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Erschienen in: Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 11/2013

01.11.2013 | Bekanntmachungen - Amtliche Mitteilungen

Prävention der nosokomialen beatmungsassoziierten Pneumonie

Empfehlung der Kommission für Krankenhaushygiene und Infektionsprävention (KRINKO) beim Robert Koch-Institut

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Erschienen in: Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz | Ausgabe 11/2013

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1
Einleitung und Hintergrund
1.1
Zielgruppe der Empfehlung
 
1.2
Bezug zu anderen Empfehlungen
 
1.3
Risikofaktoren für die Entstehung beatmungsassoziierter Pneumonien
 
 
2
Basismaßnahmen
2.1
Händehygiene
 
2.2
Arbeitskleidung auf Intensivstationen (Bereichskleidung) und persönliche Schutzausrüstung
 
2.3
Schulung der Mitarbeiter
 
2.4
Personelle Besetzung
 
2.5
Surveillance
2.5.1
Mikrobiologisches Monitoring zur Therapiesteuerung
 
2.5.2
Epidemiologische Surveillance
 
 
 
3
Apparativ-technische Maßnahmen
3.1
Beatmungsschläuche
 
3.2
Aktive und passive Atemgasbefeuchtung
 
3.3
Endotrachealtuben
3.3.1
Material von Endotrachealtuben (Silberbeschichtung)
 
3.3.2
Cuffdruck und subglottische Absaugung
 
3.3.3
Besonderheiten in der Pädiatrie
 
 
3.4
Endotracheale Absaugung
 
3.5
Medikamentenvernebler im Beatmungssystem
 
 
4
Patientenbezogene Maßnahmen
4.1
Endotracheale Intubation: orotracheal versus nasotracheal
 
4.2
Frühe versus späte Tracheotomie
 
4.3
Nicht-invasive Beatmung (NIV)
 
4.4
Lagerungsmaßnahmen
 
4.5
Hygienische Mundpflege
 
4.6
Enterale Ernährung
 
4.7
Probiotika
 
 
5
Pharmakologische Maßnahmen
5.1
Selektive Darmdekontamination (SDD)/selektive orale Dekontamination (SOD)
 
5.2
Stressblutungsprophylaxe
 
5.3
Sedierung
 
 
6
Maßnahmenbündel zur Prävention beatmungsassoziierter Pneumonien
 
7
Beispiele für gängige Bündel zur Prävention der Beatmungspneumonie
 
  • Literatur
Literatur
1.
Zurück zum Zitat Kommission für Krankenhaushygiene und Infektionsprävention (KRINKO) (2000) Prävention der nosokomialen Pneumonie. Bundesgesundheitsbl 43:302–309 Kommission für Krankenhaushygiene und Infektionsprävention (KRINKO) (2000) Prävention der nosokomialen Pneumonie. Bundesgesundheitsbl 43:302–309
2.
Zurück zum Zitat Paul-Ehrlich-Gesellschaft für Chemotherapie (2012) Epidemiologie, Diagnostik und Therapie erwachsener Patienten mit nosokomialer Pneumonie. http://www.p-e-g.org → Leitlinien. Pneumologie 66:707–765 Paul-Ehrlich-Gesellschaft für Chemotherapie (2012) Epidemiologie, Diagnostik und Therapie erwachsener Patienten mit nosokomialer Pneumonie. http://​www.​p-e-g.​org → Leitlinien. Pneumologie 66:707–765
3.
Zurück zum Zitat Klompas M (2013) Complications of mechanical ventilation – the CDC’s new surveillance paradigm. N Engl J Med 368:1472–1475PubMed Klompas M (2013) Complications of mechanical ventilation – the CDC’s new surveillance paradigm. N Engl J Med 368:1472–1475PubMed
4.
Zurück zum Zitat Kommission für Krankenhaushygiene und Infektionsprävention (KRINKO) (2010) Die Kategorien in der Richtlinie für Krankenhaushygiene und Infektionsprävention – Aktualisierung der Definitionen. Bundesgesundheitsbl 53:754–756 Kommission für Krankenhaushygiene und Infektionsprävention (KRINKO) (2010) Die Kategorien in der Richtlinie für Krankenhaushygiene und Infektionsprävention – Aktualisierung der Definitionen. Bundesgesundheitsbl 53:754–756
5.
Zurück zum Zitat Rello J, Diaz E (2003) Pneumonia in the intensive care unit. Crit Care Med 31:2544–2551PubMed Rello J, Diaz E (2003) Pneumonia in the intensive care unit. Crit Care Med 31:2544–2551PubMed
6.
Zurück zum Zitat Krankenhaus-Infektions-Surveillance-System KISS. http://www.nrz-hygiene.de/surveillance/kiss/ Krankenhaus-Infektions-Surveillance-System KISS. http://​www.​nrz-hygiene.​de/​surveillance/​kiss/​
7.
Zurück zum Zitat Beyersmann J, Gastmeier P, Grundmann H et al (2006) Use of multistate models to assess prolongation of intensive care unit stay due to nosocomial infection. Infect Control Hosp Epidemiol 27:493–499PubMed Beyersmann J, Gastmeier P, Grundmann H et al (2006) Use of multistate models to assess prolongation of intensive care unit stay due to nosocomial infection. Infect Control Hosp Epidemiol 27:493–499PubMed
8.
Zurück zum Zitat Eber MR, Laxminarayan R, Perencevich EN, Malani A (2010) Clinical and economic outcomes attributable to health care-associated sepsis and pneumonia. Arch Intern Med 170:347–353PubMed Eber MR, Laxminarayan R, Perencevich EN, Malani A (2010) Clinical and economic outcomes attributable to health care-associated sepsis and pneumonia. Arch Intern Med 170:347–353PubMed
9.
Zurück zum Zitat Geffers C, Sohr D, Gastmeier P (2008) Mortality attributable to hospital-acquired infections among surgical patients. Infect Control Hosp Epidemiol 29:1167–1170PubMed Geffers C, Sohr D, Gastmeier P (2008) Mortality attributable to hospital-acquired infections among surgical patients. Infect Control Hosp Epidemiol 29:1167–1170PubMed
10.
Zurück zum Zitat Muscedere JG, Day A, Heyland DK (2010) Mortality, attributable mortality, and clinical events as end points for clinical trials of ventilator-associated pneumonia and hospital-acquired pneumonia. Clin Infect Dis 51(Suppl 1):S120–S125PubMed Muscedere JG, Day A, Heyland DK (2010) Mortality, attributable mortality, and clinical events as end points for clinical trials of ventilator-associated pneumonia and hospital-acquired pneumonia. Clin Infect Dis 51(Suppl 1):S120–S125PubMed
11.
Zurück zum Zitat Cook DJ, Walter SD, Cook RJ et al (1998) Incidence of and risk factors for ventilator-associated pneumonia in critically ill patients. Ann Intern Med 129:433–440PubMed Cook DJ, Walter SD, Cook RJ et al (1998) Incidence of and risk factors for ventilator-associated pneumonia in critically ill patients. Ann Intern Med 129:433–440PubMed
12.
Zurück zum Zitat Melsen WG, Rovers MM, Groenwold RH et al (2013) Attributable mortality of ventilator-associated pneumonia: a meta-analysis of individual patient data from randomised prevention studies. Lancet Infect Dis 13:665–671PubMed Melsen WG, Rovers MM, Groenwold RH et al (2013) Attributable mortality of ventilator-associated pneumonia: a meta-analysis of individual patient data from randomised prevention studies. Lancet Infect Dis 13:665–671PubMed
13.
Zurück zum Zitat Kommission für Krankenhaushygiene und Infektionsprävention (KRINKO) (2000) Händehygiene. Bundesgesundheitsbl 43:230–233 Kommission für Krankenhaushygiene und Infektionsprävention (KRINKO) (2000) Händehygiene. Bundesgesundheitsbl 43:230–233
14.
Zurück zum Zitat Kommission für Krankenhaushygiene und Infektionsprävention (KRINKO) (1999) Empfehlung zur Prävention und Kontrolle von Methicillin-resistenten Staphylococcus aureus-Stämmen (MRSA) in Krankenhäusern und anderen medizinischen Einrichtungen. Bundesgesundheitsbl 42:954–958 Kommission für Krankenhaushygiene und Infektionsprävention (KRINKO) (1999) Empfehlung zur Prävention und Kontrolle von Methicillin-resistenten Staphylococcus aureus-Stämmen (MRSA) in Krankenhäusern und anderen medizinischen Einrichtungen. Bundesgesundheitsbl 42:954–958
15.
Zurück zum Zitat Kommission für Krankenhaushygiene und Infektionsprävention (KRINKO) (2012) Hygienemaßnahmen bei Infektionen oder Besiedlung mit multiresistenten gramnegativen Stäbchen. Bundesgesundheitsbl 55:1311–1354 Kommission für Krankenhaushygiene und Infektionsprävention (KRINKO) (2012) Hygienemaßnahmen bei Infektionen oder Besiedlung mit multiresistenten gramnegativen Stäbchen. Bundesgesundheitsbl 55:1311–1354
16.
Zurück zum Zitat Kommission für Krankenhaushygiene und Infektionsprävention (KRINKO), Bundesinstitut für Arzneimittel und Medizinprodukte (BfArM) (2012) Anforderungen an die Hygiene bei der Aufbereitung von Medizinprodukten. Bundesgesundheitsbl 55:1244–1310 Kommission für Krankenhaushygiene und Infektionsprävention (KRINKO), Bundesinstitut für Arzneimittel und Medizinprodukte (BfArM) (2012) Anforderungen an die Hygiene bei der Aufbereitung von Medizinprodukten. Bundesgesundheitsbl 55:1244–1310
17.
Zurück zum Zitat Kommission für Krankenhaushygiene und Infektionsprävention (KRINKO) (2004) Anforderungen an die Hygiene bei der Reinigung und Desinfektion von Flächen. Bundesgesundheitsbl 47:51–61 Kommission für Krankenhaushygiene und Infektionsprävention (KRINKO) (2004) Anforderungen an die Hygiene bei der Reinigung und Desinfektion von Flächen. Bundesgesundheitsbl 47:51–61
18.
Zurück zum Zitat Makris D, Desrousseaux B, Zakynthinos E et al (2011) The impact of COPD on ICU mortality in patients with ventilator-associated pneumonia. Respir Med 105:1022–1029PubMed Makris D, Desrousseaux B, Zakynthinos E et al (2011) The impact of COPD on ICU mortality in patients with ventilator-associated pneumonia. Respir Med 105:1022–1029PubMed
19.
Zurück zum Zitat Nseir S, Di Pompeo C, Soubrier S et al (2005) Impact of ventilator-associated pneumonia on outcome in patients with COPD. Chest 128:1650–1656PubMed Nseir S, Di Pompeo C, Soubrier S et al (2005) Impact of ventilator-associated pneumonia on outcome in patients with COPD. Chest 128:1650–1656PubMed
20.
Zurück zum Zitat Rello J (2010) Ventilator associated pneumonia in patients with COPD. Risk factors and evolutionary impact. In: X Simposium Fundació La Marató de TV3 Chronic Respiratory Diseases Rello J (2010) Ventilator associated pneumonia in patients with COPD. Risk factors and evolutionary impact. In: X Simposium Fundació La Marató de TV3 Chronic Respiratory Diseases
21.
Zurück zum Zitat Charles MP, Easow JM, Joseph NM et al (2013) Incidence and risk factors of ventilator associated pneumonia in a tertiary care hospital. Australas Med J 6:178–182PubMed Charles MP, Easow JM, Joseph NM et al (2013) Incidence and risk factors of ventilator associated pneumonia in a tertiary care hospital. Australas Med J 6:178–182PubMed
22.
Zurück zum Zitat Kasuya Y, Hargett JL, Lenhardt R et al (2011) Ventilator-associated pneumonia in critically ill stroke patients: frequency, risk factors, and outcomes. J Crit Care 26:273–279PubMed Kasuya Y, Hargett JL, Lenhardt R et al (2011) Ventilator-associated pneumonia in critically ill stroke patients: frequency, risk factors, and outcomes. J Crit Care 26:273–279PubMed
23.
