A1 Idiopathic Normal Pressure Hydrocephalus in a Klinefelter Syndrome the first case in the literature
Gianpaolo Petrella, Silvia Ciarlo, Graziano Taddei, Angelo Pompucci, Alessandro Pesce
1A.O. “Santa Maria Goretti” General Hospital, Neurosurgery Division, Latina, Italy
Correspondence: Gianpaolo Petrella, gianpaolo_p@hotmail.com
A2 Is nausea during lumbar drainage a useful predictor of shunt responsiveness?
Linda D’Antona1,2, Zeid Abussuud1, David Rowland1, Eleanor Moncour1,2, Kanza Tariq1,2, Lucia Darie1, Aleksandra Lasica2, Lewis Thorne1, Laurence Watkins1,2, Ahmed Toma1,2
1Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, WC1N3BG, UK; 2Queen Square Institute of Neurology, University College London, London, WC1N3BG, UK
Correspondence: Linda D’Antona, linda.d’antona@nhs.net
A3 Packaging designs for medical device drug combination products - impact on required storage conditions and shelf-life
Lucas Thieme, Christoph Miethke
1Christoph Miethke GmbH & Co. KG, 14469 Potsdam, Germany
Correspondence: Lucas Thieme, Lucas.Thieme@Miethke.com
A4 Theophylline a drug efficient to increase intracranial pressure: case report and review of literature
Aoife Curran1, Laurence Watkins2, Lucia Darie2
1Medical Student at University College Dublin, Ireland; 2Department of Neurosurgery, The National Hospital for Neurology and Neurosurgery, University College Hospitals London, United Kingdom
Correspondence: Lucia Darie, darielucia@yahoo.com
A5 An investigation of the usefulness of the Rey-15 cognitive performance validity test, to detect suboptimal effort on patients with suspected idiopathic Normal Pressure Hydrocephalus (iNPH)
Aishah Hannan1, Cathryn Harries1, Emma King1, Abbie Brockway1, Beth Wheeler1, Elizabeth Cray2, Samuel Jeffery2, Samiul Muquit2, Thomas Davis1, Rupert Noad1
1Department of Neuropsychology, University Hospital Plymouth, Plymouth, United Kingdom; 2Department of Neurosurgery, University Hospital Plymouth, Plymouth, United Kingdom
Correspondence: Aishah Hannan, aishah.hannan@nhs.net
A6 Hydroflex: The Use of Patient Reported Outcomes in a Clinical Setting Among Patients with Hydrocephalus
Arnar Astradsson1, Nana Txvig Sorensen2, Anne Sofie Graversen1, Ivona Nemeiko1, Arzu Bilgin-Freiert1, Liz Marit Valen3, Marianne Juhler1, Toben Skovbo Hansen1
1Aarhus University Hospital; 2AmbuFlex - Center for Patient-reported Outcomes, Central Denmark Region, Gødstrup Hospital, Herning, Denmark; 3Center for Patient-reported Outcomes, Central Denmark Region, Gødstrup Hospital, Herning, Denmark
Correspondence: Arnar Astradsson, arnar.astradsson@gmail.com
A7 Spinal tumours as cause of normal pressure hydrocephalus: a case series
Zeid A. Abussuud, Lucia Darie, Ahmed Toma, Laurence Watkins
1Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, University College London Hospitals, United Kingdom
Correspondence: Zeid A Abussuud, z.abussuud@nhs.net
A8 Distal Catheter Migration In Ventriculoperitoneal Shunt: Gastric Perforation and Scrotal Migration – Report of two uncommon cases
Cristian Leonardo Ortiz Alonso, Juan Rial Basalo, Patricia Barrio Fernandez, Jenny Leon Rivera, Noelia Miron Jimenez, Cristina Ferreras Garcia, Belen Alvarez Fernandez
1Hospital Universitario Central de Asturias, Oviedo, Spain
Correspondence: Cristian Leonardo Ortiz Alonso, cristian.or9202@gmail.com
A9 Gait improvement following cerebrospinal fluid tap test in normal pressure hydrocephalus patients with striatal dopaminergic deficit: a preliminary study
Minju Kim1, Young Ho Park1, Yoo Sung Song2, SangYun Kim1
1Department of Neurology, Seoul National University College of Medicine and Department of Neurology, Seoul National University Bundang Hospital, Seongnam, Korea; 2Department of Nuclear Medicine, Seoul National University College of Medicine and Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seongnam, Korea
Correspondence: Young Ho Park, kumimesy@snubh.org
A10 Does the intensive care monitor show the correct intracranial pressure? Comparison of monitor output values with raw data from high-frequency recordings
C. B. Bluemel1, C. Raak2, L. Wistorf2, B. Petzold1, D. Cysarz2, W. Scharbrodt1,2
1Department of Neurosurgery, GKH Herdecke, 58313 Herdecke, Germany; 2University of Witten/Herdecke, 58455 Witten, Germany
Correspondence: Carl Benjamin Blümel, c.bluemel@gemeinschaftskrankenhaus.de
A11 Slit Ventricle Without Subdural Hematoma After Ventriculo-atrial Shunt (VAS) For idiopathic normal pressure hydrocephalus (INPH)
Kiyoshi Takagi1,2,3, Shuichiro Asano4, Ryosuke Takagi5, Takashi Kawahara3, Masamichi Atsuchi3
1NPH Center, Abiko Seijinkai Hospital, Abiko, Japan; 2Department of Neurosurgery, Fujita Health University, Nagoya, Japan; 3NPH Center, Jifukai Atsuchi Neurosurgical Hospital, Kagoshima, Japan; 4Department of Neurosurgery, Kashiwatanaka Hospital, Kashiwa, Japan; 5Department of Neurosurgery, Yokohama City University, Yokohama, Japan
Correspondence: Kiyoshi Takagi, paulktkg@mac.com
A12 Early emergence of isolated fourth ventricle following meningitis in adult: a case report
Han-Lin Yen1, I-i Chen2
1Department of Neurosurgery, Tainan Municipal Hospital (Managed by Show Chwan Medical Care Corporation), Tainan, Taiwan; 2Department of hepatogastroenterology, Tainan Municipal Hospital (Managed by Show Chwan Medical Care Corporation), Tainan, Taiwan
Correspondence: Dr. Han-Lin Yen, hanlin.yen@me.com
A13 Ability for Basic Movement Scale 2 (ABMS-2) Evaluation in iNPH Diagnosis
Masamichi Atsuchi
Atsuchi Neurosurgical Hospital, Kagoshima, 892-0842, Japan
Correspondence: Masamichi Atsuchi, atsuchi0824@yahoo.co.jp
A14 The impact of a standardized surgical protocol on shunt revision in people with Idiopathic Intracranial Hypertension and a pre-existing shunt
Yousra Rasool1, Joseph Welch2, Sheikh M. B. Momin1, Marian Byrne1, Alexandra J. Sinclair3,4, Susan P. Mollan4,5, Georgios Tsermoulas1,4
1Department of Neurosurgery, Queen Elizabeth Hospital Birmingham, United Kingdom; 2Department of Emergency Medicine, City Hospital, Birmingham, United Kingdom; 3Department of Neurology, Queen Elizabeth Hospital Birmingham, United Kingdom; 4Institute of Metabolism and Systems Research, University of Birmingham, United Kingdom; 5Birmingham Neuro-Ophthalmology, Queen Elizabeth Hospital Birmingham, United Kingdom
Correspondence: Georgios Tsermoulas, georgios.tsermoulas@nhs.net
A15 Risk factors for slit ventricles in hydrocephalic children treated with ventriculo-peritoneal shunt
Sadahiro Nomura1, Natsumi Fujii1, Hideyuki Ishihara1
1Department of Neurosurgery, Yamaguchi University School of Medicine, Ube, Yamaguchi, 7558505, Japan
Correspondence: Sadahiro Nomura, snomura@yamaguchi-u.ac.jp
A16 Syndromic validity of idiopathic normal pressure hydrocephalus (iNPH)
Eric A. Schmidt1, Lubin Klotz1, Fabienne Ory Magne2, Margherita Fabbri2
1Department of Neurosurgery, University Hospital, Toulouse, France; 2Department of Neurology, University Hospital, Toulouse, France
Correspondence: Eric A Schmidt: schmidt.e@chu-toulouse.fr
A17 Key Concepts in Minimally Invasive Neurosurgery (MIN): Application in Complex Hydrocephalus
Klaus D. M. Resch1, Susanna M. Antal2
1MIN/Univ. Guadalajara, Mexico; 2LKH Feldkirch Ophthalmology, Feldkirch, Austria
Correspondence: Klaus Resch, klausdmresch@ens-surgery.com
A18 Normal Pressure Hydrocephalus and Cerebral Atrophy: A Scoping review
Afroditi D. Lalou*1,2,3, Thanasis Paschalis*1, Zofia H. Czosnyka1, Marek Czosnyka1
1Department of Clinical Neurosciences, Division of Neurosurgery, University of Cambridge & Cambridge University Hospital NHS Foundation Trust, United Kingdom; 2Department of Radiation Sciences, Umea University, Sweden; 3Department of Neurology, King’s College Hospital NHS Foundation Trust, London, United Kingdom
Correspondence: Afroditi Lalou, adl43@cam.ac.uk
A19 Minimal Invasive Neurosurgery (MIN) and Ophthalmology: Observation Series of Complex Hydrocephalus Cases
Susanna Antal1, LKHF, Klaus D. M. Resch2
1Ophthalmology, Feldkirch; Austria; 2MIN, Univ. Guadalajara; Mexico
Correspondence: Susanna Antal, zsuzsinak@yahoo.de
A20 Technical analysis of Hydrocephalus Shunt Revisions: How MIETHKE investigates? What do we learn? The importance of data for patients, clinics & industry!
