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Erschienen in: Indian Journal of Otolaryngology and Head & Neck Surgery 1/2024

07.11.2023 | Original Article

Nasal Microbiota and Sensitivity Pattern in Rhinosinusitis

verfasst von: Prerana P., Arvind Sangavi, Venkatesh U, Saif Naziruddin Saiyad, Bhushan Chickle

Erschienen in: Indian Journal of Otolaryngology and Head & Neck Surgery | Ausgabe 1/2024

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Abstract

Aims

To know the microorganism causing rhinosinusitis & to study the antibiotic sensitivity pattern for the isolated nasal microbiota in this region.

Background

Rhinosinusitis is inflammatory condition of nose and paranasal sinuses [1]. It is multifactorial condition, in which microorganisms play pathogenic role [2]. Interactions between microorganisms, mucosa and environmental changes influence on composition of bacterial ecosystem [2]. Though antibiotics are frequently used for medical management of rhinosinusitis, sensitivity directed antibiotics are rarely prescribed. So, this study is directed to know microbial isolate in rhinosinusitis and its antibiotic sensitivity pattern.

Methodology

in this 6 months prospective study during March to September 2022, done at Department of Otorhinolaryngology, Raichur Institute of Medical Sciences, Raichur; patients attending Otorhinolaryngology outpatient department and diagnosed to have rhinosinusitis were selected. Nasal swabs were collected from the middle meatus by diagnostic nasal endoscopy and were sent for culture and sensitivity. Statistical tests were applied for results(Size = 100).

Results

Out of 100 patients, 52 were males, 48 were females; 88 were adults & 12 were paediatric patients. 59 patients had acute, 32 chronic and 9 had recurrent rhinosinusitis. Most common organisms isolated in acute rhinosinusitis was Klebsiella 28%, Staphylococcus aureus 56% & 66% in chronic & recurrent rhinosinusitis respectively. Klebsiella was sensitive to beta lactams & quinolones, while Staphylococcus aureus was sensitive to beta lactams & cephalosporins.

