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High-speed imaging of human retina in vivo with swept-source optical coherence tomography

H. Lim, M. Mujat, C. Kerbage, E. C. W. Lee, Y. Chen, Teresa C. Chen, and J. F. de Boer

Open Access Open Access

Abstract

We present the first demonstration of human retinal imaging in vivo using optical frequency domain imaging (OFDI) in the 800-nm range. With 460-µW incident power on the eye, the sensitivity is 91 dB at maximum and >85 dB over 2-mm depth range. The axial resolution is 13 µm in air. We acquired images of retina at 43,200 depth profiles per second and a continuous acquisition speed of 84 frames/s (512 A-lines per frame) could be maintained over more than 2 seconds.

©2006 Optical Society of America

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Supplementary Material (4)

Media 1: AVI (2479 KB)     
Media 2: AVI (2481 KB)     
Media 3: AVI (3620 KB)     
Media 4: AVI (6540 KB)     

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Figures (6)
Fig. 1.
Fig. 1. Schematic of the wavelength-swept laser. TF: tunable filter, SOA: semiconductor optical amplifier, FLM: fiber loop mirror, PC: Polarization controller. The focal length f1 and f2 is 75 and 40 mm, respectively.

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Fig. 2.
Fig. 2. (a). Wavelength-swept laser output characteristics. Oscilloscope trace shows 43.2-kHz sweep rate. (b). Instantaneous optical power in the reference arm.

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Fig. 3.
Fig. 3. Experimental configuration of the optical frequency domain imaging system.

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Fig. 4.
Fig. 4. (a). Sensitivity as a function of depth. (b). Axial resolution in air as a function of depth. Dashed line is the theoretical axial resolution calculated from the raw laser spectrum.

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Fig. 5.
Fig. 5. Macular region, 6.4 mm wide×1.4 mm deep (in tissue). Scale bar, 500 µm. RNFL: retinal nerve fiber layer. IPL: inner plexiform layer. INL: inner nuclear layer. OPL: outer plexiform layer. ONL: outer nuclear layer. IPRL: inner photoreceptor layer. RPE: retinal pigment epithelium. C: choroids. [Media 1, Media 3]

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Fig. 6.
Fig. 6. Area that includes optic disk and fovea, 6.4 mm wide×1.9 mm deep (in tissue). Scale bar, 500 µm. Inset; en face image with a red line whose cross section is shown in the left, 6.4 mm×3.5 mm. [Media 2, Media 4]

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