Zurück zum Zitat Alp E, Voss A (2006) Ventilator associated pneumonia and infection control. Ann Clin Microbiol Antimicrob 5:7PubMed Alp E, Voss A (2006) Ventilator associated pneumonia and infection control. Ann Clin Microbiol Antimicrob 5:7PubMed
24.
Zurück zum Zitat Leal-Noval SR, Marquez-Vacaro JA, Garcia-Curiel A et al (2000) Nosocomial pneumonia in patients undergoing heart surgery. Crit Care Med 28:935–940PubMed Leal-Noval SR, Marquez-Vacaro JA, Garcia-Curiel A et al (2000) Nosocomial pneumonia in patients undergoing heart surgery. Crit Care Med 28:935–940PubMed
25.
Zurück zum Zitat Nseir S, Zerimech F, Jaillette E et al (2011) Microaspiration in intubated critically ill patients: diagnosis and prevention. Infect Disord Drug Targets 11:413–423PubMed Nseir S, Zerimech F, Jaillette E et al (2011) Microaspiration in intubated critically ill patients: diagnosis and prevention. Infect Disord Drug Targets 11:413–423PubMed
26.
Zurück zum Zitat Ibrahim EH, Tracy L, Hill C et al (2001) The occurrence of ventilator-associated pneumonia in a community hospital: risk factors and clinical outcomes. Chest 120:555–561PubMed Ibrahim EH, Tracy L, Hill C et al (2001) The occurrence of ventilator-associated pneumonia in a community hospital: risk factors and clinical outcomes. Chest 120:555–561PubMed
27.
Zurück zum Zitat Elward AM, Fraser VJ (2006) Risk factors for nosocomial primary bloodstream infection in pediatric intensive care unit patients: a 2-year prospective cohort study. Infect Control Hosp Epidemiol 27:553–560PubMed Elward AM, Fraser VJ (2006) Risk factors for nosocomial primary bloodstream infection in pediatric intensive care unit patients: a 2-year prospective cohort study. Infect Control Hosp Epidemiol 27:553–560PubMed
28.
Zurück zum Zitat Fayon MJ, Tucci M, Lacroix J et al (1997) Nosocomial pneumonia and tracheitis in a pediatric intensive care unit: a prospective study. Am J Respir Crit Care Med 155:162–169PubMed Fayon MJ, Tucci M, Lacroix J et al (1997) Nosocomial pneumonia and tracheitis in a pediatric intensive care unit: a prospective study. Am J Respir Crit Care Med 155:162–169PubMed
29.
Zurück zum Zitat Srinivasan R, Asselin J, Gildengorin G et al (2009) A prospective study of ventilator-associated pneumonia in children. Pediatrics 123:1108–1115PubMed Srinivasan R, Asselin J, Gildengorin G et al (2009) A prospective study of ventilator-associated pneumonia in children. Pediatrics 123:1108–1115PubMed
30.
Zurück zum Zitat Taira BR, Fenton KE, Lee TK et al (2009) Ventilator-associated pneumonia in pediatric trauma patients. Pediatr Crit Care Med 10:491–494PubMed Taira BR, Fenton KE, Lee TK et al (2009) Ventilator-associated pneumonia in pediatric trauma patients. Pediatr Crit Care Med 10:491–494PubMed
31.
Zurück zum Zitat Zolfaghari PS, Wyncoll DL (2011) The tracheal tube: gateway to ventilator-associated pneumonia. Crit Care 15:310PubMed Zolfaghari PS, Wyncoll DL (2011) The tracheal tube: gateway to ventilator-associated pneumonia. Crit Care 15:310PubMed
32.
Zurück zum Zitat Rello J, Lode H, Cornaglia G et al (2010) A European care bundle for prevention of ventilator-associated pneumonia. Intensive Care Med 36:773–780PubMed Rello J, Lode H, Cornaglia G et al (2010) A European care bundle for prevention of ventilator-associated pneumonia. Intensive Care Med 36:773–780PubMed
33.
Zurück zum Zitat ABAS (2003) Biologische Arbeitsstoffe im Gesundheitswesen und in der Wohlfahrtspflege (TRBA 250). http://www.baua.de/de/Themen-von-A-Z/Biologische-Arbeitsstoffe/TRBA/pdf/TRBA-250.pdf?__blob=publicationFile&v=4 ABAS (2003) Biologische Arbeitsstoffe im Gesundheitswesen und in der Wohlfahrtspflege (TRBA 250). http://​www.​baua.​de/​de/​Themen-von-A-Z/​Biologische-Arbeitsstoffe/​TRBA/​pdf/​TRBA-250.​pdf?​_​_​blob=​publicationFile&​v=​4
34.
Zurück zum Zitat ABAS (2012) Grundlegende Maßnahmen bei Tätigkeiten mit biologischen Arbeitsstoffen (TRBA 500). http://www.baua.de/cae/servlet/contentblob/672878/publicationFile/ ABAS (2012) Grundlegende Maßnahmen bei Tätigkeiten mit biologischen Arbeitsstoffen (TRBA 500). http://​www.​baua.​de/​cae/​servlet/​contentblob/​672878/​publicationFile/​
35.
Zurück zum Zitat Zack JE, Garrison T, Trovillion E et al (2002) Effect of an education program aimed at reducing the occurrence of ventilator-associated pneumonia. Crit Care Med 30:2407–2412PubMed Zack JE, Garrison T, Trovillion E et al (2002) Effect of an education program aimed at reducing the occurrence of ventilator-associated pneumonia. Crit Care Med 30:2407–2412PubMed
36.
Zurück zum Zitat Zuschneid I, Schwab F, Geffers C et al (2007) Trends in ventilator-associated pneumonia rates within the German nosocomial infection surveillance system (KISS). Infect Control Hosp Epidemiol 28:314–318PubMed Zuschneid I, Schwab F, Geffers C et al (2007) Trends in ventilator-associated pneumonia rates within the German nosocomial infection surveillance system (KISS). Infect Control Hosp Epidemiol 28:314–318PubMed
37.
Zurück zum Zitat Babcock HM, Zack JE, Garrison T et al (2004) An educational intervention to reduce ventilator-associated pneumonia in an integrated health system: a comparison of effects. Chest 125:2224–2231PubMed Babcock HM, Zack JE, Garrison T et al (2004) An educational intervention to reduce ventilator-associated pneumonia in an integrated health system: a comparison of effects. Chest 125:2224–2231PubMed
38.
Zurück zum Zitat http://www.hps.scot.nhs.uk/haiic/ic/bundles.aspx http://www.hps.scot.nhs.uk/haiic/ic/bundles.aspx
39.
Zurück zum Zitat Schwab F, Meyer E, Geffers C, Gastmeier P (2012) Understaffing, overcrowding, inappropriate nurse:ventilated patient ratio and nosocomial infections: Which parameter is the best reflection of deficits? J Hosp Infect 80:133–139PubMed Schwab F, Meyer E, Geffers C, Gastmeier P (2012) Understaffing, overcrowding, inappropriate nurse:ventilated patient ratio and nosocomial infections: Which parameter is the best reflection of deficits? J Hosp Infect 80:133–139PubMed
40.
Zurück zum Zitat Deutsche interdisziplinäre Vereinigung für Intensiv- und Notfallmedizin. Empfehlungen zur Struktur und Ausstattung von Intensivstationen. http://www.divi-org.de/fileadmin/pdfs/struktur/Langversion_201105.pdf Deutsche interdisziplinäre Vereinigung für Intensiv- und Notfallmedizin. Empfehlungen zur Struktur und Ausstattung von Intensivstationen. http://​www.​divi-org.​de/​fileadmin/​pdfs/​struktur/​Langversion_​201105.​pdf
41.
Zurück zum Zitat Weiss M, Marx G, Vagts DA et al (2012) Calculation of personnel requirement „intensive care medicine“ 2012 – Revision of the 2008 calculation tool for the medical profession. (Personalbedarfskalkulation „Intensivmedizin“ 2012 – Überarbeitung der Kalkulationsgrundlagen für den ärztlichen Dienst aus dem Jahr 2008). Anästh Intensivmed 53:S82 Weiss M, Marx G, Vagts DA et al (2012) Calculation of personnel requirement „intensive care medicine“ 2012 – Revision of the 2008 calculation tool for the medical profession. (Personalbedarfskalkulation „Intensivmedizin“ 2012 – Überarbeitung der Kalkulationsgrundlagen für den ärztlichen Dienst aus dem Jahr 2008). Anästh Intensivmed 53:S82
42.
Zurück zum Zitat Depuydt PO, Blot SI, Benoit DD et al (2006) Antimicrobial resistance in nosocomial bloodstream infection associated with pneumonia and the value of systematic surveillance cultures in an adult intensive care unit. Crit Care Med 34:653–659PubMed Depuydt PO, Blot SI, Benoit DD et al (2006) Antimicrobial resistance in nosocomial bloodstream infection associated with pneumonia and the value of systematic surveillance cultures in an adult intensive care unit. Crit Care Med 34:653–659PubMed
43.
Zurück zum Zitat Hayon J, Figliolini C, Combes A et al (2002) Role of serial routine microbiologic culture results in the initial management of ventilator-associated pneumonia. Am J Respir Crit Care Med 165:41–46PubMed Hayon J, Figliolini C, Combes A et al (2002) Role of serial routine microbiologic culture results in the initial management of ventilator-associated pneumonia. Am J Respir Crit Care Med 165:41–46PubMed
44.
Zurück zum Zitat Joost I, Lange C, Seifert H (2010) Microbiological monitoring of ventilator-associated pneumonia in an intensive care unit. Dtsch Med Wochenschr 135:197–202PubMed Joost I, Lange C, Seifert H (2010) Microbiological monitoring of ventilator-associated pneumonia in an intensive care unit. Dtsch Med Wochenschr 135:197–202PubMed
45.
Zurück zum Zitat Pirracchio R, Mateo J, Raskine L et al (2009) Can bacteriological upper airway samples obtained at intensive care unit admission guide empiric antibiotherapy for ventilator-associated pneumonia? Crit Care Med 37:2559–2563PubMed Pirracchio R, Mateo J, Raskine L et al (2009) Can bacteriological upper airway samples obtained at intensive care unit admission guide empiric antibiotherapy for ventilator-associated pneumonia? Crit Care Med 37:2559–2563PubMed
46.
Zurück zum Zitat Gastmeier P, Schwab F, Sohr D et al (2009) Reproducibility of the surveillance effect to decrease nosocomial infection rates. Infect Control Hosp Epidemiol 30:993–999PubMed Gastmeier P, Schwab F, Sohr D et al (2009) Reproducibility of the surveillance effect to decrease nosocomial infection rates. Infect Control Hosp Epidemiol 30:993–999PubMed
47.
Zurück zum Zitat Dreyfuss D, Djedaini K, Weber P et al (1991) Prospective study of nosocomial pneumonia and of patient and circuit colonization during mechanical ventilation with circuit changes every 48 hours versus no change. Am Rev Respir Dis 143:738–743PubMed Dreyfuss D, Djedaini K, Weber P et al (1991) Prospective study of nosocomial pneumonia and of patient and circuit colonization during mechanical ventilation with circuit changes every 48 hours versus no change. Am Rev Respir Dis 143:738–743PubMed
48.
Zurück zum Zitat Han JN, Liu YP, Ma S et al (2001) Effects of decreasing the frequency of ventilator circuit changes to every 7 days on the rate of ventilator-associated pneumonia in a Beijing hospital. Respir Care 46:891–896PubMed Han JN, Liu YP, Ma S et al (2001) Effects of decreasing the frequency of ventilator circuit changes to every 7 days on the rate of ventilator-associated pneumonia in a Beijing hospital. Respir Care 46:891–896PubMed
49.
Zurück zum Zitat Hsieh TC, Hsia SH, Wu CT et al (2010) Frequency of ventilator-associated pneumonia with 3-day versus 7-day ventilator circuit changes. Pediatr Neonatol 51:37–43PubMed Hsieh TC, Hsia SH, Wu CT et al (2010) Frequency of ventilator-associated pneumonia with 3-day versus 7-day ventilator circuit changes. Pediatr Neonatol 51:37–43PubMed
