nach oben

Cancer Causes & Control

Erschienen in:

20.08.2022 | Original Paper

Physical activity from menarche-to-first pregnancy and risk of breast cancer: the California teachers study

verfasst von: Dan Lin, Ying Liu, Deirdre K. Tobias, Kathleen Sturgeon

Erschienen in: Cancer Causes & Control | Ausgabe 11/2022

Einloggen, um Zugang zu erhalten

Abstract

Purpose

A longer menarche-to-first pregnancy window of susceptibility (WOS) is associated with increased breast cancer risk. Whether physical activity, an established preventive risk factor, during the menarche-to-first pregnancy WOS offsets breast cancer risk overall or for specific molecular subtypes is unclear.

Methods

We examined the prospective association between physical activity during the menarche-to-first pregnancy WOS and breast cancer risk in the California Teachers Study (N = 78,940). Recreational physical activity at multiple timepoints were recalled at cohort entry, and converted to metabolic equivalent of task hours per week (MET-hrs/wk). We used multivariable Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).

Results

We observed 5,157 invasive breast cancer cases over 21.6 years of follow-up. Longer menarche-to-first pregnancy WOS (≥ 20 vs. < 15 years) was associated with higher breast cancer risk (HR = 1.23, 95% CI = 1.13–1.34). Women with higher physical activity level during menarche-to-first pregnancy had lower risk of invasive breast cancer (≥ 40 vs. < 9 MET-hrs/wk: HR = 0.89, 95% CI = 0.83–0.97) and triple-negative subtype (≥ 40 vs. < 9 MET-hrs/wk: HR = 0.53, 95% CI = 0.32–0.87). No association was observed for luminal A-like and luminal B-like subtypes. Higher physical activity level was associated with lower breast cancer risk among women with moderate (15–19 years) menarche-to-first pregnancy intervals (≥ 40 vs. < 9 MET-hrs/wk: HR = 0.80, 95% CI = 0.69–0.92), but not with short (< 15 years) or long (≥ 20 years) intervals.

Conclusion

Physical activity during a WOS was associated with lower breast cancer risk in our cohort. Understanding timing of physical activity throughout the life course in relationship with breast cancer risk maybe important for cancer prevention strategies.

Nur mit Berechtigung zugänglich

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68:394–424. https://doi.org/10.3322/caac.21492CrossRefPubMed

Howlader NNA, Krapcho M, Miller D, Brest A, Yu M, Ruhl J, Tatalovich Z, Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (2020) SEER cancer statistics review, 1975–2017. National Cancer Institute, Bethesda, MD

Siegel RL, Miller KD, Fuchs HE, Jemal A (2021) Cancer statistics, 2021. CA Cancer J Clin 71:7–33. https://doi.org/10.3322/caac.21654CrossRefPubMed

Li CI, Malone KE, Daling JR et al (2008) Timing of menarche and first full-term birth in relation to breast cancer risk. Am J Epidemiol 167:230–239. https://doi.org/10.1093/aje/kwm271CrossRefPubMed

Terry MB, Michels KB, Brody JG et al (2019) Environmental exposures during windows of susceptibility for breast cancer: a framework for prevention research. Breast Cancer Res 21:96. https://doi.org/10.1186/s13058-019-1168-2CrossRefPubMedPubMedCentral

Liu Y, Tobias DK, Sturgeon KM et al (2016) Physical activity from menarche to first pregnancy and risk of breast cancer. Int J Cancer 139:1223–1230. https://doi.org/10.1002/ijc.30167CrossRefPubMedPubMedCentral

Martinez GM (2020) Trends and patterns in Menarche in the United States: 1995 through 2013–2017. Natl Health Stat Report, pp 1–12

Mathews TJ, Hamilton BE (2016) Mean age of mothers is on the rise: United States, 2000–2014. NCHS Data Brief, pp 1–8

Hardefeldt PJ, Penninkilampi R, Edirimanne S, Eslick GD (2018) Physical activity and weight loss reduce the risk of breast cancer: a meta-analysis of 139 prospective and retrospective studies. Clin Breast Cancer 18:e601–e612. https://doi.org/10.1016/j.clbc.2017.10.010CrossRefPubMed

10.

Neilson HK, Farris MS, Stone CR, Vaska MM, Brenner DR, Friedenreich CM (2017) Moderate-vigorous recreational physical activity and breast cancer risk, stratified by menopause status: a systematic review and meta-analysis. Menopause 24:322–344. https://doi.org/10.1097/GME.0000000000000745CrossRefPubMed

11.