Conclusion

Increase in antibiotic use has led to antibiotic resistance. Hence judicious, sensitivity directed antibiotic usage reduces the risk of antibiotic resistance and unnecessary use of antibiotics.
Literatur
1.
Zurück zum Zitat Lux CA et al (2020) Antibiotic treatment for chronic rhinosinusitis: prescription patterns and associations with patient outcome and the sinus microbiota.Frontiers in microbiology : 3251 Lux CA et al (2020) Antibiotic treatment for chronic rhinosinusitis: prescription patterns and associations with patient outcome and the sinus microbiota.Frontiers in microbiology : 3251
2.
Zurück zum Zitat Rahuram Sivasubramaniam Richard Douglas ; The microbiome and chronic rhinosinusitis; World Journal of Otorhinolaryngology - Head and Neck Surgery Volume 4, Issue 3, September 2018,Pages216-221 Rahuram Sivasubramaniam Richard Douglas ; The microbiome and chronic rhinosinusitis; World Journal of Otorhinolaryngology - Head and Neck Surgery Volume 4, Issue 3, September 2018,Pages216-221
3.
Zurück zum Zitat Brad A, Rawlings MD, Thomas S, Higgim MD MSPH, Joseph K, Han MD ; Bacterial pathogens in nasopharynx, nasal cavity &osteomeatal complex during wellness & viral Infection; Am J Rhinology Allergy 2013 Jan-Feb 27(1);39–42 Brad A, Rawlings MD, Thomas S, Higgim MD MSPH, Joseph K, Han MD ; Bacterial pathogens in nasopharynx, nasal cavity &osteomeatal complex during wellness & viral Infection; Am J Rhinology Allergy 2013 Jan-Feb 27(1);39–42
4.
Zurück zum Zitat Osama A, Marglani a, Ameen Z, Alherabi a, Islam R, Herzallah b, Faisal A, Saati A, Tantawy A, Alandejani S (2016) Faidah f, Naif A. Bawazeer a, Abdullah A. Marghalani g, Tariq A. Madani. Acute rhinosinusitis during Hajj season 2014: Prevalence of bacterial infection and patterns of antimicrobial susceptibility. Travel Medicine and Infectious Disease Osama A, Marglani a, Ameen Z, Alherabi a, Islam R, Herzallah b, Faisal A, Saati A, Tantawy A, Alandejani S (2016) Faidah f, Naif A. Bawazeer a, Abdullah A. Marghalani g, Tariq A. Madani. Acute rhinosinusitis during Hajj season 2014: Prevalence of bacterial infection and patterns of antimicrobial susceptibility. Travel Medicine and Infectious Disease
5.
Zurück zum Zitat Mahdavinia M, Keshavarzian A, Tobin MC, Landay AL and R. P. Schleimer. A comprehensive review of the nasal microbiome in chronic rhinosinusitis (CRS). Clinical & Experimental Allergy, 46, 21–41. American Academy of Otolaryngology–Head and Neck Surgery Mahdavinia M, Keshavarzian A, Tobin MC, Landay AL and R. P. Schleimer. A comprehensive review of the nasal microbiome in chronic rhinosinusitis (CRS). Clinical & Experimental Allergy, 46, 21–41. American Academy of Otolaryngology–Head and Neck Surgery
6.
Zurück zum Zitat Neil Bhattacharya MD, Lyon J (1999) The microbiology of recurrent rhinosinusitis after endoscopic sinus Surgery. Arch Otolaryngol Head Neck Surgery 125(10):1117–1120CrossRef Neil Bhattacharya MD, Lyon J (1999) The microbiology of recurrent rhinosinusitis after endoscopic sinus Surgery. Arch Otolaryngol Head Neck Surgery 125(10):1117–1120CrossRef
7.
Zurück zum Zitat Cleland EJ, Bassiouni A, Wormald PJ (2013) The bacteriology of chronic rhinosinusitis and the pre-eminence of Staphylococcus aureus in revision patients. Int Forum Allergy Rhinol 3:642–646CrossRefPubMed Cleland EJ, Bassiouni A, Wormald PJ (2013) The bacteriology of chronic rhinosinusitis and the pre-eminence of Staphylococcus aureus in revision patients. Int Forum Allergy Rhinol 3:642–646CrossRefPubMed
8.
Zurück zum Zitat Boase S, Foreman A, Cleland E et al (2013) The microbiome of chronic rhinosinusitis: culture, molecular diagnostics and biofilm detection. BMC Infect Dis 13:210CrossRefPubMedPubMedCentral Boase S, Foreman A, Cleland E et al (2013) The microbiome of chronic rhinosinusitis: culture, molecular diagnostics and biofilm detection. BMC Infect Dis 13:210CrossRefPubMedPubMedCentral