50.
Zurück zum Zitat Kollef MH, Shapiro SD, Fraser VJ et al (1995) Mechanical ventilation with or without 7-day circuit changes. A randomized controlled trial. Ann Intern Med 123:168–174PubMed Kollef MH, Shapiro SD, Fraser VJ et al (1995) Mechanical ventilation with or without 7-day circuit changes. A randomized controlled trial. Ann Intern Med 123:168–174PubMed
51.
Zurück zum Zitat Samransamruajkit R, Jirapaiboonsuk S, Siritantiwat S et al (2010) Effect of frequency of ventilator circuit changes (3 vs 7 days) on the rate of ventilator-associated pneumonia in PICU. J Crit Care 25:56–61PubMed Samransamruajkit R, Jirapaiboonsuk S, Siritantiwat S et al (2010) Effect of frequency of ventilator circuit changes (3 vs 7 days) on the rate of ventilator-associated pneumonia in PICU. J Crit Care 25:56–61PubMed
52.
Zurück zum Zitat Hess DR, Kallstrom TJ, Mottram CD et al (2003) Care of the ventilator circuit and its relation to ventilator-associated pneumonia. Respir Care 48:869–879PubMed Hess DR, Kallstrom TJ, Mottram CD et al (2003) Care of the ventilator circuit and its relation to ventilator-associated pneumonia. Respir Care 48:869–879PubMed
53.
Zurück zum Zitat Nakos G, Tsangaris H, Liokatis S et al (2003) Ventilator-associated pneumonia and atelectasis: evaluation through bronchoalveolar lavage fluid analysis. Intensive Care Med 29:555–563PubMed Nakos G, Tsangaris H, Liokatis S et al (2003) Ventilator-associated pneumonia and atelectasis: evaluation through bronchoalveolar lavage fluid analysis. Intensive Care Med 29:555–563PubMed
54.
Zurück zum Zitat Pasquina P, Tramer MR, Granier JM, Walder B (2006) Respiratory physiotherapy to prevent pulmonary complications after abdominal surgery: a systematic review. Chest 130:1887–1899PubMed Pasquina P, Tramer MR, Granier JM, Walder B (2006) Respiratory physiotherapy to prevent pulmonary complications after abdominal surgery: a systematic review. Chest 130:1887–1899PubMed
55.
Zurück zum Zitat Kola A, Eckmanns T, Gastmeier P (2005) Efficacy of heat and moisture exchangers in preventing ventilator-associated pneumonia: meta-analysis of randomized controlled trials. Intensive Care Med 31:5–11PubMed Kola A, Eckmanns T, Gastmeier P (2005) Efficacy of heat and moisture exchangers in preventing ventilator-associated pneumonia: meta-analysis of randomized controlled trials. Intensive Care Med 31:5–11PubMed
56.
Zurück zum Zitat Dodek P, Keenan S, Cook D et al (2004) Evidence-based clinical practice guideline for the prevention of ventilator-associated pneumonia. Ann Intern Med 141:305–313PubMed Dodek P, Keenan S, Cook D et al (2004) Evidence-based clinical practice guideline for the prevention of ventilator-associated pneumonia. Ann Intern Med 141:305–313PubMed
57.
Zurück zum Zitat Boots RJ, George N, Faoagali JL et al (2006) Double-heater-wire circuits and heat-and-moisture exchangers and the risk of ventilator-associated pneumonia. Crit Care Med 34:687–693PubMed Boots RJ, George N, Faoagali JL et al (2006) Double-heater-wire circuits and heat-and-moisture exchangers and the risk of ventilator-associated pneumonia. Crit Care Med 34:687–693PubMed
58.
Zurück zum Zitat Dreyfuss D, Djedaini K, Gros I et al (1995) Mechanical ventilation with heated humidifiers or heat and moisture exchangers: effects on patient colonization and incidence of nosocomial pneumonia. Am J Respir Crit Care Med 151:986–992PubMed Dreyfuss D, Djedaini K, Gros I et al (1995) Mechanical ventilation with heated humidifiers or heat and moisture exchangers: effects on patient colonization and incidence of nosocomial pneumonia. Am J Respir Crit Care Med 151:986–992PubMed
59.
Zurück zum Zitat Kollef MH, Shapiro SD, Boyd V et al (1998) A randomized clinical trial comparing an extended-use hygroscopic condenser humidifier with heated-water humidification in mechanically ventilated patients. Chest 113:759–767PubMed Kollef MH, Shapiro SD, Boyd V et al (1998) A randomized clinical trial comparing an extended-use hygroscopic condenser humidifier with heated-water humidification in mechanically ventilated patients. Chest 113:759–767PubMed
60.
Zurück zum Zitat Lacherade JC, Auburtin M, Cerf C et al (2005) Impact of humidification systems on ventilator-associated pneumonia: a randomized multicenter trial. Am J Respir Crit Care Med 172:1276–1282PubMed Lacherade JC, Auburtin M, Cerf C et al (2005) Impact of humidification systems on ventilator-associated pneumonia: a randomized multicenter trial. Am J Respir Crit Care Med 172:1276–1282PubMed
61.
Zurück zum Zitat Siempos II, Vardakas KZ, Kopterides P, Falagas ME (2007) Impact of passive humidification on clinical outcomes of mechanically ventilated patients: a meta-analysis of randomized controlled trials. Crit Care Med 35:2843–2851PubMed Siempos II, Vardakas KZ, Kopterides P, Falagas ME (2007) Impact of passive humidification on clinical outcomes of mechanically ventilated patients: a meta-analysis of randomized controlled trials. Crit Care Med 35:2843–2851PubMed
62.
Zurück zum Zitat Kelly M, Gillies D, Todd DA, Lockwood C (2010) Heated humidification versus heat and moisture exchangers for ventilated adults and children. Cochrane Database Syst Rev CD004711 Kelly M, Gillies D, Todd DA, Lockwood C (2010) Heated humidification versus heat and moisture exchangers for ventilated adults and children. Cochrane Database Syst Rev CD004711
63.
Zurück zum Zitat Davis K Jr, Evans SL, Campbell RS et al (2000) Prolonged use of heat and moisture exchangers does not affect device efficiency or frequency rate of nosocomial pneumonia. Crit Care Med 28:1412–1418PubMed Davis K Jr, Evans SL, Campbell RS et al (2000) Prolonged use of heat and moisture exchangers does not affect device efficiency or frequency rate of nosocomial pneumonia. Crit Care Med 28:1412–1418PubMed
64.
Zurück zum Zitat Hess D (2000) Prolonged use of heat and moisture exchangers: why do we keep changing things? Crit Care Med 28:1667–1668PubMed Hess D (2000) Prolonged use of heat and moisture exchangers: why do we keep changing things? Crit Care Med 28:1667–1668PubMed
65.
Zurück zum Zitat Ricard JD, Le Miere E, Markowicz P et al (2000) Efficiency and safety of mechanical ventilation with a heat and moisture exchanger changed only once a week. Am J Respir Crit Care Med 161:104–109PubMed Ricard JD, Le Miere E, Markowicz P et al (2000) Efficiency and safety of mechanical ventilation with a heat and moisture exchanger changed only once a week. Am J Respir Crit Care Med 161:104–109PubMed
66.
Zurück zum Zitat Thomachot L, Leone M, Razzouk K et al (2002) Randomized clinical trial of extended use of a hydrophobic condenser humidifier: 1 vs. 7 days. Crit Care Med 30:232–237PubMed Thomachot L, Leone M, Razzouk K et al (2002) Randomized clinical trial of extended use of a hydrophobic condenser humidifier: 1 vs. 7 days. Crit Care Med 30:232–237PubMed
67.
Zurück zum Zitat Berra L, Coppadoro A, Bittner EA et al (2012) A clinical assessment of the Mucus Shaver: a device to keep the endotracheal tube free from secretions. Crit Care Med 40:119–124PubMed Berra L, Coppadoro A, Bittner EA et al (2012) A clinical assessment of the Mucus Shaver: a device to keep the endotracheal tube free from secretions. Crit Care Med 40:119–124PubMed
68.
Zurück zum Zitat Fernandez JF, Levine SM, Restrepo MI (2012) Technologic advances in endotracheal tubes for prevention of ventilator-associated pneumonia. Chest 142:231–238PubMed Fernandez JF, Levine SM, Restrepo MI (2012) Technologic advances in endotracheal tubes for prevention of ventilator-associated pneumonia. Chest 142:231–238PubMed
69.
Zurück zum Zitat Kollef MH, Afessa B, Anzueto A et al (2008) Silver-coated endotracheal tubes and incidence of ventilator-associated pneumonia: the NASCENT randomized trial. JAMA 300:805–813PubMed Kollef MH, Afessa B, Anzueto A et al (2008) Silver-coated endotracheal tubes and incidence of ventilator-associated pneumonia: the NASCENT randomized trial. JAMA 300:805–813PubMed
70.
Zurück zum Zitat Gentile MA, Siobal MS (2010) Are specialized endotracheal tubes and heat-and-moisture exchangers cost-effective in preventing ventilator associated pneumonia? Respir Care 55:184–196 (discussion 196–197)PubMed Gentile MA, Siobal MS (2010) Are specialized endotracheal tubes and heat-and-moisture exchangers cost-effective in preventing ventilator associated pneumonia? Respir Care 55:184–196 (discussion 196–197)PubMed
71.
Zurück zum Zitat Cook DJ, Kollef MH (1998) Risk factors for ICU-acquired pneumonia. JAMA 279:1605–1606PubMed Cook DJ, Kollef MH (1998) Risk factors for ICU-acquired pneumonia. JAMA 279:1605–1606PubMed
72.
Zurück zum Zitat Moulin GC du, Paterson DG, Hedley-Whyte J, Lisbon A (1982) Aspiration of gastric bacteria in antacid-treated patients: a frequent cause of postoperative colonisation of the airway. Lancet 1:242–245PubMed Moulin GC du, Paterson DG, Hedley-Whyte J, Lisbon A (1982) Aspiration of gastric bacteria in antacid-treated patients: a frequent cause of postoperative colonisation of the airway. Lancet 1:242–245PubMed
73.
Zurück zum Zitat Rello J, Sonora R, Jubert P et al (1996) Pneumonia in intubated patients: role of respiratory airway care. Am J Respir Crit Care Med 154:111–115PubMed Rello J, Sonora R, Jubert P et al (1996) Pneumonia in intubated patients: role of respiratory airway care. Am J Respir Crit Care Med 154:111–115PubMed
74.
Zurück zum Zitat Liu J, Zhang X, Gong W et al (2010) Correlations between controlled endotracheal tube cuff pressure and postprocedural complications: a multicenter study. Anesth Analg 111:1133–1137PubMed Liu J, Zhang X, Gong W et al (2010) Correlations between controlled endotracheal tube cuff pressure and postprocedural complications: a multicenter study. Anesth Analg 111:1133–1137PubMed
75.
Zurück zum Zitat Valencia M, Ferrer M, Farre R et al (2007) Automatic control of tracheal tube cuff pressure in ventilated patients in semirecumbent position: a randomized trial. Crit Care Med 35:1543–1549PubMed Valencia M, Ferrer M, Farre R et al (2007) Automatic control of tracheal tube cuff pressure in ventilated patients in semirecumbent position: a randomized trial. Crit Care Med 35:1543–1549PubMed
76.