August V. Hardenberg, Jörg Knebel, Christoph Miethke
Christoph Miethke GmbH & Co. KG, Potsdam, 14469, Germany
Correspondence: August v. Hardenberg, august.hardenberg@miethke.com
A21 Idiopathic Normal Pressure Hydrocephalus (iNPH) Is Common among Nonagenarians in the Takahata Cohort
Chifumi Iseki1,2, Yoshimi Takahashi3, Michito Adachi4, Shigenori Kanno1, Ryosuke Igari2, Hiroyasu Sato2, Kyoko Suzuki1, Takeo Kato5, Yasuyuki Ohta2
1Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai-city, Miyagi, 980-8575, Japan;2Division of Neurology and Clinical Neuroscience, Department of Internal Medicine III, Yamagata University School of Medicine, Yamagata-city, Yamagata, 990-3221, Japan; 3Haneda clinic, Yamagata, Japan; 4Oshima clinic, Yamagata, Japan; 5Yamagata University, Yamagata, Japan
Correspondence: Chifumi Iseki email: chi-iseki@hyper.ocn.ne.jp
A22 Idiopathic Normal Pressure Hydrocephalus (iNPH) in advanced age: profiling patients through quantitative variables
Liliana Mazza1, Sevil Yaşar2, Alessandro Pirina3, Giulia Giannini4, David Milletti5, Fabiola Maioli1, Giorgio Palandri3
1U.O.C. Percorsi Geriatrici Integrati, Dipartimento dell’Integrazione, Azienda USL di Bologna, Italia; 2Johns Hopkins School of Medicine, Department of Medicine and Neurology, Baltimore, USA; 3IRCSS Istituto delle Scienze Neurologiche di Bologna, UOC Neurochirurgia, Bologna, Italia; 4IRCCS Istituto delle Scienze Neurologiche di Bologna, Clinica Neurologica Metropolitana NEUROMET, Bologna, Italia; 5IRCCS Istituto delle Scienze Neurologiche, UOSI Medicina Riabilitativa, Bologna, Italia
Correspondence: Liliana Mazza, liliana.mazza3@gmail.com
A23 In 2023 is NPH still underdiagnosed? The social and economic burden of the problem
Gianpaolo Petrella, Silvia Ciarlo, Graziano Taddei, Angelo Pompucci, Alessandro Pesce
1A.O. “Santa Maria Goretti” General Hospital, Neurosurgery Department, Latina, Italy
Correspondence: Gianpaolo Petrella, gianpaolo_p@hotmail.com
A24 Levels of inflammatory cytokines MCP-1, CCL4 and PD-L1 in CSF differentiate idiopathic normal pressure hydrocephalus from neurodegenerative diseases
Madelene Braun1, Gustaf Boström2, Martin Ingelsson2, Lena Kilander2, Malin Löwenmark2, Dag Nyholm1, Joachim Burman1, Valter Niemelä1, Eva Freyhult3,4, Kim Kultima5, Johan Virhammar1
1Department of Medical Sciences, Neurology, Uppsala University, Sweden; 2Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Sweden; 3Department of Medical Sciences, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Uppsala University, Sweden; 4Department of Cell and Molecular biology, Uppsala University, Sweden; 5Department of Medical Sciences, Clinical Chemistry, Uppsala University, Sweden
Correspondence: Madelene Braun, madelen.braun@akademiska.se
A25 Directed Topographical Changes to Reduce Cellular Adhesion and Ventricular Wall Pull in
Aaron A. Gonzales, Carolyn A. Harris
1Chemical Engineering and Materials Science, Wayne State University, Detroit, MI, 48201, USA
Correspondence: Aaron A Gonzales, AaronGonzales@wayne.edu
A26 An In-vitro Setup for Testing of Ventricular Catheters under Physiologic and Pathophysiologic Flow Rates
Ahmad Faryami1, Adam Menkara1, Shaheer Ajaz1, Christopher Roberts2, Carolyn A. Harris2
1Biomedical Engineering, Wayne State University, Detroit, Michigan,48202 USA; 2Chemical Engineering and Material Science, Wayne State University, Detroit, Michigan,48202 USA
Correspondence: Ahmad Faryami: gw7895@wayne.edu
A27 Novel 3D Printed Microfluidic Chip for Hydrocephalus Treatment: Fabrication and In vitro Evaluation
Seunghyun Lee1, Leandro Castaneyra-Ruiz1, Jenna Ledbetter1, Michael Le1, Michael Muhonen2
1CHOC Children’s Research Institute, Orange, CA 92868, USA; 2Neurosurgery department at CHOC Children’s Hospital, Orange, CA 92868, USA
Correspondence: Seunghyun Lee, Seunghyun.Lee@choc.org
A28. A model of normal pressure hydrocephalus (NPH) as a disorder of intracranial thermodynamics
Michael Egnor1, Liu Yang2, Racheed Mani1, Susan Fiore1, Peter Djuric2
1Department of Neurological Surgery, Stony Brook University Hospital, Stony Brook, New York, USA; 2Department of Electrical and Computer Engineering, Stony Brook University, Stony Brook, New York,USA..
Correspondence: Michael Egnor, michael.egnor@stonybrookmedicine.edu
A29 Computer vision pipeline to synchronize cranio-spinal pressures with posture in chronic in-vivo trials
Anthony Podgorsak1, Fabian Flürenbrock2, Andreas Kaufmann3, Nina Eva Trimmel4, Margarete Arras4, Markus Florian Oertel5, Miriam Weisskopf4, Marianne Schmid Daners2
1Product Development Group Zurich, Department of Mechanical and Process Engineering, ETH Zurich, Zurich, 8092, Switzerland; 2Institute for Dynamic Systems and Control, Department of Mechanical and Process Engineering, ETH Zurich, Zurich, 8092, Switzerland; 3Department of Computer Science, ETH Zurich, Zurich, 8092, Switzerland; 4Center for Preclinical Development, University Hospital Zurich, University of Zurich, Zurich, 8092, Switzerland; 5Department of Neurosurgery, University Hospital Zurich, University of Zurich, Zurich, 8092, Switzerland
Correspondence: Marianne Schmid Daners, marischm@ethz.ch
A30 Prolonged Spaceflight Alters Intracranial Tissues, Fluids and Ocular Morphology
Katherine G. Warthen1, Stuart H. Sater1, Gabryel Conley Natividad1, Larry A. Kramer2, Khader M. Hasan2, Michael A. Williams3, Brandon R. Macias4, Steven S. Laurie5, Bryn A. Martin1
1Alcyone Therapeutics, Moscow, ID, USA; 2University of Texas Health Science Center, Houston, TX, USA; 3University of Washington School of Medicine, Seattle, Washington, USA; 4NASA Johnson Space Center, Houston, TX, USA; 5KBR, Houston, TX, USA
Correspondence: Bryn Martin, bryn@alcyonetx.com
A31 Modeling congenital hydrocephalus genes SMARCC1 and TRIM71 in the Xenopus model system
Stephen Viviano1, Amrita Singh2, Engin Deniz3
1Department of Pediatrics, Yale University, New Haven, CT, 06525, USA; 2Department of Neurosurgery, Yale University, New Haven, CT, 06525, USA
Correspondence: Engin Deniz, engin.deniz@yale.edu
A32 Genetic determinants and molecular mechanisms of human cerebral ventricular size and congenital hydrocephalus
Garrett Allington1,2, Kedous Y. Mekbib2, Evan Dennis2, Emre Kiziltug2, Stephen McGee3, Sheng Chih Jin4,5, Kristopher T. Kahle2,6-8
1Department of Pathology, Yale University School of Medicine, New Haven, CT, 06511, USA; 2Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, 02114, USA; 3GeneDx, Gaithersburg, MD, 20697, USA; 4Department of Genetics, Washington University School of Medicine, St. Louis, MO, 63130, USA; 5Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, 63130, USA; 6Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Department of Pediatrics, and Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA, 02115, USA; 7Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA; 8Harvard Center for Hydrocephalus and Neurodevelopmental Disorders, Massachusetts General Hospital, Boston, MA, 02114, USA
Correspondence: Kristopher T. Kahle, Kahle.Kristopher@mgh.harvard.edu
A33 Cerebrospinal fluid oscillations and cerebral blood flows in hydrocephalic premature infants who have had intraventricular hemorrhage
Olivier Balédent1,2, Margaux Aye3, Cyrille Capel2,4, Catherine Gondry-Jouet2,3
1Image processing, University hospital, Amiens, France; 2CHIMERE UR7516, Jules Verne University , Amiens, France; 3Radiology, University hospital, Amiens, France; 4Neurosurgery, University hospital, Amiens, France
Correspondence: Olivier Balédent, olivier.baledent@chu-amiens.fr
A34 CSF-based extracellular vesicle signaling and related T-cell activation mediate the pathogenesis of post-hemorrhagic hydrocephalus
Maria Garcia Bonilla1, David Giles1, Emre Kiziltug2, Diego Morales1, Corrine Gardner4, Kirill Shumilov Bartenev1, Pat MacAllister1, Kristopher Kahle3, David Limbrick1
1Washington University in St. Louis School of Medicine, Missouri, USA; 2Yale School of Medicine, Connecticut, USA; 3Pediatric Neurosurgery at the Massachusetts General Hospital and the Harvard Center for Hydrocephalus and Neurodevelopment, Massachusetts, USA; 4St. Louis Children's Hospital, Missouri, USA
Correspondence: Maria Garcia Bonilla, mariag@wustl.edu
A35 Patterns of Clinical Presentation of Pediatrics Hydrocephalus at The National Center for Neurological Sciences . 2017–2021
Nidaa Ahmed1, Arwa Nasr1, Asma Abdalla2, Safa Hamid1,3
1Department of Surgery, University of Khartoum, 11111, Sudan; 2Department of Community, University of Khartoum, 11111, Sudan; 3Department of Neurosurgery, National Center for Neurological Sciences, Khartoum, 11111, Sudan
Correspondence: Nidaa Munir Osman Ahmed, nidaamunir98@gmail.com
A37 Adjustable ventriculoperitoneal shunt valve for the treatment of hydrocephalus in newborns
T. Freiman1, A. Cattani2, A. Spyrantis2, S. Schubert-Bast3
Departments of 1Neurosurgery Medical Centre Rostock, Schillingallee 35, 18057 Rostock, Germany; 2Neurosurgery; 3Neuropediatrics, Frankfurt University Hospital, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
Correspondence: Thomas Freiman thomas.freiman@med.uni-rostock.de
A38 What can be learned from hydrocephalus induction failures?
