25 patients with BP and 31 healthy volunteers. For each participant, serum levels of essential and nonessential elements were measured using the atomic absorption spectrophotometer method.

Results

Serum levels of essential elements were significantly lower in the patient group compared to the control group (p < 0.001, for each). Serum levels of Pb increased in the patient group compared to the control group although no significant difference was achieved (p = 0.105). In contrast, serum Cd levels increased significantly in the patient group compared to the control group (p < 0.001).

Conclusion

Our findings suggest that decreased essential and increased nonessential elements may be associated with BP and thus, serum concentrations of these elements should be taken into account in BP. Studies are warranted to determine the role of these elements in treatment of BP.

Zhang W, Xu L, Luo T, Wu F, Zhao B, Li X (2020) The etiology of Bell’s palsy: a review. J Neurol 267(7):1896–1905. https://doi.org/10.1007/s00415-019-09282-4CrossRefPubMed

Singh A, Deshmukh P (2022) Bell’s Palsy: a review. Cureus 14(10):e30186. https://doi.org/10.7759/cureus.30186CrossRefPubMedPubMedCentral

Chern A, Mudry A, Lustig LR (2023) Bell’s palsy and its semantic change over time. Otol Neurotol 44(1):90–95. https://doi.org/10.1097/MAO.0000000000003742CrossRefPubMed

Gagyor I, Madhok VB, Daly F, Sullivan F (2019) Antiviral treatment for Bell’s palsy (idiopathic facial paralysis). Cochrane Database Syst Rev 9(9):CD001869. https://doi.org/10.1002/14651858.CD001869.pub9CrossRefPubMed

Heckmann JG, Urban PP, Pitz S, Guntinas-Lichius O, Gágyor I (2019) The diagnosis and treatment of idiopathic facial paresis (Bell’s Palsy). Dtsch Arztebl Int 116(41):692–702. https://doi.org/10.3238/arztebl.2019.0692CrossRefPubMed

Jaishankar M, Tseten T, Anbalagan N, Mathew BB, Beeregowda KN (2014) Toxicity, mechanism and health effects of some heavy metals. Interdiscip Toxicol 7(2):60–72. https://doi.org/10.2478/intox-2014-0009CrossRefPubMedPubMedCentral

Fu Z, Xi S (2020) The effects of heavy metals on human metabolism. Toxicol Mech Methods 30(3):167–176. https://doi.org/10.1080/15376516.2019.1701594CrossRefPubMed

Briffa J, Sinagra E, Blundell R (2020) Heavy metal pollution in the environment and their toxicological effects on humans. Heliyon 6(9):e04691. https://doi.org/10.1016/j.heliyon.2020.e04691CrossRefPubMedPubMedCentral

Zatta P, Lucchini R, van Rensburg SJ, Taylor A (2003) The role of metals in neurodegenerative processes: aluminum, manganese, and zinc. Brain Res Bull 62(1):15–28. https://doi.org/10.1016/s0361-9230(03)00182-5CrossRefPubMed

10.

Kitzberger R, Madl C, Ferenci P (2005) Wilson disease. Metab Brain Dis 20(4):295–302. https://doi.org/10.1007/s11011-005-7910-8CrossRefPubMed

11.

Aaseth J, Flaten TP, Andersen O (2007) Hereditary iron and copper deposition: diagnostics, pathogenesis and therapeutics. Scand J Gastroenterol 42(6):673–681. https://doi.org/10.1080/00365520601075662CrossRefPubMed

12.

Strausak D, Mercer JF, Dieter HH, Stremmel W, Multhaup G (2001) Copper in disorders with neurological symptoms: Alzheimer’s, Menkes, and Wilson diseases. Brain Res Bull 55(2):175–185. https://doi.org/10.1016/s0361-9230(01)00454-3CrossRefPubMed

13.

Savary T, Fieux M, Douplat M, Tournegros R, Daubie S, Pavie D, Denoix L, Pialat JB, Tringali S (2023) Incidence of underlying abnormal findings on routine magnetic resonance imaging for Bell Palsy. JAMA Netw Open 6(4):e239158. https://doi.org/10.1001/jamanetworkopen.2023.9158CrossRefPubMedPubMedCentral

14.

Kaźmierczak K, Malukiewicz G, Lesiewska-Junk H, Laudencka A, Szady-Grad M, Klawe J, Nowicki K (2014) Blood plasma levels of microelements in patients with history of optic neuritis. Curr Eye Res 39(1):93–98. https://doi.org/10.3109/02713683.2013.833244CrossRefPubMed

15.

Anka AU, Usman AB, Kaoje AN et al (2022) Potential mechanisms of some selected heavy metals in the induction of inflammation and autoimmunity. Eur J Inflamm 20:1–14. https://doi.org/10.1177/1721727X221122719CrossRef

16.

Popov Aleksandrov A, Mirkov I, Tucovic D et al (2021) Immunomodulation by heavy metals as a contributing factor to inflammatory diseases and autoimmune reactions: Cadmium as an example. Immunol Lett 240:106–122. https://doi.org/10.1016/j.imlet.2021.10.003CrossRefPubMed

17.

Behera SN, Xian H, Balasubramanian R (2014) Human health risk associated with exposure to toxic elements in mainstream and sidestream cigarette smoke. Sci Total Environ 472:947–956. https://doi.org/10.1016/j.scitotenv.2013.11.063CrossRefPubMed

18.

Olson AD, Hamlin WB (1969) A new method for serum iron and total iron-binding capacity by atomic absorption spectrophotometry. Clin Chem 15(6):438–444CrossRefPubMed

19.

Faul F, Erdfelder E (2004) GPOWER: a priori, post-hoc, and compromise power analyses for MS-DOS [Computer program]. Bonn University, Department of Psychology, Bonn

20.