Zurück zum Zitat Nseir S, Zerimech F, Fournier C et al (2011) Continuous control of tracheal cuff pressure and microaspiration of gastric contents in critically ill patients. Am J Respir Crit Care Med 184:1041–1047PubMed Nseir S, Zerimech F, Fournier C et al (2011) Continuous control of tracheal cuff pressure and microaspiration of gastric contents in critically ill patients. Am J Respir Crit Care Med 184:1041–1047PubMed
77.
Zurück zum Zitat Valles J, Artigas A, Rello J et al (1995) Continuous aspiration of subglottic secretions in preventing ventilator-associated pneumonia. Ann Intern Med 122:179–186PubMed Valles J, Artigas A, Rello J et al (1995) Continuous aspiration of subglottic secretions in preventing ventilator-associated pneumonia. Ann Intern Med 122:179–186PubMed
78.
Zurück zum Zitat Dezfulian C, Shojania K, Collard HR et al (2005) Subglottic secretion drainage for preventing ventilator-associated pneumonia: a meta-analysis. Am J Med 118:11–18PubMed Dezfulian C, Shojania K, Collard HR et al (2005) Subglottic secretion drainage for preventing ventilator-associated pneumonia: a meta-analysis. Am J Med 118:11–18PubMed
79.
Zurück zum Zitat Lacherade JC, De Jonghe B, Guezennec P et al (2010) Intermittent subglottic secretion drainage and ventilator-associated pneumonia: a multicenter trial. Am J Respir Crit Care Med 182:910–917PubMed Lacherade JC, De Jonghe B, Guezennec P et al (2010) Intermittent subglottic secretion drainage and ventilator-associated pneumonia: a multicenter trial. Am J Respir Crit Care Med 182:910–917PubMed
80.
Zurück zum Zitat Muscedere J, Rewa O, McKechnie K et al (2011) Subglottic secretion drainage for the prevention of ventilator-associated pneumonia: a systematic review and meta-analysis. Crit Care Med 39:1985–1991PubMed Muscedere J, Rewa O, McKechnie K et al (2011) Subglottic secretion drainage for the prevention of ventilator-associated pneumonia: a systematic review and meta-analysis. Crit Care Med 39:1985–1991PubMed
81.
Zurück zum Zitat Wang F, Bo L, Tang L et al (2012) Subglottic secretion drainage for preventing ventilator-associated pneumonia: an updated meta-analysis of randomized controlled trials. J Trauma Acute Care Surg 72:1276–1285PubMed Wang F, Bo L, Tang L et al (2012) Subglottic secretion drainage for preventing ventilator-associated pneumonia: an updated meta-analysis of randomized controlled trials. J Trauma Acute Care Surg 72:1276–1285PubMed
82.
Zurück zum Zitat Lorente L, Blot S, Rello J (2010) New issues and controversies in the prevention of ventilator-associated pneumonia. Am J Respir Crit Care Med 182:870–876PubMed Lorente L, Blot S, Rello J (2010) New issues and controversies in the prevention of ventilator-associated pneumonia. Am J Respir Crit Care Med 182:870–876PubMed
83.
Zurück zum Zitat Dillier CM, Trachsel D, Baulig W et al (2004) Laryngeal damage due to an unexpectedly large and inappropriately designed cuffed pediatric tracheal tube in a 13-month-old child. Can J Anaesth 51:72–75PubMed Dillier CM, Trachsel D, Baulig W et al (2004) Laryngeal damage due to an unexpectedly large and inappropriately designed cuffed pediatric tracheal tube in a 13-month-old child. Can J Anaesth 51:72–75PubMed
84.
Zurück zum Zitat Holzki J, Laschat M, Puder C (2009) Stridor is not a scientifically valid outcome measure for assessing airway injury. Paediatr Anaesth 19(Suppl 1):180–197PubMed Holzki J, Laschat M, Puder C (2009) Stridor is not a scientifically valid outcome measure for assessing airway injury. Paediatr Anaesth 19(Suppl 1):180–197PubMed
85.
Zurück zum Zitat Flynn PE, Black AE, Mitchell V (2008) The use of cuffed tracheal tubes for paediatric tracheal intubation, a survey of specialist practice in the United Kingdom. Eur J Anaesthesiol 25:685–688PubMed Flynn PE, Black AE, Mitchell V (2008) The use of cuffed tracheal tubes for paediatric tracheal intubation, a survey of specialist practice in the United Kingdom. Eur J Anaesthesiol 25:685–688PubMed
86.
Zurück zum Zitat Weber T, Salvi N, Orliaguet G, Wolf A (2009) Cuffed vs non-cuffed endotracheal tubes for pediatric anesthesia. Paediatr Anaesth 19(Suppl 1):46–54PubMed Weber T, Salvi N, Orliaguet G, Wolf A (2009) Cuffed vs non-cuffed endotracheal tubes for pediatric anesthesia. Paediatr Anaesth 19(Suppl 1):46–54PubMed
87.
Zurück zum Zitat Khine HH, Corddry DH, Kettrick RG et al (1997) Comparison of cuffed and uncuffed endotracheal tubes in young children during general anesthesia. Anesthesiology 86:627–631 (discussion 627A)PubMed Khine HH, Corddry DH, Kettrick RG et al (1997) Comparison of cuffed and uncuffed endotracheal tubes in young children during general anesthesia. Anesthesiology 86:627–631 (discussion 627A)PubMed
88.
Zurück zum Zitat Weiss M, Dullenkopf A, Fischer JE et al (2009) Prospective randomized controlled multi-centre trial of cuffed or uncuffed endotracheal tubes in small children. Br J Anaesth 103:867–873PubMed Weiss M, Dullenkopf A, Fischer JE et al (2009) Prospective randomized controlled multi-centre trial of cuffed or uncuffed endotracheal tubes in small children. Br J Anaesth 103:867–873PubMed
89.
Zurück zum Zitat Gopalareddy V, He Z, Soundar S et al (2008) Assessment of the prevalence of microaspiration by gastric pepsin in the airway of ventilated children. Acta Paediatr 97:55–60PubMed Gopalareddy V, He Z, Soundar S et al (2008) Assessment of the prevalence of microaspiration by gastric pepsin in the airway of ventilated children. Acta Paediatr 97:55–60PubMed
90.
Zurück zum Zitat Ashtekar CS, Wardhaugh A (2005) Do cuffed endotracheal tubes increase the risk of airway mucosal injury and post-extubation stridor in children? Arch Dis Child 90:1198–1199PubMed Ashtekar CS, Wardhaugh A (2005) Do cuffed endotracheal tubes increase the risk of airway mucosal injury and post-extubation stridor in children? Arch Dis Child 90:1198–1199PubMed
91.
Zurück zum Zitat Dullenkopf A, Bernet-Buettiker V, Maino P, Weiss M (2006) Performance of a novel pressure release valve for cuff pressure control in pediatric tracheal tubes. Paediatr Anaesth 16:19–24PubMed Dullenkopf A, Bernet-Buettiker V, Maino P, Weiss M (2006) Performance of a novel pressure release valve for cuff pressure control in pediatric tracheal tubes. Paediatr Anaesth 16:19–24PubMed
92.
Zurück zum Zitat Fertl S, Bernet V, Schmitz A et al (2009) Clinical evaluation of a pressure release valve for paediatric cuffed tracheal tubes. Anaesthesist 58:16–23PubMed Fertl S, Bernet V, Schmitz A et al (2009) Clinical evaluation of a pressure release valve for paediatric cuffed tracheal tubes. Anaesthesist 58:16–23PubMed
93.
Zurück zum Zitat Deakers TW, Reynolds G, Stretton M, Newth CJ (1994) Cuffed endotracheal tubes in pediatric intensive care. J Pediatr 125:57–62PubMed Deakers TW, Reynolds G, Stretton M, Newth CJ (1994) Cuffed endotracheal tubes in pediatric intensive care. J Pediatr 125:57–62PubMed
94.
Zurück zum Zitat Newth CJ, Rachman B, Patel N, Hammer J (2004) The use of cuffed versus uncuffed endotracheal tubes in pediatric intensive care. J Pediatr 144:333–337PubMed Newth CJ, Rachman B, Patel N, Hammer J (2004) The use of cuffed versus uncuffed endotracheal tubes in pediatric intensive care. J Pediatr 144:333–337PubMed
95.
Zurück zum Zitat Weiss M, Dullenkopf A (2007) Cuffed tracheal tubes in children: past, present and future. Expert Rev Med Devices 4:73–82PubMed Weiss M, Dullenkopf A (2007) Cuffed tracheal tubes in children: past, present and future. Expert Rev Med Devices 4:73–82PubMed
96.
Zurück zum Zitat Weiss M, Gerber AC, Dullenkopf A (2005) Appropriate placement of intubation depth marks in a new cuffed paediatric tracheal tube. Br J Anaesth 94:80–87PubMed Weiss M, Gerber AC, Dullenkopf A (2005) Appropriate placement of intubation depth marks in a new cuffed paediatric tracheal tube. Br J Anaesth 94:80–87PubMed
97.
Zurück zum Zitat Simon A, Tutdibi L, Müller L von, Gortner L (2011) Beatmungsassoziierte Pneumonie bei Kindern. Monatsschr Kinderheilkd 159:224–232 Simon A, Tutdibi L, Müller L von, Gortner L (2011) Beatmungsassoziierte Pneumonie bei Kindern. Monatsschr Kinderheilkd 159:224–232
98.
Zurück zum Zitat Cereda M, Villa F, Colombo E et al (2001) Closed system endotracheal suctioning maintains lung volume during volume-controlled mechanical ventilation. Intensive Care Med 27:648–654PubMed Cereda M, Villa F, Colombo E et al (2001) Closed system endotracheal suctioning maintains lung volume during volume-controlled mechanical ventilation. Intensive Care Med 27:648–654PubMed
99.
Zurück zum Zitat Cobley M, Atkins M, Jones PL (1991) Environmental contamination during tracheal suction. A comparison of disposable conventional catheters with a multiple-use closed system device. Anaesthesia 46:957–961PubMed Cobley M, Atkins M, Jones PL (1991) Environmental contamination during tracheal suction. A comparison of disposable conventional catheters with a multiple-use closed system device. Anaesthesia 46:957–961PubMed
100.
Zurück zum Zitat Vonberg RP, Eckmanns T, Welte T, Gastmeier P (2006) Impact of the suctioning system (open vs. closed) on the incidence of ventilation-associated pneumonia: meta-analysis of randomized controlled trials. Intensive Care Med 32:1329–1335PubMed Vonberg RP, Eckmanns T, Welte T, Gastmeier P (2006) Impact of the suctioning system (open vs. closed) on the incidence of ventilation-associated pneumonia: meta-analysis of randomized controlled trials. Intensive Care Med 32:1329–1335PubMed
101.
Zurück zum Zitat Deppe SA, Kelly JW, Thoi LL et al (1990) Incidence of colonization, nosocomial pneumonia, and mortality in critically ill patients using a Trach Care closed-suction system versus an open-suction system: prospective, randomized study. Crit Care Med 18:1389–1393PubMed Deppe SA, Kelly JW, Thoi LL et al (1990) Incidence of colonization, nosocomial pneumonia, and mortality in critically ill patients using a Trach Care closed-suction system versus an open-suction system: prospective, randomized study. Crit Care Med 18:1389–1393PubMed
102.
Zurück zum Zitat Johnson KL, Kearney PA, Johnson SB et al (1994) Closed versus open endotracheal suctioning: costs and physiologic consequences. Crit Care Med 22:658–666PubMed Johnson KL, Kearney PA, Johnson SB et al (1994) Closed versus open endotracheal suctioning: costs and physiologic consequences. Crit Care Med 22:658–666PubMed
103.
