Introduction
Methods
Study design
Measures
Generalized anxiety disorder (GAD-7)
Patient health questionnaire (PHQ-9)
Statistical analyses
Results
Baseline characteristic | Total (n = 86) | UC (n = 46) | CD (n = 40) | |||
---|---|---|---|---|---|---|
Gender | ||||||
Female | 31 | 36% | 18 | 39% | 13 | 32% |
Male | 55 | 64% | 28 | 61% | 27 | 68% |
Age (years) | 15.6 | ± 2.8 | 15 | ± 3 | 16 | ± 3 |
BMI (kg/m2) | 20.3 | ± 5.5 | 21.2 | ± 5.5 | 19.4 | ± 5.5 |
Disease duration (months) | 50 | ± 46 | 55 | ± 53 | 44 | ± 39 |
Medication | ||||||
Mesalamine | 40 | 48.2% | 26 | 56% | 14 | 35% |
Immunomodulator | 14 | 16.9% | 11 | 24% | 3 | 7% |
Oral corticosteroid | 13 | 17.7% | 9 | 19% | 4 | 10% |
Biologic | 27 | 31.4% | 10 | 22% | 17 | 42% |
Previous surgical resection | 2 | 1.4% | 1 | 2% | 1 | 2% |
Biologics initiation or switching therapy within 2y | 36 | 41.9% | 18 | 39% | 18 | 45% |
PHQ-9 > 10 | 17 | 19.7% | 11 | 24% | 6 | 15% |
GAD-7 > 10 | 18 | 20.9% | 10 | 22% | 8 | 20% |
PHQ-9 score | 6.3 | ± 4.8 | 6.4 | ± 4.5 | 6.1 | ± 5.2 |
GAD-7 score | 5.8 | ± 3.8 | 6.1 | ± 3.9 | 5.5 | ± 3.7 |
Previous psychotropic medication a | 6 | 7% | 3 | 6% | 3 | 7% |
Measure | UC | CD | X2 | p-value | |||
---|---|---|---|---|---|---|---|
N | % | N | % | ||||
Depression symptoms (PHQ-9) | |||||||
No symptoms | 20 | 43.5 | 22 | 55 | 2.3 | 0.50 | |
Mild | 15 | 32.6 | 13 | 32.5 | |||
Moderate | 6 | 13 | 2 | 5 | |||
Severe | 5 | 11 | 3 | 7.5 | |||
Anxiety symptoms (GAD-7) | |||||||
No symptoms | 19 | 41 | 20 | 50 | 0.87 | 0.83 | |
Mild | 17 | 37 | 12 | 30 | |||
Moderate | 8 | 17.4 | 7 | 17.5 | |||
Severe | 2 | 4.3 | 1 | 2.5 |
OR | 95%CI | ||
---|---|---|---|
Unadjusted | Depression | 4.5 | 1.4–14.3 |
Adjusted | Depression | 4.2 | 1.2–14.9 |
Disease type (CD) | 1.8 | 0.7–4.7 | |
Sex (male) | 0.4 | 0.1–1.1 | |
Age (years) | 0.9 | 0.7 − 1.0 | |
Unadjusted | Anxiety | 2.7 | 0.9–7.8 |
Adjusted | Anxiety | 2.3 | 0.7–7.3 |
Disease type (CD) | 1.6 | 0.6–4.1 | |
Sex (male) | 0.4 | 0.1–1.0 | |
Age (years) | 0.6 | 0.7 − 1.0 |