Gao G, You L, Zhang J, Chang YZ, Yu P (2023) Brain iron metabolism redox balance and neurological diseases. Antioxidants (Basel) 12(6):1289. https://doi.org/10.3390/antiox12061289CrossRefPubMed

21.

Zhou Q, Xue S, Zhang L, Chen G (2022) Trace elements and the thyroid. Front Endocrinol (Lausanne) 13:904889. https://doi.org/10.3389/fendo.2022.904889CrossRefPubMed

22.

Paoletti P, Vergnano AM, Barbour B, Casado M (2009) Zinc at glutamatergic synapses. Neuroscience 158(1):126–136. https://doi.org/10.1016/j.neuroscience.2008.01.061CrossRefPubMed

23.

Takeda A (2000) Movement of zinc and its functional significance in the brain. Brain Res Brain Res Rev 34(3):137–148. https://doi.org/10.1016/s0165-0173(00)00044-8CrossRefPubMed

24.

Terzi S, Dursun E, Yılmaz A, Özergin Coşkun Z, Özgür A, Çeliker M, Demirci M (2017) Oxidative stress and antioxidant status in patients with Bell’s Palsy. J Med Biochem 36(1):18–22. https://doi.org/10.1515/jomb-2016-0033CrossRefPubMedPubMedCentral

25.

Li Z, Liu Y, Wei R, Yong VW, Xue M (2022) The important role of zinc in neurological diseases. Biomolecules 13(1):28. https://doi.org/10.3390/biom13010028CrossRefPubMedPubMedCentral

26.

Kumar V, Kumar A, Singh K, Avasthi K, Kim JJ (2021) Neurobiology of zinc and its role in neurogenesis. Eur J Nutr 60(1):55–64. https://doi.org/10.1007/s00394-020-02454-3CrossRefPubMed

27.

Jung KH, Chu K, Lee ST et al (2016) Experimental induction of cerebral aneurysms by developmental low copper diet. J Neuropathol Exp Neurol 75(5):455–463. https://doi.org/10.1093/jnen/nlw020CrossRefPubMed

28.

Takikita S, Takano T, Narita T, Maruo Y (2015) Increased apoptosis and hypomyelination in cerebral white matter of macular mutant mouse brain. Mol Genet Metab Rep 4:25–29. https://doi.org/10.1016/j.ymgmr.2015.05.005CrossRefPubMedPubMedCentral

29.

Rapoport Y, Lavin PJ (2016) Nutritional optic neuropathy caused by copper deficiency after bariatric surgery. J Neuroophthalmol 36(2):178–181. https://doi.org/10.1097/WNO.0000000000000333CrossRefPubMed

30.

Pineles SL, Wilson CA, Balcer LJ, Slater R, Galetta SL (2010) Combined optic neuropathy and myelopathy secondary to copper deficiency. Surv Ophthalmol 55(4):386–392. https://doi.org/10.1016/j.survophthal.2010.02.002CrossRefPubMed

31.

Tan JC, Burns DL, Jones HR (2006) Severe ataxia, myelopathy, and peripheral neuropathy due to acquired copper deficiency in a patient with history of gastrectomy. JPEN J Parenter Enteral Nutr 30(5):446–450. https://doi.org/10.1177/0148607106030005446CrossRefPubMed

32.

Yamada K (2013) Cobalt: its role in health and disease. Met Ions Life Sci 13:295–320. https://doi.org/10.1007/978-94-007-7500-8_9CrossRefPubMed

33.

Ata F, Bilal BI, A, Javed S, et al (2020) Optic neuropathy as a presenting feature of vitamin B-12 deficiency: a systematic review of literature and a case report. Ann Med Surg (Lond) 60:316–322. https://doi.org/10.1016/j.amsu.2020.11.010CrossRefPubMed

34.

Bouattour N, Sakka S, Farhat N, Kacem HH, Hdiji O, Dammak M, Mhiri C (2018) Vitamin B12 deficiency neuropathy: a clinical and electrophysiological study. Neurophysiol Clin 48(3):130. https://doi.org/10.1016/j.neucli.2018.05.007CrossRef

35.

Horning KJ, Caito SW, Tipps KG, Bowman AB, Aschner M (2015) Manganese is essential for neuronal health. Annu Rev Nutr 35:71–108. https://doi.org/10.1146/annurev-nutr-071714-034419CrossRefPubMedPubMedCentral

36.

Chen P, Bornhorst J, Aschner M (2018) Manganese metabolism in humans. Front Biosci (Landmark Ed) 23:1655–1679. https://doi.org/10.2741/4665CrossRefPubMed

37.

Mason LH, Harp JP, Han DY (2014) Pb neurotoxicity: neuropsychological effects of lead toxicity. Biomed Res Int 2014:840547. https://doi.org/10.1155/2014/840547CrossRefPubMedPubMedCentral

38.

Gorkhali R, Huang K, Kirberger M, Yang JJ (2016) Defining potential roles of Pb(2+) in neurotoxicity from a calciomics approach. Metallomics 8(6):563–578. https://doi.org/10.1039/c6mt00038jCrossRefPubMed

Titel: Serum levels of heavy metals in patients with Bell’s palsy: a case–control study
verfasst von: Nazim Bozan
Ömer Faruk Koçak
Canser Yılmaz Demir
Koray Avcı
Ömer Erdağ
Mahfuz Turan
Halit Demir
Publikationsdatum: 28.09.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: European Archives of Oto-Rhino-Laryngology / Ausgabe 2/2024
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-023-08253-w

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Serum levels of heavy metals in patients with Bell’s palsy: a case–control study