nach oben

Erschienen in:

01.12.2022 | Original Contribution

Metabolism regulator adiponectin prevents cardiac remodeling and ventricular arrhythmias via sympathetic modulation in a myocardial infarction model

verfasst von: Zhen Zhou, Chengzhe Liu, Saiting Xu, Jun Wang, Fuding Guo, Shoupeng Duan, Qiang Deng, Ji Sun, Fu Yu, Yuyang Zhou, Meng Wang, Yueyi Wang, Liping Zhou, Hong Jiang, Lilei Yu

Erschienen in: Basic Research in Cardiology | Ausgabe 1/2022

Einloggen, um Zugang zu erhalten

Abstract

The stellate ganglia play an important role in cardiac remodeling after myocardial infarction (MI). This study aimed to investigate whether adiponectin (APN), an adipokine mainly secreted by adipose tissue, could modulate the left stellate ganglion (LSG) and exert cardioprotective effects through the sympathetic nervous system (SNS) in a canine model of MI. APN microinjection and APN overexpression with recombinant adeno-associated virus vector in the LSG were performed in acute and chronic MI models, respectively. The results showed that acute APN microinjection decreased LSG function and neural activity, and suppressed ischemia-induced ventricular arrhythmia. Chronic MI led to a decrease in the effective refractory period and action potential duration at 90% and deterioration in echocardiography performance, all of which was blunted by APN overexpression. Moreover, APN gene transfer resulted in favorable heart rate variability alteration, and decreased cardiac SNS activity, serum noradrenaline and neuropeptide Y, which were augmented after MI. APN overexpression also decreased the expression of nerve growth factor and growth associated protein 43 in the LSG and peri-infarct myocardium, respectively. Furthermore, RNA sequencing of LSG indicated that 4-week MI up-regulated the mRNA levels of macrophage/microglia activation marker Iba1, chemokine ligands (CXCL10, CCL20), chemokine receptor CCR5 and pro-inflammatory cytokine IL6, and downregulated IL1RN and IL10 mRNA, which were reversed by APN overexpression. Our results reveal that APN inhibits cardiac sympathetic remodeling and mitigates cardiac remodeling after MI. APN-mediated gene therapy may provide a potential therapeutic strategy for the treatment of MI.

Nur mit Berechtigung zugänglich

Ajijola OA, Hoover DB, Simerly TM, Brown TC, Yanagawa J, Biniwale RM, Lee JM, Sadeghi A, Khanlou N, Ardell JL, Shivkumar K (2017) Inflammation, oxidative stress, and glial cell activation characterize stellate ganglia from humans with electrical storm. JCI insight. https://doi.org/10.1172/jci.insight.94715CrossRef

Bourke T, Vaseghi M, Michowitz Y, Sankhla V, Shah M, Swapna N, Boyle NG, Mahajan A, Narasimhan C, Lokhandwala Y, Shivkumar K (2010) Neuraxial modulation for refractory ventricular arrhythmias: value of thoracic epidural anesthesia and surgical left cardiac sympathetic denervation. Circulation 121:2255–2262. https://doi.org/10.1161/CIRCULATIONAHA.109.929703CrossRef

Chan KY, Jang MJ, Yoo BB, Greenbaum A, Ravi N, Wu WL, Sanchez-Guardado L, Lois C, Mazmanian SK, Deverman BE, Gradinaru V (2017) Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems. Nat Neurosci 20:1172–1179. https://doi.org/10.1038/nn.4593CrossRef

Cui X, Jing J, Wu R, Cao Q, Li F, Li K, Wang S, Yu L, Schwartz G, Shi H, Xue B, Shi H (2021) Adipose tissue-derived neurotrophic factor 3 regulates sympathetic innervation and thermogenesis in adipose tissue. Nat Commun 12:5362. https://doi.org/10.1038/s41467-02125766-2CrossRef

D’Alonzo AJ, Hess TA, Darbenzio RB, Sewter JC, Conder ML, McCullough JR (1994) Effects of cromakalim or pinacidil on pacing- and ischemia-induced ventricular fibrillation in the anesthetized pig. Basic Res Cardiol 89:163–176. https://doi.org/10.1007/BF00788735CrossRef