Pat MacAllister1, Maria Garcia Bonilla1, Jason Moore1, Michael Talcott1, Albert Isaacs2, Leandro Castaneyra Ruiz3, Diego Morales1, David Limbrick1
1Washington University in St. Louis School of Medicine, Missouri, USA; 2Ohio State University and Nationwide Hospital, Ohio, USA; 3Children's Hospital of Orange County, California, USA
Correspondence: Maria Garcia Bonilla mariag@wustl.edu
A39 Modulation of Toll-like receptor (TLR)-calpain pathway may prevent acquired hydrocephalus
Leandro Castaneyra-Ruiz1, Jenna Ledbetter1, Seunghyun Lee1, Anthony Rangel1, Evelyn Torres1, Michael Muhonen2
1CHOC Children’s Research Institute, Orange, CA 92868, USA; 2Neurosurgery department at CHOC Children’s Hospital, Orange, CA 92868, USA
Correspondence: Leandro Castaneyra-Ruiz, Leandro.castaneyra.ruiz@choc.org
A40 Brain pathologic change due to ciliary dysfunction in chronic hydrocephalus model mice
Kaito Kawamura1,2, Madoka Nakajima2, Masakazu Miyajima 3, Chihiro Akiba3, Koichiro Sakamoto2, Kou Horikoshi1,2, Ryo Miyahara2, Chihiro Kamohara2, Ikuko Ogino2, Shinya Yamada2,4, Kostadin Karagiozov2, Akihide Kondo2
1Department of Neurosurgery, Saiseikai Kawaguchi General Hospital, Saitama, Japan; 2Department of Neurosurgery, Juntendo University School of Medicine, Tokyo, Japan; 3Department of Neurosurgery, Juntendo Koto Geriatric Medical Center, Tokyo, Japan; 4Department of Neurosurgery, Kugayama Hospital, Tokyo, Japan
Correspondence: Kaito Kawamura, k-kawamu@juntendo.ac.jp
A41 Exploring the Influence of Catheter Materials on Neuroinflammation and the Intracranial Microbiome
Michael Meggyesy1, Yinghao Li2, Dipankar Biswas1, Gwendolyn Williams1, Ryan P. Lee1, Enoch Kim3, Jun Hua2,4,5, Horst A. von Recum6, Jeffrey R Capadona6, Mark G. Luciano1
1Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA; 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA; 3Nova Southeastern University Dr. Kiran C. Patel College of Allopathic Medicine, Fort Lauderdale, FL, USA; 4Department of Biomedical Engineering, Johns Hopkins, Baltimore, MD, USA; 5Neurosection, Division of MRI Research, Department of Radiology, Johns Hopkins, Baltimore, MD, USA; 6Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA
Correspondence: Mark Luciano, markluciano@jhu.edu
A42 Acute hydrocephalus and cortical neurodegeneration in Dnah5 knockout mice: exploring mechanisms and pathogenesis
Koichiro Sakamoto1, Kaito Kawamura1,2, Madoka Nakajima1, Masakazu Miyajima3, Chihiro Akiba.3, Kou Horikoshi1,2, Ryo Miyahara1, Chihiro Kamohara1, Ikuko Ogino1, Shinya Yamada1,4, Kostadin Karagiozov1, Akihide Kondo1
1Department of Neurosurgery, Juntendo University School of Medicine, Tokyo, Japan; 2Department of Neurosurgery, Saiseikai Kawaguchi General Hospital, Saitama, Japan; 3Department of Neurosurgery, Juntendo Koto Geriatric Medical Center, Tokyo, Japan; 4Department of Neurosurgery, Kugayama Hospital, Tokyo, Japan
Correspondence: Koichiro Sakamoto, k-sakamo@juntendo.ac.jp
A43 In-Vitro Evaluation of Shunt Valve Flow Dynamics
Gwendolyn Williams1, Michael Meggyesy1, Kenae Thompson2, Enoch Kim3, Dipankar Biswas1, Mark Luciano1
1Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA; 2Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore, MD, 21287, USA; 3Nova Southeastern University Dr. Kiran C. Patel College of Allopathic Medicine, Fort Lauderdale, FL, 33314, USA
Correspondence: Mark Luciano, markluciano@jh.edu
A44 Quantitative Analysis of Flow and Pressure Changes Through Explanted Biobank Ventricular Catheters
Ahmad Faryami1, Adam Menkara1, Shaheer Ajaz1, Christopher Roberts2, Carolyn A. Harris2
1Biomedical Engineering, Wayne State University, Detroit, Michigan,48202 USA; 2Chemical Engineering and Material Science, Wayne State University, Detroit, Michigan,48202 USA
Correspondence: Ahmad Faryami: gw7895@wayne.edu
A45 A Flow Optimized Ventricular Catheter; Flow Redistribution, Shear Reduction, and Reduced Astrocytic Activation
Ahmad Faryami1, Nathan G. Tappen2, Chris Roberts2, Carolyn A. Harris2
1Biomedical Engineering, Wayne State University, Detroit, Michigan,48202 USA; 2Chemical Engineering and Material Science, Wayne State University, Detroit, Michigan,48202 USA
Correspondence: Ahmad Faryami, GW7895@wayne.edu
A46 Vascular Risk Factors, Causes of Death and 10-year Mortality in idiopathic normal pressure hydrocephalus (INPH)
Sanna A. Eklund1, Hanna Israelsson2, Mattias Brunström3, Karin Forsberg1, Jan Malm1
1Department of Clinical Science, Neurosciences, Umeå University, Umeå, Sweden; 2Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden; 3Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden
Correspondence: Sanna Andrea Eklund, sanna.eklund@umu.se
A47 Smartphone monitoring of multidomain gait parameters to facilitate remote monitoring of gait in Normal Pressure Hydrocephalus
Aida Kamalian, Abhay Moghekar
1Neurology Department, Johns Hopkins University School of Medicine, Baltimore, MD, 21224, USA
Correspondence: Abhay Moghekar, am@jh.edu
A48 Endoscopic third ventriculostomy versus Ventriculoperitoneal shunt in the treatment of normal pressure hydrocephalus: Preliminary results of a randomized approach
Loay Shoubash, Ina Lange, Maximilian Schilling, Sascha Marx, Henry H. W. Schroeder
1Department of Neurosurgery, University Medicine of Greifswald, Greifswald, Germany
Correspondence: Loay Shoubash, E-mail: loay.shoubash@uni-greifswald.de
A49 Cerebrospinal fluid and intracranial blood rapid interactions in normal pressure hydrocephalus
Cyrille Capel1,2, Kimi Owashi2, Serge Metanbou1, Alexis Joannides3, Zofia Czosnyka3, Marek Czosnyka3, Peter Smielewski3, Olivier Balédent1,2
1University hospital, Amiens, France.; 2CHIMERE UR7516, Jules Verne University , Amiens, France; 3Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
Correspondence: Olivier Balédent, olivier.baledent@chu-amiens.fr
A50 Characteristics of human meningeal lymphatic vessels
César Luis Vera Quesada1,2, Shreyas Balachandra Rao3, Reidun Torp3, Per Kristian Eide1,2
1Department of Neurosurgery, Oslo University Hospital-Rikshospitalet, Oslo, Norway; 2Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; 3Division of Anatomy, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
Correspondence: Per Kristian Eide, p.k.eide@medisin.uio.no
A51 Urinary Incontinence and Normal Pressure Hydrocephalus: Some clues for what is still uncertain
Julián Azuero1, Alexandra Ramos2, Diana Valentina Garrido2, Isabella Mejía3, Diego F. Gómez3, Juan A. Mejía3, Mauricio Plata1, Fernando Hakim3, Juan F. Ramón3
1Department of Urology, Hospital Universitario Fundación Santa Fe de Bogotá, Colombia; 2Faculty of Medicine, Universidad de los Andes, Bogotá, Colombia; 3Department of Neurosurgery, Hospital Universitario Fundación Santa Fe de Bogotá, Colombia
Correspondence: Juan F. Ramón, juanfernandoramon@yahoo.com
A52 Multi-Domain Assessment of Gait at Baseline Visit in patients with Idiopathic Normal Pressure Hydrocephalus (iNPH)
Megha Patel, Abhay Moghekar
1Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA
Correspondence: Abhay Moghekar, am@jhmi.edu
A53 Audiovestibular Symptoms in Shunted Idiopathic Normal Pressure Hydrocephalus
Enoch Kim1,2, Michael Meggyesy1, Ryan P. Lee1, Christina Ritter1, Sevil Yasar3, Mark G. Luciano1
1Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA; 2Nova Southeastern University Dr. Kiran C. Patel College of Allopathic Medicine, Fort Lauderdale, FL, 33328, USA; 3Division of Geriatric Medicine & Gerontology and Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA
Correspondence: Mark G. Luciano, markluciano@jhu.com
A54 AQP4 levels in CSF correlate with clinical severity in iNPH patients. A preliminary report
Enrico Belgrado1, Yan Tereshko2, Adriana Cifù4,5, Martina Fabris4,5, Daniele Piccolo3, Mariarosaria Valente2, Francesco Tuniz3
1Neurology Department, ASUFC, S.M della Misericordia, Udine Italy; 2 Neurologic Clinic, University of Udine, Italy; 3Neurosurgery Department, ASUFC, S.M della Misericordia, Udine Italy; 4Department of Laboratory Medicine, ASUFC, S.M della Misericordia, Udine, Italy; 5Institute of Clinical Pathology, DAME, University of Udine, Italy.
