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Erschienen in: Current Rheumatology Reports 10/2020

01.10.2020 | Inflammatory Muscle Disease (L Diederichsen and H Chinoy, Section Editors)

Impact and Management of Dysphagia in Inflammatory Myopathies

verfasst von: Rachel Zeng, Jens Schmidt

Erschienen in: Current Rheumatology Reports | Ausgabe 10/2020

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Abstract

Purpose of Review

Dysphagia is a common symptom in inflammatory myopathies. This review provides an overview on the epidemiology, clinical impact, and management of dysphagia in myositis. Relevant diagnostic tools and treatment strategies are discussed.

Recent Findings

Dysphagia can occur in any inflammatory myopathy, particularly in inclusion body myositis (IBM). It can lead to malnutrition or aspiration with subsequent pneumonia or even death. Dysphagia can be explored and monitored by patient-reported outcome scales for swallowing. New diagnostic tools such as real-time MRI and oro-pharyngo-esophageal scintigraphy have been studied for assessing dysphagia. Botulinum toxin injection can alleviate dysphagia in IBM. High-dose glucocorticosteroids are considered a first-line treatment for dysphagia in all other myositis subforms.

Summary

Evaluation of dysphagia in myositis requires thorough clinical workup and appropriate instrumental procedures. Treatment options are available for dysphagia, but controlled trials and consensus on best patient care are required for this important symptom.
Literatur
3.
Zurück zum Zitat • Lilleker JB, Vencovsky J, Wang G, Wedderburn LR, Diederichsen LP, Schmidt J, et al. The EuroMyositis registry: an international collaborative tool to facilitate myositis research. Ann Rheum Dis. 2018;77:30–9. https://doi.org/10.1136/annrheumdis-2017-211868. This large multicenter cohort analysis included 3067 patients from 11 countries; associations between different myositis subtypes, extramuscular involvement, environmental exposure and medications were assessed. • Lilleker JB, Vencovsky J, Wang G, Wedderburn LR, Diederichsen LP, Schmidt J, et al. The EuroMyositis registry: an international collaborative tool to facilitate myositis research. Ann Rheum Dis. 2018;77:30–9. https://​doi.​org/​10.​1136/​annrheumdis-2017-211868. This large multicenter cohort analysis included 3067 patients from 11 countries; associations between different myositis subtypes, extramuscular involvement, environmental exposure and medications were assessed.
5.
Zurück zum Zitat Marie I, Menard J-F, Hatron PY, Hachulla E, Mouthon L, Tiev K, et al. Intravenous immunoglobulins for steroid-refractory esophageal involvement related to polymyositis and dermatomyositis: a series of 73 patients. Arthritis Care Res (Hoboken). 2010;62:1748–55. https://doi.org/10.1002/acr.20325.CrossRef Marie I, Menard J-F, Hatron PY, Hachulla E, Mouthon L, Tiev K, et al. Intravenous immunoglobulins for steroid-refractory esophageal involvement related to polymyositis and dermatomyositis: a series of 73 patients. Arthritis Care Res (Hoboken). 2010;62:1748–55. https://​doi.​org/​10.​1002/​acr.​20325.CrossRef
9.
Zurück zum Zitat Needham M, James I, Corbett A, Day T, Christiansen F, Phillips B, et al. Sporadic inclusion body myositis: phenotypic variability and influence of HLA-DR3 in a cohort of 57 Australian cases. J Neurol Neurosurg Psychiatry. 2008;79:1056–60. https://doi.org/10.1136/jnnp.2007.138891. Needham M, James I, Corbett A, Day T, Christiansen F, Phillips B, et al. Sporadic inclusion body myositis: phenotypic variability and influence of HLA-DR3 in a cohort of 57 Australian cases. J Neurol Neurosurg Psychiatry. 2008;79:1056–60. https://​doi.​org/​10.​1136/​jnnp.​2007.​138891.
12.
Zurück zum Zitat Lotz BP, Engel AG, Nishino H, Stevens JC, Litchy WJ. Inclusion body myositis: observations in 40 patients. Brain. 1989;112:727–47.CrossRef Lotz BP, Engel AG, Nishino H, Stevens JC, Litchy WJ. Inclusion body myositis: observations in 40 patients. Brain. 1989;112:727–47.CrossRef
13.