Dahlstrom M, Madjid N, Nordvall G, Halldin MM, Vazquez-Juarez E, Lindskog M, Sandin J, Winblad B, Eriksdotter M, Forsell P (2021) Identification of novel positive allosteric modulators of neurotrophin receptors for the treatment of cognitive dysfunction. Cells 10(8):1871. https://doi.org/10.3390/cells10081871CrossRef

Davis H, Herring N, Paterson DJ (2020) Downregulation of M current is coupled to membrane excitability in sympathetic neurons before the onset of hypertension. Hypertension 76:1915–1923. https://doi.org/10.1161/HYPERTENSIONAHA.120.15922CrossRef

Diaz HS, Toledo C, Andrade DC, Marcus NJ, Del Rio R (2020) Neuroinflammation in heart failure: new insights for an old disease. J Physiol 598:33–59. https://doi.org/10.1113/JP278864CrossRef

Dusi V, De Ferrari GM, Schwartz PJ (2020) There are 100 ways by which the sympathetic nervous system can trigger life-threatening arrhythmias. Eur Heart J 41:2180–2182. https://doi.org/10.1093/eurheartj/ehz950CrossRef

10.

Garan H, Fallon JT, Ruskin JN (1980) Sustained ventricular tachycardia in recent canine myocardial infarction. Circulation 62:980–987. https://doi.org/10.1161/01.cir.62.5.980CrossRef

11.

Goldberger JJ, Arora R, Buckley U, Shivkumar K (2019) Autonomic nervous system dysfunction: JACC focus seminar. J Am Coll Cardiol 73:1189–1206. https://doi.org/10.1016/j.jacc.2018.12.064CrossRef

12.

Han S, Kobayashi K, Joung B, Piccirillo G, Maruyama M, Vinters HV, March K, Lin SF, Shen C, Fishbein MC, Chen PS, Chen LS (2012) Electroanatomic remodeling of the left stellate ganglion after myocardial infarction. J Am Coll Cardiol 59:954–961. https://doi.org/10.1016/j.jacc.2011.11.030CrossRef

13.

Hansen CS, Vistisen D, Jorgensen ME, Witte DR, Brunner EJ, Tabak AG, Kivimaki M, Roden M, Malik M, Herder C (2017) Adiponectin, biomarkers of inflammation and changes in cardiac autonomic function: Whitehall II study. Cardiovasc Diabetol 16:153. https://doi.org/10.1186/s12933-017-0634-3CrossRef

14.

Hasan W, Jama A, Donohue T, Wernli G, Onyszchuk G, Al-Hafez B, Bilgen M, Smith PG (2006) Sympathetic hyperinnervation and inflammatory cell NGF synthesis following myocardial infarction in rats. Brain Res 1124:142–154. https://doi.org/10.1016/j.brainres.2006.09.054CrossRef

15.

Herring N, Kalla M, Paterson DJ (2019) The autonomic nervous system and cardiac arrhythmias: current concepts and emerging therapies. Nat Rev Cardiol 16:707–726. https://doi.org/10.1038/s41569-019-0221-2CrossRef

16.

Herring N, Tapoulal N, Kalla M, Ye X, Borysova L, Lee R, Dall’Armellina E, Stanley C, Ascione R, Lu CJ, Banning AP, Choudhury RP, Neubauer S, Dora K, Kharbanda RK, Channon KM, Oxford Acute Myocardial Infarction S (2019) Neuropeptide-Y causes coronary microvascular constriction and is associated with reduced ejection fraction following ST-elevation myocardial infarction. Eur Heart J 40:1920–1929. https://doi.org/10.1093/eurheartj/ehz115CrossRef

17.

Heusch G, Deussen A, Thamer V (1985) Cardiac sympathetic nerve activity and progressive vasoconstriction distal to coronary stenoses: feed-back aggravation of myocardial ischemia. J Auton Nerv Syst 13:311–326. https://doi.org/10.1016/01651838(85)90020-7CrossRef

18.

Hinterdobler J, Schott S, Jin H, Meesmann A, Steinsiek AL, Zimmermann AS, Wobst J, Muller P, Mauersberger C, Vilne B, Baecklund A, Chen CS, Moggio A, Braster Q, Molitor M, Krane M, Kempf WE, Ladwig KH, Hristov M, Hulsmans M, Hilgendorf I, Weber C, Wenzel P, Scheiermann C, Maegdefessel L, Soehnlein O, Libby P, Nahrendorf M, Schunkert H, Kessler T, Sager HB (2021) Acute mental stress drives vascular inflammation and promotes plaque destabilization in mouse atherosclerosis. Eur Heart J 42:4077–4088. https://doi.org/10.1093/eurheartj/ehab371CrossRef

19.

