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CardioVascular and Interventional Radiology

Erschienen in:

20.03.2024 | Review

Advanced Interventional Treatments in Retinoblastoma Management: A Comprehensive Review

verfasst von: Peter Kolyvas, Aazrin Mir, Thomas Stirrat, Brittany Brookner, Nathanael Pilar, Eric Monroe, Rakesh Ahuja

Erschienen in: CardioVascular and Interventional Radiology | Ausgabe 4/2024

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Abstract

Retinoblastoma is the most common eye malignancy in children that if left untreated can invade intraocular structures, metastasize, and rarely lead to death. Traditionally treated with systemic chemotherapy, Intra-arterial chemotherapy is gaining popularity as it allows for the direct administration of chemotherapy through the ophthalmic artery, thus reducing systemic side effects. Intra-arterial chemotherapy procedures have evolved, with refinements to reduce risks and radiation exposure. Intra-arterial chemotherapy boasts an impressive technical success rate and one year ocular survival even amongst advanced cases. This review offers a thorough examination of the technique, indications, contraindications, outcomes, and alternative options for Intra-arterial chemotherapy.

Siegel RL, Miller KD, Wagle NS, Jemal A. Cancer statistics, 2023. CA Cancer J Clin. 2023;73(1):17–48. https://doi.org/10.3322/caac.21763.CrossRefPubMed

Kivelä T. The epidemiological challenge of the most frequent eye cancer: retinoblastoma, an issue of birth and death. Br J Ophthalmol. 2009;93(9):1129–31. https://doi.org/10.1136/bjo.2008.150292.CrossRefPubMed

Fabian ID, Sagoo MS. Understanding retinoblastoma: epidemiology and genetics. Community Eye Health. 2018;31(101):7.PubMedPubMedCentral

Cruz-Gálvez CC, Ordaz-Favila JC, Villar-Calvo VM, Cancino-Marentes ME, Bosch-Canto V. Retinoblastoma: review and new insights. Front Oncol. 2022;12:963780. https://doi.org/10.3389/fonc.2022.963780.CrossRefPubMedPubMedCentral

Dimaras H, Corson TW, Cobrinik D, et al. Retinoblastoma. Nat Rev Dis Primers. 2015;1:15021. https://doi.org/10.1038/nrdp.2015.21.CrossRefPubMedPubMedCentral

Aerts I, Lumbroso-Le Rouic L, Gauthier-Villars M, Brisse H, Doz F, Desjardins L. Retinoblastoma. Orphanet J Rare Dis. 2006;1:31. https://doi.org/10.1186/1750-1172-1-31.CrossRefPubMedPubMedCentral

Monroe EJ, Otjen JP, Wright JN, et al. Prospective determination of orbital perfusion dominance before intra-arterial chemotherapy for retinoblastoma using time-of-flight magnetic resonance angiography. J Clinic Intervent Radiol isvir. 2022;07(01):064–8. https://doi.org/10.1055/s-0042-1743498.CrossRef

Chen Q, Zhang B, Dong Y, et al. Evaluating primary intra-arterial chemotherapy versus intravenous plus intra-arterial chemotherapy for advanced intraocular retinoblastoma. Cancer Chemother Pharmacol. 2020;85(4):723–30. https://doi.org/10.1007/s00280-020-04036-w.CrossRefPubMed

Runnels J, Acosta G, Rose A, et al. The role for intra-arterial chemotherapy for refractory retinoblastoma: a systematic review. Clin Transl Oncol. 2021;23(10):2066–77. https://doi.org/10.1007/s12094-021-02610-z.CrossRefPubMed

10.

Rishi P, Agarwal A, Chatterjee P, Sharma T, Sharma M, Saravanan M, Ravikumar R. Intra-arterial chemotherapy for retinoblastoma: four-year results from tertiary center in India. Ocular Oncol Pathol. 2020;6(1):66–73. https://doi.org/10.1159/000500010.CrossRef

11.

Monroe EJ, Chick JFB, Stacey AW, et al. Radiation dose reduction during intra-arterial chemotherapy for retinoblastoma: a retrospective analysis of 96 consecutive pediatric interventions using five distinct protocols. Pediatr Radiol. 2021;51(4):649–57. https://doi.org/10.1007/s00247-020-04892-x.CrossRefPubMed

12.