Ma H, Xu X, Clague J et al (2016) Recreational physical activity and risk of triple negative breast cancer in the California Teachers Study. Breast Cancer Res 18:62. https://doi.org/10.1186/s13058-016-0723-3CrossRefPubMedPubMedCentral

12.

Chen X, Wang Q, Zhang Y, Xie Q, Tan X (2019) Physical activity and risk of breast cancer: a meta-analysis of 38 cohort studies in 45 study reports. Value Health 22:104–128. https://doi.org/10.1016/j.jval.2018.06.020CrossRefPubMed

13.

Gillman AS, Helmuth T, Koljack CE, Hutchison KE, Kohrt WM, Bryan AD (2021) The effects of exercise duration and intensity on breast cancer-related DNA methylation: a randomized controlled trial. Cancers (Basel). https://doi.org/10.3390/cancers13164128CrossRef

14.

McCullough LE, Collin LJ, Conway K et al (2019) Reproductive characteristics are associated with gene-specific promoter methylation status in breast cancer. BMC Cancer 19:926. https://doi.org/10.1186/s12885-019-6120-4CrossRefPubMedPubMedCentral

15.

California Teachers Study. California Teachers Study. https://www.calteachersstudy.org/about-us. Accessed 12 April 2021

16.

Bernstein L, Allen M, Anton-Culver H et al (2002) High breast cancer incidence rates among California teachers: results from the California Teachers Study (United States). Cancer Causes Control 13:625–635. https://doi.org/10.1023/a:1019552126105CrossRefPubMed

17.

Ainsworth BE, Haskell WL, Herrmann SD et al (2011) 2011 compendium of physical activities: a second update of codes and MET values. Med Sci Sports Exerc 43:1575–1581. https://doi.org/10.1249/MSS.0b013e31821ece12CrossRefPubMed

18.

Eime RM, Harvey JT, Sawyer NA, Craike MJ, Symons CM, Payne WR (2016) Changes in sport and physical activity participation for adolescent females: a longitudinal study. BMC Public Health 16:533. https://doi.org/10.1186/s12889-016-3203-xCrossRefPubMedPubMedCentral

19.

California Cancer Registry (2018) About California Cancer Registry. https://www.ccrcal.org/learn-about-ccr/about-cancer-registries/. Accessed 12 May 2021

20.

Bauer KR, Brown M, Cress RD, Parise CA, Caggiano V (2007) Descriptive analysis of estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and HER2-negative invasive breast cancer, the so-called triple-negative phenotype: a population-based study from the California cancer registry. Cancer 109:1721–1728. https://doi.org/10.1002/cncr.22618CrossRefPubMed

21.

Santen RJ, Yue W, Wang JP (2015) Estrogen metabolites and breast cancer. Steroids 99:61–66. https://doi.org/10.1016/j.steroids.2014.08.003CrossRefPubMed

22.

Liu R, Nelson DO, Hurley S, Hertz A, Reynolds P (2015) Residential exposure to estrogen disrupting hazardous air pollutants and breast cancer risk: the California Teachers Study. Epidemiology 26:365–373. https://doi.org/10.1097/EDE.0000000000000277CrossRefPubMedPubMedCentral

23.

Phipps AI, Buist DS, Malone KE et al (2011) Reproductive history and risk of three breast cancer subtypes defined by three biomarkers. Cancer Causes Control 22:399–405. https://doi.org/10.1007/s10552-010-9709-0CrossRefPubMed

24.

Gaudet MM, Press MF, Haile RW et al (2011) Risk factors by molecular subtypes of breast cancer across a population-based study of women 56 years or younger. Breast Cancer Res Treat 130:587–597. https://doi.org/10.1007/s10549-011-1616-xCrossRefPubMedPubMedCentral

25.

Ma H, Henderson KD, Sullivan-Halley J et al (2010) Pregnancy-related factors and the risk of breast carcinoma in situ and invasive breast cancer among postmenopausal women in the California Teachers Study cohort. Breast Cancer Res 12:R35. https://doi.org/10.1186/bcr2589CrossRefPubMedPubMedCentral

26.

Phipps AI, Chlebowski RT, Prentice R et al (2011) Reproductive history and oral contraceptive use in relation to risk of triple-negative breast cancer. J Natl Cancer Inst 103:470–477. https://doi.org/10.1093/jnci/djr030CrossRefPubMedPubMedCentral

27.

Ritte R, Tikk K, Lukanova A et al (2013) Reproductive factors and risk of hormone receptor positive and negative breast cancer: a cohort study. BMC Cancer 13:584. https://doi.org/10.1186/1471-2407-13-584CrossRefPubMedPubMedCentral

28.