Hoang JD, Salavatian S, Yamaguchi N, Swid MA, David H, Vaseghi M (2020) Cardiac sympathetic activation circumvents high-dose beta blocker therapy in part through release of neuropeptide Y. JCI insight. https://doi.org/10.1172/jci.insight.135519CrossRef

20.

Hoyda TD, Ferguson AV (2010) Adiponectin modulates excitability of rat paraventricular nucleus neurons by differential modulation of potassium currents. Endocrinology 151:3154–3162. https://doi.org/10.1210/en.2009-1390CrossRef

21.

Joy MT, Ben Assayag E, Shabashov-Stone D, Liraz-Zaltsman S, Mazzitelli J, Arenas M, Abduljawad N, Kliper E, Korczyn AD, Thareja NS, Kesner EL, Zhou M, Huang S, Silva TK, Katz N, Bornstein NM, Silva AJ, Shohami E, Carmichael ST (2019) CCR5 is a therapeutic target for recovery after stroke and traumatic brain injury. Cell 176(1143–1157):e1113. https://doi.org/10.1016/j.cell.2019.01.044CrossRef

22.

Kajimura D, Lee HW, Riley KJ, Arteaga-Solis E, Ferron M, Zhou B, Clarke CJ, Hannun YA, DePinho RA, Guo XE, Mann JJ, Karsenty G (2013) Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1. Cell Metab 17:901–915. https://doi.org/10.1016/j.cmet.2013.04.009CrossRef

23.

Kalla M, Hao G, Tapoulal N, Tomek J, Liu K, Woodward L, Oxford Acute Myocardial Infarction S, Dall’Armellina E, Banning AP, Choudhury RP, Neubauer S, Kharbanda RK, Channon KM, Ajijola OA, Shivkumar K, Paterson DJ, Herring N (2020) The cardiac sympathetic co-transmitter neuropeptide Y is pro-arrhythmic following ST-elevation myocardial infarction despite beta-blockade. Eur Heart J 41:2168–2179. https://doi.org/10.1093/eurheartj/ehz852CrossRef

24.

Kang YM, He RL, Yang LM, Qin DN, Guggilam A, Elks C, Yan N, Guo Z, Francis J (2009) Brain tumour necrosis factor-alpha modulates neurotransmitters in hypothalamic paraventricular nucleus in heart failure. Cardiovasc Res 83:737–746. https://doi.org/10.1093/cvr/cvp160CrossRef

25.

Kojima S, Funahashi T, Sakamoto T, Miyamoto S, Soejima H, Hokamaki J, Kajiwara I, Sugiyama S, Yoshimura M, Fujimoto K, Miyao Y, Suefuji H, Kitagawa A, Ouchi N, Kihara S, Matsuzawa Y, Ogawa H (2003) The variation of plasma concentrations of a novel, adipocyte derived protein, adiponectin, in patients with acute myocardial infarction. Heart 89:667. https://doi.org/10.1136/heart.89.6.667CrossRef

26.

Lai Y, Zhou X, Guo F, Jin X, Meng G, Zhou L, Chen H, Liu Z, Yu L, Jiang H (2021) Noninvasive transcutaneous vagal nerve stimulation improves myocardial performance in doxorubicin-induced cardiotoxicity. Cardiovasc Res. https://doi.org/10.1093/cvr/cvab209CrossRef

27.

Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L, Flachskampf FA, Foster E, Goldstein SA, Kuznetsova T, Lancellotti P, Muraru D, Picard MH, Rietzschel ER, Rudski L, Spencer KT, Tsang W, Voigt JU (2015) Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American society of echocardiography and the European association of cardiovascular imaging. Eur Heart J Cardiovasc Imaging 16:233–270. https://doi.org/10.1093/ehjci/jev014CrossRef

28.

