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01.12.2013 | e-Herz: Original article

NT-proBNP is associated with SYNTAX score and aortic distensibility in patients with stable CAD

verfasst von: D.Y. Şahin, MD, M. Gür, Z. Elbasan, N.Y. Koyunsever, C. Türkoğlu, S. Akyol, A. Yıldırım, G. Gözübüyük, B. Özaltun, M. Çaylı

Erschienen in: Herz | Ausgabe 8/2013

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Abstract

Objective

A high N-terminal pro-brain natriuretic peptide (NT-proBNP) level provides significant prognostic information on patients with coronary artery disease (CAD). It is unclear whether aortic distensibility (AD), which reflects the aortic stiffness, and the extent and complexity of CAD, assessed with the SYNTAX score (SS), affect the secretion of NT-proBNP in stable CAD. We aimed to investigate the relationship between NT-proBNP levels and AD as well as with the extent and complexity of CAD in stable CAD patients.

Methods

The study included 411 patients with stable CAD (mean age = 61.7 ± 9.9 years, male/female = 247/164). The patients were divided into two groups according to the median NT-proBNP value (NT-proBNP_low group < 114 pg/ml and NT-proBNP_high group ≥ 114 pg/ml). AD was calculated from the echocardiographically derived ascending aorta diameters and hemodynamic pressure measurements. Coronary angiography was performed and SS was determined in all patients. NT-proBNP and other biochemical markers were measured in all subjects.

Results

The AD and ejection fraction values of the NT-proBNP_high group were lower and their SS levels were higher compared with those from the NT-proBNP_low group (p < 0.05, for all). The NT-proBNP level was independently associated with AD (β = -0.378, p < 0.001), SS (β = 0.262, p < 0.001), and ejection fraction (β = − 0.295, p < 0.001) on multiple linear regression analysis.

Conclusion

NT-proBNP was independently associated with an impaired elastic property of the aorta and with the extent and complexity of CAD as well as with left ventricular systolic dysfunction.

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Titel: NT-proBNP is associated with SYNTAX score and aortic distensibility in patients with stable CAD
verfasst von: D.Y. Şahin, MD
M. Gür
Z. Elbasan
N.Y. Koyunsever
C. Türkoğlu
S. Akyol
A. Yıldırım
G. Gözübüyük
B. Özaltun
M. Çaylı
Publikationsdatum: 01.12.2013
Verlag: Urban & Vogel
Erschienen in: Herz / Ausgabe 8/2013
Print ISSN: 0340-9937
Elektronische ISSN: 1615-6692
DOI: https://doi.org/10.1007/s00059-013-3767-5

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NT-proBNP is associated with SYNTAX score and aortic distensibility in patients with stable CAD