Sweid A, Hammoud B, Weinberg JH, Texakalidis P, Xu V, Shivashankar K, Baldassari MP, Das S, Ramesh S, Tjoumakaris S, Shields CL, Ancona-Lezama D, Lim LS, Dalvin LA, Jabbour P. Intra-arterial chemotherapy for retinoblastoma in infants ≤10 kg: 74 treated eyes with 222 IAC sessions. AJNR Am J Neuroradiol. 2020;41(7):1286–92. https://doi.org/10.3174/ajnr.A6590.CrossRefPubMedPubMedCentral

13.

Liang T, Zhang X, Li J, Hua X, Zhao P, Ji X. Intra-arterial chemotherapy as primary treatment for advanced unilateral retinoblastoma in China. Front Med. 2022;9: 855661. https://doi.org/10.3389/fmed.2022.855661.CrossRef

14.

Saglam M, Sarici A, Anagnostakou V, et al. An alternative technique of the superselective catheterization of the ophthalmic artery for intra-arterial chemotherapy of the retinoblastoma: retrograde approach through the posterior communicating artery to the ophthalmic artery. Neuroradiology. 2014;56(9):751–4. https://doi.org/10.1007/s00234-014-1388-1.CrossRefPubMed

15.

Abruzzo TA, Geller JI, Kimbrough DA, et al. Adjunctive techniques for optimization of ocular hemodynamics in children undergoing ophthalmic artery infusion chemotherapy. J Neurointerv Surg. 2015;7(10):770–6. https://doi.org/10.1136/neurintsurg-2014-011295.CrossRefPubMed

16.

Chen Q, Zhang B, Dong Y, et al. Intra-arterial chemotherapy as primary or secondary treatment for infants diagnosed with advanced retinoblastoma before 3 months of age. BMC Cancer. 2019;19(1):693. https://doi.org/10.1186/s12885-019-5844-5.CrossRefPubMedPubMedCentral

17.

Abramson DH, Daniels AB, Marr BP, et al. Intra-arterial chemotherapy (ophthalmic artery chemosurgery) for group D retinoblastoma. PLoS ONE. 2016;11(1):e0146582. https://doi.org/10.1371/journal.pone.0146582.CrossRefPubMedPubMedCentral

18.

Suzuki S, Yamane T, Mohri M, Kaneko A. Selective ophthalmic arterial injection therapy for intraocular retinoblastoma: the long-term prognosis. Ophthalmology. 2011;118(10):2081–7. https://doi.org/10.1016/j.ophtha.2011.03.013.CrossRefPubMed

19.

Fabian ID, Reddy A, Sagoo MS. Classification and staging of retinoblastoma. Comm Eye Health. 2018;31(101):11–3.

20.

Shields CL, Dockery PW, Yaghy A, et al. Intra-arterial chemotherapy for retinoblastoma in 341 consecutive eyes (1,292 infusions): comparative analysis of outcomes based on patient age, race, and sex. J Amer Assoc Pediatric Ophthalmol Strabismus. 2021;25(3):150.e1-150.e9. https://doi.org/10.1016/j.jaapos.2020.12.006.CrossRef

21.

Manjandavida FP, Stathopoulos C, Zhang J, Honavar SG, Shields CL. Intra-arterial chemotherapy in retinoblastoma—A paradigm change. Indian J Ophthalmol. 2019;67(6):740–54. https://doi.org/10.4103/ijo.IJO_866_19.CrossRefPubMedPubMedCentral

22.

Cao Y, Zhou M, Tian M, Lv HB. The safety and effectiveness of melphalan-based intra-arterial chemotherapy for retinoblastoma: an updated single-arm systematic review and meta-analysis. Evid Based Complement Alternat Med. 2022;2022:3156503. https://doi.org/10.1155/2022/3156503.CrossRefPubMedPubMedCentral

23.

Friedman EL, Froehler MT, Daniels AB. Orbital swelling in a child with retinoblastoma following intra-arterial chemotherapy. JAMA Ophthalmol. 2021;139(3):357. https://doi.org/10.1001/jamaophthalmol.2020.4675.CrossRefPubMed

24.

