Skip to main content
Erschienen in: Current Pain and Headache Reports 6/2023

28.04.2023 | Chronic Pain Management (O Viswanath, Section Editor)

Flushing After Lumbar Epidural Steroid Injection with Dexamethasone

verfasst von: Suzanne Shermon, Gustaf Van Acker, Vladimir Suric, Chong Kim, Alaa Abd-Elsayed, Nicholas Mata

Erschienen in: Current Pain and Headache Reports | Ausgabe 6/2023

Einloggen, um Zugang zu erhalten

Abstract

Purpose of Review

Epidural steroid injections are an accepted treatment for low back pain and radicular symptoms. While epidural steroid injections are routinely performed without complications, side effects can be seen, including flushing. Flushing has been studied using various steroid preparations, including dexamethasone, but at significantly higher doses. This was a prospective cohort study that examines the rate of flushing in ESIs with a lower dose (4 mg) of dexamethasone. Subjects undergoing lumbar epidural steroid injection were asked about the presence of flushing following the procedure prior to discharge and again at 48 h after. A total of 80 participants received fluoroscopically guided interlaminar and transforaminal epidural injections. All participants received 4 mg of dexamethasone. Of the 80 subjects, 52 were female, and 28 were male. Seventy-one underwent a transforaminal epidural injection and 9 underwent an interlaminar epidural injection. Four (5%) subjects experienced flushing—1 subject experienced immediate post-procedural flushing and 3 experienced flushing within 48 h. All 4 subjects (100%) were female. All 4 subjects received transforaminal injections (100%).

Recent Findings

There is a gap of knowledge about the flushing after lumbar epidural steroid injection with dexamethasone.