9.
Zurück zum Zitat Aliyu EM, Kodiya M, Musa A, KirfiOnyekwere, Nwaorgu GB Antibiotic Sensitivity Pattern of Bacterial Isolates in Patients with Chronic Rhinosinusitis in Kaduna, Nigeria; Int. Arch. Otorhinolaryngol. 23 (02); Apr-Jun 2019 Aliyu EM, Kodiya M, Musa A, KirfiOnyekwere, Nwaorgu GB Antibiotic Sensitivity Pattern of Bacterial Isolates in Patients with Chronic Rhinosinusitis in Kaduna, Nigeria; Int. Arch. Otorhinolaryngol. 23 (02); Apr-Jun 2019
10.
Zurück zum Zitat Merkley MA et al (2015) The effect of antibiotics on the microbiome in acute exacerbations of chronic rhinosinusitis. Int Forum Allergy Rhinology” Vol 5:10 Merkley MA et al (2015) The effect of antibiotics on the microbiome in acute exacerbations of chronic rhinosinusitis. Int Forum Allergy Rhinology” Vol 5:10
11.
Zurück zum Zitat Ramakrishnan VR, Feazel LM, Gitomer SA, Ir D, Robertson CE, Frank DN (2013) ; The microbiome of the middle meatus in healthy adults; PLoS ONE, 8 Article e85507. Ramakrishnan VR, Feazel LM, Gitomer SA, Ir D, Robertson CE, Frank DN (2013) ; The microbiome of the middle meatus in healthy adults; PLoS ONE, 8 Article e85507.
12.
Zurück zum Zitat Carolyn L, Mulvey, MD1, Eleanor P, Kiell MD, Rizzi MD (2018) MD3, and AdvaBuzi, MD3The Microbiology of Complicated Acute Sinusitis among Pediatric Patients: A Case Series. November 2, Carolyn L, Mulvey, MD1, Eleanor P, Kiell MD, Rizzi MD (2018) MD3, and AdvaBuzi, MD3The Microbiology of Complicated Acute Sinusitis among Pediatric Patients: A Case Series. November 2,
13.
Zurück zum Zitat Biswas K, Hoggard M, Jain R, Taylor MW, Douglas RG (2015) The nasal microbiota in health and Disease: variation within and between subjects. Front Microbiol 9:134CrossRefPubMed Biswas K, Hoggard M, Jain R, Taylor MW, Douglas RG (2015) The nasal microbiota in health and Disease: variation within and between subjects. Front Microbiol 9:134CrossRefPubMed
14.
Zurück zum Zitat Psaltis AJ, Wormald PJ (2017) Therapy of sinonasal microbiome in CRS: a critical approach. Curr Allergy Asthma Rep 17:59CrossRefPubMed Psaltis AJ, Wormald PJ (2017) Therapy of sinonasal microbiome in CRS: a critical approach. Curr Allergy Asthma Rep 17:59CrossRefPubMed
15.
Zurück zum Zitat Kr T, Bhattacharyya YN, Mehra (1972) Agarwal.INCIDENCE OF BACTERIA, L-FORM AND MYCOPLASMA IN CHRONIC SINUSITIS. Acta Otolaryng 74:293–296CrossRef Kr T, Bhattacharyya YN, Mehra (1972) Agarwal.INCIDENCE OF BACTERIA, L-FORM AND MYCOPLASMA IN CHRONIC SINUSITIS. Acta Otolaryng 74:293–296CrossRef
16.
Zurück zum Zitat Singh NK, Garg LN, Baisakhiya N, Kuhar H, Shekhar S (2017) Naiya Rao, Anshul Singh. Antibiotic susceptibility pattern of organisms in chronic rhinosinusitis. Int J Otorhinolaryngol Head Neck Surger 3(4):868–873CrossRef Singh NK, Garg LN, Baisakhiya N, Kuhar H, Shekhar S (2017) Naiya Rao, Anshul Singh. Antibiotic susceptibility pattern of organisms in chronic rhinosinusitis. Int J Otorhinolaryngol Head Neck Surger 3(4):868–873CrossRef
17.
Zurück zum Zitat Santosh Malashetti AH, Karembelkar R (2017) Bacteriology and antibiotics treatment of maxillary sinusitis: a prospective study. Int J Otorhinolaryngol Head Neck Surg 3(4):979–985CrossRef Santosh Malashetti AH, Karembelkar R (2017) Bacteriology and antibiotics treatment of maxillary sinusitis: a prospective study. Int J Otorhinolaryngol Head Neck Surg 3(4):979–985CrossRef
18.