Li CI, Beaber EF, Tang MT, Porter PL, Daling JR, Malone KE (2013) Reproductive factors and risk of estrogen receptor positive, triple-negative, and HER2-neu overexpressing breast cancer among women 20–44 years of age. Breast Cancer Res Treat 137:579–587. https://doi.org/10.1007/s10549-012-2365-1CrossRefPubMed

29.

Dall G, Risbridger G, Britt K (2017) Mammary stem cells and parity-induced breast cancer protection- new insights. J Steroid Biochem Mol Biol 170:54–60. https://doi.org/10.1016/j.jsbmb.2016.02.018CrossRefPubMed

30.

Miller N, Delbecchi L, Petitclerc D, Wagner GF, Talbot BG, Lacasse P (2006) Effect of stage of lactation and parity on mammary gland cell renewal. J Dairy Sci 89:4669–4677. https://doi.org/10.3168/jds.S0022-0302(06)72517-6CrossRefPubMed

31.

Tsukamoto R, Mikami T, Miki K et al (2007) N-methyl-N-nitrosourea-induced mammary carcinogenesis is promoted by short-term treatment with estrogen and progesterone mimicking pregnancy in aged female Lewis rats. Oncol Rep 18:337–342PubMed

32.

Hanasoge Somasundara AV, Moss MA, Feigman MJ et al (2021) Parity-induced changes to mammary epithelial cells control NKT cell expansion and mammary oncogenesis. Cell Rep 37:110099. https://doi.org/10.1016/j.celrep.2021.110099CrossRefPubMed

33.

Maruti SS, Willett WC, Feskanich D, Rosner B, Colditz GA (2008) A prospective study of age-specific physical activity and premenopausal breast cancer. J Natl Cancer Inst 100:728–737. https://doi.org/10.1093/jnci/djn135CrossRefPubMed

34.

Colditz GA, Feskanich D, Chen WY, Hunter DJ, Willett WC (2003) Physical activity and risk of breast cancer in premenopausal women. Br J Cancer 89:847–851. https://doi.org/10.1038/sj.bjc.6601175CrossRefPubMedPubMedCentral

35.

Steindorf K, Schmidt M, Kropp S, Chang-Claude J (2003) Case-control study of physical activity and breast cancer risk among premenopausal women in Germany. Am J Epidemiol 157:121–130CrossRef

36.

Magnusson C, Roddam A, Pike M et al (2005) Body fatness and physical activity at young ages and the risk of breast cancer in premenopausal women. Br J Cancer 93:817–824CrossRef

37.

Bernstein L, Henderson BE, Hanisch R, Sullivan-Halley J, Ross RK (1994) Physical exercise and reduced risk of breast cancer in young women. J Natl Cancer Inst 86:1403–1408. https://doi.org/10.1093/jnci/86.18.1403CrossRefPubMed

38.

Boeke CE, Eliassen AH, Oh H, Spiegelman D, Willett WC, Tamimi RM (2014) Adolescent physical activity in relation to breast cancer risk. Breast Cancer Res Treat 145:715–724. https://doi.org/10.1007/s10549-014-2919-5CrossRefPubMedPubMedCentral

39.

Niehoff NM, White AJ, Sandler DP (2017) Childhood and teenage physical activity and breast cancer risk. Breast Cancer Res Treat 164:697–705. https://doi.org/10.1007/s10549-017-4276-7CrossRefPubMedPubMedCentral

40.

Sturgeon KM, Schweitzer A, Leonard JJ et al (2017) Physical activity induced protection against breast cancer risk associated with delayed parity. Physiol Behav 169:52–58. https://doi.org/10.1016/j.physbeh.2016.11.026CrossRefPubMed

41.

Rosenberg L, Palmer JR, Bethea TN, Ban Y, Kipping-Ruane K, Adams-Campbell LL (2014) A prospective study of physical activity and breast cancer incidence in African-American women. Cancer Epidemiol Biomarkers Prev 23:2522–2531. https://doi.org/10.1158/1055-9965.EPI-14-0448CrossRefPubMedPubMedCentral

42.

Fournier A, Dos Santos G, Guillas G et al (2014) Recent recreational physical activity and breast cancer risk in postmenopausal women in the E3N cohort. Cancer Epidemiol Biomarkers Prev 23:1893–1902. https://doi.org/10.1158/1055-9965.EPI-14-0150CrossRefPubMed

43.