Lu CJ, Hao G, Nikiforova N, Larsen HE, Liu K, Crabtree MJ, Li D, Herring N, Paterson DJ (2015) CAPON modulates neuronal calcium handling and cardiac sympathetic neurotransmission during dysautonomia in hypertension. Hypertension 65:1288–1297. https://doi.org/10.1161/HYPERTENSIONAHA.115.05290CrossRef

29.

Lyu J, Wang M, Kang X, Xu H, Cao Z, Yu T, Huang K, Wu J, Wei X, Lei Q (2020) Macrophage-mediated regulation of catecholamines in sympathetic neural remodeling after myocardial infarction. Basic Res Cardiol 115:56. https://doi.org/10.1007/s00395020-0813-3CrossRef

30.

Miao W, Jiang L, Xu F, Lyu J, Jiang X, He M, Liu Y, Yang T, Leak RK, Stetler RA, Chen J, Hu X (2021) Adiponectin ameliorates hypoperfusive cognitive deficits by boosting a neuroprotective microglial response. Prog Neurobiol 205:102125. https://doi.org/10.1016/j.pneurobio.2021.102125CrossRef

31.

Musunuru K, Chadwick AC, Mizoguchi T, Garcia SP, DeNizio JE, Reiss CW, Wang K, Iyer S, Dutta C, Clendaniel V, Amaonye M, Beach A, Berth K, Biswas S, Braun MC, Chen HM, Colace TV, Ganey JD, Gangopadhyay SA, Garrity R, Kasiewicz LN, Lavoie J, Madsen JA, Matsumoto Y, Mazzola AM, Nasrullah YS, Nneji J, Ren H, Sanjeev A, Shay M, Stahley MR, Fan SHY, Tam YK, Gaudelli NM, Ciaramella G, Stolz LE, Malyala P, Cheng CJ, Rajeev KG, Rohde E, Bellinger AM, Kathiresan S (2021) In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates. Nature 593:429–434. https://doi.org/10.1038/s41586-02103534-yCrossRef

32.

Ng RC, Jian M, Ma OK, Bunting M, Kwan JS, Zhou GJ, Senthilkumar K, Iyaswamy A, Chan PK, Li M, Leung KM, Kumar Durairajan SS, Lam KS, Chu LW, Festenstein R, Chung SK, Chan KH (2021) Chronic oral administration of adipoRon reverses cognitive impairments and ameliorates neuropathology in an Alzheimer’s disease mouse model. Mol Psychiatry 26:5669–5689. https://doi.org/10.1038/s41380-020-0701-0CrossRef

33.

Okamoto LE, Raj SR, Gamboa A, Shibao CA, Arnold AC, Garland EM, Black BK, Farley G, Diedrich A, Biaggioni I (2015) Sympathetic activation is associated with increased IL-6, but not CRP in the absence of obesity: lessons from postural tachycardia syndrome and obesity. Am J Physiol Heart Circ Physiol 309:H2098-2107. https://doi.org/10.1152/ajpheart.00409.2015CrossRef

34.

Scheja L, Heeren J (2019) The endocrine function of adipose tissues in health and cardiometabolic disease. Nat Rev Endocrinol 15:507–524. https://doi.org/10.1038/s41574-0190230-6CrossRef

35.

Schwartz PJ, Ackerman MJ (2022) Cardiac sympathetic denervation in the prevention of genetically mediated life-threatening ventricular arrhythmias. Eur Heart J. https://doi.org/10.1093/eurheartj/ehac134CrossRef

36.

Shah R, Assis F, Alugubelli N, Okada DR, Cardoso R, Shivkumar K, Tandri H (2019) Cardiac sympathetic denervation for refractory ventricular arrhythmias in patients with structural heart disease: a systematic review. Heart Rhythm 16:1499–1505. https://doi.org/10.1016/j.hrthm.2019.06.018CrossRef

37.

Sharp TE 3rd, Polhemus DJ, Li Z, Spaletra P, Jenkins JS, Reilly JP, White CJ, Kapusta DR, Lefer DJ, Goodchild TT (2018) Renal denervation prevents heart failure progression via inhibition of the renin-angiotensin system. J Am Coll Cardiol 72:2609–2621. https://doi.org/10.1016/j.jacc.2018.08.2186CrossRef

38.

