Background
Objectives
Methods and analysis
Eligibility criteria
Participants/population
Intervention and comparator treatment
Outcomes
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Overall survival
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Disease-free survival
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Local recurrence-free survival
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Quality of life
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Postoperative weight loss/changes in body-mass index
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Frequency of postoperative anemia
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Postoperative changes in the following: serum-hemoglobin, serum-iron, serum-vitamin b12, serum-albumin, serum-total-protein, and serum-total-cholesterol.
Study types
Information sources
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MEDLINE, MEDLINE Daily Update, MEDLINE In-Process and Other Non-Indexed Citations, MEDLINE Epub Ahead of Print (via Ovid) (a preliminary search strategy is displayed in Table 1).
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Web of Science Core Collection: Science Citation Index-EXPANDED (SCI-EXPANDED) (via Clarivate Analytics).
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Cochrane Library (via Wiley).
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ScienceDirect (via Elsevier).
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Searches for unpublished and ongoing studies will be performed in ClinicalTrials.gov (www.clinicaltrials.gov) and WHO International Clinical Trials Registry Platform (http://www.who.int/ictrp/search/en) and the German study register (www.drks.de).
Search | Query | Results |
---|---|---|
#7 | Search: #6 NOT (animals [mh] NOT humans [mh]) | 924 |
#6 | Search: (#1 AND ((#2 AND #3) OR #4)) AND #5 | 929 |
#5 | Search: random*[tiab] OR RCT[tiab] OR “Randomized Controlled Trial”[pt] OR “Randomized Controlled Trials as Topic”[Mesh] OR “Clinical Trial”[pt] OR “Clinical Study” [pt] OR “Controlled Clinical Trials as Topic”[Mesh] OR “Observational study” [pt] OR “Comparative Study” [Publication Type] OR “Multicenter Study”[Publication Type] OR “controlled study”[tiab] OR group*[tiab] OR cohort*[tiab] OR “Control Groups”[Mesh] OR “Prospective Studies”[Mesh] OR control[tiab] OR controls[tiab] OR versus[tiab] OR compar*[tiab] OR matched[tiab] | 11,653,482 |
#4 | Search: “double tract”[tiab] or “double-tract”[tiab] or “two tract”[tiab] or “two-tract”[tiab] OR DTR [tiab] | 1113 |
#3 | Search: proximal[tiab] | 224,119 |
#2 | Search: gastrectom*[tiab] OR “Gastrectomy”[Mesh] | 49,888 |
#1 | Search: ((gastric*[tiab] OR stomach[tiab] OR gastrointestinal*[tiab] OR gastro-oesophageal*[tiab] OR gastrooesophageal*[tiab] OR gastro-esophageal*[tiab] OR gastroesophageal*[tiab] OR esophagogastric*[tiab]) AND (cancer[tiab] OR carcinoma*[tiab] OR adenocarcinoma*[tiab] OR neoplas*[tiab] OR tumor[tiab] OR tumors[tiab] OR tumour*[tiab] OR malignan*[tiab])) OR “Stomach Neoplasms”[Mesh] | 218,033 |
Identification of relevant studies
Extraction of study data
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Study characteristics: Title, author, year of publication, journal, language, setting (geographical), trial duration, trial design (RCT/NRS/observational study), eligible diseases (esophageal cancer/gastric cancer), eligible tumor stages of patients according to the TNM-classification, total number of patients, number of treatment groups, and patients per group (matched cohorts).
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Patient characteristics: Age, gender, disease (esophageal cancer/gastric cancer), tumor stage (TNM stage of patients included to the study), multimodal treatment/(neo-)adjuvant treatment, operative time (minutes), number of harvested lymph nodes, length of postoperative hospital stay (days), complications according to Clavien-Dindo classification [20], incidence of anastomotic leakages, incidence of reflux esophagitis according to the Los Angeles classification [21], incidence of anastomotic stricture, and duration of follow-up (months).
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Outcome parameters: As previously mentioned.