Correspondence: Fransesco Tuniz, tuniz.francesco@gmail.com
A55 Does ventriculomegaly correlate with intelligence and cognition? Neuropsychological findings and profile in longstanding overt ventriculomegaly of adults (LOVA)
Lucia Darie1, Marco Pitteri2, Olatomiwa Olukoya1, Linda D’Antona1, Lewis Thorne1, Ahmed Toma1, Laurence Watkins1
1Department of Neurosurgery, The National Hospital for Neurology and Neurosurgery, University College London Hospitals, United Kingdom; 2Department of Neuropsychology, The National Hospital for Neurology and Neurosurgery, University College London Hospitals, United Kingdom
Correspondence: Lucia Darie, darielucia@yahoo.com
A56 Reproducibility of The Timed 10-meter walking test in Normal Pressure Hydrocephalus
Kanza Tariq, Ahmed Toma, Lewis Thorne, Laurence Watkins
1National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
Correspondence: Kanza Tariq kanza.tariq@nhs.net
A57 Advances in 3D and 4D imaging of cerebrospinal fluid and AI-based diagnosis of DESH
Shigeki Yamada1,2, Satoshi Ii3, Tomohiro Otani 4, Hirotaka Ito5, Motoki Tanikawa1, Chifumi Iseki6, Yoshiyuki Watanabe7, Shigeo Wada4, Marie Oshima2, Mitsuhito Mase1
1Department of Neurosurgery, Nagoya City University Graduate School of Medical Science, Aichi, Japan; 2Interfaculty Initiative in Information Studies/Institute of Industrial Science, The University of Tokyo, Tokyo; 3Faculty of System Design, Tokyo Metropolitan University, Tokyo; 4Department of Mechanical Science and Bioengineering, Graduate School of Engineering Science, Osaka University, Osaka; 5Medical System Research & Development Center, FUJIFILM Corporation, Tokyo; 6Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Miyagi; 7Department of Radiology, Shiga University of Medical Science, Shiga
Correspondence: Shigeki Yamada, shigekiyamada393@gmail.com
A58 Distinct cerebral cortical microstructural changes in idiopathic normal-pressure hydrocephalus
Kyunghun Kang1, Myong Hun Hahm2, Uicheul Yoon3, Ki-Su Park4, Eunhee Park5, Sang-Woo Lee6, Shin Young Jeong6
1Department of Neurology, School of Medicine, Kyungpook National University, Daegu, 41404, South Korea; 2Department of Radiology, School of Medicine, Kyungpook National University, Daegu, 41404, South Korea; 3Department of Biomedical Engineering, Daegu Catholic University, Gyeongsan-si, 38430, South Korea; 4Department of Neurosurgery, School of Medicine, Kyungpook National University, Daegu, 41404, South Korea; 5Department of Rehabilitation Medicine, School of Medicine, Kyungpook National University, Daegu, 41404, South Korea; 6Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu, 41404, South Korea
Correspondence: Kyunghun Kang, Kyunghun.Kang@hotmail.com
A59 Reversibility of the Radiological Signs of Raised Intracranial Pressure Following Intraparenchymal Brain Tumour Resection
Kanza Tariq, James Yeomans, Ahmed Toma, Laurence Watkins, Lewis Thorne
1National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
Correspondence: Kanza Tariq, kanza.tariq@nhs.net
A60 Respiratory and cardiac signal analysis of CSF dynamics in normal pressure hydrocephalus and Alzheimer’s disease
Pragalv Karki1, Matthew C. Murphy1, Sandeep Ganji1, Jeffrey L. Gunter1, Jonathan Graff-Radford2, David T. Jones3, Hugo Botha3, Jeremy K. Cutsforth-Gregory3, Benjamin D. Elder3-5, Clifford R. Jack Jr1, John Huston III1, Petrice M. Cogswell1
1Department of Radiology, Mayo Clinic, Rochester, MN, 55905, USA; 2Department of Neurology; 3Department of Neurologic Surgery; 4Department of Biomedical Engineering; 5Department of Orthopedics
Correspondence: Pragalv Karki, karki.pragalv@mayo.edu
A61 Structural Volumetric and Periodic Table DTI Patterns in Complex Normal Pressure Hydrocephalus – Towards the Principles of a Translational Taxonomy
Christine Lock1, Nicole C. H. Keong1,2, for the Alzheimer's Disease Neuroimaging Initiative*
1Department of Neurosurgery, National Neuroscience Institute, 308433, Singapore; 2Duke-NUS Medical School, 169857, Singapore
Correspondence: Nicole CH Keong, nchkeong@cantab.net
A62 The relationship between dual-task cost and cognitive performance among patients with probable idiopathic Normal Pressure Hydrocephalus
Elizabeth Cray1, Rupert Noad2, Samiul Muquit1, Samuel Jeffery1
1Department of Neurosurgery, Southwest Neurosurgery Centre, University Hospital Plymouth, Plymouth, PL6 8DH;2Department of Neuropsychology, University Hospital Plymouth, Plymouth, PL6 8DH
Correspondence: Elizabeth Cray, elizabethcray@nhs.net
A63 Long-term care in older persons suspected of idiopathic normal pressure hydrocephalus (iNPH)
Eric A Schmidt1, Laurent Balardy2, Hélène Villars2
1Department of Neurosurgery, University Hospital, Toulouse, France; 2Department of Geriatrics, University Hospital, Toulouse, France
Correspondence: Hélène Villars, villars.h@chu-toulouse.fr
A64 Thirty years of experience in CSF dynamics testing in adult hydrocephalus
Zofia Czosnyka, Marek Czosnyka, Afroditi Lalou, Peter Smielewski, Alexis Joannides, John D. Pickard
1Division of Neurosurgery, Cambridge University Hospital, Cambridge Biomedical Campus, cb20qq, Cambridge UK
Correspondence: Zofia Czosnyka, zc200@medschl.cam.ac.uk
A65 Use of non-invasive ICP waveform monitoring in a csf collection laboratory: experience and learning points
Carlos O. Brandão1, Ricardo C. Benesi1, Celina de Oliveira1, Cristiane S. Casanova1, Francisjane de J. Lopes1, Ana L. L. Diblasi1, Léo F. Corrêa1, Dalton L. D. Ferreira1, Maria P. F. dos Santos1, Maria F. G. D Dubourqc1, Raphael Bertani2
1Neurolife, laboratório especializado no estudo do líquido cefalorraquiano (Neurolife, CSF laboratory); 2Cerebral Hydrodynamics Group, University of São Paulo (USP), São Paulo, SP, Brazil
Correspondence: Raphael Bertani, contato@rbertani.com
A66 In vivo performance of the Kitea intracranial pressure (ICP) System
Sarah-Jane Guild1,2, Abdel-Hamed Dabbour1,2, Natalia Lopez2, Bryon Wright2, Robert Gallichan2, Dixon Leung2, Daniel McCormick1,2, Masahiro Kondo2, Peter Heppner3, Simon Malpas1,2
1University of Auckland, New Zealand; 2Kitea Health Ltd, Auckland, New Zealand; 3Auckland City Hospital, New Zealand
Correspondence: Sarah-Jane Guild, s.guild@auckland.ac.nz
A67 Validation of the Kitea intracranial pressure (ICP) monitoring system over 6 months in sheep
Sang Ho Kim1,3, Sarah-Jane Guild1,2, Abdel-Hamed Dabbour1,2, Natalia Lopez2, Bryon Wright2, Robert Gallichan2, Dixon Leung2, Daniel McCormick1,2, Masahiro Kondo2, Mark Oliver1,4, Eric Ai1,4, Gregg Pardoe1,4, Simon Malpas1,2
1University of Auckland, New Zealand; 2Kitea Health Ltd, Auckland, New Zealand; 3Auckland City Hospital, New Zealand; 4Ngapouri Research Farm Laboratory, University of Auckland, New Zealand
Correspondence: Sarah-Jane Guild, s.guild@auckland.ac.nz
A68 Safety of the Kitea intracranial pressure (ICP) implant in the growing brain
Sarah-Jane Guild1,2, Sheryl Tan1, Abdel-Hamed Dabbour1,2, Natalia Lopez2, Bryon Wright2, Robert Gallichan2, Dixon Leung2, Daniel McCormick1,2, Masahiro Kondo2, Mark Oliver1,3, Eric Ai1,3, Gregg Pardoe1,3, Simon Malpas1,2
1University of Auckland, New Zealand; 2Kitea Health Ltd, Auckland, New Zealand; 3Ngapouri Research Farm Laboratory, University of Auckland, New Zealand
Correspondence: Sarah-Jane Guild, s.guild@auckland.ac.nz
A69 AI-trained mixed reality head-mounted display to place ventricular catheters -preliminary data
Martin Mersch1, Patrick House2,3, Erke Can Tellal4, Sirko Pelzl4, Uwe Kehler1
1Department of Neurosurgery, Asklepios Klinik Altona, Hamburg, 22763, Germany; 2theBlue.ai GmbH, Hamburg, 20095, Germany; 3Epileptologicum Hamburg, Specialist´s Practice for Epileptology, 22299, Germany; 4apoQlar GmbH, Hamburg, 20095, Germany
Correspondence: Martin Mersch, Martin.Mersch@outlook.com
A70 Comparison between conventional surgery and robotic endoscopic third ventriculostomy in occlusive hydrocephalus
Thomas M. Freiman1, Lennard Spanehl1, Daniel Dubinski1, Florian Gessler1, Johannes Buchmann2, Sae-Yeon Won1
Departments of 1Neurosurgery and 2Child- and Adolescence Neuropsychiatry, University Medical Centre Rostock, Schillingallee 35, D-18057 Rostock, Germany
Correspondence: Thomas Freiman thomas.freiman@med.uni-rostock.de
A71 Unravelling mechanisms driving ventricular catheter obstruction - a multicenter shunt biobank approach
Hariharan Prashant1, Carolyn Harris1,2
1Department of Biomedical Engineering, Wayne State University, Detroit, MI, United States; 2Department of Chemical Engineering and Materials Science, Wayne State University, Detroit, MI, United States;
Correspondence: Prashant Hariharan, fj1852@wayne.edu
A72 Blood GFAP, NFL and abeta42/40 Correlate Modestly with CSF levels in idiopathic normal pressure hydrocephalus (iNPH) But Do Not Predict Short Term Response To CSF Diversion
Alexandria Lewis, Abhay Moghekar
1Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA
Correspondence: Abhay Moghekar, am@jhmi.edu
A73 Watkins 2.0: The Next Generation In Gait-Assessment Apps For Normal Pressure Hydrocephalus And Decompensated Long-Standing Overt Ventriculomegaly Patients
Kanza Tariq, Ahmed Toma, Lewis Thorne, Laurence Watkins
1National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
Correspondence: Kanza Tariq kanza.tariq@nhs.net
A74 Quantitative measurement of finger tapping before and after the tap test in idiopathic normal pressure hydrocephalus
Yoko Shimizu1,2, Mitsuya Horiba1, Kento Sahashi1, Shoji Kawashima3, Akihiko Kandori4, Motoki Tanikawa2, Shigeki Yamada2, Noriyuki Matsukawa3, Hideki Okamoto1, Yoshino Ueki1, Mitsuhito Mase2
1Department of Rehabilitation Medicine, Nagoya City University Graduate School of Medical Science, Nagoya, Japan; 2Department of Neurosurgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan; 3Department of Neurology and Neuroscience, Nagoya City University Graduate School of Medical Science, Nagoya, Japan; 4Hitachi, Ltd, Research and Development Group, Center for Exploratory Research, Tokyo, Japan
Correspondence: Yoko Shimizu, otyokos@med.nagoya-cu.ac.jp
A75 Machine Learning Analysis of Voice Data from Patients with Normal Pressure Hydrocephalus
Ki-Su Park1, Jiho Lee2, Janghyeok Yoon2, Ji-Wan Ha3, Kyunghun Kang4, Eunhee Park5
1Department of Neurosurgery, School of Medicine, Kyungpook National University, Daegu, Republic of Korea; 2Department of Industrial Engineering, Konkuk University, Seoul, Republic of Korea; 3Department of Speech Pathology, Daegu University, Gyeongsan, Republic of Korea; 4Department of Neurology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea; 5Department of Physical and Rehabilitation Medicine, Kyungpook National University Medical Center, Daegu, Republic of Korea.