Sinnreich R, Kark JD, Friedlander Y, Sapoznikov D, Luria MH (1998) Five minute recordings of heart rate variability for population studies: repeatability and age-sex characteristics. Heart 80:156–162. https://doi.org/10.1136/hrt.80.2.156CrossRef

39.

Sulimai N, Lominadze D (2020) Fibrinogen and neuroinflammation during traumatic brain injury. Mol Neurobiol 57:4692–4703. https://doi.org/10.1007/s12035-020-02012-2CrossRef

40.

Swissa M, Zhou S, Gonzalez-Gomez I, Chang CM, Lai AC, Cates AW, Fishbein MC, Karagueuzian HS, Chen PS, Chen LS (2004) Long-term subthreshold electrical stimulation of the left stellate ganglion and a canine model of sudden cardiac death. J Am Coll Cardiol 43:858–864. https://doi.org/10.1016/j.jacc.2003.07.053CrossRef

41.

Tanida M, Shen J, Horii Y, Matsuda M, Kihara S, Funahashi T, Shimomura I, Sawai H, Fukuda Y, Matsuzawa Y, Nagai K (2007) Effects of adiponectin on the renal sympathetic nerve activity and blood pressure in rats. Exp Biol Med (Maywood) 232:390–397

42.

Tentolouris N, Doulgerakis D, Moyssakis I, Kyriaki D, Makrilakis K, Kosmadakis G, Stamatiadis D, Katsilambros N, Stathakis C (2004) Plasma adiponectin concentrations in patients with chronic renal failure: relationship with metabolic risk factors and ischemic heart disease. Horm Metab Res 36:721–727. https://doi.org/10.1055/s-2004-826022CrossRef

43.

Tse R, Garland J, McCarthy S, Ondruschka B, Bardsley EN, Wong CX, Stables S, Paton JFR (2022) Sudden cardiac deaths have higher proportion of left stellate ganglionitis. Forensic Sci Med Pathol. https://doi.org/10.1007/s12024-022-00466-5CrossRef

44.

Vaseghi M, Barwad P, Malavassi Corrales FJ, Tandri H, Mathuria N, Shah R, Sorg JM, Gima J, Mandal K, Saenz Morales LC, Lokhandwala Y, Shivkumar K (2017) Cardiac sympathetic denervation for refractory ventricular arrhythmias. J Am Coll Cardiol 69:3070–3080. https://doi.org/10.1016/j.jacc.2017.04.035CrossRef

45.

Wang M, Li S, Zhou X, Huang B, Zhou L, Li X, Meng G, Yuan S, Wang Y, Wang Z, Wang S, Yu L, Jiang H (2017) Increased inflammation promotes ventricular arrhythmia through aggravating left stellate ganglion remodeling in a canine ischemia model. Int J Cardiol 248:286–293. https://doi.org/10.1016/j.ijcard.2017.08.011CrossRef

46.

Wang S, Zhou X, Huang B, Wang Z, Liao K, Saren G, Lu Z, Chen M, Yu L, Jiang H (2015) Spinal cord stimulation protects against ventricular arrhythmias by suppressing left stellate ganglion neural activity in an acute myocardial infarction canine model. Heart Rhythm 12:1628–1635. https://doi.org/10.1016/j.hrthm.2015.03.023CrossRef

47.

Wang Z, Yu L, Wang S, Huang B, Liao K, Saren G, Tan T, Jiang H (2014) Chronic intermittent low-level transcutaneous electrical stimulation of auricular branch of vagus nerve improves left ventricular remodeling in conscious dogs with healed myocardial infarction. Circ Heart Fail 7:1014–1021. https://doi.org/10.1161/CIRCHEARTFAILURE.114.001564CrossRef

48.

Ye TY, Lai YQ, Wang ZY, Zhang XG, Meng GN, Zhou LP, Zhang YF, Zhou Z, Deng JL, Wang M, Wang YH, Zhang QQ, Zhou XY, Yu LL, Jiang H, Xiao XH (2019) Precise modulation of gold nanorods for protecting against malignant ventricular arrhythmias via near-infrared neuromodulation. Adv Funct Mater. https://doi.org/10.1002/adfm.201902128CrossRef

49.