Stathopoulos C, Bartolini B, Marie G, Beck-Popovic M, Saliou G, Munier FL. Risk factors for acute choroidal ischemia after intra-arterial melphalan for retinoblastoma. Ophthalmology. 2021;128(5):754–64. https://doi.org/10.1016/j.ophtha.2020.09.021.CrossRefPubMed

25.

Bogan CM, Kaczmarek JV, Pierce JM, et al. Evaluation of intravitreal topotecan dose levels, toxicity and efficacy for retinoblastoma vitreous seeds: a preclinical and clinical study. Br J Ophthalmol. 2021;106(2):288–96. https://doi.org/10.1136/bjophthalmol-2020-318529.CrossRefPubMed

26.

Zhou M, Wen X, Jia S, et al. Risk factors for ophthalmic artery stenosis and occlusion in patients with retinoblastoma treated with intra-arterial chemotherapy. Br J Ophthalmol. 2021;106(11):1581–6. https://doi.org/10.1136/bjophthalmol-2021-319118.CrossRefPubMed

27.

Daniels AB, Froehler MT, Kaczmarek JV, et al. Efficacy, toxicity, and pharmacokinetics of intra-arterial chemotherapy versus intravenous chemotherapy for retinoblastoma in animal models and patients. Transl Vision Sci Technol. 2021;10(11):10. https://doi.org/10.1167/tvst.10.11.10.CrossRef

28.

Francis JH, Levin AM, Zabor EC, Pierre GY, Abramson DH. Ten-year experience with ophthalmic artery chemosurgery: ocular and recurrence-free survival. PLoS ONE. 2018;13(5):e0197081. https://doi.org/10.1371/journal.pone.0197081.e0197081.CrossRefPubMedPubMedCentral

29.

Yousef YA, Soliman SE, Astudillo PPP, et al. Intra-arterial chemotherapy for retinoblastoma: a systematic review. JAMA Ophthalmol. 2016;134(5):584–91. https://doi.org/10.1001/jamaophthalmol.2016.0244.CrossRefPubMed

30.

Shields CL, Mashayekhi A, Au AK, et al. The international classification of retinoblastoma predicts chemoreduction success. Ophthalmology. 2006;113(12):2276–80. https://doi.org/10.1016/j.ophtha.2006.06.018.CrossRefPubMed

31.

Wen X, Fan J, Jin M, et al. Intravenous versus super-selected intra-arterial chemotherapy in children with advanced unilateral retinoblastoma: an open-label, multicentre, randomised trial. Lancet Child Adolesc Health. 2023;7(9):613–20. https://doi.org/10.1016/S2352-4642(23)00141-4.CrossRefPubMed

32.

Ancona-Lezama D, Dalvin LA, Shields CL. Modern treatment of retinoblastoma: a 2020 review. Indian J Ophthalmol. 2020;68(11):2356–65. https://doi.org/10.4103/ijo.IJO_721_20.CrossRefPubMedPubMedCentral

33.

Shields CL, Lally SE, Leahey AM, et al. Targeted retinoblastoma management: when to use intravenous, intra-arterial, periocular, and intravitreal chemotherapy. Curr Opin Ophthalmol. 2014;25(5):374–85. https://doi.org/10.1097/ICU.0000000000000091.CrossRefPubMed

34.

Shields CL, Fulco EM, Arias JD, et al. Retinoblastoma frontiers with intravenous, intra-arterial, periocular, and intravitreal chemotherapy. Eye (Lond). 2013;27(2):253–64. https://doi.org/10.1038/eye.2012.175.CrossRefPubMed

35.

Chawla B, Jain A, Azad R. Conservative treatment modalities in retinoblastoma. Indian J Ophthalmol. 2013;61(9):479–85. https://doi.org/10.4103/0301-4738.119424.CrossRefPubMedPubMedCentral

36.

Shields CL, Shields JA, Kiratli H, De Potter PV. Treatment of retinoblastoma with indirect ophthalmoscope laser photocoagulation. J Pediatr Ophthalmol Strabismus. 1995;32(5):317–22. https://doi.org/10.3928/0191-3913-19950901-12.CrossRefPubMed

37.