Zurück zum Zitat Madhavi Jangala1,2 (2016) Koralla1, Santoshi Kumari Manche1,2 and Jyothy Akka2. Microbial Prevalence and Antimicrobial Resistance in Children and adolescents with Chronic Rhinosinusitis in South Indian Population. Otolaryngol (Sunnyvale) 6:248 Madhavi Jangala1,2 (2016) Koralla1, Santoshi Kumari Manche1,2 and Jyothy Akka2. Microbial Prevalence and Antimicrobial Resistance in Children and adolescents with Chronic Rhinosinusitis in South Indian Population. Otolaryngol (Sunnyvale) 6:248
19.
Zurück zum Zitat Panduranga Kamath M, Shenoy V, Mittal SN, Sharma N (2013) Microbiological analysis of paranasal sinuses in chronic sinusitis – a south Indian coastal study. Egypt J Ear Nose Throat Allied Sci 14:185–189CrossRef Panduranga Kamath M, Shenoy V, Mittal SN, Sharma N (2013) Microbiological analysis of paranasal sinuses in chronic sinusitis – a south Indian coastal study. Egypt J Ear Nose Throat Allied Sci 14:185–189CrossRef
20.
Zurück zum Zitat Rohit Singh R, Shilpa Chiranjay Mukhopadhyay,Padmaja A, Shenoy R, Balakrishnan K (2019) Devaraja. Correlation between microbiological profiles of adenoid tissue and nasal discharge in children with co-existent chronic adenoiditis and chronic Rhinosinusitis. Indian J Otolaryngol Head Neck Surg December Rohit Singh R, Shilpa Chiranjay Mukhopadhyay,Padmaja A, Shenoy R, Balakrishnan K (2019) Devaraja. Correlation between microbiological profiles of adenoid tissue and nasal discharge in children with co-existent chronic adenoiditis and chronic Rhinosinusitis. Indian J Otolaryngol Head Neck Surg December
21.
Zurück zum Zitat James Chan MD, Jame s Hadley MD, FACS. The microbiology of chronic rhinosinusitis: Results of a community surveillance study. Otolaryngology, University of Rochester School of Medicine and Dentistry, Rochester, Ear NY (2001) nose, & throat journal. ;80:143–145 James Chan MD, Jame s Hadley MD, FACS. The microbiology of chronic rhinosinusitis: Results of a community surveillance study. Otolaryngology, University of Rochester School of Medicine and Dentistry, Rochester, Ear NY (2001) nose, & throat journal. ;80:143–145
22.
Zurück zum Zitat a Ildefonso Tellez M (2006) Duran Alba,b Margarita Gutierrez Reyes,b Elena Patton,c and Hector De La Garza Heslesb. Microbiology of Acute Sinusitis in Mexican patients. Arch Med Res 37:395–398PubMed a Ildefonso Tellez M (2006) Duran Alba,b Margarita Gutierrez Reyes,b Elena Patton,c and Hector De La Garza Heslesb. Microbiology of Acute Sinusitis in Mexican patients. Arch Med Res 37:395–398PubMed
23.
Zurück zum Zitat Karunasagar A, Garag SS, Appannavar SB et al (2018) Bacterial biofilms in Chronic Rhinosinusitis and their implications for Clinical Management. Indian J Otolaryngol Head Neck Surg 70:43–48CrossRefPubMed Karunasagar A, Garag SS, Appannavar SB et al (2018) Bacterial biofilms in Chronic Rhinosinusitis and their implications for Clinical Management. Indian J Otolaryngol Head Neck Surg 70:43–48CrossRefPubMed
24.
Zurück zum Zitat Gupta N, Ahmed A, Galib R et al (2023) A prospective clinical study of Bacteriological Profile and their antibiotic Susceptibilty Profile in patients with chronic Rhinosinusitis: the recent scenario in Northern India. Indian J Otolaryngol Head Neck Surg Gupta N, Ahmed A, Galib R et al (2023) A prospective clinical study of Bacteriological Profile and their antibiotic Susceptibilty Profile in patients with chronic Rhinosinusitis: the recent scenario in Northern India. Indian J Otolaryngol Head Neck Surg
Metadaten
Titel
Nasal Microbiota and Sensitivity Pattern in Rhinosinusitis
verfasst von
Prerana P.
Arvind Sangavi
Venkatesh U
Saif Naziruddin Saiyad
Bhushan Chickle
Publikationsdatum
07.11.2023
Verlag
Springer India
Erschienen in
Indian Journal of Otolaryngology and Head & Neck Surgery / Ausgabe 1/2024
Print ISSN: 2231-3796
Elektronische ISSN: 0973-7707
DOI
https://doi.org/10.1007/s12070-023-04321-z

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