Erschienen in:
07.09.2021 | Invited Editorial
Is It Safe (and When) to Stop Oral Anticoagulation After Ablation for Atrial fibrillation? (Do We Have Enough Evidence to Solve the Dilemma?)
verfasst von:
José Luis Merino, Juan Tamargo
Erschienen in:
Cardiovascular Drugs and Therapy
|
Ausgabe 6/2021
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Excerpt
Atrial fibrillation (AF), the most common sustained cardiac arrhythmia, is associated with significant impairment in functional capacity and quality of life and increased morbidity and mortality [
1‐
3]. Indeed, AF is independently associated with an overall 3.5-fold risk increase of mortality, which is predominantly due to increased risk of stroke and systemic embolic events (S/SE) and ventricular dysfunction [
4]. Non-anticoagulated patients with AF have a 3- to 5 fold increased risk of ischemic strokes, and it is estimated that up to 30% of all ischemic strokes and 10% of cryptogenic strokes are related to this arrhythmia [
1‐
3]. Furthermore, ischemic strokes associated with AF are nearly twice as likely to be fatal and generally more severe and more recurrent than strokes unrelated to AF [
5,
6]. …