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04.11.2022 | COVID-19 | Review articles

Overview of pharmacotherapy targeting COVID-19 disease based on ACE-2: current challenges and future directions

verfasst von: Antonio Vitiello, MD, Andrea Zovi, PD, Ugo Trama, MD, Francesco Ferrara, MD

Erschienen in: Herz | Ausgabe 5/2023

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Abstract

The new Severe acute respiratory syndrome coronavirus 2 (SARS-CoV‑2) triggered the pandemic of COVID-19, which is currently still ongoing. In 2021 a worldwide vaccine campaign was launched, and in parallel the lines of research are continuing to target the most effective drug therapies for the treatment of COVID-19 disease. SARS-CoV‑2 enters host cells via glycoprotein angiotensin-converting enzyme 2 (ACE-2), which plays a major role in renin–angiotensin system interactions and undergoes changes in expression during metabolic and viral diseases, including COVID-19. It seems that the severe lung damage that occurs in several cases of COVID-19 disease may be connected to a deregulated expression of ACE‑2. In this manuscript we focus on the line of research that studies the pharmacological modification of ACE‑2 expression, a promising weapon to counter the severe harms caused by COVID-19.

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Titel: Overview of pharmacotherapy targeting COVID-19 disease based on ACE-2: current challenges and future directions
verfasst von: Antonio Vitiello, MD
Andrea Zovi, PD
Ugo Trama, MD
Francesco Ferrara, MD
Publikationsdatum: 04.11.2022
Verlag: Springer Medizin
Schlagwort: COVID-19
Erschienen in: Herz / Ausgabe 5/2023
Print ISSN: 0340-9937
Elektronische ISSN: 1615-6692
DOI: https://doi.org/10.1007/s00059-022-05142-6

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