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Rheumatology International
Erschienen in: Rheumatology International 1/2018

01.11.2017 | Comorbidities

Cardiovascular disease in patients with autoinflammatory syndromes

verfasst von: Rainer Hintenberger, Agnes Falkinger, Kathrin Danninger, Herwig Pieringer

Erschienen in: Rheumatology International | Ausgabe 1/2018

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Abstract

Autoinflammatory syndromes (AIS) are characterized by recurring events of inflammation, leading to a variety of organ manifestations and fever attacks. A subgroup of AIS is commonly referred to as hereditary periodic fever syndromes (HPFS). There is substantial evidence that autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus are strongly associated with cardiovascular morbidity and mortality. The link between AIS and cardiovascular disease is not that clear, even if the concept of continuous inflammation as a risk factor for cardiovascular disease is widely accepted. Research on the association of AIS and cardiovascular disease is increasing within the last years. In this review, we will discuss the association of several AIS with cardiovascular disease. Based on the rarity of some entities, lack of data, however, led to exclusion of some rare AIS. Especially, for Behcet’s disease (BD), adult-onset Still’s disease (AOSD), and Familial Mediterranean fever (FMF), there is an association with a number of cardiovascular abnormalities. BD is the AIS, which is most strongly associated with manifestation in the arterial and venous system. AOSD is strongly associated with cardiac inflammation (peri-/myocarditis). FMF patients are likely to suffer from serositis. Of note, there seems to be a link between variants of AOSD as well as FMF and idiopathic recurrent acute pericarditis.
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Metadaten
Titel
Cardiovascular disease in patients with autoinflammatory syndromes
verfasst von
Rainer Hintenberger
Agnes Falkinger
Kathrin Danninger
Herwig Pieringer
Publikationsdatum
01.11.2017
Verlag
Springer Berlin Heidelberg
Erschienen in
Rheumatology International / Ausgabe 1/2018
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-017-3854-7

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