Correspondence: Janghyeok Yoon, janghyoon@gmail.com
A76 Optimizing Gait and Balance Metric Acquisition from the “Tap Test” in Normal Pressure Hydrocephalus
Philip W. Tipton1, Olga P. Fermo1, Kaisorn L. Chaichana2, Christian Lachner1,3, Gregory S. Day1, Sanjeet S. Grewal2, Bjorn E. Oskarsson1, Nilufer Ertekin-Taner1,4, Zbigniew K. Wszolek1, Neill R. Graff-Radford1
1Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA; 2Department of Neurosurgery, Mayo Clinic, Jacksonville, Florida, USA; 3Department of Psychiatry and Psychology, Mayo Clinic, Jacksonville, Florida, USA; 4Department of Neurosurgery, Mayo Clinic, Jacksonville, Florida, USA
Correspondence: Philip W Tipton, tipton.philip@mayo.edu
A77 Lumboperitoneal (LP) shunt in the patients with idiopathic normal pressure hydrocephalus (iNPH): Surgical technique
Naoyuki Samejima, Nobmasa Kuwana, Akira Watanabe
1NPH Center, Department of Neurosurgery, Tokyo Kyosai Hospital, Tokyo, Japan
Correspondence: Naoyuki Samejima samejima@tkh.meguro.tokyo.jp
A78 Neuralgia after Lumboperitoneal Shunt Can Be Reduced with Surgery under Local Anesthesia
Yasuaki Inoue, Ryo Oike
1Department of Neurosurgery, Nadogaya Hospital, Kashiwa, Japan
Correspondence: Yasuaki Inoue, Inoue.yasuaki@gmail.com
A79 Impact of shunt placement in CSF dynamics
Cyrille Capel1,2, Kimi Owashi2,3, Serge Metanbou4, Olivier Balédent2,3
1Neurosurgery, University hospital, Amiens, France; 2CHIMERE UR7516, Jules Verne University , Amiens, France; 3Image processing, University hospital, Amiens, France; 4Radiology, University hospital, Amiens, France
Correspondence: Olivier Balédent, olivier.baledent@chu-amiens.fr
A80 Influence of ventricular size and surgical approach on flow distribution in ventricular catheters
Cristopher Roberts, Prashant Hariharan, Carolyn Harris, Bryn Martin
1Wayne State University, Michigan, USA
Correspondence: Cristopher Roberts bb9561@wayne.edu
A81 Shunt testing in vivo: Performance of Certas Valve integrated with SiphonGuard
Marek Czosnyka, Benjamin Dias-Dougan, Indu Lawes, Zofia Czosnyka, Alexis Joannides
1Division of Neurosurgery, Cambridge University Hospital, Cambridge, UK
Correspondence: Marek Czosnyka , mc141@medschl.cam.ac.uk
A82 Prognostic Significance Of Cerebrospinal Fluid Production Rate In Idiopathic Intracranial Hypertension And The Impact Of Medical Therapy
Kanza Tariq, Ahmed Toma, Sogha Khawari, Lewis Thorne, Laurence Watkins
1National Hospital for Neurology and Neurosurgery, Queen Square, London, U.K
Correspondence: Kanza Tariq kanza.tariq@nhs.net
A83 The Peking University Medical College Hospital (PUMCH) Evaluation System of Idiopathic Normal Pressure Hydrocephalus and Clinical Practice
Rui Yin1*, Junxian Wen1*, Jianbo Chang1, Xiao Zhang1, Caiyan Liu2, Jing Gao2, Yihao Chen1, Lang Yang1, Xiying Dong1, Feng Feng3, Hui You3, Wei Zuo4, Junji Wei1
1Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, 100730 Beijing, China; 2Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, 100730 Beijing, China; 3Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, 100730 Beijing, China; 4Department of Pharmacy, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, 100730 Beijing, China
Correspondence: Junji Wei, weijj1999@163.com
A84 Consistency and sensitivity analysis of instrumental and traditional methods for evaluating the CSF tap test (CSF-TT) responsiveness in patients with iNPH
Chunyan Liua, Hongliang Lia, Qiong Yanga, Yanfeng Lib, Yan Xinga*
aDepartment of Neurology, Aviation General Hospital, 100012 Beijing, China; bDepartment of Neurology, Peking Union Medical College Hospital, Beijing, China 100730
Correspondence: Yan Xing drxingyan@163.com
A85 Effectiveness of the Clock Drawing test in the Tap Test
Koichi Miyazaki
1Department of Neurosurgery, Osaka Kaisei Hospital, Osaka, Osaka, 532-0003, Japan
Correspondence: Koichi Miyazaki, rpmy69126@nike.eonet.ne.jp
A86 Efficacy and safety of a novel programmable valve (Sphera Pro®) in the treatment of idiopathic normal pressure hydrocephalus: a multicenter study
Rodolfo C. Reis1, Marina M. Melo1, Matheus M. Mendes2, Gabriel A. da S. Mendes3, Camila S. Cechi4, Manoel J. Teixeira2, Fernando C. G. Pinto2, José M. Rotta1
1Department of Neurosurgery, IAMSPE, São Paulo, SP, Brazil; 2Department of Neurosurgery, Hospital das Clínicas, University of São Paulo, SP, Brazil; 3Physiotherapy Section, IAMSPE, São Paulo, SP, Brazil; 4Neuropsychology Section, Hospital das Clínicas, SP, Brazil
Correspondence: Rodolfo Casimiro Reis, rodolfocr84@yahoo.com.br
A87 Placebo–controlled effectiveness in INPH shunting (PENS) – Study Update
Mark Luciano1, Richard Holubkov2, Sean Nagel3, Jeffrey Wisoff4, Guy McKhann, II5, Thomas Zwimpfer6, Richard Edwards7, Michael Williams8, Jan Malm9, Abhay Moghekar10, Anders Eklund9, James Golomb11, Heather Katzen12, Nickolas Dasher13, Michael Meggyesy1, Mark Hamilton14
1Neurosurgery, 10Neurology, Johns Hopkins School of Medicine, Baltimore, USA; 2University of Utah, Salt Lake City, USA; 3Neurosurgery, Cleveland Clinic Foundation, Cleveland, USA; 4Pediatric Neurosurgery, 11Neurology, NYU Langone Health, New York City, USA; 5Neurological Surgery, Columbia University School of Medicine, 6Neurosurgery, University of British Columbia, Vancouver, Canada; 7Neurosurgery, Southmead Hospital, Birstol, UK; 8Neurology, 13Rehabilitation Medicine, University of Washington School of Medicine, Seattle, USA; 9Neurology, Umeå University, Umea, Sweden, 12Neurology, University of Miami Miller School of Medicine, Florida, USA; 14Neurosurgery, University of Calgary School of Medicine, Calgary, Canada
Correspondence: Mark Luciano, markluciano@jhmi.edu
A88 Safety of Ventriculoperitoneal Shunt Placement in Patients with Idiopathic Normal Pressure Hydrocephalus in the Setting of Systemic Anticoagulation
Abdelrahman Hamouda1, Mahnoor Shafi1, Zach Pennington1, Hannah Hallak1, Jonathan Graff-Radford2, David T Jones2, Hugo Botha2, Jeremy K. Cutsforth-Gregory2, Petrice M Cogswell3, Benjamin D. Elder1
1Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, 55905, USA; 2Department of Neurology; 3Department of Radiology
Correspondence: Benjamin Elder, elder.benjamin@mayo.edu
A89 Frailty and medium-term overall survival following ventriculoperitoneal shunting for patients with idiopathic Normal Pressure Hydrocephalus
Elizabeth Cray1, Rupert Noad2, Samiul Muquit1, Samuel Jeffery1
1Department of Neurosurgery, Southwest Neurosurgery Centre, University Hospital Plymouth, Plymouth, PL6 8DH. UK; 2Department of Neuropsychology, University Hospital Plymouth, Plymouth, PL6 8DH, UK
Correspondence: Elizabeth Cray, elizabethcray@nhs.net
A90 Analysis of Intracranial Pressure Pulse Shape Index in Normal Pressure Hydrocephalus
Magdalena Kasprowicz1, Agnieszka Kazimierska1, Eric Schmidt2, Olivier Balédent3, Agata Pudełko1, Marek Czosnyka4, Zofia Czosnyka4
1Department of Biomedical Engineering, Faculty of Fundamental Problems of Technology, Wroclaw University of Science and Technology, Wroclaw, Poland; 2Department of Neurosurgery, University Hospital of Toulouse, Toulouse, France; 3Department of Imaging and Biophysics, Teaching Hospitals, Jules Verne University of Picardie, Amiens, France; 4Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke’s Hospital, University of Cambridge, Cambridge, United Kingdom
Correspondence: Magdalena Kasprowicz, magdalena.kasprowicz@pwr.edu.pl
A91 Oscillation of Intracranial Pressure (ICP) during walking is locked to head motion
Matthew J. Bancroft1,2,3, Eleanor M. Moncur1,3, Lewis Thorne1,3, Laurence D. Watkins1,3, Ahmed K. Toma1,3
1Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London, WC1N 3BG, UK; 2Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, WC1N 3BG, UK; 3Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK
Correspondence: Matthew J Bancroft, matthew.bancroft.13@ucl.ac.uk
A92 Cut-off point of the noninvasive measurement of intracranial compliance for the diagnosis of idiopathic Normal Pressure Hydrocephalus
Gabriel A. S. Mendes1,2, Raphael Bertani2, Cintya Hayashi2, Gustavo H. Frigieri³, Rodolfo C. Reis4, Manoel J. Teixeira2, Fernando C. G. Pinto2
1Physiotherapy Nucleous, Hospital of the State Public Servant of São Paulo, São Paulo, SP, Brazil; 2Cerebral Hydrodynamics Group, Department of Neurosurgery, Hospital das Clínicas, University of São Paulo, SP, Brazil; 3Brain4Care, São Carlos, SP, Brazil; 4Neurosurgery Department, Hospital of the State Public Servant of São Paulo, São Paulo, SP, Brazil.