Zurück zum Zitat Jongerden IP, Rovers MM, Grypdonck MH, Bonten MJ (2007) Open and closed endotracheal suction systems in mechanically ventilated intensive care patients: a meta-analysis. Crit Care Med 35:260–270PubMed Jongerden IP, Rovers MM, Grypdonck MH, Bonten MJ (2007) Open and closed endotracheal suction systems in mechanically ventilated intensive care patients: a meta-analysis. Crit Care Med 35:260–270PubMed
104.
Zurück zum Zitat Niel-Weise BS, Snoeren RL, Broek PJ van den (2007) Policies for endotracheal suctioning of patients receiving mechanical ventilation: a systematic review of randomized controlled trials. Infect Control Hosp Epidemiol 28:531–536PubMed Niel-Weise BS, Snoeren RL, Broek PJ van den (2007) Policies for endotracheal suctioning of patients receiving mechanical ventilation: a systematic review of randomized controlled trials. Infect Control Hosp Epidemiol 28:531–536PubMed
105.
Zurück zum Zitat Rabitsch W, Kostler WJ, Fiebiger W et al (2004) Closed suctioning system reduces cross-contamination between bronchial system and gastric juices. Anesth Analg 99:886–892PubMed Rabitsch W, Kostler WJ, Fiebiger W et al (2004) Closed suctioning system reduces cross-contamination between bronchial system and gastric juices. Anesth Analg 99:886–892PubMed
106.
Zurück zum Zitat Siempos II, Vardakas KZ, Falagas ME (2008) Closed tracheal suction systems for prevention of ventilator-associated pneumonia. Br J Anaesth 100:299–306PubMed Siempos II, Vardakas KZ, Falagas ME (2008) Closed tracheal suction systems for prevention of ventilator-associated pneumonia. Br J Anaesth 100:299–306PubMed
107.
Zurück zum Zitat Subirana M, Sola I, Benito S (2007) Closed tracheal suction systems versus open tracheal suction systems for mechanically ventilated adult patients. Cochrane Database Syst Rev CD004581 Subirana M, Sola I, Benito S (2007) Closed tracheal suction systems versus open tracheal suction systems for mechanically ventilated adult patients. Cochrane Database Syst Rev CD004581
108.
Zurück zum Zitat Zeitoun SS, Barros AL de, Diccini S (2003) A prospective, randomized study of ventilator-associated pneumonia in patients using a closed vs. open suction system. J Clin Nurs 12:484–489PubMed Zeitoun SS, Barros AL de, Diccini S (2003) A prospective, randomized study of ventilator-associated pneumonia in patients using a closed vs. open suction system. J Clin Nurs 12:484–489PubMed
109.
Zurück zum Zitat Darvas JA, Hawkins LG (2003) The closed tracheal suction catheter: 24 hour or 48 hour change? Aust Crit Care 16:86–92PubMed Darvas JA, Hawkins LG (2003) The closed tracheal suction catheter: 24 hour or 48 hour change? Aust Crit Care 16:86–92PubMed
110.
Zurück zum Zitat Quirke S (1998) A comparative study of the incidence of nosocomial colonisation in patients with closed suction catheter changes at 24 versus 48 hours. Care Critically Ill 14:116–120 Quirke S (1998) A comparative study of the incidence of nosocomial colonisation in patients with closed suction catheter changes at 24 versus 48 hours. Care Critically Ill 14:116–120
111.
Zurück zum Zitat Stoller JK, Orens DK, Fatica C et al (2003) Weekly versus daily changes of in-line suction catheters: impact on rates of ventilator-associated pneumonia and associated costs. Respir Care 48:494–499PubMed Stoller JK, Orens DK, Fatica C et al (2003) Weekly versus daily changes of in-line suction catheters: impact on rates of ventilator-associated pneumonia and associated costs. Respir Care 48:494–499PubMed
112.
Zurück zum Zitat Freytag CC, Thies FL, Konig W, Welte T (2003) Prolonged application of closed in-line suction catheters increases microbial colonization of the lower respiratory tract and bacterial growth on catheter surface. Infection 31:31–37PubMed Freytag CC, Thies FL, Konig W, Welte T (2003) Prolonged application of closed in-line suction catheters increases microbial colonization of the lower respiratory tract and bacterial growth on catheter surface. Infection 31:31–37PubMed
113.
Zurück zum Zitat Lorente L, Lecuona M, Jimenez A et al (2006) Tracheal suction by closed system without daily change versus open system. Intensive Care Med 32:538–544PubMed Lorente L, Lecuona M, Jimenez A et al (2006) Tracheal suction by closed system without daily change versus open system. Intensive Care Med 32:538–544PubMed
114.
Zurück zum Zitat Kollef MH (2004) Prevention of hospital-associated pneumonia and ventilator-associated pneumonia. Crit Care Med 32:1396–1405PubMed Kollef MH (2004) Prevention of hospital-associated pneumonia and ventilator-associated pneumonia. Crit Care Med 32:1396–1405PubMed
115.
Zurück zum Zitat Estivariz CF, Bhatti LI, Pati R et al (2006) An outbreak of Burkholderia cepacia associated with contamination of albuterol and nasal spray. Chest 130:1346–1353PubMed Estivariz CF, Bhatti LI, Pati R et al (2006) An outbreak of Burkholderia cepacia associated with contamination of albuterol and nasal spray. Chest 130:1346–1353PubMed
116.
Zurück zum Zitat Holzapfel L, Chastang C, Demingeon G et al (1999) A randomized study assessing the systematic search for maxillary sinusitis in nasotracheally mechanically ventilated patients. Influence of nosocomial maxillary sinusitis on the occurrence of ventilator-associated pneumonia. Am J Respir Crit Care Med 159:695–701PubMed Holzapfel L, Chastang C, Demingeon G et al (1999) A randomized study assessing the systematic search for maxillary sinusitis in nasotracheally mechanically ventilated patients. Influence of nosocomial maxillary sinusitis on the occurrence of ventilator-associated pneumonia. Am J Respir Crit Care Med 159:695–701PubMed
117.
Zurück zum Zitat Koenig SM, Truwit JD (2006) Ventilator-associated pneumonia: diagnosis, treatment, and prevention. Clin Microbiol Rev 19:637–657PubMed Koenig SM, Truwit JD (2006) Ventilator-associated pneumonia: diagnosis, treatment, and prevention. Clin Microbiol Rev 19:637–657PubMed
118.
Zurück zum Zitat Agrafiotis M, Vardakas KZ, Gkegkes ID et al (2012) Ventilator-associated sinusitis in adults: systematic review and meta-analysis. Respir Med 106:1082–1095PubMed Agrafiotis M, Vardakas KZ, Gkegkes ID et al (2012) Ventilator-associated sinusitis in adults: systematic review and meta-analysis. Respir Med 106:1082–1095PubMed
119.
Zurück zum Zitat Bishop MJ (1989) Mechanisms of laryngotracheal injury following prolonged tracheal intubation. Chest 96:185–186PubMed Bishop MJ (1989) Mechanisms of laryngotracheal injury following prolonged tracheal intubation. Chest 96:185–186PubMed
120.
Zurück zum Zitat Colice GL, Stukel TA, Dain B (1989) Laryngeal complications of prolonged intubation. Chest 96:877–884PubMed Colice GL, Stukel TA, Dain B (1989) Laryngeal complications of prolonged intubation. Chest 96:877–884PubMed
121.
Zurück zum Zitat Kastanos N, Estopa Miro R, Marin Perez A et al (1983) Laryngotracheal injury due to endotracheal intubation: incidence, evolution, and predisposing factors. A prospective long-term study. Crit Care Med 11:362–367PubMed Kastanos N, Estopa Miro R, Marin Perez A et al (1983) Laryngotracheal injury due to endotracheal intubation: incidence, evolution, and predisposing factors. A prospective long-term study. Crit Care Med 11:362–367PubMed
122.
Zurück zum Zitat Wang F, Wu Y, Bo L et al (2011) The timing of tracheotomy in critically ill patients undergoing mechanical ventilation: a systematic review and meta-analysis of randomized controlled trials. Chest 140:1456–1465PubMed Wang F, Wu Y, Bo L et al (2011) The timing of tracheotomy in critically ill patients undergoing mechanical ventilation: a systematic review and meta-analysis of randomized controlled trials. Chest 140:1456–1465PubMed
123.
Zurück zum Zitat Young D, Harrison DA, Cuthbertson BH et al (2013) Effect of early vs late tracheostomy placement on survival in patients receiving mechanical ventilation: the TracMan randomized trial. JAMA 309:2121–2129PubMed Young D, Harrison DA, Cuthbertson BH et al (2013) Effect of early vs late tracheostomy placement on survival in patients receiving mechanical ventilation: the TracMan randomized trial. JAMA 309:2121–2129PubMed
124.
Zurück zum Zitat Rumbak MJ, Newton M, Truncale T et al (2004) A prospective, randomized, study comparing early percutaneous dilational tracheotomy to prolonged translaryngeal intubation (delayed tracheotomy) in critically ill medical patients. Crit Care Med 32:1689–1694PubMed Rumbak MJ, Newton M, Truncale T et al (2004) A prospective, randomized, study comparing early percutaneous dilational tracheotomy to prolonged translaryngeal intubation (delayed tracheotomy) in critically ill medical patients. Crit Care Med 32:1689–1694PubMed
125.
Zurück zum Zitat Trouillet JL, Luyt CE, Guiguet M et al (2011) Early percutaneous tracheotomy versus prolonged intubation of mechanically ventilated patients after cardiac surgery: a randomized trial. Ann Intern Med 154:373–383PubMed Trouillet JL, Luyt CE, Guiguet M et al (2011) Early percutaneous tracheotomy versus prolonged intubation of mechanically ventilated patients after cardiac surgery: a randomized trial. Ann Intern Med 154:373–383PubMed
126.
Zurück zum Zitat Burns KE, Adhikari NK, Keenan SP, Meade M (2009) Use of non-invasive ventilation to wean critically ill adults off invasive ventilation: meta-analysis and systematic review. BMJ 338:b1574PubMed Burns KE, Adhikari NK, Keenan SP, Meade M (2009) Use of non-invasive ventilation to wean critically ill adults off invasive ventilation: meta-analysis and systematic review. BMJ 338:b1574PubMed
127.
Zurück zum Zitat Carlucci A, Richard JC, Wysocki M et al (2001) Noninvasive versus conventional mechanical ventilation. An epidemiologic survey. Am J Respir Crit Care Med 163:874–880PubMed Carlucci A, Richard JC, Wysocki M et al (2001) Noninvasive versus conventional mechanical ventilation. An epidemiologic survey. Am J Respir Crit Care Med 163:874–880PubMed
128.
Zurück zum Zitat Essouri S, Chevret L, Durand P et al (2006) Noninvasive positive pressure ventilation: five years of experience in a pediatric intensive care unit. Pediatr Crit Care Med 7:329–334PubMed Essouri S, Chevret L, Durand P et al (2006) Noninvasive positive pressure ventilation: five years of experience in a pediatric intensive care unit. Pediatr Crit Care Med 7:329–334PubMed
129.
Zurück zum Zitat Javouhey E, Barats A, Richard N et al (2008) Non-invasive ventilation as primary ventilatory support for infants with severe bronchiolitis. Intensive Care Med 34:1608–1614PubMed Javouhey E, Barats A, Richard N et al (2008) Non-invasive ventilation as primary ventilatory support for infants with severe bronchiolitis. Intensive Care Med 34:1608–1614PubMed