Yu L, Huang B, Po SS, Tan T, Wang M, Zhou L, Meng G, Yuan S, Zhou X, Li X, Wang Z, Wang S, Jiang H (2017) Low-level tragus stimulation for the treatment of ischemia and reperfusion injury in patients with ST-segment elevation myocardial infarction: a proof-of-concept study. JACC Cardiovasc Interv 10:1511–1520. https://doi.org/10.1016/j.jcin.2017.04.036CrossRef

50.

Yu L, Huang B, Zhou X, Wang S, Wang Z, Wang M, Li X, Zhou L, Meng G, Yuan S, Wang Y, Jiang H (2017) Renal sympathetic stimulation and ablation affect ventricular arrhythmia by modulating autonomic activity in a cesium-induced long QT canine model. Heart Rhythm 14:912–919. https://doi.org/10.1016/j.hrthm.2017.02.010CrossRef

51.

Yu L, Scherlag BJ, Sha Y, Li S, Sharma T, Nakagawa H, Jackman WM, Lazzara R, Jiang H, Po SS (2012) Interactions between atrial electrical remodeling and autonomic remodeling: how to break the vicious cycle. Heart Rhythm 9:804–809. https://doi.org/10.1016/j.hrthm.2011.12.023CrossRef

52.

Yu L, Wang S, Zhou X, Wang Z, Huang B, Liao K, Saren G, Chen M, Po SS, Jiang H (2016) Chronic intermittent low-level stimulation of tragus reduces cardiac autonomic remodeling and ventricular arrhythmia inducibility in a post-infarction canine model. JACC Clin Electrophysiol 2:330–339. https://doi.org/10.1016/j.jacep.2015.11.006CrossRef

53.

Yu L, Zhou L, Cao G, Po SS, Huang B, Zhou X, Wang M, Yuan S, Wang Z, Wang S, Jiang H (2017) Optogenetic modulation of cardiac sympathetic nerve activity to prevent ventricular arrhythmias. J Am Coll Cardiol 70:2778–2790. https://doi.org/10.1016/j.jacc.2017.09.1107CrossRef

54.

Yu YL, Thijs L, Yu CG, Yang WY, Melgarejo JD, Wei DM, Wei FF, Nawrot TS, Verhamme P, Roels HA, Staessen JA, Zhang ZY (2021) Two-year responses of heart rate and heart rate variability to first occupational lead exposure. Hypertension 77:1775–1786. https://doi.org/10.1161/HYPERTENSIONAHA.120.16545CrossRef

55.

Zhang D, Hu W, Tu H, Hackfort BT, Duan B, Xiong W, Wadman MC, Li YL (2021) Macrophage depletion in stellate ganglia alleviates cardiac sympathetic overactivation and ventricular arrhythmogenesis by attenuating neuroinflammation in heart failure. Basic Res Cardiol 116:28. https://doi.org/10.1007/s00395-021-00871-xCrossRef

56.

Zhang Q, Yao F, Raizada MK, O’Rourke ST, Sun C (2009) Apelin gene transfer into the rostral ventrolateral medulla induces chronic blood pressure elevation in normotensive rats. Circ Res 104:1421–1428. https://doi.org/10.1161/CIRCRESAHA.108.192302CrossRef

57.

Zhao S, Kusminski CM, Scherer PE (2021) Adiponectin, leptin and cardiovascular disorders. Circ Res 128:136–149. https://doi.org/10.1161/CIRCRESAHA.120.314458CrossRef

58.

Zhou S, Chen LS, Miyauchi Y, Miyauchi M, Kar S, Kangavari S, Fishbein MC, Sharifi B, Chen PS (2004) Mechanisms of cardiac nerve sprouting after myocardial infarction in dogs. Circ Res 95:76–83. https://doi.org/10.1161/01.RES.0000133678.22968.e3CrossRef

59.

Zhou Z, Li S, Sheng X, Liu Z, Lai Y, Wang M, Wang Z, Zhou L, Meng G, Chen H, Zhou H, Zhou X, Jiang H (2020) Interactions between metabolism regulator adiponectin and intrinsic cardiac autonomic nervous system: a potential treatment target for atrial fibrillation. Int J Cardiol 302:59–66. https://doi.org/10.1016/j.ijcard.2019.12.031CrossRef

60.