Correspondence: Gabriel André da Silva Mendes, mendes1986@yahoo.com.br
A93 Prediction of optimal Intracranial Pressure (ICP) level to achieve normalization of pulse amplitude
Leon Gramss1,2, Linda D’Antona1,2, Eleanor Moncour1,2, Kanza Tariq1,2, Lucia Darie1, Lewis Thorne1, Laurence Watkins1,2, Ahmed Toma1,2
1Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, WC1N3BG, UK; 2Queen Square Institute of Neurology, University College London, London, WC1N3BG, UK
Correspondence: Linda D’Antona, linda.d’antona@nhs.net
A94 Characteristics of the M.scio Telemetric ICP Measurement System with Lumbar Catheter
Anders Eklund1, Tomas Bäcklund1, Michael A. Williams2, Jan Malm3
1Department of Radiation Sciences, Biomedical Engineering, Umeå University, Umeå, Sweden; 2University of Washington, Seattle, USA; 3Department of Clinical Science, Neurosciences, Umeå University, Umeå, Sweden
Correspondence: Anders Eklund, anders.eklund@umu.se
A95 Early feasibility study of implantation of a telemetric Intracranial Pressure (ICP) sensor in a commercial spaceflight participant
Michael A. Williams1, Karen N. Adams1, Elisa McGee1, Robert Bonow1, Andrew Ko1, Danial Hallam1, Courtney Gomez1, Jan Malm2, Anders Eklund2, Tomas Bäcklund2, J. E. Schmitt3, Eric M. Bershad4, Christoph Miethke5, Andreas Bunge5
1University of Washington, Seattle, USA; 2University of Umeå, Sweden; 3University of Pennsylvania, Philadelphia, USA; 4Baylor College of Medicine, Houston, USA; 5Christoph Miethke GmbH & Co. KG, Potsdam, Germany
Correspondence: Michael A. Williams, maw99@uw.edu
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April 18, 2022 – FDA pre‐application submitted
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July 5, 2022 – Teleconference with FDA reviewers
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August 19, 2022 – Teleconference with FDA/NASA liaisons, and TRISH and NASA leaders
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October 24, 2022 – Teleconference with FDA reviewers
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November 2022 –M.scio system preclinical quality testing by Miethke GmbH
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January 3, 2023 – IDE early feasibility study and research protocol with safety assessments submitted
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February 14, 2023 – IDE approved by FDA
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March 2023 – Bench testing of M.scio implant assembly by Umeå
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March 16, 2023 – Baylor College of Medicine IRB approved the protocol
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May 1, 2023 – Awaiting spaceflight opportunity
A96 Effect of shunt adjustment on short term telemetric Intracranial Pressure (ICP) readings
Karina Hoffmann1, Linda D’Antona1,2, Zeid Abussuud2, Eleanor Moncour1,2, Kanza Tariq1,2, Lucia Darie2, Lewis Thorne2, Laurence Watkins1,2, Ahmed Toma1,2
1Queen Square Institute of Neurology, University College London, London, WC1N3BG, UK; 2Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, WC1N3BG, UK
Correspondence: Linda D’Antona, linda.d’antona@nhs.net
A97 Age-stratified presentation and outcomes of ventriculoperitoneal shunt implantation in a cohort of normal pressure hydrocephalus (NPH) patients
Aleksandra B. Lasica1, Zeid A. Abussuud1, Christos Soumpasis1, Astri M. V. Luoma2, Ahmed K. Toma1
1Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, University College London Hospitals, NHS Foundation Trust, Queen Square, London, UK; 2Department of Neuroanaesthesia and Neurocritical Care, National Hospital for Neurology and Neurosurgery, University College London Hospitals, NHS Foundation Trust, Queen Square, London, UK
Correspondence: Alexandra B. Lasica, a.lasica@nhs.net , Zeid A. Abussuud, z.abussuud@nhs.net
A98 Effective shunt surgery for elderly patients after a fall with definite idiopathic normal pressure hydrocephalus can prevent the following fall
Ryo Oike, Yasuaki Inoue
1Department of Neurosurgery, Nadogaya Hospital, Kashiwa, Japan
Correspondence: Ryo Oike, ryo.st2b@gmail.com
A99 Comparison of female and male outcomes in a cohort of normal pressure hydrocephalus (NPH) patients undergoing ventriculoperitoneal shunt implantation
Aleksandra B. Lasica1, Zeid A. Abussuud1, Christos Soumpasis1, Astri M. V. Luoma2, Ahmed K. Toma1
1Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, University College London Hospitals, NHS Foundation Trust, Queen Square, London, UK; 2Department of Neuroanaesthesia and Neurocritical Care, National Hospital for Neurology and Neurosurgery, University College London Hospitals, NHS Foundation Trust, Queen Square, London, UK
Correspondence: Alexandra B. Lasica, a.lasica@nhs.net, Zeid A. Abussuud, z.abussuud@nhs.net
A100 Baseline PROMIS Score Characteristics and Temporal Changes Following Shunt Placement in Patients with Idiopathic Normal Pressure Hydrocephalus (iNPH)
Abdelrahman Hamouda1, Mahnoor Shafi1, Zach Pennington1, Hannah Hallak1, Maria Astudillo1, Jonathan Graff-Radford2, David T. Jones2, Hugo Botha2, Jeremy K. Cutsforth-Gregory2, Petrice M. Cogswell3, Benjamin D. Elder1
1Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, 55905, USA; 2Department of Neurology; 3Department of Radiology
Correspondence: Benjamin Elder, MD/PhD, elder.benjamin@mayo.edu
A101 Long-term Cognitive and Gait Outcomes after Primary Endoscopic Third Ventriculostomy (ETV) in Adults from the AHCRN with Chronic Obstructive Hydrocephalus
Thomas J. Zwimpfer1, Richard Holubkov2, Heather Katzen3, Mark G. Luciano4, Sean J. Nagel5, Michael A. Williams6, Jeffrey H. Wisoff7, Guy M. McKhann8, Richard Edwards9, Abhay Moghekar10, Nickolas Dasher11, Mark G. Hamilton12
1Department of Surgery, University of British Columbia, Vancouver, V5Z 1M9, Canada; 2Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, USA; 3Department of Neurology, University of Miami Miller School of Medicine, USA; 4Department of Neurosurgery, Johns Hopkins University, Baltimore, USA; 5Department of Neurosurgery, Center for Neurological Restoration, Cleveland Clinic, USA; 6Departments of Neurology and Neurological Surgery, University of Washington School of Medicine, Seattle, USA; 7Department of Neurosurgery, New York University School of Medicine, USA; 8Department of Neurological Surgery, Columbia University Irving Medical Center, New York, USA; 9Department of Neurosurgery, Southmead Hospital, Bristol, United Kingdom; 10Department of Neurology, Johns Hopkins University, Baltimore, USA; 11Department of Rehabilitation Medicine, University of Washington School of Medicine, Seattle, USA; 12Department of Clinical Neurosciences, Division of Neurosurgery, University of Calgary Cumming School of Medicine, Canada
Correspondence: Thomas J. Zwimpfer, thomas.zwimpfer@ubc.ca
A102 Safety, sequelae, and efficacy of nerve root clipping in patients with spontaneous spinal CSF leaks
A. El Rahal, B. Haupt, F, Volz, K. Wolf, B. Blass, L. M. Kraus, I, Vassilikos, N, Lützen, L. Häni, J. Beck, C. Fung
1Medical Center University of Freiburg, Freiburg, Germany
Correspondence: Amir El Rahal, amir.elrahal@uniklinik-freiburg.de
A103 Prognostic Significance of Cerebrospinal Fluid Production Rate in the Management of Cerebrospinal Fluid Leak
Kanza Tariq, Ahmed Toma, Sogha Khawari, Lewis Thorne, Laurence Watkins
1National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
Correspondence: Kanza Tariq kanza.tariq@nhs.net
A104 Surgical closure of spinal CSF leaks improves symptoms in patients with superficial siderosis
Amir El Rahal1,2, Benedikt Haupt1, Christian Fung1, Debora Cipriani1, Levin Häni1 , Niklas Lützen1, Tomas Dobrocky2, Eike Piechowiak2, Oliver Schnell1, Andreas Raabe3, Katharina Wolf1, Horst Urbach1, Luisa Mona Kraus1, Florian Volz1, Jürgen Beck1
1Medical Center University of Freiburg, Freiburg, Germany; 2Inselspital Bern, Bern, Switzerland
Correspondence: Amir El Rahal amir.elrahal@uniklinik-freiburg.de
A105 Recovery and long-term outcome after neurosurgical closure of spinal CSF leaks in patients with spontaneous intracranial hypotension (SIH)
Florian Volz1 Christian Fung1, Katharina Wolf1, Niklas Lützen2, Horst Urbach2, Luisa Mona Kraus1, Mazin Omer1, Jürgen Beck1, Amir El Rahal1,3