Summary

Flushing is a known and common side effect of epidural steroid injections, varying in frequency based on type of steroid as well as dose. We found 5% incidence in flushing reaction with 4 mg of dexamethasone.
Literatur
1.
Zurück zum Zitat GBD 2017 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018;392(10159):1789–858.CrossRef GBD 2017 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018;392(10159):1789–858.CrossRef
2.
Zurück zum Zitat Henschke N, Kamper SJ, Maher CG. The epidemiology and economic consequences of pain. Mayo Clin Proc. 2015;90(1):139–47.CrossRefPubMed Henschke N, Kamper SJ, Maher CG. The epidemiology and economic consequences of pain. Mayo Clin Proc. 2015;90(1):139–47.CrossRefPubMed
3.
Zurück zum Zitat Patel K, Chopra P, Upadhyayula S. Epidural steroid injections. [Updated 2022 Jul 4]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022. Patel K, Chopra P, Upadhyayula S. Epidural steroid injections. [Updated 2022 Jul 4]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022.
4.
Zurück zum Zitat Goppelt-Struebe M. Molecular mechanisms involved in the regulation of prostaglandin biosynthesis by glucocorticoids. Biochem Pharmacol. 1997;53(10):1389–95.CrossRefPubMed Goppelt-Struebe M. Molecular mechanisms involved in the regulation of prostaglandin biosynthesis by glucocorticoids. Biochem Pharmacol. 1997;53(10):1389–95.CrossRefPubMed
5.
Zurück zum Zitat Devor M, Govrin-Lippmann R, Raber P. Corticosteroids suppress ectopic neural discharge originating in experimental neuromas. Pain. 1985;22(2):127–37.CrossRefPubMed Devor M, Govrin-Lippmann R, Raber P. Corticosteroids suppress ectopic neural discharge originating in experimental neuromas. Pain. 1985;22(2):127–37.CrossRefPubMed
6.
Zurück zum Zitat Fukusaki M, Kobayashi I, Hara T, Sumikawa K. Symptoms of spinal stenosis do not improve after epidural steroid injection. Clin J Pain. 1998;14(2):148–51.CrossRefPubMed Fukusaki M, Kobayashi I, Hara T, Sumikawa K. Symptoms of spinal stenosis do not improve after epidural steroid injection. Clin J Pain. 1998;14(2):148–51.CrossRefPubMed
7.
Zurück zum Zitat Johansson A, Hao J, Sjolund B. Local corticosteroid application blocks transmission in normal nociceptive C-fibers. Acta Anaesthesiology Scand. 1990;34:335–8.CrossRef Johansson A, Hao J, Sjolund B. Local corticosteroid application blocks transmission in normal nociceptive C-fibers. Acta Anaesthesiology Scand. 1990;34:335–8.CrossRef
8.
Zurück zum Zitat Rabinovitch DL, Peliowski A, Furlan AD. Influence of lumbar epidural injection volume on pain relief for radicular leg pain and/or low back pain. Spine J. 2009;9(6):509–17.CrossRefPubMed Rabinovitch DL, Peliowski A, Furlan AD. Influence of lumbar epidural injection volume on pain relief for radicular leg pain and/or low back pain. Spine J. 2009;9(6):509–17.CrossRefPubMed
9.
Zurück zum Zitat Bicket MC, Gupta A, Brown CH 4th, Cohen SP. Epidural injections for spinal pain: a systematic review and meta-analysis evaluating the “control” injections in randomized controlled trials. Anesthesiology. 2013;119(4):907–31.CrossRefPubMed Bicket MC, Gupta A, Brown CH 4th, Cohen SP. Epidural injections for spinal pain: a systematic review and meta-analysis evaluating the “control” injections in randomized controlled trials. Anesthesiology. 2013;119(4):907–31.CrossRefPubMed
11.
Zurück zum Zitat Smith CC, McCormick ZL, Mattie R, MacVicar J, Duszynski B, Stojanovic MP. The effectiveness of lumbar transforaminal injection of steroid for the treatment of radicular pain: a comprehensive review of the published data. Pain Med. 2020;21(3):472–87.CrossRefPubMed Smith CC, McCormick ZL, Mattie R, MacVicar J, Duszynski B, Stojanovic MP. The effectiveness of lumbar transforaminal injection of steroid for the treatment of radicular pain: a comprehensive review of the published data. Pain Med. 2020;21(3):472–87.CrossRefPubMed
12.
Zurück zum Zitat Manchikanti L, Boswell MV, Singh V, Benyamin RM, Fellows B, Abdi S, et al. Comprehensive evidence-based guidelines for interventional techniques in the management of chronic spinal pain. Pain Physician. 2009;12:699–802.CrossRefPubMed Manchikanti L, Boswell MV, Singh V, Benyamin RM, Fellows B, Abdi S, et al. Comprehensive evidence-based guidelines for interventional techniques in the management of chronic spinal pain. Pain Physician. 2009;12:699–802.CrossRefPubMed
13.
Zurück zum Zitat Arden NK, Price C, Reading I, Stubbing J, Hazelgrove J, Dunne C, et al. A multicentre randomized controlled trial of epidural corticosteroid injections for sciatica: the WESET study. Rheumatology. 2005;44:1399–406.CrossRefPubMed Arden NK, Price C, Reading I, Stubbing J, Hazelgrove J, Dunne C, et al. A multicentre randomized controlled trial of epidural corticosteroid injections for sciatica: the WESET study. Rheumatology. 2005;44:1399–406.CrossRefPubMed
14.
Zurück zum Zitat Rozin L, Rozin R, Koehler SA, Shakir A, Ladham S, Barmada M, et al. Death during transforaminal epidural steroid nerve root block (C7) due to per-foration of the left vertebral artery. Am J Forensic Med Pathol. 2003;24:351–5.CrossRefPubMed Rozin L, Rozin R, Koehler SA, Shakir A, Ladham S, Barmada M, et al. Death during transforaminal epidural steroid nerve root block (C7) due to per-foration of the left vertebral artery. Am J Forensic Med Pathol. 2003;24:351–5.CrossRefPubMed
15.
