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29.09.2023 | Research

Effect of a gel containing green tea extract and hyaluronic acid on palate pain scores and wound healing after free gingival graft: a quasi-randomized controlled clinical trial

verfasst von: Jovânia Alves Oliveira, Marcela Iunes da Silveira, Roberta de Oliveira Alves, Fábio José Barbosa Bezerra, Guilherme José Pimentel Lopes de Oliveira, Suzane Cristina Pigossi

Erschienen in: Clinical Oral Investigations | Ausgabe 11/2023

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Abstract

Objectives

The aim of this study was to evaluate the effect of a gel containing green tea extract and hyaluronic acid (HA) on pain scores and wound healing in donor sites after free gingival graft (FGG).

Materials and methods

Forty-two patients requiring FGG were included in three groups: (1) control group (n = 14), no material was placed in the donor area; only the clot was kept in position by sutures; (2) placebo group (n = 14), vehicle gel applied 3 times a day for 7 days; and (3) test group (n = 14), gel containing green tea extract and HA applied 3 times a day for 7 days. The wound size by clinical measurement (WS-CM) and photographic image (WS-PI), complete wound epithelialization (CWE), and palatal mucosa color were evaluated after 3 days and 1, 2, and 4 weeks postoperatively. The visual analog scale (VAS) for pain and analgesic consumption were used to assess participant’s perception in the same postoperative periods.

Results

A similar progressive reduction in the wound size, associated with an improvement in the color pattern, was observed in all groups (p > 0.05). No significant differences were found for CWE and pain assessment between the examined groups (p > 0.05).

Conclusion

The gel containing green tea extract and HA application in palatal wounds after FGG removal does not provide clinical healing benefits using this investigated protocol.

Clinical relevance

This is the first clinical study evaluating the effect of gel containing green tea extract and HA on the palate postoperative pain control and wound healing after FGG.

Trial registration

http://clinicaltrials.gov: NCT05270161

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Titel: Effect of a gel containing green tea extract and hyaluronic acid on palate pain scores and wound healing after free gingival graft: a quasi-randomized controlled clinical trial
verfasst von: Jovânia Alves Oliveira
Marcela Iunes da Silveira
Roberta de Oliveira Alves
Fábio José Barbosa Bezerra
Guilherme José Pimentel Lopes de Oliveira
Suzane Cristina Pigossi
Publikationsdatum: 29.09.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Oral Investigations / Ausgabe 11/2023
Print ISSN: 1432-6981
Elektronische ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-023-05282-x

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Effect of a gel containing green tea extract and hyaluronic acid on palate pain scores and wound healing after free gingival graft: a quasi-randomized controlled clinical trial