1Department of Neurosurgery, Medical Center University of Freiburg, Freiburg im Breisgau, Germany; 2Department of Neuroradiology, Medical Center University of Freiburg, Freiburg im Breisgau, Germany; 3Faculty of Medicine, University of Geneva, Geneva, Switzerland
Correspondence: Amir El Rahal amir.elrahal@uniklinik-freiburg.de
A106 Impact of Ventriculoperitoneal Shunt on Systemic Hypertension
Kanza Tariq, Ahmed Toma, Lewis Thorne, Laurence Watkins
1National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
Correspondence: Kanza Tariq: kanza.tariq@nhs.net
A107 Cognitive Improvement after Endoscopic Third Ventriculostomy Surgery in Long-standing Overt Ventriculomegaly in Adults
Fabio Campanella1, Daniele Piccolo1,2,3, Giulia Sebastianutto1,4, Francesca Marotta1,2, Miran Skrap1, Francesco Tuniz1
1Neurosurgery Unit, Udine University Hospital, Udine (UD), 33100, Italy; 2Department of Neuroscience, University of Padua, Padova (PD), 35121, Italy; 3Department of Clinical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia (PV), 27100, Italy; 4Department of General Psychology, University of Padua, Padova (PD), 35131, Italy
Correspondence: Daniele Piccolo, ing.daniele@gmail.com
A108 Estimation of ventricular volume changes for smart shunt systems
Fabian Flürenbrock1, Leonie Korn1, Anthony Podgoršak2, Melanie Zeilinger1, Marianne Schmid Daners1
1Institute for Dynamic Systems and Control, Department of Mechanical and Process Engineering, ETH Zurich, Switzerland; 2Product Development Group Zurich, Department of Mechanical and Process Engineering, ETH Zurich, Switzerland
Correspondence: Fabian Flürenbrock, ffluerenb@ethz.ch
A109 Transcranial Direct Current Stimulation for Cognition Improvement in Postoperative Normal Pressure Hydrocephalus Patients with Programmable Pressure Valves: A Pilot Study
Camila Santos Cechi1, Raphael Bertani1, Savio Batista2, Matheus Miranda1, Caio Perret3, Stefan Koester4, Tamires Guimarães Cavalcante Carlos de Carvalho5, Gabriel A. S. Mendes1,6, Fernando C. G. Pinto1
1Cerebral Hydrodynamics Group, Department of Neurosurgery, Hospital das Clínicas, University of São Paulo, SP, Brazil; 2Medical School, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil; 3Department of Neurosurgery, Hospital Municipal Miguel Couto, Rio de Janeiro, RJ, Brazil; 4Medical School, Universidade Nove de Julho (UNINOVE), São Paulo, SP, Brazil; 5Medical School, University of Vanderbilt, Nashville, TN, USA; 6Physiotherapy Nucleous,Hospital of the State Public Servant of São Paulo, São Paulo, SP, Brazil
Correspondence: Raphael Bertani, contato@rbertani.com
A110 Shunt readmission rates and factors influencing them in hydrocephalus of all etiologies across the age spectrum in the Nationwide Readmissions Database
Jenna Koschnitzky1, Monica Chau2, Yifan Zhang3, Abhay Moghekar3
1Rhaeos, Inc., Chicago, IL, USA; 2Hydrocephalus Association, Bethesda, MD, USA; 3Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA
Correspondence: Abhay Moghekar, am@jhmi.edu
A111 Mechanical complications of Sophysa SM8 shunt in adult hydrocephalus: a monocentric experience
Arrighi Marta, Berton Quentin, Coll Guillaume
1Service de Neurochirurgie, CHU Clermont-Ferrand, Clermont-Ferrand, F-63000, France ;
Correspondence: Guillaume Coll, gcol@chu-clermontferrand.fr
A112 Incidence and Nature of Complications Associated with Ventriculoatrial Shunt Placement: A Meta-Analysis
Oliveira Leonardo1, Bertani Raphael2, Batista Sávio3, Wouters Kim4, Ribas Luiz, Machinski Elcio1, Wesselovicz Rubens1, Dos Santos Gabriel1, Viegas Fabio1, C. G. Pinto Fernando2
1State University of Ponta Grossa, Faculty of Medicine, Paraná, Brazil; 2Cerebral Hydrodinamics Group, Department of Neurosurgery, University of São Paulo, São Paulo, Brazil; 3Federal University of Rio de Janeiro, Faculty of Medicine, Rio de Janeiro, Brazil; 4Open University of the Netherlands, Faculty of psychology, Heerle, The Netherlands
Correspondence: Wouters Kim, k.wouters82@gmail.com
A113 After 15 years, what is changed in the knowledge of hydrocephalus? Survey of Harold O. Conn 15 years later
Gianpaolo Petrella, Silvia Ciarlo, Graziano Taddei, Angelo Pompucci, Alessandro Pesce
1A.O. “Santa Maria Goretti” General Hospital, Neurosurgery Division, Latina, Italy
Correspondence: Gianpaolo Petrella, gianpaolo_p@hotmail.com
A114 Reducing Over-Drainage Complications in Idiopathic Normal Pressure Hydrocephalus
Adam Nunn, Antonina Dembinska-Kenner, Cristina Cernei, Kelly McManus, Olivier Sluijters, Richard J. Edwards
1Department of Neurosurgery, Southmead Hospital, Bristol, UK
Correspondence: Richard Edwards, richard.edwards@nbt.nhs.uk
A115 Time to Resolution of Normal Pressure Hydrocephalus (NPH)-associated Subdural Hematomas
Michael Meggyesy1, Gwendolyn Williams1, Ryan P. Lee1, Jheesoo Ahn1, Christina Ritter1, Enoch Kim2, Mark G. Luciano1
1Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA; 2Nova Southeastern University Dr. Kiran C. Patel College of Allopathic Medicine, Fort Lauderdale, FL, 33314, USA
Correspondence: Michael Meggyesy, mmeggye1@jhmi.edu
A116 Abdominal pain after ventriculoperitoneal shunting for normal pressure hydrocephalus (NPH): prevalence, timeline, and impact of quality of life
Lennard-Quirin Rohde1, Anita Ulrich2, Uwe Kehler3
1Department of Neurosurgery, Asklepios Klinik Altona, Hamburg, 22763, Germany
Correspondence: Prof. Dr. Dr. Uwe Kehler, u.kehler@asklepios.com
A117 Frequency Of Abdominal Pain Related To Types Of Shunt Tubing: The difference in the tubing
Kanza Tariq, Ahmed Toma, Lewis Thorne, Simon Thompson, Celine Vicedo, Laurence Watkins
1National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
Correspondence: Kanza Tariq kanza.tariq@nhs.net
A118 Transendoscopic Ultrasound for Neuroendoscopy
Klaus D. M. Resch
1MIN Univ. Guadalajara; Mexico
Correspondence: Klaus D. M. Resch klausdmresch@ens-surgery.com
A119 Choroid plexus-on-a-chip: a microfluidic model to study how cerebrospinal fluid secretion and blood-cerebrospinal fluid barrier function are affected by inflammation associated with hydrocephalus
Hariharan Prashant1, Schwerk Christian4, Schroten Horst4, Blazer-Yost Bonnie3, Harris A. Carolyn1,2
1Department of Biomedical Engineering, Wayne State University, Detroit, MI, United States; 2Department of Chemical Engineering and Materials Science, Wayne State University, Detroit, MI, United States; 3Department of Biology, Indiana University - Purdue University Indianapolis, IN, United States; 4Mannheim Medical Faculty, University of Heidelberg, Children’s Hospital, Mannheim, Germany
Correspondence: Prashant Hariharan, fj1852@wayne.edu
A120 Patient-specific automated cerebrospinal fluid pressure control to augment spinal wound closure: a case series using the LIQUOGUARD®
Danyal Z. Khan1,2, Kanza Tariq1,3*, Keng Siang Lee4, Edward W. Dyson1,3, Vittorio Russo1, †Laurence D. Watkins1,3, †Antonino Russo1
1Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, UK; 2Wellcome/EPSRC Centre for Interventional and Surgical Sciences, University College London, London, UK; 3Department of Brain Repair & Rehabilitation, UCL Queen Square Institute of Neurology, London, UK; 4Bristol Medical School, Faculty of Health Sciences, University of Bristol, Bristol, UK
Correspondence: Kanza Tariq kanza.tariq@nhs.net
A121 Validation and Application of In Silico and In Vitro Modelling to Optimize Cerebrospinal Fluid Drug Delivery to the Brain
Bryn A. Martin1,2, Lucas Sass1, Mohammadreza Khani1, Ostin Arters1, Stuart Sater1, Gabryel Conley Natividad1, Omolola Bangudu1, Katie Warthen1, Howard Dobson3, Scott Haller4, Richard Watts5, Kathrin Meyer1,6, Deep Singh1
1Alcyone Therapeutics, Lowell, USA; 2University of Idaho, Moscow, ID, USA; 3InVicro Research Organization; 4Charles River Laboratory; 5Dept of Psychology, Yale University, 6Center for Gene Therapy, The Abigail Wexner Research Institute at Nationwide Children’s Hospital, Department of Pediatrics, The Ohio State University, Ohio, USA
Correspondence: Bryn A. Martin, bryn@alcyonetx.com
A122 Quantification of Regional Neural Tissue Strain in Type I Chiari Malformation
Gwendolyn Williams1, Michael Meggyesy1, Dipankar Biswas1, Bryn Martin2, Mark Luciano1, Ari Blitz3, John Oshinski4
1Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA; 2Alycone Therapeutics, Inc., Lowell, MA, 01852, USA; 3Department of Radiology, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA; 4Department of Radiology & Imaging Science and Biomedical Engineering, Emory University, Atlanta, GA, 30322, USA