Zurück zum Zitat Casal-Dominguez M, Pinal-Fernandez I, Mego M, Accarino A, Jubany L, Azpiroz F, et al. High-resolution manometry in patients with idiopathic inflammatory myopathy: elevated prevalence of esophageal involvement and differences according to autoantibody status and clinical subset. Muscle Nerve. 2017;56:386–92. https://doi.org/10.1002/mus.25507. Casal-Dominguez M, Pinal-Fernandez I, Mego M, Accarino A, Jubany L, Azpiroz F, et al. High-resolution manometry in patients with idiopathic inflammatory myopathy: elevated prevalence of esophageal involvement and differences according to autoantibody status and clinical subset. Muscle Nerve. 2017;56:386–92. https://​doi.​org/​10.​1002/​mus.​25507.
31.
Zurück zum Zitat Price MA, Barghout V, Benveniste O, Christopher-Stine L, Corbett A, de Visser M, et al. Mortality and causes of death in patients with sporadic inclusion body myositis: survey study based on the clinical experience of specialists in Australia, Europe and the USA. J Neuromuscul Dis. 2016;3:67–75. https://doi.org/10.3233/JND-150138. Price MA, Barghout V, Benveniste O, Christopher-Stine L, Corbett A, de Visser M, et al. Mortality and causes of death in patients with sporadic inclusion body myositis: survey study based on the clinical experience of specialists in Australia, Europe and the USA. J Neuromuscul Dis. 2016;3:67–75. https://​doi.​org/​10.​3233/​JND-150138.
34.
Zurück zum Zitat • Taira K, Yamamoto T, Mori-Yoshimura M, Fujita S, Oya Y, Nishino I, et al. Obstruction-related dysphagia in inclusion body myositis: cricopharyngeal bar on videofluoroscopy indicates risk of aspiration. J Neurol Sci. 2020;413:116764. https://doi.org/10.1016/j.jns.2020.116764. This study analyzed the predictive risk factors for aspiration pneumonia in patients with inclusion body myositis; one of these factors was the presence of a cricopharyngeal bar (CB) on videofluoroscopic examination. • Taira K, Yamamoto T, Mori-Yoshimura M, Fujita S, Oya Y, Nishino I, et al. Obstruction-related dysphagia in inclusion body myositis: cricopharyngeal bar on videofluoroscopy indicates risk of aspiration. J Neurol Sci. 2020;413:116764. https://​doi.​org/​10.​1016/​j.​jns.​2020.​116764. This study analyzed the predictive risk factors for aspiration pneumonia in patients with inclusion body myositis; one of these factors was the presence of a cricopharyngeal bar (CB) on videofluoroscopic examination.
36.
Zurück zum Zitat Wallace KL, Middleton S, Cook IJ. Development and validation of a self-report symptom inventory to assess the severity of oral-pharyngeal dysphagia. Gastroenterology. 2000;118:678–87.CrossRef Wallace KL, Middleton S, Cook IJ. Development and validation of a self-report symptom inventory to assess the severity of oral-pharyngeal dysphagia. Gastroenterology. 2000;118:678–87.CrossRef
38.
Zurück zum Zitat McHorney CA, Robbins J, Lomax K, Rosenbek JC, Chignell K, Kramer AE, et al. The SWAL-QOL and SWAL-CARE outcomes tool for oropharyngeal dysphagia in adults: III. Documentation of reliability and validity. Dysphagia. 2002;17:97–114. https://doi.org/10.1007/s00455-001-0109-1. McHorney CA, Robbins J, Lomax K, Rosenbek JC, Chignell K, Kramer AE, et al. The SWAL-QOL and SWAL-CARE outcomes tool for oropharyngeal dysphagia in adults: III. Documentation of reliability and validity. Dysphagia. 2002;17:97–114. https://​doi.​org/​10.​1007/​s00455-001-0109-1.
40.
44.
Zurück zum Zitat Cichero JAY, Murdoch BE. Dysphagia: foundation, theory and practice. Chichester, West Sussex PO19 8SQ, England: John Wiley & Sons, Ltd; 2006. Cichero JAY, Murdoch BE. Dysphagia: foundation, theory and practice. Chichester, West Sussex PO19 8SQ, England: John Wiley & Sons, Ltd; 2006.
55.
Zurück zum Zitat Barsotti S, Puccini G, Tripoli A, Cardelli C, Minichilli F, Volterrani D, et al. Assessment of swallowing function with oro-pharyngeal-esophageal scintigraphy in patients with idiopathic inflammatory myopathies. Neurogastroenterol Motil. 2019;31:e13599. https://doi.org/10.1111/nmo.13599. Barsotti S, Puccini G, Tripoli A, Cardelli C, Minichilli F, Volterrani D, et al. Assessment of swallowing function with oro-pharyngeal-esophageal scintigraphy in patients with idiopathic inflammatory myopathies. Neurogastroenterol Motil. 2019;31:e13599. https://​doi.​org/​10.​1111/​nmo.​13599.
59.
63.