130.
Zurück zum Zitat Bernet V, Hug MI, Frey B (2005) Predictive factors for the success of noninvasive mask ventilation in infants and children with acute respiratory failure. Pediatr Crit Care Med 6:660–664PubMed Bernet V, Hug MI, Frey B (2005) Predictive factors for the success of noninvasive mask ventilation in infants and children with acute respiratory failure. Pediatr Crit Care Med 6:660–664PubMed
131.
Zurück zum Zitat Yanez LJ, Yunge M, Emilfork M et al (2008) A prospective, randomized, controlled trial of noninvasive ventilation in pediatric acute respiratory failure. Pediatr Crit Care Med 9:484–489PubMed Yanez LJ, Yunge M, Emilfork M et al (2008) A prospective, randomized, controlled trial of noninvasive ventilation in pediatric acute respiratory failure. Pediatr Crit Care Med 9:484–489PubMed
132.
Zurück zum Zitat Pancera CF, Hayashi M, Fregnani JH et al (2008) Noninvasive ventilation in immunocompromised pediatric patients: eight years of experience in a pediatric oncology intensive care unit. J Pediatr Hematol Oncol 30:533–538PubMed Pancera CF, Hayashi M, Fregnani JH et al (2008) Noninvasive ventilation in immunocompromised pediatric patients: eight years of experience in a pediatric oncology intensive care unit. J Pediatr Hematol Oncol 30:533–538PubMed
133.
Zurück zum Zitat Drakulovic MB, Torres A, Bauer TT et al (1999) Supine body position as a risk factor for nosocomial pneumonia in mechanically ventilated patients: a randomised trial. Lancet 354:1851–1858PubMed Drakulovic MB, Torres A, Bauer TT et al (1999) Supine body position as a risk factor for nosocomial pneumonia in mechanically ventilated patients: a randomised trial. Lancet 354:1851–1858PubMed
134.
Zurück zum Zitat Nieuwenhoven CA van, Vandenbroucke-Grauls C, Tiel FH van et al (2006) Feasibility and effects of the semirecumbent position to prevent ventilator-associated pneumonia: a randomized study. Crit Care Med 34:396–402PubMed Nieuwenhoven CA van, Vandenbroucke-Grauls C, Tiel FH van et al (2006) Feasibility and effects of the semirecumbent position to prevent ventilator-associated pneumonia: a randomized study. Crit Care Med 34:396–402PubMed
135.
Zurück zum Zitat Burk RS, Grap MJ (2012) Backrest position in prevention of pressure ulcers and ventilator-associated pneumonia: conflicting recommendations. Heart Lung 41:536–545PubMed Burk RS, Grap MJ (2012) Backrest position in prevention of pressure ulcers and ventilator-associated pneumonia: conflicting recommendations. Heart Lung 41:536–545PubMed
136.
Zurück zum Zitat Loan HT, Parry J, Nga NT et al (2012) Semi-recumbent body position fails to prevent healthcare-associated pneumonia in Vietnamese patients with severe tetanus. Trans R Soc Trop Med Hyg 106:90–97PubMed Loan HT, Parry J, Nga NT et al (2012) Semi-recumbent body position fails to prevent healthcare-associated pneumonia in Vietnamese patients with severe tetanus. Trans R Soc Trop Med Hyg 106:90–97PubMed
137.
Zurück zum Zitat Institute for Healthcare Improvement (2012) How-to guide: prevent ventilator-associated pneumonia. http://www.ihi.org/knowledge/Pages/Tools/HowtoGuidePreventVAP.aspx Institute for Healthcare Improvement (2012) How-to guide: prevent ventilator-associated pneumonia. http://​www.​ihi.​org/​knowledge/​Pages/​Tools/​HowtoGuidePreven​tVAP.​aspx
138.
Zurück zum Zitat Niel-Weise BS, Gastmeier P, Kola A et al (2011) An evidence-based recommendation on bed head elevation for mechanically ventilated patients. Crit Care 15:R111PubMed Niel-Weise BS, Gastmeier P, Kola A et al (2011) An evidence-based recommendation on bed head elevation for mechanically ventilated patients. Crit Care 15:R111PubMed
139.
Zurück zum Zitat Delaney A, Gray H, Laupland KB, Zuege DJ (2006) Kinetic bed therapy to prevent nosocomial pneumonia in mechanically ventilated patients: a systematic review and meta-analysis. Crit Care 10:R70PubMed Delaney A, Gray H, Laupland KB, Zuege DJ (2006) Kinetic bed therapy to prevent nosocomial pneumonia in mechanically ventilated patients: a systematic review and meta-analysis. Crit Care 10:R70PubMed
140.
Zurück zum Zitat Houston S, Hougland P, Anderson JJ et al (2002) Effectiveness of 0.12 % chlorhexidine gluconate oral rinse in reducing prevalence of nosocomial pneumonia in patients undergoing heart surgery. Am J Crit Care 11:567–570PubMed Houston S, Hougland P, Anderson JJ et al (2002) Effectiveness of 0.12 % chlorhexidine gluconate oral rinse in reducing prevalence of nosocomial pneumonia in patients undergoing heart surgery. Am J Crit Care 11:567–570PubMed
141.
Zurück zum Zitat Pineda LA, Saliba RG, El Solh AA (2006) Effect of oral decontamination with chlorhexidine on the incidence of nosocomial pneumonia: a meta-analysis. Crit Care 10:R35PubMed Pineda LA, Saliba RG, El Solh AA (2006) Effect of oral decontamination with chlorhexidine on the incidence of nosocomial pneumonia: a meta-analysis. Crit Care 10:R35PubMed
142.
Zurück zum Zitat Labeau SO, Van de Vyver K, Brusselaers N et al (2011) Prevention of ventilator-associated pneumonia with oral antiseptics: a systematic review and meta-analysis. Lancet Infect Dis 11:845–854PubMed Labeau SO, Van de Vyver K, Brusselaers N et al (2011) Prevention of ventilator-associated pneumonia with oral antiseptics: a systematic review and meta-analysis. Lancet Infect Dis 11:845–854PubMed
143.
Zurück zum Zitat Tantipong H, Morkchareonpong C, Jaiyindee S, Thamlikitkul V (2008) Randomized controlled trial and meta-analysis of oral decontamination with 2 % chlorhexidine solution for the prevention of ventilator-associated pneumonia. Infect Control Hosp Epidemiol 29:131–136PubMed Tantipong H, Morkchareonpong C, Jaiyindee S, Thamlikitkul V (2008) Randomized controlled trial and meta-analysis of oral decontamination with 2 % chlorhexidine solution for the prevention of ventilator-associated pneumonia. Infect Control Hosp Epidemiol 29:131–136PubMed
144.
Zurück zum Zitat Mori H, Hirasawa H, Oda S et al (2006) Oral care reduces incidence of ventilator-associated pneumonia in ICU populations. Intensive Care Med 32:230–236PubMed Mori H, Hirasawa H, Oda S et al (2006) Oral care reduces incidence of ventilator-associated pneumonia in ICU populations. Intensive Care Med 32:230–236PubMed
145.
Zurück zum Zitat Chan EY, Ruest A, Meade MO, Cook DJ (2007) Oral decontamination for prevention of pneumonia in mechanically ventilated adults: systematic review and meta-analysis. BMJ 334:889PubMed Chan EY, Ruest A, Meade MO, Cook DJ (2007) Oral decontamination for prevention of pneumonia in mechanically ventilated adults: systematic review and meta-analysis. BMJ 334:889PubMed
146.
Zurück zum Zitat Chlebicki MP, Safdar N (2007) Topical chlorhexidine for prevention of ventilator-associated pneumonia: a meta-analysis. Crit Care Med 35:595–602PubMed Chlebicki MP, Safdar N (2007) Topical chlorhexidine for prevention of ventilator-associated pneumonia: a meta-analysis. Crit Care Med 35:595–602PubMed
147.
Zurück zum Zitat Kola A, Gastmeier P (2007) Efficacy of oral chlorhexidine in preventing lower respiratory tract infections. Meta-analysis of randomized controlled trials. J Hosp Infect 66:207–216PubMed Kola A, Gastmeier P (2007) Efficacy of oral chlorhexidine in preventing lower respiratory tract infections. Meta-analysis of randomized controlled trials. J Hosp Infect 66:207–216PubMed
148.
Zurück zum Zitat Gu WJ, Gong YZ, Pan L et al (2012) Impact of oral care with versus without toothbrushing on the prevention of ventilator-associated pneumonia: a systematic review and meta-analysis of randomized controlled trials. Crit Care 16:R190PubMed Gu WJ, Gong YZ, Pan L et al (2012) Impact of oral care with versus without toothbrushing on the prevention of ventilator-associated pneumonia: a systematic review and meta-analysis of randomized controlled trials. Crit Care 16:R190PubMed
149.
Zurück zum Zitat Alhazzani W, Smith O, Muscedere J et al (2013) Toothbrushing for critically ill mechanically ventilated patients: a systematic review and meta-analysis of randomized trials evaluating ventilator-associated pneumonia. Crit Care Med 41:646–655PubMed Alhazzani W, Smith O, Muscedere J et al (2013) Toothbrushing for critically ill mechanically ventilated patients: a systematic review and meta-analysis of randomized trials evaluating ventilator-associated pneumonia. Crit Care Med 41:646–655PubMed
150.
Zurück zum Zitat Artinian V, Krayem H, DiGiovine B (2006) Effects of early enteral feeding on the outcome of critically ill mechanically ventilated medical patients. Chest 129:960–967PubMed Artinian V, Krayem H, DiGiovine B (2006) Effects of early enteral feeding on the outcome of critically ill mechanically ventilated medical patients. Chest 129:960–967PubMed
151.
Zurück zum Zitat Chen YC (2009) Critical analysis of the factors associated with enteral feeding in preventing VAP: a systematic review. J Chin Med Assoc 72:171–178PubMed Chen YC (2009) Critical analysis of the factors associated with enteral feeding in preventing VAP: a systematic review. J Chin Med Assoc 72:171–178PubMed
152.
Zurück zum Zitat Gramlich L, Kichian K, Pinilla J et al (2004) Does enteral nutrition compared to parenteral nutrition result in better outcomes in critically ill adult patients? A systematic review of the literature. Nutrition 20:843–848PubMed Gramlich L, Kichian K, Pinilla J et al (2004) Does enteral nutrition compared to parenteral nutrition result in better outcomes in critically ill adult patients? A systematic review of the literature. Nutrition 20:843–848PubMed
153.
Zurück zum Zitat Kreymann KG, Berger MM, Deutz NE et al (2006) ESPEN Guidelines on Enteral Nutrition: intensive care. Clin Nutr 25:210–223PubMed Kreymann KG, Berger MM, Deutz NE et al (2006) ESPEN Guidelines on Enteral Nutrition: intensive care. Clin Nutr 25:210–223PubMed
154.
Zurück zum Zitat Hsu CW, Sun SF, Lin SL et al (2009) Duodenal versus gastric feeding in medical intensive care unit patients: a prospective, randomized, clinical study. Crit Care Med 37:1866–1872PubMed Hsu CW, Sun SF, Lin SL et al (2009) Duodenal versus gastric feeding in medical intensive care unit patients: a prospective, randomized, clinical study. Crit Care Med 37:1866–1872PubMed
155.