Correspondence: Gwendolyn Williams, gwilli85@jh.edu
A123 Correlation of cerebrospinal fluid and plasma adipokines in obese versus non-obese idiopathic intracranial hypertension (IIH) patients
Sara Ho, Aida Kamalian, Abhay Moghekar
1Department of Neurology, Johns HopkinsUniversity, Baltimore, MD, 21224, USA
Correspondence: Abhay Moghekar, am@jhmi.edu
A124 A comparison of outcomes between pediatric and adult patients with idiopathic intracranial hypertension (IIH)
Thaddeus Harbaugh, Manvita Mareboina, Derek Barnett, Elias Rizk
1Department of Neurosurgery, Penn State Hershey Medical Center, Pennsylvania, 17033, USA
Correspondence: Thaddeus Daniel Harbaugh, tdh5264@psu.edu
A125 Long-term outcomes after dural venous stenting in Idiopathic intracranial hypertension: a single centre experience
Muhammad A. Kamal, Zeid Abussuud, Natasha Angadi, Ahmed Toma
1Victor Horsley Department of Neurosurgery, National Hospital for Neurosurgery and Neurosurgery, London UK
Correspondence: Muhammad Ahmad Kamal, muhammadakamal@hotmail.com
A126 IIH Intervention: opening of a randomised clinical trial comparing Dural Venous Sinus Stenting with Cerebrospinal Fluid shunting in Idiopathic Intracranial Hypertension
Gopiga Thanabalasundaram1, Ahmed Toma2, Fergus Robertson3, Phil White4, Susan P. Mollan5,6, Alexandra J. Sinclair6,7, Georgios Tsermoulas1,6
1Department of Neurosurgery, Queen Elizabeth Hospital Birmingham, United Kingdom; 2Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, United Kingdom; 3Department of Neuro-Radiology, National Hospital for Neurology and Neurosurgery, London, United Kingdom; 4Department of Neuro-Radiology, Royal Victoria Infirmary, Newcastle-Upon-Tyne, United Kingdom; 5Birmingham Neuro-Ophthalmology, Queen Elizabeth Hospital Birmingham, United Kingdom; 6Institute of Metabolism and Systems Research, University of Birmingham, United Kingdom; 7Department of Neurology, Queen Elizabeth Hospital Birmingham, United Kingdom
Correspondence: Georgios Tsermoulas, georgios.tsermoulas@nhs.net
A127 ICP dynamics during movement in Chiari malformation and idiopathic intracranial hypertension
Eleanor M. Moncur1,2, Matthew J. Bancroft2, Linda D’Antona1,2, Graziella Favarato2, Lewis Thorne1, Laurence D. Watkins1, Ahmed K. Toma1,2
1Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, WC1N3BG, UK; 2Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, University College London, London, WC1N3BG, UK
Correspondence: Eleanor Moncur, e.moncur@nhs.net
A128 Synthetic MRI: a fast and reliable method for ventricular volumetry
Rafael T. Holmgren1, Anders Tisell2, Marcel Warntjes3, Charalampos Georgiopoulos4
1Department of Neurosurgery, and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden; 2Department of medical radiation physics, and department of caring sciences, Linköping University. Center for medical image science and visualization (CMIV), Linköping University, Sweden; 3Center for medical image science and visualization (CMIV), Linköping University. SyntheticMR AB, Linköping, Sweden; 4Diagnostic Radiology, Department of Clinical Sciences, Medical Faculty, Lund University, Lund, Sweden
Correspondence: Rafael T. Holmgren, Rafael.holmgren@gmail.com
A129 Non-invasive phase-contrast MRI in idiopathic intracranial hypertension - first promising data from a prospective study
Katharina Wolf1,2, Wolf Lagrèze3, Marco Reisert4, Alexandra Camp3, Tim Bleul3, Mukesh Shah2, Hansjörg Mast5, Sebastian Küchlin3, Samer Elsheikh5, Niklas Lützen5, Jürgen Beck2, Horst Urbach5
1Department of Neurology, Medical Center, University of Freiburg, 79106, Germany; 2Department of Neurosurgery, Medical Center, University of Freiburg, 79106, Germany; 3Department of Ophthalmology, Medical Center, University of Freiburg, 79106, Germany; 4Department of Radiology, Medical Physics, Medical Center, University of Freiburg, 79106, Germany; 5Department of Neuroradiology, Medical Center, University of Freiburg, 79106, Germany
Correspondence: Dr. Katharina Wolf, katharina.wolf@uniklinik-freiburg.de
A130 Cerebral arterial dynamic in hydrocephalus patients
Kimi P. Owashi1, Cyrille Capel1,2, Serge Metanbou3, Zofia Czosnyka5, Marek Czosnyka5, Peter Smielewski5, Alexis Joannides5, Olivier Balédent1,4
1CHIMERE UR7516, Jules Verne University, Amiens, France; 2Neurosurgery, University Hospital, Amiens, France; 3Radiology, University Hospital, Amiens, France; 4Image processing, University Hospital, Amiens, France; 5Department of Clinical Neurosciences, University of Cambridge, UK
Correspondence: Kimi Piedad Owashi, kimi.owashi@u-picardie.fr
A131 Intracranial CSF-ISF Flow Patterns in Large Animal Model
Michael Meggyesy1, Di Cao2,3,4, Dipankar Biswas1, Gwendolyn Williams1, Enoch Kim5, Jun Hua2,3, Mark G. Luciano1
1Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA; 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA; 3Neurosection, Division of MRI Research, Department of Radiology, Johns Hopkins, Baltimore, MD, USA; 4Department of Biomedical Engineering, Johns Hopkins, Baltimore, MD, USA; 5Nova Southeastern University Dr. Kiran C. Patel College of Allopathic Medicine, Fort Lauderdale, FL, 33314, USA
Correspondence: Michael Meggyesy, mmeggye1@jhmi.edu
A132 Optic nerve sheath diameter distension in normal pressure hydrocephalus: a potential marker for shunt responsiveness
Linda D’Antona1,2, Zeid Abussuud1, David Rowland1, Eleanor Moncour1,2, Kanza Tariq1,2, Lucia Darie1, Aleksandra Lasica2, Lewis Thorne1, Laurence Watkins1,2, Ahmed Toma1,2
1Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, WC1N3BG, UK; 2Queen Square Institute of Neurology, University College London, London, WC1N3BG, UK
Correspondence: Linda D’Antona, linda.d’antona@nhs.net
A133 Potential impact of non-invasive phase-contrast MRI in the diagnosis of spontaneous intracranial hypotension (SIH)
Katharina Wolf1, Niklas Lützen2, Marco Reisert3, Hansjörg Mast2, Florian Volz1, Amir El Rahal1, Christian Fung1, Jürgen Beck1, Horst Urbach2
1Department of Neurosurgery, Medical Center, University of Freiburg, 79106, Germany; 2Department of Neuroradiology, Medical Center, University of Freiburg, 79106, Germany; 3Department of Radiology, Medical Physics, Medical Center, University of Freiburg, 79106, Germany
Correspondence: Dr. Katharina Wolf, katharina.wolf@uniklinik-freiburg.de Full
A134 Reversible dementia project (REVERT): impact on improvement in awareness, diagnosis and management of normal pressure hydrocephalus
Peter Smielewski1, Alexis J. Joannides1,3, Cyrille Capel4, Yael Fregier5, Michael Martin6, Zofia Czosnyka1,3, Olivier Peltre5, Michal Placek1, Kimi Owashi2, Pan Liu4, Serge Metanbo4, Rocio Fernandez-Mendez3, Toby Meek3, Lisa Healy3, Benjamin Dias-Dougan3, Rebecca Reece3, Romuald Seizeur7, Alin Bohra8, Marija Drinjakovic1, John Pickard3, Marek Czosnyka1,3, Olivier Baledent2,4
1Brain Physics Laboratory, Department of Clinical Neurosciences, University of Cambridge, Cambridge UK; 2CHIMERE Laboratory, University of Picardie Jules Verne, Amiens, France; 3Division of Neurosurgery, Cambridge University Hospitals, Cambridge Biomedical Campus, Cambridge, UK; 4Jules Verne University hospital, Amiens, France; 5Lens Mathematics Laboratory, University of Artois, Arras, France; 6Obex Technologies, Cambridge, UK; 7Neurosurgery Dept, University Hospital of Brest, Brest, France; 8Neurosurgery Dept, University Hospital of Caen, Caen, France
Correspondence: Peter Smielewski, p10011@cam.ac.uk
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insufficient referrals, due to low awareness of the disease in the context of dementia like symptoms
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lack of clear guidelines for optimal diagnostic workup
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incomplete understanding of physiology of pressure-flow-volume relationships in the cerebrospinal space
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inadequate understanding of the interplay between the cerebro-vascular and CSF circulation systems
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limited access and familiarity to advanced supplementary tests (CSF dynamics tests, PC MRI imaging)
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lack of consistent and appropriate outcomes measures to determine improvement after shunting