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Preeclampsia predicts higher incidence of bronchopulmonary dysplasia

Journal of Perinatology volume 38, pages 1165–1173 (2018)Cite this article

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A Correction to this article was published on 03 August 2018

This article has been updated

Abstract

Introduction:

It is not known whether very preterm infants born to preeclamptic women have worse outcomes than those delivered preterm for other causes.

Objective:

We assessed the association between preeclampsia (PE) and the neonatal morbidity and mortality of very preterm infants.

Methods:

Over 2015 and 2016, 11 collaborating Portuguese level III NICUs prospectively enrolled a cohort of mothers with or without PE who delivered liveborn premature infants between 24 and 30 completed weeks of gestation. Data on neonatal morbidities were collected and their association to PE was assessed.

Results:

The final cohort consisted of 410 mothers who delivered 494 preterm infants. Infants from PE mothers weighed less than those of non-PE mothers (819 ± 207 g vs. 989 ± 256 g, p < 0.0001). Incidences of respiratory distress syndrome, patent ductus arteriosus, early and nosocomial sepsis, necrotizing enterocolitis, pneumonia, meningitis, retinopathy of prematurity, intraventricular hemorrhage, periventricular infarction, periventricular leukomalacia, and mortality did not differ significantly between infants of PE or non-PE mothers. Incidence of bronchopulmonary dysplasia (BPD—defined as oxygen dependency at 36 weeks) was higher in PE infants compared with non-PE infants by both univariate and multivariate logistic regression (p = 0.007).

Conclusion:

We conclude that, when controlling for gestational age, maternal PE results in higher incidence of only BPD among preterm Portuguese infants.

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  • 03 August 2018

    Text for Correction

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Author Contributions

Collaborators of the Hypertensive Disorders of Pregnancy Study Group: Elisa Proença, Carmen Carvalho, Luís Guedes Martins (Centro Materno Infantil do Norte, Porto, Portugal); Teresa Martins (Hospital Pedro Hispâno, Matosinhos, Portugal); Alice Freitas, Clara Paz Dias (Hospital da Senhora da Oliveira, Guimarães, Portugal); Albina Silva, Almerinda Barroso (Hospital de Braga, Braga, Portugal); Isabel Diogo, Gonçalo Cassiano, Helena Ramos (Centro Hospitalar Lisboa Central, Maternidade Dr Alfredo da Costa, Lisboa, Portugal); Maria Margarida Abrantes, Paula Costa (Centro Hospitalar Lisboa Norte, Hospital de Santa Maria, Lisboa, Portugal); Anabela Salazar, Filipa Vieira, Dora Fontes (Centro Hospitalar Lisboa Ocidental, Hospital São Francisco Xavier, Lisboa, Portugal); Rosalina Barrosos, Tânia Marques (Hospital Prof. Dr Fernando Fonseca, Amadora, Portugal, Portugal); Vera Santos, Ecaterina Scortenschi, Celeste Santos, Fernanda Vilela (Centro Hospitalar do Algarve, Hospital de Faro, Faro, Portugal); Conceição Quintas (Centro Hospitalar de Vila Nova de Gaia/ Espinho, Hospital de Vila Nova de Gaia, Vila Nova de Gaia, Portugal)

Author information

Authors and Affiliations

  1. Department of Neonatology, Centro Hospitalar São João, Porto, Portugal

    Gustavo Rocha, Filipa Flor de Lima & Hercília Guimarães

  2. Faculty of Medicine, University of Porto, Porto, Portugal

    Filipa Flor de Lima & Hercília Guimarães

  3. Department of Obstetrics and Gynaecology, Centro Hospitalar São João, Porto, Portugal

    Ana Paula Machado

  4. Centro Materno Infantil do Norte, Porto, Portugal

    Elisa Proença, Carmen Carvalho & Luís Guedes Martins

  5. Hospital Pedro Hispâno, Matosinhos, Portugal

    Teresa Martins

  6. Hospital da Senhora da Oliveira, Guimarães, Portugal

    Alice Freitas & Clara Paz Dias

  7. Hospital de Braga, Braga, Portugal

    Albina Silva & Almerinda Barroso

  8. Centro Hospitalar Lisboa Central, Maternidade Dr Alfredo da Costa, Lisboa, Portugal

    Isabel Diogo, Gonçalo Cassiano & Helena Ramos

  9. Centro Hospitalar Lisboa Norte, Hospital de Santa Maria, Lisboa, Portugal

    Maria Margarida Abrantes & Paula Costa

  10. Centro Hospitalar Lisboa Ocidental, Hospital São Francisco Xavier, Lisboa, Portugal

    Anabela Salazar, Filipa Vieira & Dora Fontes

  11. Hospital Prof. Dr Fernando Fonseca, Amadora, Portugal, Portugal

    Rosalina Barroso & Tânia Marques

  12. Centro Hospitalar do Algarve, Hospital de Faro, Faro, Portugal

    Vera Santos, Ecaterina Scortenschi, Celeste Santos & Fernanda Vilela

  13. Centro Hospitalar de Vila Nova de Gaia/ Espinho, Vila Nova de Gaia, Portugal

    Conceição Quintas

Authors
  1. Gustavo Rocha
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  2. Filipa Flor de Lima
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  3. Ana Paula Machado
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  4. Hercília Guimarães
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Consortia

Collaborators of the Hypertensive Disorders of Pregnancy Study Group

  • Elisa Proença
  • , Carmen Carvalho
  • , Luís Guedes Martins
  • , Teresa Martins
  • , Alice Freitas
  • , Clara Paz Dias
  • , Albina Silva
  • , Almerinda Barroso
  • , Isabel Diogo
  • , Gonçalo Cassiano
  • , Helena Ramos
  • , Maria Margarida Abrantes
  • , Paula Costa
  • , Anabela Salazar
  • , Filipa Vieira
  • , Dora Fontes
  • , Rosalina Barroso
  • , Tânia Marques
  • , Vera Santos
  • , Ecaterina Scortenschi
  • , Celeste Santos
  • , Fernanda Vilela
  •  & Conceição Quintas

Corresponding author

Correspondence to Gustavo Rocha.

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The authors declare that they have no conflict of interest.

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Rocha, G., de Lima, F.F., Machado, A.P. et al. Preeclampsia predicts higher incidence of bronchopulmonary dysplasia. J Perinatol 38, 1165–1173 (2018). https://doi.org/10.1038/s41372-018-0133-8

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  • DOI: https://doi.org/10.1038/s41372-018-0133-8

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