Introduction
Methods
Patient data
Histopathology and immunohistochemistry
Statistical analysis
Results
Clinical characteristics
Characteristics (N = 174) | Number |
---|---|
Age at surgery, years, median (range) | 43 (14–75) |
Male (%) | 84 (48.3) |
Lesion site (%) | |
Vestibular nerve | 132 (75.9) |
Trigeminal nerve | 16 (9.2) |
Lower cranial nerve | 21 (12.1) |
Others | 5 (2.9) |
Laterality (%) | |
Left | 84 (48.3) |
Right | 89 (51.1) |
Meningioma (%) | 4 (2.3) |
Maximum tumor diameter, mm, median (range) | 30 (8–102) |
≥ 30 mm (%) | 88 (50.6) |
Cyst (%) | 84 (48.3) |
Bleeding (%) | 17 (9.8) |
Calcification (%) | 4 (2.3) |
Tumor stain (%) | 25 (14.4) |
Gross total resection (%) | 130 (74.7) |
Pathology (%) | |
Conventional schwannoma | 159 (91.4) |
Ancient schwannoma | 13 (7.5) |
Cellular schwannoma | 2 (1.1) |
Ki-67 index (mean ± SD) | 2.2 ± 3.3 |
Symptom to surgery, months, median (range) | 12.0 (2.0–144.0) |
Postoperative follow-up, months, median (range) | 61.4 (0.7–222.6) |
Salvage treatment (%) | 13 (7.5) |
Postoperative recurrence (%) | 14 (8.0) |
Histopathological features
Comparison of conventional schwannoma and AS
Variable | Conventional schwannoma (N = 159) | AS (N = 13) | Cellular schwannoma (N = 2) | p value* |
---|---|---|---|---|
Age, years, median (range) | 43 (15–75) | 44 (14–73) | 31 (24–37) | 0.522 |
Male (%) | 76 (47.8%) | 6 (46.2%) | 1 (50.0%) | > 0.99 |
Meningioma (%) | 3 (1.9%) | 1 (7.7%) | 0 (0.0%) | 0.272 |
Maximum tumor diameter, mm, median (range) | 29 (8–102) | 35 (25–60) | 38 (32–44) | 0.017 |
Cyst (%) | 71 (44.7%) | 12 (92.3%) | 1 (50.0%) | < 0.001 |
Bleeding (%) | 11 (6.9%) | 5 (38.5%) | 1 (50.0%) | 0.003 |
Calcification (%) | 2 (1.3%) | 2 (15.4%) | 0 (0.0%) | 0.029 |
Tumor stain (%) | 22 (13.8%) | 2 (15.4%) | 1 (50.0%) | > 0.99 |
Gross total resection (%) | 118 (74.2%) | 11 (84.6%) | 1 (50.0%) | 0.522 |
Ki-67 index (mean ± SD) | 2.1 ± 2.6 | 1.6 ± 1.2 | 15.5 ± 14.5 | 0.578 |
Symptom onset to surgery, months, median (range) | 12.5 (2.0–144.0) | 7.0 (3.0–120.0) | 3 (3–3) | 0.740 |
Salvage treatment (%) | 11 (6.9%) | 1 (7.7%) | 1 (50.0%) | > 0.99 |
Postoperative recurrence (%) | 12 (7.5%) | 1 (7.7%) | 1 (50.0%) | > 0.99 |
Variable | Odds ratio | 95%CI | p value |
---|---|---|---|
Maximum tumor diametera | 1.58 | 0.41–6.06 | 0.506 |
Cyst | 10.00 | 1.19–84.60 | 0.034 |
Bleeding | 3.72 | 0.90–15.30 | 0.070 |
Calcification | 11.10 | 1.02–120.00 | 0.048 |