Zurück zum Zitat • Beck AM, Kjaersgaard A, Hansen T, Poulsen I. Systematic review and evidence based recommendations on texture modified foods and thickened liquids for adults (above 17 years) with oropharyngeal dysphagia - an updated clinical guideline. Clin Nutr. 2018;37:1980–91. https://doi.org/10.1016/j.clnu.2017.09.002. This review discusses the evidence for the use of thickened liquids and modified food in patients with dysphagia; clinical recommendations are made. • Beck AM, Kjaersgaard A, Hansen T, Poulsen I. Systematic review and evidence based recommendations on texture modified foods and thickened liquids for adults (above 17 years) with oropharyngeal dysphagia - an updated clinical guideline. Clin Nutr. 2018;37:1980–91. https://​doi.​org/​10.​1016/​j.​clnu.​2017.​09.​002. This review discusses the evidence for the use of thickened liquids and modified food in patients with dysphagia; clinical recommendations are made.
65.
Zurück zum Zitat Ogawa-Momohara M, Muro Y, Kono M, Akiyama M. Prognosis of dysphagia in dermatomyositis. Clin Exp Rheumatol. 2019;165. Ogawa-Momohara M, Muro Y, Kono M, Akiyama M. Prognosis of dysphagia in dermatomyositis. Clin Exp Rheumatol. 2019;165.
66.
67.
Zurück zum Zitat Marie I, Hachulla E, Levesque H, Reumont G, Ducrotte P, Cailleux N, et al. Intravenous immunoglobulins as treatment of life threatening esophageal involvement in polymyositis and dermatomyositis. J Rheumatol. 1999;26:2706–9. Marie I, Hachulla E, Levesque H, Reumont G, Ducrotte P, Cailleux N, et al. Intravenous immunoglobulins as treatment of life threatening esophageal involvement in polymyositis and dermatomyositis. J Rheumatol. 1999;26:2706–9.
71.
Zurück zum Zitat Dobloug C, Walle-Hansen R, Gran JT, Molberg O. Long-term follow-up of sporadic inclusion body myositis treated with intravenous immunoglobulin: a retrospective study of 16 patients. Clin Exp Rheumatol. 2012:838–42. Dobloug C, Walle-Hansen R, Gran JT, Molberg O. Long-term follow-up of sporadic inclusion body myositis treated with intravenous immunoglobulin: a retrospective study of 16 patients. Clin Exp Rheumatol. 2012:838–42.
76.
Zurück zum Zitat Parres C. Pharyngoesophageal dilation and botulinum toxin therapy for dysphagia in patients with inclusion body myositis (P3.157). Neurology. 2015:P3.157. Parres C. Pharyngoesophageal dilation and botulinum toxin therapy for dysphagia in patients with inclusion body myositis (P3.157). Neurology. 2015:P3.157.
79.
Zurück zum Zitat Alfonsi E, Merlo IM, Ponzio M, Montomoli C, Tassorelli C, Biancardi C, et al. An electrophysiological approach to the diagnosis of neurogenic dysphagia: implications for botulinum toxin treatment. J Neurol Neurosurg Psychiatry. 2010;81:54–60. https://doi.org/10.1136/jnnp.2009.174698. Alfonsi E, Merlo IM, Ponzio M, Montomoli C, Tassorelli C, Biancardi C, et al. An electrophysiological approach to the diagnosis of neurogenic dysphagia: implications for botulinum toxin treatment. J Neurol Neurosurg Psychiatry. 2010;81:54–60. https://​doi.​org/​10.​1136/​jnnp.​2009.​174698.
83.
Zurück zum Zitat Liu LWC, Tarnopolsky M, Armstrong D. Injection of botulinum toxin A to the upper esophageal sphincter for oropharyngeal dysphagia in two patients with inclusion body myositis. Can J Gastroenterol. 2004;18:397–9.CrossRef Liu LWC, Tarnopolsky M, Armstrong D. Injection of botulinum toxin A to the upper esophageal sphincter for oropharyngeal dysphagia in two patients with inclusion body myositis. Can J Gastroenterol. 2004;18:397–9.CrossRef
88.
Zurück zum Zitat Verma A, Bradley WG, Adesina AM, Sofferman R, Pendebury WW. Inclusion body myositis with cricopharyngeus muscle involvement and severe dysphagia. Muscle Nerve. 1991;14:470–3.CrossRef Verma A, Bradley WG, Adesina AM, Sofferman R, Pendebury WW. Inclusion body myositis with cricopharyngeus muscle involvement and severe dysphagia. Muscle Nerve. 1991;14:470–3.CrossRef
Metadaten
Titel
Impact and Management of Dysphagia in Inflammatory Myopathies
verfasst von
Rachel Zeng
Jens Schmidt
Publikationsdatum
01.10.2020
Verlag
Springer US
Erschienen in
Current Rheumatology Reports / Ausgabe 10/2020
Print ISSN: 1523-3774
Elektronische ISSN: 1534-6307
DOI
https://doi.org/10.1007/s11926-020-00950-3

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