Zurück zum Zitat Heyland DK, Drover JW, Dhaliwal R, Greenwood J (2002) Optimizing the benefits and minimizing the risks of enteral nutrition in the critically ill: role of small bowel feeding. J Parenter Enteral Nutr 26:S51–S55 (discussion S56–S57) Heyland DK, Drover JW, Dhaliwal R, Greenwood J (2002) Optimizing the benefits and minimizing the risks of enteral nutrition in the critically ill: role of small bowel feeding. J Parenter Enteral Nutr 26:S51–S55 (discussion S56–S57)
156.
Zurück zum Zitat Marik PE, Zaloga GP (2003) Gastric versus post-pyloric feeding: a systematic review. Crit Care 7:R46–51PubMed Marik PE, Zaloga GP (2003) Gastric versus post-pyloric feeding: a systematic review. Crit Care 7:R46–51PubMed
157.
Zurück zum Zitat Reignier J, Mercier E, Le Gouge A et al (2013) Effect of not monitoring residual gastric volume on risk of ventilator-associated pneumonia in adults receiving mechanical ventilation and early enteral feeding: a randomized controlled trial. JAMA 309:249–256PubMed Reignier J, Mercier E, Le Gouge A et al (2013) Effect of not monitoring residual gastric volume on risk of ventilator-associated pneumonia in adults receiving mechanical ventilation and early enteral feeding: a randomized controlled trial. JAMA 309:249–256PubMed
158.
Zurück zum Zitat Alhazzani W, Almasoud A, Jaeschke R et al (2013) Small bowel feeding and risk of pneumonia in adult critically ill patients: a systematic review and meta-analysis of randomized trials. Crit Care 17:R127PubMed Alhazzani W, Almasoud A, Jaeschke R et al (2013) Small bowel feeding and risk of pneumonia in adult critically ill patients: a systematic review and meta-analysis of randomized trials. Crit Care 17:R127PubMed
159.
Zurück zum Zitat Siempos II, Ntaidou TK, Falagas ME (2010) Impact of the administration of probiotics on the incidence of ventilator-associated pneumonia: a meta-analysis of randomized controlled trials. Crit Care Med 38:954–962PubMed Siempos II, Ntaidou TK, Falagas ME (2010) Impact of the administration of probiotics on the incidence of ventilator-associated pneumonia: a meta-analysis of randomized controlled trials. Crit Care Med 38:954–962PubMed
160.
Zurück zum Zitat Schultz MJ, Haas LE (2011) Antibiotics or probiotics as preventive measures against ventilator-associated pneumonia: a literature review. Crit Care 15:R18PubMed Schultz MJ, Haas LE (2011) Antibiotics or probiotics as preventive measures against ventilator-associated pneumonia: a literature review. Crit Care 15:R18PubMed
161.
Zurück zum Zitat Kotzampassi K, Giamarellos-Bourboulis EJ, Voudouris A et al (2006) Benefits of a synbiotic formula (Synbiotic 2000Forte) in critically ill trauma patients: early results of a randomized controlled trial. World J Surg 30:1848–1855PubMed Kotzampassi K, Giamarellos-Bourboulis EJ, Voudouris A et al (2006) Benefits of a synbiotic formula (Synbiotic 2000Forte) in critically ill trauma patients: early results of a randomized controlled trial. World J Surg 30:1848–1855PubMed
162.
Zurück zum Zitat Morrow LE, Kollef MH, Casale TB (2010) Probiotic prophylaxis of ventilator-associated pneumonia: a blinded, randomized, controlled trial. Am J Respir Crit Care Med 182:1058–1064PubMed Morrow LE, Kollef MH, Casale TB (2010) Probiotic prophylaxis of ventilator-associated pneumonia: a blinded, randomized, controlled trial. Am J Respir Crit Care Med 182:1058–1064PubMed
163.
Zurück zum Zitat Spindler-Vesel A, Bengmark S, Vovk I et al (2007) Synbiotics, prebiotics, glutamine, or peptide in early enteral nutrition: a randomized study in trauma patients. JPEN J Parenter Enteral Nutr 31:119–126PubMed Spindler-Vesel A, Bengmark S, Vovk I et al (2007) Synbiotics, prebiotics, glutamine, or peptide in early enteral nutrition: a randomized study in trauma patients. JPEN J Parenter Enteral Nutr 31:119–126PubMed
164.
Zurück zum Zitat Petrof EO, Dhaliwal R, Manzanares W et al (2012) Probiotics in the critically ill: a systematic review of the randomized trial evidence. Crit Care Med 40:3290–3302PubMed Petrof EO, Dhaliwal R, Manzanares W et al (2012) Probiotics in the critically ill: a systematic review of the randomized trial evidence. Crit Care Med 40:3290–3302PubMed
165.
Zurück zum Zitat Borriello SP, Hammes WP, Holzapfel W et al (2003) Safety of probiotics that contain lactobacilli or bifidobacteria. Clin Infect Dis 36:775–780PubMed Borriello SP, Hammes WP, Holzapfel W et al (2003) Safety of probiotics that contain lactobacilli or bifidobacteria. Clin Infect Dis 36:775–780PubMed
166.
Zurück zum Zitat Cassone M, Serra P, Mondello F et al (2003) Outbreak of Saccharomyces cerevisiae subtype boulardii fungemia in patients neighboring those treated with a probiotic preparation of the organism. J Clin Microbiol 41:5340–5343PubMed Cassone M, Serra P, Mondello F et al (2003) Outbreak of Saccharomyces cerevisiae subtype boulardii fungemia in patients neighboring those treated with a probiotic preparation of the organism. J Clin Microbiol 41:5340–5343PubMed
167.
Zurück zum Zitat Munoz P, Bouza E, Cuenca-Estrella M et al (2005) Saccharomyces cerevisiae fungemia: an emerging infectious disease. Clin Infect Dis 40:1625–1634PubMed Munoz P, Bouza E, Cuenca-Estrella M et al (2005) Saccharomyces cerevisiae fungemia: an emerging infectious disease. Clin Infect Dis 40:1625–1634PubMed
168.
Zurück zum Zitat Trialists‘ Collaborative Group (1993) Meta-analysis of randomised controlled trials of selective decontamination of the digestive tract. Selective decontamination of the digestive tract. BMJ 307:525–532 Trialists‘ Collaborative Group (1993) Meta-analysis of randomised controlled trials of selective decontamination of the digestive tract. Selective decontamination of the digestive tract. BMJ 307:525–532
169.
Zurück zum Zitat Agrafiotis M, Siempos II, Falagas ME (2010) Frequency, prevention, outcome and treatment of ventilator-associated tracheobronchitis: systematic review and meta-analysis. Respir Med 104:325–336PubMed Agrafiotis M, Siempos II, Falagas ME (2010) Frequency, prevention, outcome and treatment of ventilator-associated tracheobronchitis: systematic review and meta-analysis. Respir Med 104:325–336PubMed
170.
Zurück zum Zitat Hurley JC (1995) Prophylaxis with enteral antibiotics in ventilated patients: selective decontamination or selective cross-infection? Antimicrob Agents Chemother 39:941–947PubMed Hurley JC (1995) Prophylaxis with enteral antibiotics in ventilated patients: selective decontamination or selective cross-infection? Antimicrob Agents Chemother 39:941–947PubMed
171.
Zurück zum Zitat Kollef MH (1994) The role of selective digestive tract decontamination on mortality and respiratory tract infections. A meta-analysis. Chest 105:1101–1108PubMed Kollef MH (1994) The role of selective digestive tract decontamination on mortality and respiratory tract infections. A meta-analysis. Chest 105:1101–1108PubMed
172.
Zurück zum Zitat Pileggi C, Bianco A, Flotta D et al (2011) Prevention of ventilator-associated pneumonia, mortality and all intensive care unit acquired infections by topically applied antimicrobial or antiseptic agents: a meta-analysis of randomized controlled trials in intensive care units. Crit Care 15:R155PubMed Pileggi C, Bianco A, Flotta D et al (2011) Prevention of ventilator-associated pneumonia, mortality and all intensive care unit acquired infections by topically applied antimicrobial or antiseptic agents: a meta-analysis of randomized controlled trials in intensive care units. Crit Care 15:R155PubMed
173.
Zurück zum Zitat Safdar N, Said A, Lucey MR (2004) The role of selective digestive decontamination for reducing infection in patients undergoing liver transplantation: a systematic review and meta-analysis. Liver Transpl 10:817–827PubMed Safdar N, Said A, Lucey MR (2004) The role of selective digestive decontamination for reducing infection in patients undergoing liver transplantation: a systematic review and meta-analysis. Liver Transpl 10:817–827PubMed
174.
Zurück zum Zitat Silvestri L, Saene HK van, Casarin A et al (2008) Impact of selective decontamination of the digestive tract on carriage and infection due to gram-negative and gram-positive bacteria: a systematic review of randomised controlled trials. Anaesth Intensive Care 36:324–338PubMed Silvestri L, Saene HK van, Casarin A et al (2008) Impact of selective decontamination of the digestive tract on carriage and infection due to gram-negative and gram-positive bacteria: a systematic review of randomised controlled trials. Anaesth Intensive Care 36:324–338PubMed
175.
Zurück zum Zitat Silvestri L, Saene HK van, Milanese M, Gregori D (2005) Impact of selective decontamination of the digestive tract on fungal carriage and infection: systematic review of randomized controlled trials. Intensive Care Med 31:898–910PubMed Silvestri L, Saene HK van, Milanese M, Gregori D (2005) Impact of selective decontamination of the digestive tract on fungal carriage and infection: systematic review of randomized controlled trials. Intensive Care Med 31:898–910PubMed
176.
Zurück zum Zitat Silvestri L, Saene HK van, Milanese M et al (2007) Selective decontamination of the digestive tract reduces bacterial bloodstream infection and mortality in critically ill patients. Systematic review of randomized, controlled trials. J Hosp Infect 65:187–203PubMed Silvestri L, Saene HK van, Milanese M et al (2007) Selective decontamination of the digestive tract reduces bacterial bloodstream infection and mortality in critically ill patients. Systematic review of randomized, controlled trials. J Hosp Infect 65:187–203PubMed
177.
Zurück zum Zitat Nieuwenhoven CA van, Buskens E, Tiel FH van, Bonten MJ (2001) Relationship between methodological trial quality and the effects of selective digestive decontamination on pneumonia and mortality in critically ill patients. JAMA 286:335–340PubMed Nieuwenhoven CA van, Buskens E, Tiel FH van, Bonten MJ (2001) Relationship between methodological trial quality and the effects of selective digestive decontamination on pneumonia and mortality in critically ill patients. JAMA 286:335–340PubMed
178.
Zurück zum Zitat Liberati A, D’Amico R, Pifferi S et al (2009) Antibiotic prophylaxis to reduce respiratory tract infections and mortality in adults receiving intensive care. Cochrane Database Syst Rev CD000022 Liberati A, D’Amico R, Pifferi S et al (2009) Antibiotic prophylaxis to reduce respiratory tract infections and mortality in adults receiving intensive care. Cochrane Database Syst Rev CD000022
