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03.06.2019 | Original Article

Sleep disturbance and cancer-related fatigue symptom cluster in breast cancer patients undergoing chemotherapy

verfasst von: Rina S. Fox, Sonia Ancoli-Israel, Scott C. Roesch, Erin L. Merz, Sarah D. Mills, Kristen J. Wells, Georgia Robins Sadler, Vanessa L. Malcarne

Erschienen in: Supportive Care in Cancer | Ausgabe 2/2020

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Abstract

Purpose

Sleep disturbance and cancer-related fatigue (CRF) are among the most commonly reported symptoms associated with breast cancer and its treatment. This study identified symptom cluster groups of breast cancer patients based on multidimensional assessment of sleep disturbance and CRF prior to and during chemotherapy.

Methods

Participants were 152 women with stage I–IIIA breast cancer. Data were collected before chemotherapy (T1) and during the final week of the fourth chemotherapy cycle (T2). Latent profile analysis was used to derive groups of patients at each timepoint who scored similarly on percent of the day/night asleep per actigraphy, the Pittsburgh Sleep Quality Index global score, and the five subscales of the Multidimensional Fatigue Symptom Inventory-Short Form. Bivariate logistic regression evaluated if sociodemographic/medical characteristics at T1 were associated with group membership at each timepoint.

Results

Three groups (Fatigued with sleep complaints, Average, Minimal symptoms) were identified at T1, and five groups (Severely fatigued with poor sleep, Emotionally fatigued with average sleep, Physically fatigued with average sleep, Average, Minimal symptoms) at T2. The majority of individuals in a group characterized by more severe symptoms at T1 were also in a more severe symptom group at T2. Sociodemographic/medical variables at T1 were significantly associated with group membership at T1 and T2.

Conclusions

This study identified groups of breast cancer patients with differentially severe sleep disturbance and CRF symptom profiles prior to and during chemotherapy. Identifying groups with different symptom management needs and distinguishing groups by baseline sociodemographic/medical variables can identify patients at risk for greater symptom burden.

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Titel: Sleep disturbance and cancer-related fatigue symptom cluster in breast cancer patients undergoing chemotherapy
verfasst von: Rina S. Fox
Sonia Ancoli-Israel
Scott C. Roesch
Erin L. Merz
Sarah D. Mills
Kristen J. Wells
Georgia Robins Sadler
Vanessa L. Malcarne
Publikationsdatum: 03.06.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Supportive Care in Cancer / Ausgabe 2/2020
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-019-04834-w

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Sleep disturbance and cancer-related fatigue symptom cluster in breast cancer patients undergoing chemotherapy