Ziegler KA, Ahles A, Wille T, Kerler J, Ramanujam D, Engelhardt S (2018) Local sympathetic denervation attenuates myocardial inflammation and improves cardiac function after myocardial infarction in mice. Cardiovasc Res 114:291–299. https://doi.org/10.1093/cvr/cvx227CrossRef

Titel: Metabolism regulator adiponectin prevents cardiac remodeling and ventricular arrhythmias via sympathetic modulation in a myocardial infarction model
verfasst von: Zhen Zhou
Chengzhe Liu
Saiting Xu
Jun Wang
Fuding Guo
Shoupeng Duan
Qiang Deng
Ji Sun
Fu Yu
Yuyang Zhou
Meng Wang
Yueyi Wang
Liping Zhou
Hong Jiang
Lilei Yu
Publikationsdatum: 01.12.2022
Verlag: Springer Berlin Heidelberg
Erschienen in: Basic Research in Cardiology / Ausgabe 1/2022
Print ISSN: 0300-8428
Elektronische ISSN: 1435-1803
DOI: https://doi.org/10.1007/s00395-022-00939-2

Neu im Fachgebiet Kardiologie

Nach Herzinfarkt mit Typ-1-Diabetes schlechtere Karten als mit Typ 2?

29.05.2024 Herzinfarkt Nachrichten

Bei Menschen mit Typ-2-Diabetes sind die Chancen, einen Myokardinfarkt zu überleben, in den letzten 15 Jahren deutlich gestiegen – nicht jedoch bei Betroffenen mit Typ 1.

Erhöhtes Risiko fürs Herz unter Checkpointhemmer-Therapie

28.05.2024 Nebenwirkungen der Krebstherapie Nachrichten

Kardiotoxische Nebenwirkungen einer Therapie mit Immuncheckpointhemmern mögen selten sein – wenn sie aber auftreten, wird es für Patienten oft lebensgefährlich. Voruntersuchung und Monitoring sind daher obligat.

GLP-1-Agonisten können Fortschreiten diabetischer Retinopathie begünstigen

24.05.2024 Diabetische Retinopathie Nachrichten

Möglicherweise hängt es von der Art der Diabetesmedikamente ab, wie hoch das Risiko der Betroffenen ist, dass sich sehkraftgefährdende Komplikationen verschlimmern.

TAVI versus Klappenchirurgie: Neue Vergleichsstudie sorgt für Erstaunen

21.05.2024 TAVI Nachrichten

Bei schwerer Aortenstenose und obstruktiver KHK empfehlen die Leitlinien derzeit eine chirurgische Kombi-Behandlung aus Klappenersatz plus Bypass-OP. Diese Empfehlung wird allerdings jetzt durch eine aktuelle Studie infrage gestellt – mit überraschender Deutlichkeit.

Update Kardiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Metabolism regulator adiponectin prevents cardiac remodeling and ventricular arrhythmias via sympathetic modulation in a myocardial infarction model

Abstract

Neu im Fachgebiet Kardiologie

Nach Herzinfarkt mit Typ-1-Diabetes schlechtere Karten als mit Typ 2?

Erhöhtes Risiko fürs Herz unter Checkpointhemmer-Therapie

GLP-1-Agonisten können Fortschreiten diabetischer Retinopathie begünstigen

TAVI versus Klappenchirurgie: Neue Vergleichsstudie sorgt für Erstaunen

Update Kardiologie

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2022

Prolonged cardiac NR4A2 activation causes dilated cardiomyopathy in mice

Sympathetic nerve innervation and metabolism in ischemic myocardium in response to remote ischemic perconditioning

Why is endothelial resilience key to maintain cardiac health?

Beta-3 adrenergic receptor overexpression reverses aortic stenosis–induced heart failure and restores balanced mitochondrial dynamics

Osteopontin promotes infarct repair

Retraction Note to: Amphiregulin enhances cardiac fibrosis and aggravates cardiac dysfunction in mice with experimental myocardial infarction partly through activating EGFR‑dependent pathway

Neu im Fachgebiet Kardiologie

Nach Herzinfarkt mit Typ-1-Diabetes schlechtere Karten als mit Typ 2?

Erhöhtes Risiko fürs Herz unter Checkpointhemmer-Therapie

GLP-1-Agonisten können Fortschreiten diabetischer Retinopathie begünstigen

TAVI versus Klappenchirurgie: Neue Vergleichsstudie sorgt für Erstaunen

Update Kardiologie