Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

LIVER CANCER

The jigsaw of dual hepatocellular–intrahepatic cholangiocarcinoma tumours

Nature Reviews Gastroenterology & Hepatology volume 16, pages 653–655 (2019)Cite this article

Subjects

A new study involving integrative genomic and transcriptomic analysis of dual hepatocellular–intrahepatic cholangiocarcinoma tumours has identified distinct subtypes that display different clinical and molecular features, and that could be used to guide therapeutic decisions.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Bray, F. et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 68, 394–424 (2018).

    Article  Google Scholar 

  2. Gera, S. et al. Clinical features, histology, and histogenesis of combined hepatocellular-cholangiocarcinoma. World J. Hepatol. 9, 300–309 (2017).

    Article  Google Scholar 

  3. Xue, R. et al. Genomic and transcriptomic profiling of combined hepatocellular and intrahepatic cholangiocarcinoma reveals distinct molecular subtypes. Cancer Cell 35, 932–947 (2019).

    Article  CAS  Google Scholar 

  4. Moeini, A. et al. Mixed hepatocellular cholangiocarcinoma tumors: cholangiolocellular carcinoma is a distinct molecular entity. J. Hepatol. 66, 952–961 (2017).

    Article  CAS  Google Scholar 

  5. Joseph, N. M. et al. Genomic profiling of combined hepatocellular-cholangiocarcinoma reveals similar genetics to hepatocellular carcinoma. J. Pathol. 248, 164–178 (2019).

    Article  CAS  Google Scholar 

  6. Bidkhori, G. et al. Metabolic network-based stratification of hepatocellular carcinoma reveals three distinct tumor subtypes. Proc. Natl Acad. Sci. USA 115, E11874–E11883 (2018).

    Article  CAS  Google Scholar 

  7. Sia, D. et al. Integrative molecular analysis of intrahepatic cholangiocarcinoma reveals 2 classes that have different outcomes. Gastroenterology 144, 829–840 (2013).

    Article  CAS  Google Scholar 

  8. Cairo, S. et al. Hepatic stem-like phenotype and interplay of Wnt/beta-catenin and Myc signaling in aggressive childhood liver cancer. Cancer Cell 14, 471–484 (2008).

    Article  CAS  Google Scholar 

  9. The Cancer Genome Atlas Research Network. Comprehensive and integrative genomic characterization of hepatocellular carcinoma. Cell 169, 1327–1341 (2017).

    Article  Google Scholar 

  10. Nepal, C. et al. Genomic perturbations reveal distinct regulatory networks in intrahepatic cholangiocarcinoma. Hepatology 68, 949–963 (2018).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The authors acknowledge J. M. Banales for his strong support, feedback, fruitful discussion and revision of the manuscript. P.M.-G. was supported by a Marie Sklodowska-Curie postdoctoral fellowship (2017–2019).

Author information

Authors and Affiliations

  1. Biotech Research and Innovation Centre, Department of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

    Patricia Munoz-Garrido

  2. Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, University of the Basque Country, San Sebastian, Spain

    Pedro M. Rodrigues

Authors
  1. Patricia Munoz-Garrido
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Pedro M. Rodrigues
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Pedro M. Rodrigues.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Munoz-Garrido, P., Rodrigues, P.M. The jigsaw of dual hepatocellular–intrahepatic cholangiocarcinoma tumours. Nat Rev Gastroenterol Hepatol 16, 653–655 (2019). https://doi.org/10.1038/s41575-019-0185-z

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41575-019-0185-z

This article is cited by

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer