Skip to main content
Erschienen in: Zeitschrift für Rheumatologie 1/2022

11.11.2022 | Anakinra | Leitlinien

DGRh-S2e-Leitlinie

Diagnostik und Therapie des adulten Still-Syndroms (AOSD)

verfasst von: Prof. Dr. Stefan Vordenbäumen, Eugen Feist, Jürgen Rech, Martin Fleck, Norbert Blank, Johannes-Peter Haas, Ina Kötter, Martin Krusche, Gamal Chehab, Bimba Hoyer, Uta Kiltz, Dorothea Fell, Julia Reiners, Christiane Weseloh, Matthias Schneider, Jürgen Braun

Erschienen in: Zeitschrift für Rheumatologie | Sonderheft 1/2022

Einloggen, um Zugang zu erhalten

Auszug

Klassifikation: S2e …
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Zurück zum Zitat Abid N, Bin Kahlid A (2009) Adult onset Stills disease in a tertiary care hospital of Pakistan. J Pak Med Assoc 59;7:464–467 Abid N, Bin Kahlid A (2009) Adult onset Stills disease in a tertiary care hospital of Pakistan. J Pak Med Assoc 59;7:464–467
2.
Zurück zum Zitat Aeberli D, Oertle S, Mauron H et al (2002) Inhibition of the TNF-pathway: use of infliximab and etanercept as remission-inducing agents in cases of therapy-resistant chronic inflammatory disorders. Swiss Med Wkly 132:414–422 Aeberli D, Oertle S, Mauron H et al (2002) Inhibition of the TNF-pathway: use of infliximab and etanercept as remission-inducing agents in cases of therapy-resistant chronic inflammatory disorders. Swiss Med Wkly 132:414–422
7.
Zurück zum Zitat Al-Arfaj AS, Al-Saleh S (2001) Adult-onset still’s disease in Saudi Arabia. Clin Rheumatol 20:197–200CrossRef Al-Arfaj AS, Al-Saleh S (2001) Adult-onset still’s disease in Saudi Arabia. Clin Rheumatol 20:197–200CrossRef
8.
Zurück zum Zitat Al-Temimi FA, George P (2006) adult onset still’s disease in oman. Sultan Qaboos Univ Med J 6:41–45 Al-Temimi FA, George P (2006) adult onset still’s disease in oman. Sultan Qaboos Univ Med J 6:41–45
11.
Zurück zum Zitat Andres E, Ruellan A, Pflumio F et al (2002) Sensitivity of the criteria used to diagnose adult still’s disease in internal medicine practice. A study of 17 cases. Eur J Intern Med 13:136–138CrossRef Andres E, Ruellan A, Pflumio F et al (2002) Sensitivity of the criteria used to diagnose adult still’s disease in internal medicine practice. A study of 17 cases. Eur J Intern Med 13:136–138CrossRef
12.
Zurück zum Zitat Appenzeller S, Castro GRW, Costallat LTL, Samara AM, Bértolo MB (2005) Adult-Onset Still Disease in Southeast Brazil. J Clin Rheumatol 11(2):76–80CrossRef Appenzeller S, Castro GRW, Costallat LTL, Samara AM, Bértolo MB (2005) Adult-Onset Still Disease in Southeast Brazil. J Clin Rheumatol 11(2):76–80CrossRef
15.
Zurück zum Zitat Aydintug AO, D’Cruz D, Cervera R et al (1992) Low dose methotrexate treatment in adult Still’s disease. J Rheumatol 19:431–435 Aydintug AO, D’Cruz D, Cervera R et al (1992) Low dose methotrexate treatment in adult Still’s disease. J Rheumatol 19:431–435
18.
Zurück zum Zitat Bambery P, Thomas RJ, Malhotra HS, Kaur U, Bhusnurmath SR, Deodhar SD (1992) Adult onset Still’s disease: clinical experience with 18 patients over 15 years in northern India. Ann Rheum Dis 51:529–532CrossRef Bambery P, Thomas RJ, Malhotra HS, Kaur U, Bhusnurmath SR, Deodhar SD (1992) Adult onset Still’s disease: clinical experience with 18 patients over 15 years in northern India. Ann Rheum Dis 51:529–532CrossRef
19.
Zurück zum Zitat Balci MA, Pamuk ÖN, Pamuk GE et al (2015) Epidemiology and outcome of adult-onset Still’s disease in Northwestern Thrace region in Turkey. Clin Exp Rheumatol 33:818–823 Balci MA, Pamuk ÖN, Pamuk GE et al (2015) Epidemiology and outcome of adult-onset Still’s disease in Northwestern Thrace region in Turkey. Clin Exp Rheumatol 33:818–823
20.
Zurück zum Zitat Bannai E, Yamashita H, Kaneko S et al (2016) Successful tocilizumab therapy in seven patients with refractory adult-onset Still’s disease. Mod Rheumatol 26:297–301CrossRef Bannai E, Yamashita H, Kaneko S et al (2016) Successful tocilizumab therapy in seven patients with refractory adult-onset Still’s disease. Mod Rheumatol 26:297–301CrossRef
21.
Zurück zum Zitat Baxevanos G, Tzimas T, Pappas G Akritidis N (2012) A series of 22 patients with adult-onset Still’s disease presenting with fever of unknown origin. A difficult diagnosis? Clin Rheumatol 31:49–53 Baxevanos G, Tzimas T, Pappas G Akritidis N (2012) A series of 22 patients with adult-onset Still’s disease presenting with fever of unknown origin. A difficult diagnosis? Clin Rheumatol 31:49–53
22.
Zurück zum Zitat Becker H, Gaubitz M, Domschke W, Willeke P (2009) Potential role of macrophage migration inhibitory factor in adult-onset Still’s disease. Scand J Rheumatol 38:69–71CrossRef Becker H, Gaubitz M, Domschke W, Willeke P (2009) Potential role of macrophage migration inhibitory factor in adult-onset Still’s disease. Scand J Rheumatol 38:69–71CrossRef
23.
Zurück zum Zitat Behrens EM, Beukelman T, Gallo L et al (2008) Evaluation of the presentation of systemic onset juvenile rheumatoid arthritis: data from the Pennsylvania Systemic Onset Juvenile Arthritis Registry (PASOJAR). J Rheumatol 35:343–348 Behrens EM, Beukelman T, Gallo L et al (2008) Evaluation of the presentation of systemic onset juvenile rheumatoid arthritis: data from the Pennsylvania Systemic Onset Juvenile Arthritis Registry (PASOJAR). J Rheumatol 35:343–348
25.
Zurück zum Zitat Bindoli S, Galozzi P, Magnani F et al (2020) (18)F-Fluorodeoxyglucose positron emission tomography and computed tomography with magnetic resonance for diagnosing adult-onset still’s disease. Front Med 7:544412CrossRef Bindoli S, Galozzi P, Magnani F et al (2020) (18)F-Fluorodeoxyglucose positron emission tomography and computed tomography with magnetic resonance for diagnosing adult-onset still’s disease. Front Med 7:544412CrossRef
27.
Zurück zum Zitat Bodard Q, Langlois V, Guilpain P et al (2021) Cardiac involvement in adult-onset Still’s disease: manifestations, treatments and outcomes in a retrospective study of 28 patients. J Autoimmun 116:102541CrossRef Bodard Q, Langlois V, Guilpain P et al (2021) Cardiac involvement in adult-onset Still’s disease: manifestations, treatments and outcomes in a retrospective study of 28 patients. J Autoimmun 116:102541CrossRef
29.
Zurück zum Zitat DGRh, Buttgereit F, Brabant T et al (2018) S3 guidelines on treatment of polymyalgia rheumatica : evidence-based guidelines of the German Society of Rheumatology (DGRh), the Austrian Society of Rheumatology and Rehabilitation (ÖGR) and the Swiss Society of Rheumatology (SGT) and participating medical scientific specialist societies and other organizations. Z Rheumatol 77:429–441. https://doi.org/10.1007/s00393-018-0476-8CrossRef DGRh, Buttgereit F, Brabant T et al (2018) S3 guidelines on treatment of polymyalgia rheumatica : evidence-based guidelines of the German Society of Rheumatology (DGRh), the Austrian Society of Rheumatology and Rehabilitation (ÖGR) and the Swiss Society of Rheumatology (SGT) and participating medical scientific specialist societies and other organizations. Z Rheumatol 77:429–441. https://​doi.​org/​10.​1007/​s00393-018-0476-8CrossRef
33.
Zurück zum Zitat Cavagna L, Caporali R, Epis O et al (2001) Infliximab in the treatment of adult Still’s disease refractory to conventional therapy. Clin Exp Rheumatol 19:329–332 Cavagna L, Caporali R, Epis O et al (2001) Infliximab in the treatment of adult Still’s disease refractory to conventional therapy. Clin Exp Rheumatol 19:329–332
34.
Zurück zum Zitat Cavalli G, Franchini S, Aiello P et al (2015) Efficacy and safety of biological agents in adult-onset Still’s disease. Scand J Rheumatol 44:309–314CrossRef Cavalli G, Franchini S, Aiello P et al (2015) Efficacy and safety of biological agents in adult-onset Still’s disease. Scand J Rheumatol 44:309–314CrossRef
35.
Zurück zum Zitat Cavalli G, Franchini S, Berti A et al (2013) Efficacy and safety of biologic agents in adult-onset still’s disease: a long-term follow-up of 19 patients at a single referral center. Abstr. 2028 Am. Coll. Rheumatol. Annu. Meet. Cavalli G, Franchini S, Berti A et al (2013) Efficacy and safety of biologic agents in adult-onset still’s disease: a long-term follow-up of 19 patients at a single referral center. Abstr. 2028 Am. Coll. Rheumatol. Annu. Meet.
38.
39.
40.
44.
Zurück zum Zitat Chen D‑Y, Hsieh T‑Y, Hsieh C‑W et al (2007) Increased apoptosis of peripheral blood lymphocytes and its association with interleukin-18 in patients with active untreated adult-onset Still’s disease. Arthritis Rheum 57:1530–1538. https://doi.org/10.1002/art.23088CrossRef Chen D‑Y, Hsieh T‑Y, Hsieh C‑W et al (2007) Increased apoptosis of peripheral blood lymphocytes and its association with interleukin-18 in patients with active untreated adult-onset Still’s disease. Arthritis Rheum 57:1530–1538. https://​doi.​org/​10.​1002/​art.​23088CrossRef
45.
Zurück zum Zitat Chen D‑Y, Lan J‑L, Lin F‑J, Hsieh T‑Y (2004) Proinflammatory cytokine profiles in sera and pathological tissues of patients with active untreated adult onset Still’s disease. J Rheumatol 31:2189–2198 Chen D‑Y, Lan J‑L, Lin F‑J, Hsieh T‑Y (2004) Proinflammatory cytokine profiles in sera and pathological tissues of patients with active untreated adult onset Still’s disease. J Rheumatol 31:2189–2198
46.
Zurück zum Zitat Chen D‑Y, Lan J‑L, Lin F‑J, Hsieh T‑Y (2005) Association of intercellular adhesion molecule‑1 with clinical manifestations and interleukin-18 in patients with active, untreated adult-onset Still’s disease. Arthritis Rheum 53:320–327. https://doi.org/10.1002/art.21164CrossRef Chen D‑Y, Lan J‑L, Lin F‑J, Hsieh T‑Y (2005) Association of intercellular adhesion molecule‑1 with clinical manifestations and interleukin-18 in patients with active, untreated adult-onset Still’s disease. Arthritis Rheum 53:320–327. https://​doi.​org/​10.​1002/​art.​21164CrossRef
47.
Zurück zum Zitat Chen D‑Y, Lan J‑L, Lin F‑J, Hsieh T‑Y (2007) Elevated levels of soluble Fas (APO‑1, CD95), soluble Fas ligand, and matrix metalloproteinase‑3 in sera from patients with active untreated adult onset Still’s disease. Clin Rheumatol 26:393–400. https://doi.org/10.1007/s10067-006-0378-zCrossRef Chen D‑Y, Lan J‑L, Lin F‑J, Hsieh T‑Y (2007) Elevated levels of soluble Fas (APO‑1, CD95), soluble Fas ligand, and matrix metalloproteinase‑3 in sera from patients with active untreated adult onset Still’s disease. Clin Rheumatol 26:393–400. https://​doi.​org/​10.​1007/​s10067-006-0378-zCrossRef
51.
Zurück zum Zitat Chi H, Wang Z, Meng J et al (2020) A cohort study of liver involvement in patients with adult-onset still’s disease: prevalence, characteristics and impact on prognosis. Front Med 7:621005CrossRef Chi H, Wang Z, Meng J et al (2020) A cohort study of liver involvement in patients with adult-onset still’s disease: prevalence, characteristics and impact on prognosis. Front Med 7:621005CrossRef
52.
Zurück zum Zitat Choi J‑H, Suh C‑H, Lee Y‑M et al (2003) Serum cytokine profiles in patients with adult onset Still’s disease. J Rheumatol 30:2422–2427 Choi J‑H, Suh C‑H, Lee Y‑M et al (2003) Serum cytokine profiles in patients with adult onset Still’s disease. J Rheumatol 30:2422–2427
54.
Zurück zum Zitat Colafrancesco S, Priori R, Aless et al (2012) IL-18 serum level in adult onset still’s disease: a marker of disease activity. Int J Inflam 2012:156890 Colafrancesco S, Priori R, Aless et al (2012) IL-18 serum level in adult onset still’s disease: a marker of disease activity. Int J Inflam 2012:156890
56.
Zurück zum Zitat Colafrancesco S, Priori R, Valesini G et al (2017) Response to Interleukin‑1 inhibitors in 140 Italian patients with adult-onset still’s disease: a multicentre retrospective observational study. Front Pharmacol 8:369CrossRef Colafrancesco S, Priori R, Valesini G et al (2017) Response to Interleukin‑1 inhibitors in 140 Italian patients with adult-onset still’s disease: a multicentre retrospective observational study. Front Pharmacol 8:369CrossRef
59.
Zurück zum Zitat Dall’Ara F, Frassi M, Tincani A, Airò P (2016) A retrospective study of patients with adult-onset Still’s disease: is pericarditis a possible predictor for biological disease-modifying anti-rheumatic drugs need? Clin Rheumatol 35:2117–2123CrossRef Dall’Ara F, Frassi M, Tincani A, Airò P (2016) A retrospective study of patients with adult-onset Still’s disease: is pericarditis a possible predictor for biological disease-modifying anti-rheumatic drugs need? Clin Rheumatol 35:2117–2123CrossRef
61.
Zurück zum Zitat Delplanque M, Pouchot J, Ducharme-Bénard S et al (2020) AA amyloidosis secondary to adult onset Still’s disease: About 19 cases. Semin Arthritis Rheum 50:156–165CrossRef Delplanque M, Pouchot J, Ducharme-Bénard S et al (2020) AA amyloidosis secondary to adult onset Still’s disease: About 19 cases. Semin Arthritis Rheum 50:156–165CrossRef
62.
Zurück zum Zitat Di Benedetto P, Cipriani P, Iacono D et al (2020) Ferritin and C‑reactive protein are predictive biomarkers of mortality and macrophage activation syndrome in adult onset Still’s disease. Analysis of the multicentre Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale (GIRRCS) cohort. PLoS ONE 15:e235326CrossRef Di Benedetto P, Cipriani P, Iacono D et al (2020) Ferritin and C‑reactive protein are predictive biomarkers of mortality and macrophage activation syndrome in adult onset Still’s disease. Analysis of the multicentre Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale (GIRRCS) cohort. PLoS ONE 15:e235326CrossRef
65.
Zurück zum Zitat Evensen KJ, Nossent HC (2006) Epidemiology and outcome of adult-onset Still’s disease in Northern Norway. Scand J Rheumatol 35:48–51CrossRef Evensen KJ, Nossent HC (2006) Epidemiology and outcome of adult-onset Still’s disease in Northern Norway. Scand J Rheumatol 35:48–51CrossRef
67.
Zurück zum Zitat Fardet L, Galicier L, Lambotte O et al (2014) Development and validation of the hscore, a score for the diagnosis of reactive hemophagocytic syndrome: score for reactive hemophagocytic syndrome. Arthritis Rheumatol 66:2613–2620. https://doi.org/10.1002/art.38690CrossRef Fardet L, Galicier L, Lambotte O et al (2014) Development and validation of the hscore, a score for the diagnosis of reactive hemophagocytic syndrome: score for reactive hemophagocytic syndrome. Arthritis Rheumatol 66:2613–2620. https://​doi.​org/​10.​1002/​art.​38690CrossRef
69.
Zurück zum Zitat Fautrel B (2008) Adult-onset Still disease. Best Pract Res Clin Rheumatol 22:773–792CrossRef Fautrel B (2008) Adult-onset Still disease. Best Pract Res Clin Rheumatol 22:773–792CrossRef
70.
Zurück zum Zitat Fautrel B, Le Moël G, Saint-Marcoux B et al (2001) Diagnostic value of ferritin and glycosylated ferritin in adult onset Still’s disease. J Rheumatol 28:322–329 Fautrel B, Le Moël G, Saint-Marcoux B et al (2001) Diagnostic value of ferritin and glycosylated ferritin in adult onset Still’s disease. J Rheumatol 28:322–329
71.
Zurück zum Zitat Feist E, Quartier P, Fautrel B et al (2018) Efficacy and safety of canakinumab in patients with Still’s disease: exposure-response analysis of pooled systemic juvenile idiopathic arthritis data by age groups. Clin Exp Rheumatol 36:668–675 Feist E, Quartier P, Fautrel B et al (2018) Efficacy and safety of canakinumab in patients with Still’s disease: exposure-response analysis of pooled systemic juvenile idiopathic arthritis data by age groups. Clin Exp Rheumatol 36:668–675
75.
Zurück zum Zitat Franchini S, Dagna L, Salvo F et al (2010) Adult onset Still’s disease: clinical presentation in a large cohort of Italian patients. Clin Exp Rheumatol 28:41–48 Franchini S, Dagna L, Salvo F et al (2010) Adult onset Still’s disease: clinical presentation in a large cohort of Italian patients. Clin Exp Rheumatol 28:41–48
79.
Zurück zum Zitat Gabay C, Fautrel B, Rech J et al (2018) Open-label, multicentre, dose-escalating phase II clinical trial on the safety and efficacy of tadekinig alfa (IL-18BP) in adult-onset Still’s disease. Ann Rheum Dis 77:840–847 Gabay C, Fautrel B, Rech J et al (2018) Open-label, multicentre, dose-escalating phase II clinical trial on the safety and efficacy of tadekinig alfa (IL-18BP) in adult-onset Still’s disease. Ann Rheum Dis 77:840–847
81.
Zurück zum Zitat Giampietro C, Ridene M, Fautrel B, Bourgeous P (2010) Long term treatment with Anakinra in patients with adult-onset still disease. Abstr. 902 Am. Coll. Rheumatol. Annu. Meet. Giampietro C, Ridene M, Fautrel B, Bourgeous P (2010) Long term treatment with Anakinra in patients with adult-onset still disease. Abstr. 902 Am. Coll. Rheumatol. Annu. Meet.
82.
Zurück zum Zitat Giampietro C, Ridene M, Lequerre T et al (2013) Anakinra in adult-onset still’s disease: long-term treatment in patients resistant to conventional therapy: long-term efficacy and safety of Anakinra in AOSD. Arthritis Care Res 65:822–826. https://doi.org/10.1002/acr.21901CrossRef Giampietro C, Ridene M, Lequerre T et al (2013) Anakinra in adult-onset still’s disease: long-term treatment in patients resistant to conventional therapy: long-term efficacy and safety of Anakinra in AOSD. Arthritis Care Res 65:822–826. https://​doi.​org/​10.​1002/​acr.​21901CrossRef
87.
Zurück zum Zitat Han JH, Suh C‑H, Jung J‑Y et al (2017) Serum levels of Interleukin 33 and soluble ST2 are associated with the extent of disease activity and cutaneous manifestations in patients with active adult-onset still’s disease. J Rheumatol 44:740–747. https://doi.org/10.3899/jrheum.170020CrossRef Han JH, Suh C‑H, Jung J‑Y et al (2017) Serum levels of Interleukin 33 and soluble ST2 are associated with the extent of disease activity and cutaneous manifestations in patients with active adult-onset still’s disease. J Rheumatol 44:740–747. https://​doi.​org/​10.​3899/​jrheum.​170020CrossRef
88.
Zurück zum Zitat Han JH, Suh C‑H, Jung J‑Y et al (2017) Elevated circulating levels of the interferon-γ–induced chemokines are associated with disease activity and cutaneous manifestations in adult-onset Still’s disease. Sci Rep 7:46652. https://doi.org/10.1038/srep46652CrossRef Han JH, Suh C‑H, Jung J‑Y et al (2017) Elevated circulating levels of the interferon-γ–induced chemokines are associated with disease activity and cutaneous manifestations in adult-onset Still’s disease. Sci Rep 7:46652. https://​doi.​org/​10.​1038/​srep46652CrossRef
91.
Zurück zum Zitat Hong D, Yang Z, Han S et al (2014) Interleukin 1 inhibition with anakinra in adult-onset Still disease: a meta-analysis of its efficacy and safety. Drug Devel Ther 8:2345–2357 Hong D, Yang Z, Han S et al (2014) Interleukin 1 inhibition with anakinra in adult-onset Still disease: a meta-analysis of its efficacy and safety. Drug Devel Ther 8:2345–2357
96.
Zurück zum Zitat Iliou C, Papagoras C, Tsifetaki N et al (2013) Adult-onset Still’s disease: clinical, serological and therapeutic considerations. Clin Exp Rheumatol 31:47–52 Iliou C, Papagoras C, Tsifetaki N et al (2013) Adult-onset Still’s disease: clinical, serological and therapeutic considerations. Clin Exp Rheumatol 31:47–52
100.
Zurück zum Zitat Jung JH, Jun JB, Yoo DH et al (2000) High toxicity of sulfasalazine in adult-onset Still’s disease. Clin Exp Rheumatol 18:245–248 Jung JH, Jun JB, Yoo DH et al (2000) High toxicity of sulfasalazine in adult-onset Still’s disease. Clin Exp Rheumatol 18:245–248
101.
Zurück zum Zitat Jung KH, Kim JJ, Lee JS et al (2014) Interleukin-18 as an efficient marker for remission and follow-up in patients with inactive adult-onset Still’s disease. Scand J Rheumatol 43:162–169CrossRef Jung KH, Kim JJ, Lee JS et al (2014) Interleukin-18 as an efficient marker for remission and follow-up in patients with inactive adult-onset Still’s disease. Scand J Rheumatol 43:162–169CrossRef
103.
Zurück zum Zitat Kallinich T, Blank N, Braun T et al (2019) Evidence-based treatment recommendations for familial Mediterranean fever : a joint statement by the society for pediatric and adolescent rheumatology and the German society for rheumatology. Z Rheumatol 78:91–101. https://doi.org/10.1007/s00393-018-0588-1CrossRef Kallinich T, Blank N, Braun T et al (2019) Evidence-based treatment recommendations for familial Mediterranean fever : a joint statement by the society for pediatric and adolescent rheumatology and the German society for rheumatology. Z Rheumatol 78:91–101. https://​doi.​org/​10.​1007/​s00393-018-0588-1CrossRef
106.
Zurück zum Zitat Kawaguchi Y, Terajima H, Harigai M et al (2001) Interleukin-18 as a novel diagnostic marker and indicator of disease severity in adult-onset Still’s disease. Arthritis Rheum 44:1716–1717. https://doi.org/10.1002/1529-0131(200107)44:7〈1716::AID-ART298〉3.0.CO;2‑ICrossRef Kawaguchi Y, Terajima H, Harigai M et al (2001) Interleukin-18 as a novel diagnostic marker and indicator of disease severity in adult-onset Still’s disease. Arthritis Rheum 44:1716–1717. https://​doi.​org/​10.​1002/​1529-0131(200107)44:7〈1716::AID-ART298〉3.0.CO;2‑ICrossRef
107.
Zurück zum Zitat Kawashima M, Yamamura M, Taniai M et al (2001) Levels of interleukin-18 and its binding inhibitors in the blood circulation of patients with adult-onset Still’s disease. Arthritis Rheum 44:550–560. https://doi.org/10.1002/1529-0131(200103)44:3〈550::AID-ANR103〉3.0.CO;2‑5CrossRef Kawashima M, Yamamura M, Taniai M et al (2001) Levels of interleukin-18 and its binding inhibitors in the blood circulation of patients with adult-onset Still’s disease. Arthritis Rheum 44:550–560. https://​doi.​org/​10.​1002/​1529-0131(200103)44:3〈550::AID-ANR103〉3.0.CO;2‑5CrossRef
108.
Zurück zum Zitat Kedor C, Listing J, Zernicke J et al (2020) Canakinumab for treatment of adult-onset still’s disease to achieve reduction of arthritic manifestation (CONSIDER): phase II, randomised, double-blind, placebo-controlled, multicentre, investigator-initiated trial. Ann Rheum Dis 79:1090–1097CrossRef Kedor C, Listing J, Zernicke J et al (2020) Canakinumab for treatment of adult-onset still’s disease to achieve reduction of arthritic manifestation (CONSIDER): phase II, randomised, double-blind, placebo-controlled, multicentre, investigator-initiated trial. Ann Rheum Dis 79:1090–1097CrossRef
109.
Zurück zum Zitat Kiltz U, Alten R, Fleck M et al (2017) Evidence-based recommendations for diagnostics and treatment of gouty arthritis in the specialist sector : S2e guidelines of the German Society of Rheumatology in cooperation with the AWMF. Z Rheumatol 76:118–124. https://doi.org/10.1007/s00393-016-0249-1CrossRef Kiltz U, Alten R, Fleck M et al (2017) Evidence-based recommendations for diagnostics and treatment of gouty arthritis in the specialist sector : S2e guidelines of the German Society of Rheumatology in cooperation with the AWMF. Z Rheumatol 76:118–124. https://​doi.​org/​10.​1007/​s00393-016-0249-1CrossRef
110.
Zurück zum Zitat Kiltz U, Kiefer D, Braun J et al (2020) Prolonged treatment with tadekinig alfa in adult-onset still’s disease. Ann Rheum Dis 79:e10CrossRef Kiltz U, Kiefer D, Braun J et al (2020) Prolonged treatment with tadekinig alfa in adult-onset still’s disease. Ann Rheum Dis 79:e10CrossRef
111.
113.
Zurück zum Zitat Kim JJ, Kim J‑K, Shim S‑C et al (2013) MEFV gene mutations and their clinical significance in Korean patients with adult-onset Still’s disease. Clin Exp Rheumatol 31:60–63 Kim JJ, Kim J‑K, Shim S‑C et al (2013) MEFV gene mutations and their clinical significance in Korean patients with adult-onset Still’s disease. Clin Exp Rheumatol 31:60–63
115.
Zurück zum Zitat Kim YJ, Koo BS, Kim Y‑G et al (2014) Clinical features and prognosis in 82 patients with adult-onset Still’s disease. Clin Exp Rheumatol 32:28–33 Kim YJ, Koo BS, Kim Y‑G et al (2014) Clinical features and prognosis in 82 patients with adult-onset Still’s disease. Clin Exp Rheumatol 32:28–33
117.
Zurück zum Zitat Kirino Y, Takeno M, Iwasaki M et al (2005) Increased serum HO‑1 in hemophagocytic syndrome and adult-onset Still’s disease: use in the differential diagnosis of hyperferritinemia. Arthritis Res Ther 7:R616–24CrossRef Kirino Y, Takeno M, Iwasaki M et al (2005) Increased serum HO‑1 in hemophagocytic syndrome and adult-onset Still’s disease: use in the differential diagnosis of hyperferritinemia. Arthritis Res Ther 7:R616–24CrossRef
120.
Zurück zum Zitat Koizumi R, Tsukada Y, Ideura H et al (2000) Treatment of adult Still’s disease with dexamethasone, an alternative to prednisolone. Scand J Rheumatol 29:396–398CrossRef Koizumi R, Tsukada Y, Ideura H et al (2000) Treatment of adult Still’s disease with dexamethasone, an alternative to prednisolone. Scand J Rheumatol 29:396–398CrossRef
122.
Zurück zum Zitat Kokkinos A, Iliopoulos A, Greka P et al (2004) Successful treatment of refractory adult-onset Still’s disease with infliximab. A prospective, non-comparative series of four patients. Clin Rheumatol 23:45–49CrossRef Kokkinos A, Iliopoulos A, Greka P et al (2004) Successful treatment of refractory adult-onset Still’s disease with infliximab. A prospective, non-comparative series of four patients. Clin Rheumatol 23:45–49CrossRef
124.
Zurück zum Zitat Kong XD, Xu D, Zhang W et al (2010) Clinical features and prognosis in adult-onset Still’s disease: a study of 104 cases. Clin Rheumatol 29:1015–1019CrossRef Kong XD, Xu D, Zhang W et al (2010) Clinical features and prognosis in adult-onset Still’s disease: a study of 104 cases. Clin Rheumatol 29:1015–1019CrossRef
125.
Zurück zum Zitat Kontzias A, Efthimiou P (2008) Adult-onset Still’s disease: pathogenesis, clinical manifestations and therapeutic advances. Drugs 68:319–337CrossRef Kontzias A, Efthimiou P (2008) Adult-onset Still’s disease: pathogenesis, clinical manifestations and therapeutic advances. Drugs 68:319–337CrossRef
127.
Zurück zum Zitat Kraetsch HG, Antoni C, Kalden JR, Manger B (1997) Successful treatment of a small cohort of patients with adult onset of Still’s disease with infliximab: first experiences. Ann Rheum Dis 60:iii55–iii57 Kraetsch HG, Antoni C, Kalden JR, Manger B (1997) Successful treatment of a small cohort of patients with adult onset of Still’s disease with infliximab: first experiences. Ann Rheum Dis 60:iii55–iii57
128.
Zurück zum Zitat Kudela H, Drynda S, Lux A et al (2019) Comparative study of Interleukin-18 (IL-18) serum levels in adult onset Still’s disease (AOSD) and systemic onset juvenile idiopathic arthritis (sJIA) and its use as a biomarker for diagnosis and evaluation of disease activity. BMC Rheumatol 3:4CrossRef Kudela H, Drynda S, Lux A et al (2019) Comparative study of Interleukin-18 (IL-18) serum levels in adult onset Still’s disease (AOSD) and systemic onset juvenile idiopathic arthritis (sJIA) and its use as a biomarker for diagnosis and evaluation of disease activity. BMC Rheumatol 3:4CrossRef
132.
Zurück zum Zitat Lambotte O, Cacoub P, Costedoat N et al (2003) High ferritin and low glycosylated ferritin may also be a marker of excessive macrophage activation. J Rheumatol 30:1027–1028 Lambotte O, Cacoub P, Costedoat N et al (2003) High ferritin and low glycosylated ferritin may also be a marker of excessive macrophage activation. J Rheumatol 30:1027–1028
140.
Zurück zum Zitat Lequerré T, Quartier P, Rosellini D et al (2008) Interleukin‑1 receptor antagonist (anakinra) treatment in patients with systemic-onset juvenile idiopathic arthritis or adult onset Still disease: preliminary experience in France. Ann Rheum Dis 67:302–308CrossRef Lequerré T, Quartier P, Rosellini D et al (2008) Interleukin‑1 receptor antagonist (anakinra) treatment in patients with systemic-onset juvenile idiopathic arthritis or adult onset Still disease: preliminary experience in France. Ann Rheum Dis 67:302–308CrossRef
141.
Zurück zum Zitat Li H, Abramova I, Chesoni S, Yao Q (2018) Molecular genetic analysis for periodic fever syndromes: a supplemental role for the diagnosis of adult-onset Still’s disease. Clin Rheumatol 37:2021–2026CrossRef Li H, Abramova I, Chesoni S, Yao Q (2018) Molecular genetic analysis for periodic fever syndromes: a supplemental role for the diagnosis of adult-onset Still’s disease. Clin Rheumatol 37:2021–2026CrossRef
144.
Zurück zum Zitat Lim E, Chng HH (1998) Adult-onset Still’s disease in an oriental population: manifestations, course and outcome in 16 patients. Ann Acad Med Singapore 27:11–15 Lim E, Chng HH (1998) Adult-onset Still’s disease in an oriental population: manifestations, course and outcome in 16 patients. Ann Acad Med Singapore 27:11–15
146.
Zurück zum Zitat Liu Z, Lv X, Tang G (2015) Clinical features and prognosis of adult-onset Still’s disease: 75 cases from China. Int J Clin Exp Med 8:16634–16639 Liu Z, Lv X, Tang G (2015) Clinical features and prognosis of adult-onset Still’s disease: 75 cases from China. Int J Clin Exp Med 8:16634–16639
147.
Zurück zum Zitat Luthi F, Zufferey P, Hofer MF, So AK (2002) “Adolescent-onset Still’s disease”: characteristics and outcome in comparison with adult-onset Still’s disease. Clin Exp Rheumatol 20:427–430 Luthi F, Zufferey P, Hofer MF, So AK (2002) “Adolescent-onset Still’s disease”: characteristics and outcome in comparison with adult-onset Still’s disease. Clin Exp Rheumatol 20:427–430
149.
Zurück zum Zitat Maeda-Aoyama N, Hamada-Ode K, Taniguchi Y et al (2020) Dyskeratotic cells in persistent pruritic skin lesions as a prognostic factor in adult-onset Still disease. Medicine 99:e19051CrossRef Maeda-Aoyama N, Hamada-Ode K, Taniguchi Y et al (2020) Dyskeratotic cells in persistent pruritic skin lesions as a prognostic factor in adult-onset Still disease. Medicine 99:e19051CrossRef
150.
Zurück zum Zitat Magadur-Joly G, Billaud E, Barrier JH et al (1995) Epidemiology of adult Still’s disease: estimate of the incidence by a retrospective study in west France. Ann Rheum Dis 54:587–590CrossRef Magadur-Joly G, Billaud E, Barrier JH et al (1995) Epidemiology of adult Still’s disease: estimate of the incidence by a retrospective study in west France. Ann Rheum Dis 54:587–590CrossRef
154.
Zurück zum Zitat Mehrpoor G, Owlia MB, Soleimani H, Ayatollahi J (2008) Adult-onset Still’s disease: a report of 28 cases and review of the literature. Mod Rheumatol 18:480–485CrossRef Mehrpoor G, Owlia MB, Soleimani H, Ayatollahi J (2008) Adult-onset Still’s disease: a report of 28 cases and review of the literature. Mod Rheumatol 18:480–485CrossRef
156.
Zurück zum Zitat Mimura T, Kondo Y, Ohta A et al (2018) Evidence-based clinical practice guideline for adult Still’s disease. Mod Rheumatol 28:736–757CrossRef Mimura T, Kondo Y, Ohta A et al (2018) Evidence-based clinical practice guideline for adult Still’s disease. Mod Rheumatol 28:736–757CrossRef
157.
Zurück zum Zitat Min JK, Cho CS, Kim HY, Oh EJ (2003) Bone marrow findings in patients with adult Still’s disease. Scand J Rheumatol 32:119–121CrossRef Min JK, Cho CS, Kim HY, Oh EJ (2003) Bone marrow findings in patients with adult Still’s disease. Scand J Rheumatol 32:119–121CrossRef
159.
Zurück zum Zitat Mitamura M, Tada Y, Koarada S et al (2009) Cyclosporin A treatment for Japanese patients with severe adult-onset Still’s disease. Mod Rheumatol 19:57–63CrossRef Mitamura M, Tada Y, Koarada S et al (2009) Cyclosporin A treatment for Japanese patients with severe adult-onset Still’s disease. Mod Rheumatol 19:57–63CrossRef
161.
Zurück zum Zitat Mok CC, Lau CS, Wong RW (1998) Clinical characteristics, treatment, and outcome of adult onset Still’s disease in southern Chinese. J Rheumatol 25:2345–2351 Mok CC, Lau CS, Wong RW (1998) Clinical characteristics, treatment, and outcome of adult onset Still’s disease in southern Chinese. J Rheumatol 25:2345–2351
164.
Zurück zum Zitat Nakamura H, Fujieda Y, Tarumi M et al (2020) Calcineurin inhibitors for adult-onset Still’s disease: a multicentre retrospective cohort study. Clin Exp Rheumatol 38(Suppl 127):11–16 Nakamura H, Fujieda Y, Tarumi M et al (2020) Calcineurin inhibitors for adult-onset Still’s disease: a multicentre retrospective cohort study. Clin Exp Rheumatol 38(Suppl 127):11–16
168.
Zurück zum Zitat Néel A, Wahbi A, Tessoulin B et al (2018) Diagnostic and management of life-threatening adult-onset still disease: a French nationwide multicenter study and systematic literature review. Crit Care 22:88CrossRef Néel A, Wahbi A, Tessoulin B et al (2018) Diagnostic and management of life-threatening adult-onset still disease: a French nationwide multicenter study and systematic literature review. Crit Care 22:88CrossRef
171.
Zurück zum Zitat Nordström D, Knight A, Luukkainen R et al (2012) Beneficial effect of interleukin 1 inhibition with anakinra in adult-onset Still’s disease. An open, randomized, multicenter study. J Rheumatol 39:2008–2011CrossRef Nordström D, Knight A, Luukkainen R et al (2012) Beneficial effect of interleukin 1 inhibition with anakinra in adult-onset Still’s disease. An open, randomized, multicenter study. J Rheumatol 39:2008–2011CrossRef
172.
Zurück zum Zitat Novak S, Anic F, Luke-Vrbanić TS (2012) Extremely high serum ferritin levels as a main diagnostic tool of adult-onset Still’s disease. Rheumatol Int 32:1091–1094CrossRef Novak S, Anic F, Luke-Vrbanić TS (2012) Extremely high serum ferritin levels as a main diagnostic tool of adult-onset Still’s disease. Rheumatol Int 32:1091–1094CrossRef
174.
Zurück zum Zitat Oommen PT, Hinze C, Holzinger D et al (2020) Therapie der juvenilen idiopathischen Arthritis (JIA): Aktualisierung der interdisziplinären AWMF-S2k-Leitlinie „Therapie der juvenilen idiopathischen Arthritis“. Arthritis Rheuma 40:260–269. https://doi.org/10.1055/a-1161-5382CrossRef Oommen PT, Hinze C, Holzinger D et al (2020) Therapie der juvenilen idiopathischen Arthritis (JIA): Aktualisierung der interdisziplinären AWMF-S2k-Leitlinie „Therapie der juvenilen idiopathischen Arthritis“. Arthritis Rheuma 40:260–269. https://​doi.​org/​10.​1055/​a-1161-5382CrossRef
175.
Zurück zum Zitat Ortiz-Sanjuán F, Blanco R, Calvo-Rio V et al (2014) Efficacy of tocilizumab in conventional treatment-refractory adult-onset still’s disease: multicenter retrospective open-label study of thirty-four patients: Tocilizumab in AOSD refractory to standard treatment. Arthritis Rheumatol 66:1659–1665. https://doi.org/10.1002/art.38398CrossRef Ortiz-Sanjuán F, Blanco R, Calvo-Rio V et al (2014) Efficacy of tocilizumab in conventional treatment-refractory adult-onset still’s disease: multicenter retrospective open-label study of thirty-four patients: Tocilizumab in AOSD refractory to standard treatment. Arthritis Rheumatol 66:1659–1665. https://​doi.​org/​10.​1002/​art.​38398CrossRef
176.
Zurück zum Zitat Ortiz-Sanjuán F, Blanco R, Calvo-Rio V et al (2015) Efficacy of tocilizumab in conventional treatment-refractory adult-onset Still’s disease: multicenter retrospective open-label study of thirty-four patients. Arthritis Rheumatol 66:1659–1665CrossRef Ortiz-Sanjuán F, Blanco R, Calvo-Rio V et al (2015) Efficacy of tocilizumab in conventional treatment-refractory adult-onset Still’s disease: multicenter retrospective open-label study of thirty-four patients. Arthritis Rheumatol 66:1659–1665CrossRef
180.
Zurück zum Zitat Pay S, Türkçapar N, Kalyoncu M et al (2006) A multicenter study of patients with adult-onset Still’s disease compared with systemic juvenile idiopathic arthritis. Clin Rheumatol 25:639–644CrossRef Pay S, Türkçapar N, Kalyoncu M et al (2006) A multicenter study of patients with adult-onset Still’s disease compared with systemic juvenile idiopathic arthritis. Clin Rheumatol 25:639–644CrossRef
182.
Zurück zum Zitat Petty RE, Southwood TR, Manners P et al (2004) International league of associations for rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001. J Rheumatol 31:390–392 Petty RE, Southwood TR, Manners P et al (2004) International league of associations for rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001. J Rheumatol 31:390–392
183.
Zurück zum Zitat Pouchot J, Sampalis JS, Beaudet F et al (1991) Adult Still’s disease: manifestations, disease course, and outcome in 62 patients. Medicine 70:118–136CrossRef Pouchot J, Sampalis JS, Beaudet F et al (1991) Adult Still’s disease: manifestations, disease course, and outcome in 62 patients. Medicine 70:118–136CrossRef
187.
Zurück zum Zitat Qiao J, Zhou S, Li S et al (2019) Histopathological diagnosis of persistent pruritic eruptions associated with adult-onset Still’s disease. Histopathology 74:759–765CrossRef Qiao J, Zhou S, Li S et al (2019) Histopathological diagnosis of persistent pruritic eruptions associated with adult-onset Still’s disease. Histopathology 74:759–765CrossRef
190.
Zurück zum Zitat Reihl Crnogaj M, Čubelić D, Babić A et al (2020) Treatment of refractory adult onset Still’s disease with tocilizumab—a single centre experience and literature review. Rheumatol Int 40:1317–1325CrossRef Reihl Crnogaj M, Čubelić D, Babić A et al (2020) Treatment of refractory adult onset Still’s disease with tocilizumab—a single centre experience and literature review. Rheumatol Int 40:1317–1325CrossRef
191.
Zurück zum Zitat Riera E, Olivé A, Narváez J et al (2011) Adult onset Still’s disease: review of 41 cases. Clin Exp Rheumatol 29:331–336 Riera E, Olivé A, Narváez J et al (2011) Adult onset Still’s disease: review of 41 cases. Clin Exp Rheumatol 29:331–336
192.
Zurück zum Zitat Rossi-Semerano L, Fautrel B, Wendling D et al (2015) Tolerance and efficacy of off-label anti-interleukin‑1 treatments in France: a nationwide survey. Orphanet J Rare Dis 10:19CrossRef Rossi-Semerano L, Fautrel B, Wendling D et al (2015) Tolerance and efficacy of off-label anti-interleukin‑1 treatments in France: a nationwide survey. Orphanet J Rare Dis 10:19CrossRef
193.
Zurück zum Zitat Ruscitti P, Berardicurti O, Iacono D et al (2020) Parenchymal lung disease in adult onset Still’s disease: an emergent marker of disease severity—characterisation and predictive factors from Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale (GIRRCS) cohort of patients. Arthritis Res Ther 22:151. https://doi.org/10.1186/s13075-020-02245-5CrossRef Ruscitti P, Berardicurti O, Iacono D et al (2020) Parenchymal lung disease in adult onset Still’s disease: an emergent marker of disease severity—characterisation and predictive factors from Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale (GIRRCS) cohort of patients. Arthritis Res Ther 22:151. https://​doi.​org/​10.​1186/​s13075-020-02245-5CrossRef
195.
197.
Zurück zum Zitat Ruscitti P, Ursini F, Sota J et al (2020) The reduction of concomitant glucocorticoids dosage following treatment with IL‑1 receptor antagonist in adult onset Still’s disease. A systematic review and meta-analysis of observational studies. Ther Adv Musculoskelet Dis 12:1759720x20933133CrossRef Ruscitti P, Ursini F, Sota J et al (2020) The reduction of concomitant glucocorticoids dosage following treatment with IL‑1 receptor antagonist in adult onset Still’s disease. A systematic review and meta-analysis of observational studies. Ther Adv Musculoskelet Dis 12:1759720x20933133CrossRef
199.
Zurück zum Zitat Sakairi T, Hiromura K, Kaneko Y et al (2016) Histological findings in the spleen affected by adult-onset Still’s disease: a report of three cases. Clin Exp Rheumatol 34:566–567 Sakairi T, Hiromura K, Kaneko Y et al (2016) Histological findings in the spleen affected by adult-onset Still’s disease: a report of three cases. Clin Exp Rheumatol 34:566–567
200.
Zurück zum Zitat Sanchez Loria DM, Alvarez MMJ, Barceló HA et al (1996) Sjögren’s in adult Still’s disease? Clin Rheumatol 15:133–136CrossRef Sanchez Loria DM, Alvarez MMJ, Barceló HA et al (1996) Sjögren’s in adult Still’s disease? Clin Rheumatol 15:133–136CrossRef
202.
Zurück zum Zitat Schanberg L, Nigrovic P, Cooper A et al (2020) A randomized, double-blind, placebo-controlled study of anakinra in pediatric and adult patients with still’s disease. Arthritis Rheumatol 72:47–49 Schanberg L, Nigrovic P, Cooper A et al (2020) A randomized, double-blind, placebo-controlled study of anakinra in pediatric and adult patients with still’s disease. Arthritis Rheumatol 72:47–49
206.
Zurück zum Zitat Shimizu T, Kikuchi-Taura A, Tsuji S et al (2020) Up-regulation of CD64 expression on monocytes in patients with active adult-onset still disease: a possible biomarker of disease activity. J Clin Rheumatol Shimizu T, Kikuchi-Taura A, Tsuji S et al (2020) Up-regulation of CD64 expression on monocytes in patients with active adult-onset still disease: a possible biomarker of disease activity. J Clin Rheumatol
210.
Zurück zum Zitat Sobieska M, Fassbender K, Aeschlimann A et al (1998) Still’s disease in children and adults: a distinct pattern of acute-phase proteins. Clin Rheumatol 17:258–260CrossRef Sobieska M, Fassbender K, Aeschlimann A et al (1998) Still’s disease in children and adults: a distinct pattern of acute-phase proteins. Clin Rheumatol 17:258–260CrossRef
211.
Zurück zum Zitat Song ST, Kim JJ, Lee S et al (2016) Efficacy of tocilizumab therapy in Korean patients with adult-onset Still’s disease: a multicentre retrospective study of 22 cases. Clin Exp Rheumatol 34:S64–S71 Song ST, Kim JJ, Lee S et al (2016) Efficacy of tocilizumab therapy in Korean patients with adult-onset Still’s disease: a multicentre retrospective study of 22 cases. Clin Exp Rheumatol 34:S64–S71
212.
Zurück zum Zitat Sota J, Rigante D, Ruscitti P et al (2019) Anakinra drug retention rate and predictive factors of long-term response in systemic juvenile idiopathic arthritis and adult onset still disease. Front Pharmacol 10:918CrossRef Sota J, Rigante D, Ruscitti P et al (2019) Anakinra drug retention rate and predictive factors of long-term response in systemic juvenile idiopathic arthritis and adult onset still disease. Front Pharmacol 10:918CrossRef
213.
Zurück zum Zitat Specker C, Schulze-Koops H, Ad-hoc-Kommission COVID-19 der DGRh, Vorstand der DGRh (2021) Vaccination against SARS-CoV‑2 in inflammatory rheumatic diseases : Recommendations of the German Society for Rheumatology for physicians and patients. Z Rheumatol 80:43–44. https://doi.org/10.1007/s00393-020-00955-4CrossRef Specker C, Schulze-Koops H, Ad-hoc-Kommission COVID-19 der DGRh, Vorstand der DGRh (2021) Vaccination against SARS-CoV‑2 in inflammatory rheumatic diseases : Recommendations of the German Society for Rheumatology for physicians and patients. Z Rheumatol 80:43–44. https://​doi.​org/​10.​1007/​s00393-020-00955-4CrossRef
217.
Zurück zum Zitat Takakuwa Y, Hanaoka H, Kiyokawa T et al (2019) Adult-onset Still’s disease-associated interstitial lung disease represents severe phenotype of the disease with higher rate of haemophagocytic syndrome and relapse. Clin Exp Rheumatol 37(Suppl 121):23–27 Takakuwa Y, Hanaoka H, Kiyokawa T et al (2019) Adult-onset Still’s disease-associated interstitial lung disease represents severe phenotype of the disease with higher rate of haemophagocytic syndrome and relapse. Clin Exp Rheumatol 37(Suppl 121):23–27
218.
Zurück zum Zitat Takakuwa Y, Hanaoka H, Kiyokawa T et al (2019) Adult-onset Still’s disease-associated interstitial lung disease represents severe phenotype of the disease with higher rate of haemophagocytic syndrome and relapse. Clin Exp Rheumatol 37:23–27 Takakuwa Y, Hanaoka H, Kiyokawa T et al (2019) Adult-onset Still’s disease-associated interstitial lung disease represents severe phenotype of the disease with higher rate of haemophagocytic syndrome and relapse. Clin Exp Rheumatol 37:23–27
220.
Zurück zum Zitat Ugurlu S, Guzelant G, Yurttas B et al (2018) Canakinumab treatment in adult-onset still’s disease: case series. Arthritis Rheumatol 70:1450 Ugurlu S, Guzelant G, Yurttas B et al (2018) Canakinumab treatment in adult-onset still’s disease: case series. Arthritis Rheumatol 70:1450
223.
Zurück zum Zitat Vanderschueren S, Hermans F, De Munter P, Knockaert D (2012) Adult-onset Still’s disease: still a diagnosis of exclusion. A nested case-control study in patients with fever of unknown origin. Clin Exp Rheumatol 30:514–519 Vanderschueren S, Hermans F, De Munter P, Knockaert D (2012) Adult-onset Still’s disease: still a diagnosis of exclusion. A nested case-control study in patients with fever of unknown origin. Clin Exp Rheumatol 30:514–519
225.
Zurück zum Zitat Vercruysse F, Barnetche T, Lazaro E et al (2019) Adult-onset Still’s disease biological treatment strategy may depend on the phenotypic dichotomy. Arthritis Res Ther 21:53CrossRef Vercruysse F, Barnetche T, Lazaro E et al (2019) Adult-onset Still’s disease biological treatment strategy may depend on the phenotypic dichotomy. Arthritis Res Ther 21:53CrossRef
227.
Zurück zum Zitat Vitale A, Berlengiero V, Sota J et al (2020) Real-life data on the efficacy of canakinumab in patients with adult-onset still’s disease. Mediators Inflamm 2020:8054961CrossRef Vitale A, Berlengiero V, Sota J et al (2020) Real-life data on the efficacy of canakinumab in patients with adult-onset still’s disease. Mediators Inflamm 2020:8054961CrossRef
228.
Zurück zum Zitat Vitale A, Cavalli G, Colafrancesco S et al (2019) Long-term retention rate of Anakinra in adult onset still’s disease and predictive factors for treatment response. Front Pharmacol 10:296CrossRef Vitale A, Cavalli G, Colafrancesco S et al (2019) Long-term retention rate of Anakinra in adult onset still’s disease and predictive factors for treatment response. Front Pharmacol 10:296CrossRef
229.
Zurück zum Zitat Vitale A, Cavalli G, Ruscitti P et al (2020) Comparison of early vs. Delayed Anakinra treatment in patients with adult onset still’s disease and effect on clinical and laboratory outcomes. Front Med 7:42CrossRef Vitale A, Cavalli G, Ruscitti P et al (2020) Comparison of early vs. Delayed Anakinra treatment in patients with adult onset still’s disease and effect on clinical and laboratory outcomes. Front Med 7:42CrossRef
230.
Zurück zum Zitat Vitale A, Insalaco A, Sfriso P et al (2016) A snapshot on the on-label and off-label use of the Interleukin‑1 inhibitors in Italy among rheumatologists and pediatric rheumatologists: a nationwide multi-center retrospective observational study. Front Pharmacol. https://doi.org/10.3389/fphar.2016.00380CrossRef Vitale A, Insalaco A, Sfriso P et al (2016) A snapshot on the on-label and off-label use of the Interleukin‑1 inhibitors in Italy among rheumatologists and pediatric rheumatologists: a nationwide multi-center retrospective observational study. Front Pharmacol. https://​doi.​org/​10.​3389/​fphar.​2016.​00380CrossRef
Metadaten
Titel
DGRh-S2e-Leitlinie
Diagnostik und Therapie des adulten Still-Syndroms (AOSD)
verfasst von
Prof. Dr. Stefan Vordenbäumen
Eugen Feist
Jürgen Rech
Martin Fleck
Norbert Blank
Johannes-Peter Haas
Ina Kötter
Martin Krusche
Gamal Chehab
Bimba Hoyer
Uta Kiltz
Dorothea Fell
Julia Reiners
Christiane Weseloh
Matthias Schneider
Jürgen Braun
Publikationsdatum
11.11.2022
Verlag
Springer Medizin
Erschienen in
Zeitschrift für Rheumatologie / Ausgabe Sonderheft 1/2022
Print ISSN: 0340-1855
Elektronische ISSN: 1435-1250
DOI
https://doi.org/10.1007/s00393-022-01276-4

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

„Jeder Fall von plötzlichem Tod muss obduziert werden!“

17.05.2024 Plötzlicher Herztod Nachrichten

Ein signifikanter Anteil der Fälle von plötzlichem Herztod ist genetisch bedingt. Um ihre Verwandten vor diesem Schicksal zu bewahren, sollten jüngere Personen, die plötzlich unerwartet versterben, ausnahmslos einer Autopsie unterzogen werden.

Hirnblutung unter DOAK und VKA ähnlich bedrohlich

17.05.2024 Direkte orale Antikoagulanzien Nachrichten

Kommt es zu einer nichttraumatischen Hirnblutung, spielt es keine große Rolle, ob die Betroffenen zuvor direkt wirksame orale Antikoagulanzien oder Marcumar bekommen haben: Die Prognose ist ähnlich schlecht.

Schlechtere Vorhofflimmern-Prognose bei kleinem linken Ventrikel

17.05.2024 Vorhofflimmern Nachrichten

Nicht nur ein vergrößerter, sondern auch ein kleiner linker Ventrikel ist bei Vorhofflimmern mit einer erhöhten Komplikationsrate assoziiert. Der Zusammenhang besteht nach Daten aus China unabhängig von anderen Risikofaktoren.

Semaglutid bei Herzinsuffizienz: Wie erklärt sich die Wirksamkeit?

17.05.2024 Herzinsuffizienz Nachrichten

Bei adipösen Patienten mit Herzinsuffizienz des HFpEF-Phänotyps ist Semaglutid von symptomatischem Nutzen. Resultiert dieser Benefit allein aus der Gewichtsreduktion oder auch aus spezifischen Effekten auf die Herzinsuffizienz-Pathogenese? Eine neue Analyse gibt Aufschluss.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.