Steindorf K, Ritte R, Eomois PP et al (2013) Physical activity and risk of breast cancer overall and by hormone receptor status: the European prospective investigation into cancer and nutrition. Int J Cancer 132:1667–1678CrossRef

44.

Dallal CM, Sullivan-Halley J, Ross RK et al (2007) Long-term recreational physical activity and risk of invasive and in situ breast cancer: the California teachers study. Arch Intern Med 167:408–415. https://doi.org/10.1001/archinte.167.4.408CrossRefPubMed

45.

McCullough LE, Eng SM, Bradshaw PT et al (2012) Fat or fit: the joint effects of physical activity, weight gain, and body size on breast cancer risk. Cancer 118:4860–4868. https://doi.org/10.1002/cncr.27433CrossRefPubMed

46.

Phipps AI, Chlebowski RT, Prentice R et al (2011) Body size, physical activity, and risk of triple-negative and estrogen receptor-positive breast cancer. Cancer Epidemiol Biomarkers Prev 20:454–463. https://doi.org/10.1158/1055-9965.EPI-10-0974CrossRefPubMedPubMedCentral

47.

Bigman G, Adebamowo S, Adebamowo C et al (2019) Leisure time physical activity is associated with substantial reduction in risk of breast cancer and breast cancer subtypes in Nigerian women (P16–007–19). Curr Dev Nutr. 3:nzz050. https://doi.org/10.1093/cdn/nzz050.P16-007-19CrossRefPubMedCentral

48.

Horn-Ross PL, Lee VS, Collins CN et al (2008) Dietary assessment in the California Teachers Study: reproducibility and validity. Cancer Causes Control 19:595–603. https://doi.org/10.1007/s10552-008-9124-yCrossRefPubMedPubMedCentral

49.

Rosner BA, Colditz GA, Hankinson SE, Sullivan-Halley J, Lacey JV Jr, Bernstein L (2013) Validation of Rosner-Colditz breast cancer incidence model using an independent data set, the California Teachers Study. Breast Cancer Res Treat 142:187–202. https://doi.org/10.1007/s10549-013-2719-3CrossRefPubMedPubMedCentral

50.

Pate RR, Stevens J, Webber LS et al (2009) Age-related change in physical activity in adolescent girls. J Adolesc Health 44:275–282. https://doi.org/10.1016/j.jadohealth.2008.07.003CrossRefPubMed

51.

Centers for Disease Control and Prevention. National Center for Health Statistics. National Vital Statistics System. Natality on CDC WONDER Online Database. (2022) Data are from the Natality Records 2007–2020, as compiled from data provided by the 57 vital statistics jurisdictions through the Vital Statistics Cooperative Program.

Titel: Physical activity from menarche-to-first pregnancy and risk of breast cancer: the California teachers study
verfasst von: Dan Lin
Ying Liu
Deirdre K. Tobias
Kathleen Sturgeon
Publikationsdatum: 20.08.2022
Verlag: Springer International Publishing
Erschienen in: Cancer Causes & Control / Ausgabe 11/2022
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-022-01617-3

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Physical activity from menarche-to-first pregnancy and risk of breast cancer: the California teachers study

Abstract

Purpose

Methods

Results

Conclusion

Neu im Fachgebiet Onkologie

Alphablocker schützt vor Miktionsproblemen nach der Biopsie

Antikörper-Wirkstoff-Konjugat hält solide Tumoren in Schach

Mammakarzinom: Senken Statine das krebsbedingte Sterberisiko?

Labor, CT-Anthropometrie zeigen Risiko für Pankreaskrebs

Update Onkologie

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 11/2022

The effect of the number of biopsies on the delay in the time from the delivery of mammography results to breast cancer histopathological diagnosis

Improving cervical cancer screening rates: a scoping review of resources and interventions

Hospitalization as an opportunity to engage underserved individuals in shared decision-making for lung cancer screening: results from two randomized pilot trials

Associations between cigarette smoking and biliary tract cancer by anatomic subsite and sex: a prospective cohort study in Japan

Antidepressant medication use and prostate cancer recurrence in men with depressive disorders

A comparison of survey incentive methods to recruit rural cancer survivors into cancer care delivery research studies

Neu im Fachgebiet Onkologie

Alphablocker schützt vor Miktionsproblemen nach der Biopsie

Antikörper-Wirkstoff-Konjugat hält solide Tumoren in Schach

Mammakarzinom: Senken Statine das krebsbedingte Sterberisiko?

Labor, CT-Anthropometrie zeigen Risiko für Pankreaskrebs

Update Onkologie