26.11.2019 | Correspondence
Histone epiproteomic profiling distinguishes oligodendroglioma, IDH-mutant and 1p/19q co-deleted from IDH-mutant astrocytoma and reveals less tri-methylation of H3K27 in oligodendrogliomas
verfasst von:
C. Feller, M. Felix, T. Weiss, C. Herold-Mende, F. Zhang, T. Kockmann, F. Sahm, R. Aebersold, A. von Deimling, D. E. Reuss
Erschienen in:
Acta Neuropathologica
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Excerpt
WHO classification for tumours of the central nervous system strongly endorses molecular tests for the precise diagnosis of diffuse gliomas. Subclassification of isocitrate dehydrogenase (IDH)-mutant gliomas into IDH-mutant astrocytomas and oligodendrogliomas requires testing for complete 1p/19q co-deletion [
1] in those cases not showing loss of ATRX expression [
2]. …