179.
Zurück zum Zitat Smet AM de, Kluytmans JA, Cooper BS et al (2009) Decontamination of the digestive tract and oropharynx in ICU patients. N Engl J Med 360:20–31PubMed Smet AM de, Kluytmans JA, Cooper BS et al (2009) Decontamination of the digestive tract and oropharynx in ICU patients. N Engl J Med 360:20–31PubMed
180.
Zurück zum Zitat Hurley JC (2011) Paradoxical ventilator associated pneumonia incidences among selective digestive decontamination studies versus other studies of mechanically ventilated patients: benchmarking the evidence base. Crit Care 15:R7PubMed Hurley JC (2011) Paradoxical ventilator associated pneumonia incidences among selective digestive decontamination studies versus other studies of mechanically ventilated patients: benchmarking the evidence base. Crit Care 15:R7PubMed
181.
Zurück zum Zitat Ochoa-Ardila ME, Garcia-Canas A, Gomez-Mediavilla K et al (2011) Long-term use of selective decontamination of the digestive tract does not increase antibiotic resistance: a 5-year prospective cohort study. Intensive Care Med 37:1458–1465PubMed Ochoa-Ardila ME, Garcia-Canas A, Gomez-Mediavilla K et al (2011) Long-term use of selective decontamination of the digestive tract does not increase antibiotic resistance: a 5-year prospective cohort study. Intensive Care Med 37:1458–1465PubMed
182.
Zurück zum Zitat Daneman N, Sarwar S, Fowler RA et al (2013) Effect of selective decontamination on antimicrobial resistance in intensive care units: a systematic review and meta-analysis. Lancet Infect Dis 13:328–341PubMed Daneman N, Sarwar S, Fowler RA et al (2013) Effect of selective decontamination on antimicrobial resistance in intensive care units: a systematic review and meta-analysis. Lancet Infect Dis 13:328–341PubMed
183.
Zurück zum Zitat Acquarolo A, Urli T, Perone G et al (2005) Antibiotic prophylaxis of early onset pneumonia in critically ill comatose patients. A randomized study. Intensive Care Med 31:510–516PubMed Acquarolo A, Urli T, Perone G et al (2005) Antibiotic prophylaxis of early onset pneumonia in critically ill comatose patients. A randomized study. Intensive Care Med 31:510–516PubMed
184.
Zurück zum Zitat Bonten MJ (2011) Healthcare epidemiology: ventilator-associated pneumonia: preventing the inevitable. Clin Infect Dis 52:115–121PubMed Bonten MJ (2011) Healthcare epidemiology: ventilator-associated pneumonia: preventing the inevitable. Clin Infect Dis 52:115–121PubMed
185.
Zurück zum Zitat Park DR (2005) The microbiology of ventilator-associated pneumonia. Respir Care 50:742–763 (discussion 763–745)PubMed Park DR (2005) The microbiology of ventilator-associated pneumonia. Respir Care 50:742–763 (discussion 763–745)PubMed
186.
Zurück zum Zitat Fohl AL, Regal RE (2011) Proton pump inhibitor-associated pneumonia: not a breath of fresh air after all? World J Gastrointest Pharmacol Ther 2:17–26PubMed Fohl AL, Regal RE (2011) Proton pump inhibitor-associated pneumonia: not a breath of fresh air after all? World J Gastrointest Pharmacol Ther 2:17–26PubMed
187.
Zurück zum Zitat Miano TA, Reichert MG, Houle TT et al (2009) Nosocomial pneumonia risk and stress ulcer prophylaxis: a comparison of pantoprazole vs ranitidine in cardiothoracic surgery patients. Chest 136:440–447PubMed Miano TA, Reichert MG, Houle TT et al (2009) Nosocomial pneumonia risk and stress ulcer prophylaxis: a comparison of pantoprazole vs ranitidine in cardiothoracic surgery patients. Chest 136:440–447PubMed
188.
Zurück zum Zitat Alhazzani W, Alenezi F, Jaeschke RZ et al (2013) Proton pump inhibitors versus histamine 2 receptor antagonists for stress ulcer prophylaxis in critically ill patients: a systematic review and meta-analysis. Crit Care Med 41:693–705PubMed Alhazzani W, Alenezi F, Jaeschke RZ et al (2013) Proton pump inhibitors versus histamine 2 receptor antagonists for stress ulcer prophylaxis in critically ill patients: a systematic review and meta-analysis. Crit Care Med 41:693–705PubMed
189.
Zurück zum Zitat Huang J, Cao Y, Liao C et al (2010) Effect of histamine-2-receptor antagonists versus sucralfate on stress ulcer prophylaxis in mechanically ventilated patients: a meta-analysis of 10 randomized controlled trials. Crit Care 14:R194PubMed Huang J, Cao Y, Liao C et al (2010) Effect of histamine-2-receptor antagonists versus sucralfate on stress ulcer prophylaxis in mechanically ventilated patients: a meta-analysis of 10 randomized controlled trials. Crit Care 14:R194PubMed
190.
Zurück zum Zitat Kahn JM, Doctor JN, Rubenfeld GD (2006) Stress ulcer prophylaxis in mechanically ventilated patients: integrating evidence and judgment using a decision analysis. Intensive Care Med 32:1151–1158PubMed Kahn JM, Doctor JN, Rubenfeld GD (2006) Stress ulcer prophylaxis in mechanically ventilated patients: integrating evidence and judgment using a decision analysis. Intensive Care Med 32:1151–1158PubMed
191.
Zurück zum Zitat Martin J, Heymann A, Basell K et al (2010) Evidence and consensus-based German guidelines for the management of analgesia, sedation and delirium in intensive care – short version. Ger Med Sci 8:Doc02PubMed Martin J, Heymann A, Basell K et al (2010) Evidence and consensus-based German guidelines for the management of analgesia, sedation and delirium in intensive care – short version. Ger Med Sci 8:Doc02PubMed
192.
Zurück zum Zitat Anifantaki S, Prinianakis G, Vitsaksaki E et al (2009) Daily interruption of sedative infusions in an adult medical-surgical intensive care unit: randomized controlled trial. J Adv Nurs 65:1054–1060PubMed Anifantaki S, Prinianakis G, Vitsaksaki E et al (2009) Daily interruption of sedative infusions in an adult medical-surgical intensive care unit: randomized controlled trial. J Adv Nurs 65:1054–1060PubMed
193.
Zurück zum Zitat Wit M de, Gennings C, Jenvey WI, Epstein SK (2008) Randomized trial comparing daily interruption of sedation and nursing-implemented sedation algorithm in medical intensive care unit patients. Crit Care 12:R70PubMed Wit M de, Gennings C, Jenvey WI, Epstein SK (2008) Randomized trial comparing daily interruption of sedation and nursing-implemented sedation algorithm in medical intensive care unit patients. Crit Care 12:R70PubMed
194.
Zurück zum Zitat Kress JP, Pohlman AS, O’Connor MF, Hall JB (2000) Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med 342:1471–1477PubMed Kress JP, Pohlman AS, O’Connor MF, Hall JB (2000) Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med 342:1471–1477PubMed
195.
Zurück zum Zitat Nseir S, Makris D, Mathieu D et al (2010) Intensive care unit-acquired infection as a side effect of sedation. Crit Care 14:R30PubMed Nseir S, Makris D, Mathieu D et al (2010) Intensive care unit-acquired infection as a side effect of sedation. Crit Care 14:R30PubMed
196.
Zurück zum Zitat Shehabi Y, Bellomo R, Mehta S et al (2013) Intensive care sedation: the past, present and the future. Crit Care 17:322PubMed Shehabi Y, Bellomo R, Mehta S et al (2013) Intensive care sedation: the past, present and the future. Crit Care 17:322PubMed
197.
Zurück zum Zitat Berenholtz SM, Pham JC, Thompson DA et al (2011) Collaborative cohort study of an intervention to reduce ventilator-associated pneumonia in the intensive care unit. Infect Control Hosp Epidemiol 32:305–314PubMed Berenholtz SM, Pham JC, Thompson DA et al (2011) Collaborative cohort study of an intervention to reduce ventilator-associated pneumonia in the intensive care unit. Infect Control Hosp Epidemiol 32:305–314PubMed
198.
Zurück zum Zitat Bouadma L, Mourvillier B, Deiler V et al (2010) A multifaceted program to prevent ventilator-associated pneumonia: impact on compliance with preventive measures. Crit Care Med 38:789–796PubMed Bouadma L, Mourvillier B, Deiler V et al (2010) A multifaceted program to prevent ventilator-associated pneumonia: impact on compliance with preventive measures. Crit Care Med 38:789–796PubMed
199.
Zurück zum Zitat Muscedere J, Dodek P, Keenan S et al (2008) Comprehensive evidence-based clinical practice guidelines for ventilator-associated pneumonia: prevention. J Crit Care 23:126–137PubMed Muscedere J, Dodek P, Keenan S et al (2008) Comprehensive evidence-based clinical practice guidelines for ventilator-associated pneumonia: prevention. J Crit Care 23:126–137PubMed
200.
Zurück zum Zitat Safdar N, Abad C (2008) Educational interventions for prevention of healthcare-associated infection: a systematic review. Crit Care Med 36:933–940PubMed Safdar N, Abad C (2008) Educational interventions for prevention of healthcare-associated infection: a systematic review. Crit Care Med 36:933–940PubMed
201.
Zurück zum Zitat Ferrer R, Artigas A, Levy MM et al (2008) Improvement in process of care and outcome after a multicenter severe sepsis educational program in Spain. JAMA 299:2294–2303PubMed Ferrer R, Artigas A, Levy MM et al (2008) Improvement in process of care and outcome after a multicenter severe sepsis educational program in Spain. JAMA 299:2294–2303PubMed
202.
Zurück zum Zitat Jansson M, Kaariainen M, Kyngas H (2013) Effectiveness of educational programmes in preventing ventilator-associated pneumonia: a systematic review. J Hosp Infect 84:206–214PubMed Jansson M, Kaariainen M, Kyngas H (2013) Effectiveness of educational programmes in preventing ventilator-associated pneumonia: a systematic review. J Hosp Infect 84:206–214PubMed
Metadaten
Titel
Prävention der nosokomialen beatmungsassoziierten Pneumonie
Empfehlung der Kommission für Krankenhaushygiene und Infektionsprävention (KRINKO) beim Robert Koch-Institut
verfasst von
-
Publikationsdatum
01.11.2013
Verlag
Springer Berlin Heidelberg
Erschienen in
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz / Ausgabe 11/2013
Print ISSN: 1436-9990
Elektronische ISSN: 1437-1588
DOI
https://doi.org/10.1007/s00103-013-1846-7

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Diabetestechnologie für alle?

15.05.2024 DDG-Jahrestagung 2024 Kongressbericht

Eine verbesserte Stoffwechseleinstellung und höhere Lebensqualität – Diabetestechnologien sollen den Alltag der Patienten erleichtern. Dass CGM, AID & Co. bei Typ-1-Diabetes helfen, ist belegt. Bei Typ-2 gestaltet sich die Sache komplizierter.

Update Allgemeinmedizin

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