Zurück zum Zitat Tiso RL, Cutler T, Catania JA, Whalen K. Adverse central nervous system sequel-ae after selective transforaminal block: the role of corticosteroids. Spine J. 2004;4:468–74.CrossRefPubMed Tiso RL, Cutler T, Catania JA, Whalen K. Adverse central nervous system sequel-ae after selective transforaminal block: the role of corticosteroids. Spine J. 2004;4:468–74.CrossRefPubMed
16.
Zurück zum Zitat Huntoon MA, Martin DP. Paralysis after transforaminal epidural injection and previous spinal surgery. Reg Anesth Pain Med. 2004;29:494–5.CrossRefPubMed Huntoon MA, Martin DP. Paralysis after transforaminal epidural injection and previous spinal surgery. Reg Anesth Pain Med. 2004;29:494–5.CrossRefPubMed
19.
Zurück zum Zitat Everett CR, Baskin MN, Speech D, Novoseletsky D, Patel R. Flushing as a side effect following lumbar transforaminal epidural steroid injection. Pain Physician. 2004;7:427–9.CrossRefPubMed Everett CR, Baskin MN, Speech D, Novoseletsky D, Patel R. Flushing as a side effect following lumbar transforaminal epidural steroid injection. Pain Physician. 2004;7:427–9.CrossRefPubMed
24.
Zurück zum Zitat Rathmell JP, Benzon HT, Dreyfuss P, Huntoon M, Wallace M, Baker R, et al. Safeguards to prevent neurologic complications after epidural steroid injections: consensus opinions from a multidisciplinary working group and national organizations. Anesthesiology. 2015;122(5):974–84.CrossRefPubMed Rathmell JP, Benzon HT, Dreyfuss P, Huntoon M, Wallace M, Baker R, et al. Safeguards to prevent neurologic complications after epidural steroid injections: consensus opinions from a multidisciplinary working group and national organizations. Anesthesiology. 2015;122(5):974–84.CrossRefPubMed
25.
Zurück zum Zitat Duszynski B. Spine Intervention Society Position Statement on best practices for epidural steroid injections in the setting of a preservative-free dexamethasone shortage. Pain Med. 2019;20:1277–80.CrossRefPubMed Duszynski B. Spine Intervention Society Position Statement on best practices for epidural steroid injections in the setting of a preservative-free dexamethasone shortage. Pain Med. 2019;20:1277–80.CrossRefPubMed
26.
Zurück zum Zitat Popescu A, McCormick ZL, Smith CC, Spine Intervention Society’s Patient Safety Committee. Strategies to minimize risk in lumbar transforaminal injections: imaging and injectate. Pain Med. 2019;20(7):1449–50.CrossRefPubMed Popescu A, McCormick ZL, Smith CC, Spine Intervention Society’s Patient Safety Committee. Strategies to minimize risk in lumbar transforaminal injections: imaging and injectate. Pain Med. 2019;20(7):1449–50.CrossRefPubMed
34.
Zurück zum Zitat Donohue NK, Tarima SS, Durand MJ, Wu H. Comparing pain relief and functional improvement between methylprednisolone and dexamethasone lumbosacral transforaminal epidural steroid injections: a self-controlled study. Korean J Pain. 2020 Apr 1;33(2):192–198. https://doi.org/10.3344/kjp.2020.33.2.192. PMID: 32235020; PMCID: PMC7136301. Donohue NK, Tarima SS, Durand MJ, Wu H. Comparing pain relief and functional improvement between methylprednisolone and dexamethasone lumbosacral transforaminal epidural steroid injections: a self-controlled study. Korean J Pain. 2020 Apr 1;33(2):192–198. https://​doi.​org/​10.​3344/​kjp.​2020.​33.​2.​192. PMID: 32235020; PMCID: PMC7136301.
35.
Zurück zum Zitat Manchikanti L, Singh V, Falco F, Cash K, Pampati, V. Evaluation of the effectiveness of lumbarinterlaminar epidural injections in managingchronic pain of lumbar disc herniation orradiculitis: a randomized, double-blind, controlled trial. Pain Physician. 2010;13(4;7):343–55. https://doi.org/10.36076/ppj.2010/13/343. Manchikanti L, Singh V, Falco F, Cash K, Pampati, V. Evaluation of the effectiveness of lumbarinterlaminar epidural injections in managingchronic pain of lumbar disc herniation orradiculitis: a randomized, double-blind, controlled trial. Pain Physician. 2010;13(4;7):343–55. https://​doi.​org/​10.​36076/​ppj.​2010/​13/​343.
37.
Zurück zum Zitat Bingham N, Dhall R, Montuori M, Padjen K, Gharibo C, Doan L. Variations in epidural steroid injection practice patterns by pain medicine physicians in the United States. Pain Physician. 2022;25(6):E857–62. PubMed Bingham N, Dhall R, Montuori M, Padjen K, Gharibo C, Doan L. Variations in epidural steroid injection practice patterns by pain medicine physicians in the United States. Pain Physician. 2022;25(6):E857–62. PubMed
40.
Zurück zum Zitat Abram SE. Treatment of lumbosacral radiculopathy with epidural steroids. Anesthesiology. 1999;91:1937–41.CrossRefPubMed Abram SE. Treatment of lumbosacral radiculopathy with epidural steroids. Anesthesiology. 1999;91:1937–41.CrossRefPubMed
41.
Zurück zum Zitat DeSio JM, Kahn CH, Warfield CA. Facial flushing and/or generalized erythema after epidural steroid injection. Anesth Analg. 1995;80:617–9.PubMed DeSio JM, Kahn CH, Warfield CA. Facial flushing and/or generalized erythema after epidural steroid injection. Anesth Analg. 1995;80:617–9.PubMed
Metadaten
Titel
Flushing After Lumbar Epidural Steroid Injection with Dexamethasone
verfasst von
Suzanne Shermon
Gustaf Van Acker
Vladimir Suric
Chong Kim
Alaa Abd-Elsayed
Nicholas Mata
Publikationsdatum
28.04.2023
Verlag
Springer US
Erschienen in
Current Pain and Headache Reports / Ausgabe 6/2023
Print ISSN: 1531-3433
Elektronische ISSN: 1534-3081
DOI
https://doi.org/10.1007/s11916-023-01117-2