Hasanreisoglu M, Saktanasate J, Schwendeman R, Shields JA, Shields CL. Indocyanine green-enhanced transpupillary thermotherapy for retinoblastoma: analysis of 42 tumors. J Pediatr Ophthalmol Strabismus. 2015;52(6):348–54. https://doi.org/10.3928/01913913-20150929-17.CrossRefPubMed

38.

Munier FL, Gaillard MC, Balmer A, et al. Intravitreal chemotherapy for vitreous disease in retinoblastoma revisited: from prohibition to conditional indications. Br J Ophthalmol. 2012;96(8):1078–83. https://doi.org/10.1136/bjophthalmol-2011-301450.CrossRefPubMed

39.

Yousef YA, Al Jboor M, Mohammad M, et al. Safety and efficacy of intravitreal chemotherapy (Melphalan) to treat vitreous seeds in retinoblastoma. Front Pharmacol. 2021;12:696787. https://doi.org/10.3389/fphar.2021.696787.CrossRefPubMedPubMedCentral

40.

Liang TY, Zhu XY, Hua XM, Ji XD, Zhao PQ. Combined intra-arterial chemotherapy and intravitreal melphalan for the treatment of advanced unilateral retinoblastoma. Int J Ophthalmol. 2020;13(2):257–62. https://doi.org/10.18240/ijo.2020.02.09.CrossRefPubMedPubMedCentral

41.

Shields JA, Parsons H, Shields CL, Giblin ME. The role of cryotherapy in the management of retinoblastoma. Am J Ophthalmol. 1989;108(3):260–4. https://doi.org/10.1016/0002-9394(89)90116-5.CrossRefPubMed

42.

Abramson DH, Ellsworth RM, Rozakis GW. Cryotherapy for retinoblastoma. Arch Ophthalmol. 1982;100(8):1253–6. https://doi.org/10.1001/archopht.1982.01030040231003.CrossRefPubMed

43.

Shields CL, Shields JA, De Potter P, et al. Plaque radiotherapy in the management of retinoblastoma. Use as a primary and secondary treatment. Ophthalmology. 1993;100(2):216–24. https://doi.org/10.1016/s0161-6420(93)31667-2.CrossRefPubMed

44.

Kim JY, Park Y. Treatment of retinoblastoma: the role of external beam radiotherapy. Yonsei Med J. 2015;56(6):1478–91. https://doi.org/10.3349/ymj.2015.56.6.1478.CrossRefPubMedPubMedCentral

45.

Blach LE, McCormick B, Abramson DH. External beam radiation therapy and retinoblastoma: long-term results in the comparison of two techniques. Int J Radiat Oncol Biol Phys. 1996;35(1):45–51. https://doi.org/10.1016/s0360-3016(96)85010-3.CrossRefPubMed

46.

Shinohara ET, DeWees T, Perkins SM. Subsequent malignancies and their effect on survival in patients with retinoblastoma. Pediatr Blood Cancer. 2014;61(1):116–9. https://doi.org/10.1002/pbc.24714.CrossRefPubMed

47.

Aerts I, Sastre-Garau X, Savignoni A, et al. Results of a multicenter prospective study on the postoperative treatment of unilateral retinoblastoma after primary enucleation. J Clin Oncol. 2013;31(11):1458–63. https://doi.org/10.1200/JCO.2012.42.3962.CrossRefPubMed

Titel: Advanced Interventional Treatments in Retinoblastoma Management: A Comprehensive Review
verfasst von: Peter Kolyvas
Aazrin Mir
Thomas Stirrat
Brittany Brookner
Nathanael Pilar
Eric Monroe
Rakesh Ahuja
Publikationsdatum: 20.03.2024
Verlag: Springer US
Erschienen in: CardioVascular and Interventional Radiology / Ausgabe 4/2024
Print ISSN: 0174-1551
Elektronische ISSN: 1432-086X
DOI: https://doi.org/10.1007/s00270-024-03692-2

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Advanced Interventional Treatments in Retinoblastoma Management: A Comprehensive Review

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