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01.07.2007 | Original Article

Relevance of CT and MRI in retinoblastoma for the diagnosis of postlaminar invasion with normal-size optic nerve: a retrospective study of 150 patients with histological comparison

verfasst von: Hervé J. Brisse, Myriam Guesmi, Isabelle Aerts, Xavier Sastre-Garau, Alexia Savignoni, Livia Lumbroso-Le Rouic, Laurence Desjardins, François Doz, Bernard Asselain, Danièle Bours, Sylvia Neuenschwander

Erschienen in: Pediatric Radiology | Ausgabe 7/2007

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Abstract

Background

Detection of optic nerve invasion is mandatory in children primarily enucleated for retinoblastoma to ensure a free resection margin.

Objective

To assess the accuracy of CT and MRI for the detection of postlaminar invasion in normal-size nerves.

Materials and methods

A total of 150 patients enucleated for retinoblastoma were included. Imaging data (119 CT and 46 MRI) were retrospectively reviewed and compared with histological findings. Abnormal contrast enhancement of the optic nerve was used as diagnostic criterion for invasion. The associations between postlaminar invasion and several indirect signs were also assessed. Statistical analysis was performed with the Kruskal-Wallis and Fisher exact tests.

Results

Postlaminar invasion on histology was observed in 8% (12/150). The sensitivity, specificity, accuracy and negative and positive predictive values were 60%, 95%, 91%, 95% and 60% for MRI, and 0%, 100%, 94% and 94% (PPV not assessable) for CT, respectively. Tumour diameter was the only indirect radiological sign significantly associated with postlaminar optic nerve invasion (P=0.002).

Conclusion

Our results suggest that MRI is more relevant than CT for preoperative detection of optic nerve invasion in patients with retinoblastoma. Tumour diameter is the only indirect sign significantly associated with postlaminar invasion.

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Titel: Relevance of CT and MRI in retinoblastoma for the diagnosis of postlaminar invasion with normal-size optic nerve: a retrospective study of 150 patients with histological comparison
verfasst von: Hervé J. Brisse
Myriam Guesmi
Isabelle Aerts
Xavier Sastre-Garau
Alexia Savignoni
Livia Lumbroso-Le Rouic
Laurence Desjardins
François Doz
Bernard Asselain
Danièle Bours
Sylvia Neuenschwander
Publikationsdatum: 01.07.2007
Verlag: Springer-Verlag
Erschienen in: Pediatric Radiology / Ausgabe 7/2007
Print ISSN: 0301-0449
Elektronische ISSN: 1432-1998
DOI: https://doi.org/10.1007/s00247-007-0491-4

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Relevance of CT and MRI in retinoblastoma for the diagnosis of postlaminar invasion with normal-size optic nerve: a retrospective study of 150 patients with histological comparison