Weitere Artikel der Ausgabe 6/2023

Current Pain and Headache Reports 6/2023 Zur Ausgabe

Anesthetic Techniques in Pain Management (D Wang, Section Editor)

Utilization of Truncal Fascial Plane Nerve Blocks for Chronic Pain Management: A Narrative Review

Neuromodulation (A Abd-Elsayed, Section Editor)

Supraorbital Nerve Stimulation for Facial Pain

Alternative Treatments for Pain Medicine (M Jones, Section Editor)

Sleep as a Therapeutic Target for Pain Management

Neuropathic Pain (A Abd-Elsayed, Section Editor)

Microbiological and Physiological Effects of Pain

Mehr Frauen im OP – weniger postoperative Komplikationen

21.05.2024 Allgemeine Chirurgie Nachrichten

Ein Frauenanteil von mindestens einem Drittel im ärztlichen Op.-Team war in einer großen retrospektiven Studie aus Kanada mit einer signifikanten Reduktion der postoperativen Morbidität assoziiert.

„Übersichtlicher Wegweiser“: Lauterbachs umstrittener Klinik-Atlas ist online

17.05.2024 Klinik aktuell Nachrichten

Sie sei „ethisch geboten“, meint Gesundheitsminister Karl Lauterbach: mehr Transparenz über die Qualität von Klinikbehandlungen. Um sie abzubilden, lässt er gegen den Widerstand vieler Länder einen virtuellen Klinik-Atlas freischalten.

Delir bei kritisch Kranken – Antipsychotika versus Placebo

16.05.2024 Delir Nachrichten

Um die Langzeitfolgen eines Delirs bei kritisch Kranken zu mildern, wird vielerorts auf eine Akuttherapie mit Antipsychotika gesetzt. Eine US-amerikanische Forschungsgruppe äußert jetzt erhebliche Vorbehalte gegen dieses Vorgehen. Denn es gibt neue Daten zum Langzeiteffekt von Haloperidol bzw. Ziprasidon versus Placebo.

Klinikreform soll zehntausende Menschenleben retten

15.05.2024 Klinik aktuell Nachrichten

Gesundheitsminister Lauterbach hat die vom Bundeskabinett beschlossene Klinikreform verteidigt. Kritik an den Plänen kommt vom Marburger Bund. Und in den Ländern wird über den Gang zum Vermittlungsausschuss spekuliert.

Update AINS

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.