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Breast Cancer Research and Treatment
Erschienen in: Breast Cancer Research and Treatment 3/2008

01.04.2008 | Review

Breast cancer in pregnancy: a literature review

verfasst von: Andrea Molckovsky, Yolanda Madarnas

Erschienen in: Breast Cancer Research and Treatment | Ausgabe 3/2008

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Abstract

Purpose

Breast cancer in pregnancy is a clinically challenging situation for patients and their physicians. A review of the literature was performed to help identify optimal treatment strategies.

Methods

A Medline search between 1966 to the present using the keywords “breast”, “carcinoma”, and “pregnancy” revealed numerous hits, from which English-language articles including epidemiologic studies, case series, and general summaries were reviewed.

Results

There is a paucity of prospective studies regarding diagnosis and treatment of breast cancer in pregnancy due to its rarity. However a general review of the literature database reveals that women diagnosed with breast cancer during pregnancy have similar disease characteristics to age-matched controls. Surgery remains the mainstay of treatment of breast cancer during pregnancy, and in some circumstances breast-conserving surgery is an acceptable option. Adjuvant treatment can proceed with some modifications that minimize harm to the fetus, namely limiting radiation exposure and timing chemotherapy properly. Post-partum decisions regarding lactation and future fertility should be addressed on a per-patient basis.

Conclusion

Breast cancer in pregnancy is an uncommon phenomenon but one which poses dilemmas for patients and their physicians. A multi-disciplinary approach is recommended for optimal clinical-decision making.
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Metadaten
Titel
Breast cancer in pregnancy: a literature review
verfasst von
Andrea Molckovsky
Yolanda Madarnas
Publikationsdatum
01.04.2008
Verlag
Springer US
Erschienen in
Breast Cancer Research and Treatment / Ausgabe 3/2008
Print ISSN: 0167-6806
Elektronische ISSN: 1573-7217
DOI
https://doi.org/10.1007/s10549-007-9616-6

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